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Compile Data Set for Download or QSAR

Found 3 hits of ic50 data for polymerid = 50004788   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive cation channel 2, neuronal


(Homo sapiens)
BDBM50096642
PNG
(CHEMBL3577296)
Show SMILES CCN(CC)CCN(Cc1ccc(Cl)cc1)c1ccc2cc(C(N)=N)c(=O)oc2c1
Show InChI InChI=1S/C23H27ClN4O2/c1-3-27(4-2)11-12-28(15-16-5-8-18(24)9-6-16)19-10-7-17-13-20(22(25)26)23(29)30-21(17)14-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H3,25,26)
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PC cid
PC sid
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n/an/a 27n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 6.7 by standard whole cell patch clamp...


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 2, neuronal


(Homo sapiens)
BDBM50348098
PNG
(CHEMBL1800430)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1ccc2CCNCc2c1
Show InChI InChI=1S/C20H17ClN2S/c21-20-17-6-4-14(10-18(17)24-19(20)11-22)2-1-13-3-5-15-7-8-23-12-16(15)9-13/h3-6,9-10,23H,7-8,11-12,22H2
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KEGG

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PC cid
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Article
PubMed
n/an/a 224n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC1a


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 2, neuronal


(Homo sapiens)
BDBM50096642
PNG
(CHEMBL3577296)
Show SMILES CCN(CC)CCN(Cc1ccc(Cl)cc1)c1ccc2cc(C(N)=N)c(=O)oc2c1
Show InChI InChI=1S/C23H27ClN4O2/c1-3-27(4-2)11-12-28(15-16-5-8-18(24)9-6-16)19-10-7-17-13-20(22(25)26)23(29)30-21(17)14-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H3,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
n/an/a 7.34E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 5.0 by standard whole cell patch clamp...


Citation and Details
More data for this
Ligand-Target Pair