BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 889 hits of affinity data for UniProtKB/TrEMBL: P06213   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin receptor


(Homo sapiens)
BDBM50256480
PNG
(CHEMBL466397 | N-(2,6-difluorophenyl)-5-(3-(2-(5-e...)
Show SMILES CCc1cc(Nc2nccc(n2)-c2c(nc3ccccn23)-c2ccc(OC)c(c2)C(=O)Nc2c(F)cccc2F)c(OC)cc1N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C44H47F2N9O5S/c1-5-28-26-35(38(60-3)27-36(28)53-19-15-30(16-20-53)52-21-23-54(24-22-52)61(4,57)58)49-44-47-17-14-34(48-44)42-40(50-39-11-6-7-18-55(39)42)29-12-13-37(59-2)31(25-29)43(56)51-41-32(45)9-8-10-33(41)46/h6-14,17-18,25-27,30H,5,15-16,19-24H2,1-4H3,(H,51,56)(H,47,48,49)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
1.3n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to insulin receptor by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50256478
PNG
(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Show SMILES COc1cc(ccc1Nc1nccc(n1)-c1c(nc2ccccn12)-c1cccc(c1)C(=O)Nc1c(F)cccc1F)N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C41H41F2N9O4S/c1-56-35-26-30(49-19-15-29(16-20-49)50-21-23-51(24-22-50)57(2,54)55)12-13-33(35)45-41-44-17-14-34(46-41)39-37(47-36-11-3-4-18-52(36)39)27-7-5-8-28(25-27)40(53)48-38-31(42)9-6-10-32(38)43/h3-14,17-18,25-26,29H,15-16,19-24H2,1-2H3,(H,48,53)(H,44,45,46)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
2.2n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to insulin receptor by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50341519
PNG
((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1
Show InChI InChI=1S/C26H31N7O2/c1-27-24-16-28-15-23(30-24)19-13-22(26(35)29-14-19)31-25(34)18-6-8-20(9-7-18)33-12-4-5-21(33)17-32-10-2-3-11-32/h6-9,13-16,21H,2-5,10-12,17H2,1H3,(H,27,30)(H,29,35)(H,31,34)/t21-/m0/s1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
>1000.0n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of IR


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM15236
PNG
(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
Purchase

ChEBI
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars


Cmpd Page

AffyNet 
Article
2600.0n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of heterologously expressed human cytochrome P450 1A2.


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
>5238.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of INSR


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50181669
PNG
(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3cc(c[nH]c3=O)-c3ccc4OCOc4c3)cc2)CC1
Show InChI InChI=1S/C25H26N4O4/c1-28-8-10-29(11-9-28)15-17-2-5-20(6-3-17)27-25(31)21-12-19(14-26-24(21)30)18-4-7-22-23(13-18)33-16-32-22/h2-7,12-14H,8-11,15-16H2,1H3,(H,26,30)(H,27,31)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
5300.0n/an/an/an/an/an/an/an/a



ChemBridge Research Laboratories and ChemBridge Corporation

Curated by ChEMBL


Assay Description
Binding affinity for Melatonin receptor using 2-[125I]-iodomelatonin as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50181670
PNG
(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2cc(c[nH]c2=O)-c2ccc3OCOc3c2)cc1
Show InChI InChI=1S/C24H24N4O4/c1-27-8-10-28(11-9-27)19-5-3-18(4-6-19)26-24(30)20-12-17(14-25-23(20)29)16-2-7-21-22(13-16)32-15-31-21/h2-7,12-14H,8-11,15H2,1H3,(H,25,29)(H,26,30)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
8800.0n/an/an/an/an/an/an/an/a



ChemBridge Research Laboratories and ChemBridge Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against IRK


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50181675
PNG
(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Show SMILES CN1CCN(CCCc2ccc(NC(=O)c3cc(c[nH]c3=O)-c3ccc4OCOc4c3)cc2)CC1
Show InChI InChI=1S/C27H30N4O4/c1-30-11-13-31(14-12-30)10-2-3-19-4-7-22(8-5-19)29-27(33)23-15-21(17-28-26(23)32)20-6-9-24-25(16-20)35-18-34-24/h4-9,15-17H,2-3,10-14,18H2,1H3,(H,28,32)(H,29,33)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
9000.0n/an/an/an/an/an/an/an/a



