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Compile Data Set for Download or QSAR

Found 470 hits of affinity data for UniProtKB/TrEMBL: Q5S007    Zinc 0: unavailable per Zinc DB. Zinc 1: purchasable, 2 weeks to supply. Zinc 2: made on demand. Zinc 4: potentially available
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2152707
PNG
(CHEBI:1523387)
Show SMILES Cn1cc(\C=C\c2n[nH]c3ccnc(OC4CCCCC4)c23)cn1
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
0.3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to LRRK2


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178135
PNG
(CHEBI:1538927)
Show SMILES COc1cc(C(=O)N2CCOCC2)c(F)cc1Nc1ncc(c(NC2CC2)n1)C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
1.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2171743
PNG
(CHEBI:1531240)
Show SMILES CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1Br
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
1.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2171745
PNG
(CHEBI:1531242)
Show SMILES CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
1.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178140
PNG
(CHEBI:1538932)
Show SMILES CCNc1nc(Nc2cc(F)c(cc2OC)C(=O)NCC(C)(C)O)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
1.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178134
PNG
(CHEBI:1538926)
Show SMILES CCNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
1.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178125
PNG
(CHEBI:1538917)
Show SMILES CNc1nc(Nc2cc(OC)c(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
1.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178137
PNG
(CHEBI:1538929)
Show SMILES CNc1nc(Nc2cc(F)c(cc2OC)S(C)(=O)=O)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
2.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178130
PNG
(CHEBI:1538922)
Show SMILES CNc1nc(Nc2cc(C)c(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
2.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2171745
PNG
(CHEBI:1531242)
Show SMILES CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
2.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178124
PNG
(CHEBI:1538916)
Show SMILES CNc1nc(Nc2cc(Cl)c(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
2.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2171743
PNG
(CHEBI:1531240)
Show SMILES CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1Br
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
2.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2152708
PNG
(CHEBI:1523388)
Show SMILES CC(C)Oc1nccc2[nH]nc(-c3cc(C(=O)NC4COC4)n(c3)C(C)C)c12
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
2.4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to LRRK2


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2170016
PNG
(CHEBI:1529495)
Show SMILES CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1Cl
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
3.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178138
PNG
(CHEBI:1538930)
Show SMILES CCNc1nc(Nc2cnc(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
3.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 127
PNG
Show SMILES C1CCN(C1)c1cc(ccn1)C1=NCc2ccnc(OC3CCOCC3)c12 |$;;;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:13|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC sid
AffyNet 
US Patent
3.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 87
PNG
Show SMILES CC(C)n1cc(cc1C(=O)NC1COC1)C1=NCc2ccnc(OC3CCOCC3)c12 |$;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:17|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC sid
AffyNet 
US Patent
3.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178127
PNG
(CHEBI:1538919)
Show SMILES CCNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCOCC2)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
3.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 164
PNG
Show SMILES C1C[C@@H](CO1)n1cc(cn1)C1=NCc2ccnc(OC3CCOCC3)c12 |r,$;;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:12|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC sid
AffyNet 
US Patent
3.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2170016
PNG
(CHEBI:1529495)
Show SMILES CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1Cl
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
3.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178141
PNG
(CHEBI:1538933)
Show SMILES CCNc1nc(Nc2cc3CN(CC(C)(C)O)C(=O)c3cc2OC)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
4.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178126
PNG
(CHEBI:1538918)
Show SMILES CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCOCC2)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
4.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 117
PNG
Show SMILES Cc1cc(cc(C)n1)C1=NCc2ccnc(OC3CCOCC3)c12 |$;;;;;;;;;;HN;;;;;;;;;;;;;$,t:9|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC sid
AffyNet 
US Patent
5.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 163
PNG
Show SMILES C1C[C@H](CO1)n1cc(cn1)C1=CCc2ccnc(OC3CCOCC3)c12 |r,$;;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:12|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC sid
AffyNet 
US Patent
5.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 115
PNG
Show SMILES C1CC(CO1)n1cc(cn1)C1=NCc2ccnc(OC3CCOCC3)c12 |$;;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:12|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC sid
AffyNet 
US Patent
5.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 149
PNG
Show SMILES Clc1ccccc1C#CC1=NCc2ccnc(OC3CCOCC3)c12 |$;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:10|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC sid
AffyNet 
US Patent
5.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178123
PNG
(CHEBI:1538915)
Show SMILES COc1cc(ccc1Nc1ncc(Br)c(OC)n1)C(=O)N1CCOCC1
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
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Article
PubMed
5.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 113
PNG
Show SMILES FC(F)(F)Cn1cc(cn1)C1=NCc2ccnc(OC3CCOCC3)c12 |$;;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:11|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC sid
AffyNet 
US Patent
6.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 128
PNG
Show SMILES CC1CCCN(C1)c1cc(ccn1)C1=NCc2ccnc(OC3CCOCC3)c12 |$;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:15|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC sid
AffyNet 
US Patent
6.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 233
PNG
Show SMILES CC(C)Oc1nccc2CN=C(c3cc(C(=O)N4CCCC4)n(c3)C(C)C)c12 |$;;;;;;;;;HN;;;;;;;;;;;;;;;;;;$,t:10|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC sid
AffyNet 
US Patent
6.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2171748
PNG
(CHEBI:1531245)
Show SMILES CNc1nc(Nc2ccc(cc2)C(=O)N2CCOCC2)ncc1Cl
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
6.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178133
PNG
(CHEBI:1538925)
Show SMILES CNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
6.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2171738
PNG
(CHEBI:1531235)
Show SMILES CNc1nc(Nc2ccccc2OC)ncc1Cl
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
6.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 31
PNG
Show SMILES CN1CCN(CC1)c1cc(ccn1)C1=NCc2ccnc(OC3CCOCC3)c12 |$;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:15|
UniProtKB/SwissProt