ChemBridge Research Laboratories and ChemBridge Corporation

Curated by ChEMBL


Assay Description
Binding affinity for Melatonin receptor using 2-[125I]-iodomelatonin as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50265869
PNG
(3-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...)
Show SMILES COc1cc2CCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2ccsc2C(N)=O)c2cc[nH]c2n1
Show InChI InChI=1S/C24H26N8O3S/c1-31(2)12-19(33)32-8-5-13-10-18(35-3)16(11-17(13)32)28-24-29-22-14(4-7-26-22)23(30-24)27-15-6-9-36-20(15)21(25)34/h4,6-7,9-11H,5,8,12H2,1-3H3,(H2,25,34)(H3,26,27,28,29,30)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of IR


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50265888
PNG
(3-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...)
Show SMILES COc1cc2CCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2ccoc2C(N)=O)c2cc[nH]c2n1
Show InChI InChI=1S/C24H26N8O4/c1-31(2)12-19(33)32-8-5-13-10-18(35-3)16(11-17(13)32)28-24-29-22-14(4-7-26-22)23(30-24)27-15-6-9-36-20(15)21(25)34/h4,6-7,9-11H,5,8,12H2,1-3H3,(H2,25,34)(H3,26,27,28,29,30)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.8n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of IR


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50340121
PNG
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 3.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Affinity towards human Opioid receptor delta 1 on CHO cell membranes using [3H]-DPDPE displacement.


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50363711
PNG
(CHEMBL370967)
Show SMILES CN(C)c1ccc(\C=C\c2sc3ccccc3[n+]2C)cc1
Show InChI InChI=1S/C18H19N2S/c1-19(2)15-11-8-14(9-12-15)10-13-18-20(3)16-6-4-5-7-17(16)21-18/h4-13H,1-3H3/q+1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 3.0n/an/an/an/an/an/a



The Ohio State University College of Medicine

Curated by ChEMBL


Assay Description
Displacement of thioflavin T from insulin receptor by thioflavin-T fluorescent dye assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50334080
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CN1c2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(N)=O)n3)cc2CCCC1=O
Show InChI InChI=1S/C22H21ClN6O2/c1-29-18-10-9-14(11-13(18)5-4-8-19(29)30)26-22-25-12-16(23)21(28-22)27-17-7-3-2-6-15(17)20(24)31/h2-3,6-7,9-12H,4-5,8H2,1H3,(H2,24,31)(H2,25,26,27,28)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.0n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of IR kinase


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50311921
PNG
(CHEMBL1086731 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)
Show SMILES Cc1ccc(NC(=O)c2ccc(s2)C(C)(C)C)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1
Show InChI InChI=1S/C27H27N7OS/c1-16-9-10-17(31-25(35)21-11-12-22(36-21)27(2,3)4)13-19(16)33-26-32-18-7-5-6-8-20(18)34(26)24-14-23(28)29-15-30-24/h5-15H,1-4H3,(H,31,35)(H,32,33)(H2,28,29,30)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 4.0n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Inhibition of Tel-fused InsR expressed in mouse BAF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50256478
PNG
(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Show SMILES COc1cc(ccc1Nc1nccc(n1)-c1c(nc2ccccn12)-c1cccc(c1)C(=O)Nc1c(F)cccc1F)N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C41H41F2N9O4S/c1-56-35-26-30(49-19-15-29(16-20-49)50-21-23-51(24-22-50)57(2,54)55)12-13-33(35)45-41-44-17-14-34(46-41)39-37(47-36-11-3-4-18-52(36)39)27-7-5-8-28(25-27)40(53)48-38-31(42)9-6-10-32(38)43/h3-14,17-18,25-26,29H,15-16,19-24H2,1-2H3,(H,48,53)(H,44,45,46)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 5.0n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged insulin receptor expressed in baculovirus by time-resolved fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50363712
PNG
(CHEMBL1945931)
Show SMILES CN(C)c1ccc(\C=C\c2sc3ccc(Cl)cc3[n+]2C)cc1
Show InChI InChI=1S/C18H18ClN2S/c1-20(2)15-8-4-13(5-9-15)6-11-18-21(3)16-12-14(19)7-10-17(16)22-18/h4-12H,1-3H3/q+1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 5.2n/an/an/an/an/an/a



The Ohio State University College of Medicine

Curated by ChEMBL


Assay Description
Displacement of thioflavin T from insulin receptor by thioflavin-T fluorescent dye assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50363710
PNG
(CHEMBL370968)
Show SMILES CC[n+]1c(\C=C\c2ccc(cc2)N(C)C)sc2ccccc12
Show InChI InChI=1S/C19H21N2S/c1-4-21-17-7-5-6-8-18(17)22-19(21)14-11-15-9-12-16(13-10-15)20(2)3/h5-14H,4H2,1-3H3/q+1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 6.0n/an/an/an/an/an/a



The Ohio State University College of Medicine

Curated by ChEMBL


Assay Description
Displacement of thioflavin T from insulin receptor by thioflavin-T fluorescent dye assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50363715
PNG
(CHEMBL1944955)
Show SMILES CN(C)c1ccc(\C=C\c2sc3cc(C)ccc3[n+]2C)cc1
Show InChI InChI=1S/C19H21N2S/c1-14-5-11-17-18(13-14)22-19(21(17)4)12-8-15-6-9-16(10-7-15)20(2)3/h5-13H,1-4H3/q+1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 6.0n/an/an/an/an/an/a



The Ohio State University College of Medicine

Curated by ChEMBL


Assay Description
Displacement of thioflavin T from insulin receptor by thioflavin-T fluorescent dye assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50436850
PNG
(CERITINIB | CHEMBL2403108)
Show SMILES CC(C)Oc1cc(C2CCNCC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1
Show InChI InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 7.0n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor (unknown origin) after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50256479
PNG
(CHEMBL448929 | N-(2,6-difluorophenyl)-3-(3-(2-(5-e...)
Show SMILES CCc1cc(Nc2nccc(n2)-c2c(nc3ccccn23)-c2cccc(c2)C(=O)Nc2c(F)cccc2F)c(OC)cc1N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C43H45F2N9O4S/c1-4-28-26-35(37(58-2)27-36(28)52-19-15-31(16-20-52)51-21-23-53(24-22-51)59(3,56)57)48-43-46-17-14-34(47-43)41-39(49-38-13-5-6-18-54(38)41)29-9-7-10-30(25-29)42(55)50-40-32(44)11-8-12-33(40)45/h5-14,17-18,25-27,31H,4,15-16,19-24H2,1-3H3,(H,50,55)(H,46,47,48)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 7.0n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged insulin receptor expressed in baculovirus by time-resolved fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50363714
PNG
(CHEMBL1944954)
Show SMILES CN(C)c1ccc(\C=C\c2sc3ccc(C)cc3[n+]2C)cc1
Show InChI InChI=1S/C19H21N2S/c1-14-5-11-18-17(13-14)21(4)19(22-18)12-8-15-6-9-16(10-7-15)20(2)3/h5-13H,1-4H3/q+1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 7.5n/an/an/an/an/an/a



The Ohio State University College of Medicine

Curated by ChEMBL


Assay Description
Displacement of thioflavin T from insulin receptor by thioflavin-T fluorescent dye assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50334082
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CN1c2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NCC#C)n3)cc2CCCC1=O
Show InChI InChI=1S/C25H23ClN6O2/c1-3-13-27-24(34)18-8-4-5-9-20(18)30-23-19(26)15-28-25(31-23)29-17-11-12-21-16(14-17)7-6-10-22(33)32(21)2/h1,4-5,8-9,11-12,14-15H,6-7,10,13H2,2H3,(H,27,34)(H2,28,29,30,31)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 8.0n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of IR kinase


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50363716
PNG
(CHEMBL1944956)
Show SMILES COc1ccc2[n+](C)c(\C=C\c3ccc(cc3)N(C)C)sc2c1
Show InChI InChI=1S/C19H21N2OS/c1-20(2)15-8-5-14(6-9-15)7-12-19-21(3)17-11-10-16(22-4)13-18(17)23-19/h5-13H,1-4H3/q+1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 8.0n/an/an/an/an/an/a



The Ohio State University College of Medicine

Curated by ChEMBL


Assay Description
Displacement of thioflavin T from insulin receptor by thioflavin-T fluorescent dye assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
Purchase

ChEBI
CHEMBL
IUPHAR‑DB
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars


Cmpd Page

AffyNet 
Article
PubMed
n/an/a 8.5n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50349687
PNG
(CHEMBL1809044)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C24H24ClN7O2/c1-16(33)30-9-11-31(12-10-30)17-6-7-19(21(13-17)34-2)28-24-27-14-18(25)23(29-24)20-15-26-22-5-3-4-8-32(20)22/h3-8,13-15H,9-12H2,1-2H3,(H,27,28,29)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 9.0n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Concentration required for inhibition of human serine dependent Phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50363721
PNG
(CHEMBL1944960)
Show SMILES COc1ccc2[n+](C)c(\N=N\c3ccc(cc3)N(C)C)sc2c1
Show InChI InChI=1S/C17H19N4OS/c1-20(2)13-7-5-12(6-8-13)18-19-17-21(3)15-10-9-14(22-4)11-16(15)23-17/h5-11H,1-4H3/q+1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 10.0n/an/an/an/an/an/a