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US Patent
6.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 56
PNG
Show SMILES C1CCC(C1)n1cc(cn1)C1=NCc2ccnc(OC3CCOCC3)c12 |$;;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:12|
UniProtKB/SwissProt

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US Patent
6.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 192
PNG
Show SMILES Cn1cccc(NC2=NCc3ccnc(OC4CCOCC4)c23)c1=O |$;;;;;;;;;HN;;;;;;;;;;;;;;;$,t:7|
UniProtKB/SwissProt

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US Patent
7.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2171741
PNG
(CHEBI:1531238)
Show SMILES CNc1nc(Nc2ccc(cc2C)C(=O)N2CCOCC2)ncc1Cl
PDB
MMDB

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UniProtKB/TrEMBL

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7.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 185
PNG
Show SMILES CC(C)c1nnc([nH]1)C1=NCc2ccnc(NC3CCOCC3)c12 |$;;;;;;;;;;HN;;;;;;;;;;;;;$,t:9|
UniProtKB/SwissProt

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US Patent
7.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2171740
PNG
(CHEBI:1531237)
Show SMILES CNc1nc(Nc2ccccc2OC(F)F)ncc1Cl
PDB
MMDB

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Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178129
PNG
(CHEBI:1538921)
Show SMILES CNc1nc(Nc2cc(C)c(cc2Cl)C(=O)N2CCOCC2)ncc1C(F)(F)F
PDB
MMDB

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Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 241
PNG
Show SMILES CC(C)n1cc(cn1)C1=NCc2ccnc(OC3CCOC3)c12 |$;;;;;;;;;;HN;;;;;;;;;;;;$,t:9|
UniProtKB/SwissProt

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US Patent
7.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178131
PNG
(CHEBI:1538923)
Show SMILES CNc1nc(Nc2cc(OC)c(cc2F)C(=O)N2CCOCC2)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
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7.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178136
PNG
(CHEBI:1538928)
Show SMILES CNc1nc(Nc2ccc(cc2Cl)-c2nnnn2C)ncc1C(F)(F)F
PDB
MMDB

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Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 235
PNG
Show SMILES CC(C)n1cc(cc1C(=O)N1CCC1)C1=NCc2ccnc(OC3CCOCC3)c12 |$;;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:16|
UniProtKB/SwissProt

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US Patent
8.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 218
PNG
Show SMILES N#Cc1cccc(c1)-c1cc(ccn1)C1=NCc2ccnc(OC3CCOCC3)c12 |$;;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:16|
UniProtKB/SwissProt

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US Patent
9.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178142
PNG
(CHEBI:1538934)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(OC)n1)C(=O)N1CCOCC1
PDB
MMDB

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Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens)
CHEMBL2178139
PNG
(CHEBI:1538931)
Show SMILES CNc1nc(Nc2cnc(cc2OC)C2CCOCC2)ncc1C(F)(F)F
PDB
MMDB

UniProtKB/SwissProt
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9.0n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay


Citation and Details

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 229
PNG
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc(ccn1)C1=NCc2ccnc(OC3CCOCC3)c12 |$;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:19|
UniProtKB/SwissProt

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US Patent
9.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 131
PNG
Show SMILES C1CN(C1)c1cc(ccn1)C1=NCc2ccnc(OC3CCOCC3)c12 |$;;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:12|
UniProtKB/SwissProt

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US Patent
9.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
US8569281, 146
PNG
Show SMILES C1CC(CO1)n1cnc2cc(ccc12)C1=NCc2ccnc(OC3CCOCC3)c12 |$;;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;$,t:17|
UniProtKB/SwissProt

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10.0n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)

More data for this
Ligand-Target Pair
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