The Ohio State University College of Medicine

Curated by ChEMBL


Assay Description
Displacement of thioflavin T from insulin receptor by thioflavin-T fluorescent dye assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50385593
PNG
(CHEMBL2042694)
Show SMILES CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3N(C)C(=O)CCCc3c2)ncc1Cl
Show InChI InChI=1S/C22H23ClN6O3S/c1-24-33(31,32)19-8-4-3-7-17(19)27-21-16(23)13-25-22(28-21)26-15-10-11-18-14(12-15)6-5-9-20(30)29(18)2/h3-4,7-8,10-13,24H,5-6,9H2,1-2H3,(H2,25,26,27,28)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 10.0n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of insulin receptor


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50383191
PNG
(CHEMBL2031893)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C29H25FN4O5/c1-17-27(29(36)34(33(17)2)19-8-6-5-7-9-19)28(35)32-18-10-11-24(21(30)14-18)39-23-12-13-31-22-16-26(38-4)25(37-3)15-20(22)23/h5-16H,1-4H3,(H,32,35)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 10.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IRK


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50442757
PNG
(CHEMBL2443026)
Show SMILES CN(C)c1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(CC2)C2CCC3(CC2)OCCO3)cc1
Show InChI InChI=1S/C31H38N4O7/c1-34(2)21-3-5-24(6-4-21)41-27-18-23(36)17-26(37)29(27)28-19-25(33-42-28)30(38)32-20-9-13-35(14-10-20)22-7-11-31(12-8-22)39-15-16-40-31/h3-6,17-20,22,36-37H,7-16H2,1-2H3,(H,32,38)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>10.0n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of IR (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50442758
PNG
(CHEMBL2443139)
Show SMILES CC(C)Nc1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(C)CC2)cc1
Show InChI InChI=1S/C25H30N4O5/c1-15(2)26-16-4-6-19(7-5-16)33-22-13-18(30)12-21(31)24(22)23-14-20(28-34-23)25(32)27-17-8-10-29(3)11-9-17/h4-7,12-15,17,26,30-31H,8-11H2,1-3H3,(H,27,32)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>10.0n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of IR (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50442759
PNG
(CHEMBL2443138)
Show SMILES CN(C)c1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(C)CC2)cc1
Show InChI InChI=1S/C24H28N4O5/c1-27(2)16-4-6-18(7-5-16)32-21-13-17(29)12-20(30)23(21)22-14-19(26-33-22)24(31)25-15-8-10-28(3)11-9-15/h4-7,12-15,29-30H,8-11H2,1-3H3,(H,25,31)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>10.0n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of IR (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50442760
PNG
(CHEMBL2443044)
Show SMILES CN1CCC(CC1)NC(=O)c1cc(on1)-c1c(O)cc(O)cc1Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C22H22N4O7/c1-25-8-6-13(7-9-25)23-22(29)17-12-20(33-24-17)21-18(28)10-15(27)11-19(21)32-16-4-2-14(3-5-16)26(30)31/h2-5,10-13,27-28H,6-9H2,1H3,(H,23,29)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>10.0n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of IR (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50363713
PNG
(CHEMBL1944953)
Show SMILES CN(C)c1ccc(\C=C\c2sc3ccc(F)cc3[n+]2C)cc1
Show InChI InChI=1S/C18H18FN2S/c1-20(2)15-8-4-13(5-9-15)6-11-18-21(3)16-12-14(19)7-10-17(16)22-18/h4-12H,1-3H3/q+1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 10.0n/an/an/an/an/an/a



The Ohio State University College of Medicine

Curated by ChEMBL


Assay Description
Displacement of thioflavin T from insulin receptor by thioflavin-T fluorescent dye assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50334086
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CCCNC(=O)c1ccccc1Nc1nc(Nc2ccc3N(C)C(=O)CCCc3c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN6O2/c1-3-13-27-24(34)18-8-4-5-9-20(18)30-23-19(26)15-28-25(31-23)29-17-11-12-21-16(14-17)7-6-10-22(33)32(21)2/h4-5,8-9,11-12,14-15H,3,6-7,10,13H2,1-2H3,(H,27,34)(H2,28,29,30,31)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 11.0n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of IR kinase


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50349687
PNG
(CHEMBL1809044)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C24H24ClN7O2/c1-16(33)30-9-11-31(12-10-30)17-6-7-19(21(13-17)34-2)28-24-27-14-18(25)23(29-24)20-15-26-22-5-3-4-8-32(20)22/h3-8,13-15H,9-12H2,1-2H3,(H,27,28,29)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 12.0n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Concentration required for inhibition of human serine dependent Phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50385602
PNG
(CHEMBL2042983)
Show SMILES CCN1c2cc(OC)c(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)cc2CCCC1=O
Show InChI InChI=1S/C26H30ClN5O4S/c1-5-32-21-14-22(36-4)20(13-17(21)9-8-12-24(32)33)30-26-28-15-18(27)25(31-26)29-19-10-6-7-11-23(19)37(34,35)16(2)3/h6-7,10-11,13-16H,5,8-9,12H2,1-4H3,(H2,28,29,30,31)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 12.0n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of insulin receptor


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50363717
PNG
(CHEMBL1944957)
Show SMILES CN(C)c1ccc(\C=C\c2sc3cc(ccc3[n+]2C)[N+]([O-])=O)cc1
Show InChI InChI=1S/C18H18N3O2S/c1-19(2)14-7-4-13(5-8-14)6-11-18-20(3)16-10-9-15(21(22)23)12-17(16)24-18/h4-12H,1-3H3/q+1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 12.0n/an/an/an/an/an/a



The Ohio State University College of Medicine

Curated by ChEMBL


Assay Description
Displacement of thioflavin T from insulin receptor by thioflavin-T fluorescent dye assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50363723
PNG
(CHEMBL1906225)
Show SMILES CN(C)c1ccc(\C=C\c2sc3ccccc3[n+]2Cc2ccccc2)cc1
Show InChI InChI=1S/C24H23N2S/c1-25(2)21-15-12-19(13-16-21)14-17-24-26(18-20-8-4-3-5-9-20)22-10-6-7-11-23(22)27-24/h3-17H,18H2,1-2H3/q+1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 12.0n/an/an/an/an/an/a



The Ohio State University College of Medicine

Curated by ChEMBL


Assay Description
Displacement of thioflavin T from insulin receptor by thioflavin-T fluorescent dye assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50363724
PNG
(CHEMBL1944962)
Show SMILES CN(C)c1ccc(\C=C\c2sc3ccccc3[n+]2C2CC2)cc1
Show InChI InChI=1S/C20H21N2S/c1-21(2)16-10-7-15(8-11-16)9-14-20-22(17-12-13-17)18-5-3-4-6-19(18)23-20/h3-11,14,17H,12-13H2,1-2H3/q+1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 12.0n/an/an/an/an/an/a



The Ohio State University College of Medicine

Curated by ChEMBL


Assay Description
Displacement of thioflavin T from insulin receptor by thioflavin-T fluorescent dye assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50363742
PNG
(CHEMBL1946209)
Show SMILES CN(C)c1ccc(\C=C\c2sc3ccccc3[n+]2Cc2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C28H25N2S/c1-29(2)25-16-12-21(13-17-25)14-18-28-30(26-9-5-6-10-27(26)31-28)20-22-11-15-23-7-3-4-8-24(23)19-22/h3-19H,20H2,1-2H3/q+1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 13.0n/an/an/an/an/an/a



The Ohio State University College of Medicine

Curated by ChEMBL


Assay Description
Displacement of thioflavin T from insulin receptor by thioflavin-T fluorescent dye assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50315887
PNG
((1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidaz...)
Show SMILES C[C@@]1(O)C[C@@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12
Show InChI InChI=1S/C26H23N5O/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16/h2-13,19,32H,14-15H2,1H3,(H2,27,28)/t19-,26+
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
n/an/a 18.0n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human testicular steroid 17-alpha-hydroxylase


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50256480
PNG
(CHEMBL466397 | N-(2,6-difluorophenyl)-5-(3-(2-(5-e...)
Show SMILES CCc1cc(Nc2nccc(n2)-c2c(nc3ccccn23)-c2ccc(OC)c(c2)C(=O)Nc2c(F)cccc2F)c(OC)cc1N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C44H47F2N9O5S/c1-5-28-26-35(38(60-3)27-36(28)53-19-15-30(16-20-53)52-21-23-54(24-22-52)61(4,57)58)49-44-47-17-14-34(48-44)42-40(50-39-11-6-7-18-55(39)42)29-12-13-37(59-2)31(25-29)43(56)51-41-32(45)9-8-10-33(41)46/h6-14,17-18,25-27,30H,5,15-16,19-24H2,1-4H3,(H,51,56)(H,47,48,49)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 19.0n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacing 125 I-deltorphin II


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50353051
PNG
(CHEMBL1822514)
Show SMILES COCCN1CCc2ccc(Nc3ncc4ccc(-c5ccccc5)n4n3)cc2CC1
Show InChI InChI=1S/C25H27N5O/c1-31-16-15-29-13-11-19-7-8-22(17-21(19)12-14-29)27-25-26-18-23-9-10-24(30(23)28-25)20-5-3-2-4-6-20/h2-10,17-18H,11-16H2,1H3,(H,27,28)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 19.0n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50333558
PNG
(2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl
Show InChI InChI=1S/C25H29ClN6O2/c1-27-24(33)20-5-3-4-6-22(20)30-23-21(26)16-28-25(31-23)29-19-8-7-17-9-11-32(13-14-34-2)12-10-18(17)15-19/h3-8,15-16H,9-14H2,1-2H3,(H,27,33)(H2,28,29,30,31)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 20.0n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50242742
PNG
(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
Purchase

CHEMBL
IUPHAR‑DB
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 20.0n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of InsR


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50334081
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3N(C)C(=O)CCCc3c2)ncc1Cl
Show InChI InChI=1S/C23H23ClN6O2/c1-25-22(32)16-7-3-4-8-18(16)28-21-17(24)13-26-23(29-21)27-15-10-11-19-14(12-15)6-5-9-20(31)30(19)2/h3-4,7-8,10-13H,5-6,9H2,1-2H3,(H,25,32)(H2,26,27,28,29)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 23.0n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of IR kinase


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50334081
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3N(C)C(=O)CCCc3c2)ncc1Cl
Show InChI InChI=1S/C23H23ClN6O2/c1-25-22(32)16-7-3-4-8-18(16)28-21-17(24)13-26-23(29-21)27-15-10-11-19-14(12-15)6-5-9-20(31)30(19)2/h3-4,7-8,10-13H,5-6,9H2,1-2H3,(H,25,32)(H2,26,27,28,29)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 23.0n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of insulin receptor


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50340143
PNG
(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Show SMILES C(COc1ccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc1)CN1CCCCC1
Show InChI InChI=1S/C27H30N6O/c1-4-15-33(16-5-1)17-6-18-34-24-11-9-22(10-12-24)31-27-28-14-13-26(32-27)30-23-19-21-7-2-3-8-25(21)29-20-23/h2-3,7-14,19-20H,1,4-6,15-18H2,(H2,28,30,31,32)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 24.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-BTX binding to cardiac voltage-gated sodium channel


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50256480
PNG
(CHEMBL466397 | N-(2,6-difluorophenyl)-5-(3-(2-(5-e...)
Show SMILES CCc1cc(Nc2nccc(n2)-c2c(nc3ccccn23)-c2ccc(OC)c(c2)C(=O)Nc2c(F)cccc2F)c(OC)cc1N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C44H47F2N9O5S/c1-5-28-26-35(38(60-3)27-36(28)53-19-15-30(16-20-53)52-21-23-54(24-22-52)61(4,57)58)49-44-47-17-14-34(48-44)42-40(50-39-11-6-7-18-55(39)42)29-12-13-37(59-2)31(25-29)43(56)51-41-32(45)9-8-10-33(41)46/h6-14,17-18,25-27,30H,5,15-16,19-24H2,1-4H3,(H,51,56)(H,47,48,49)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 25.0n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged insulin receptor expressed in baculovirus by time-resolved fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens)
BDBM50334594
PNG
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)ncc1Cl
Show InChI InChI=1S/C23H25ClN6O3/c1-25-22(31)16-5-3-4-6-18(16)27-21-17(24)14-26-23(29-21)28-19-8-7-15(13-20(19)32-2)30-9-11-33-12-10-30/h3-8,13-14H,9-12H2,1-2H3,(H,25,31)(H2,26,27,28,29)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
Antibodypedia

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 25.0n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 889 total )  |  Next  |  Last  >>
Jump to: