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Found 515 of ic50 for UniProtKB: O15111
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396920(US9981963, Compound 11)
Affinity DataIC50:  6nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50395538(CHEMBL2164410)
Affinity DataIC50:  6.31nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50395536(CHEMBL2164412)
Affinity DataIC50:  6.31nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50395537(CHEMBL2164411)
Affinity DataIC50:  6.31nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50294677(7-(3-fluorophenyl)-N,1-dimethyl-1,6-dihydroimidazo...)
Affinity DataIC50:  7nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50294680(3-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5...)
Affinity DataIC50:  7nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50395531(CHEMBL2164417)
Affinity DataIC50:  7.94nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50294679(7-(3-methoxyphenyl)-N,1-dimethyl-1,6-dihydroimidaz...)
Affinity DataIC50:  8nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396916(US9981963, Compound 7)
Affinity DataIC50:  9nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396918(US9981963, Compound 9)
Affinity DataIC50:  9nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396936(US9981963, Compound 31)
Affinity DataIC50:  9nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396919(US9981963, Compound 10)
Affinity DataIC50:  9nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396924(US9981963, Compound 15)
Affinity DataIC50:  10nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50294681(7-(3-(aminomethyl)phenyl)-N,1-dimethyl-1,6-dihydro...)
Affinity DataIC50:  11nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50576851(CHEMBL1876217)
Affinity DataIC50:  11nMAssay Description:Inhibition of IKKalpha (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50576851(CHEMBL1876217)
Affinity DataIC50:  11nMAssay Description:Inhibition of IKKalpha (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50576853(CHEMBL4859206)
Affinity DataIC50:  11nMAssay Description:Inhibition of IKKalpha (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50576853(CHEMBL4859206)
Affinity DataIC50:  11nMAssay Description:Inhibition of IKKalpha (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50294687(3-methoxy-N-(3-(1-methyl-4-(methylamino)-1,6-dihyd...)
Affinity DataIC50:  12nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50395539(CHEMBL483165)
Affinity DataIC50:  12.6nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50395539(CHEMBL483165)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50294682(CHEMBL552183 | N-(3-(1-methyl-4-(methylamino)-1,6-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396934(US9981963, Compound 25)
Affinity DataIC50:  14nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396922(US9981963, Compound 13)
Affinity DataIC50:  14nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396914(US9981963, Compound 5)
Affinity DataIC50:  16nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50576852(CHEMBL4849098)
Affinity DataIC50:  16nMAssay Description:Inhibition of IKKalpha (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50576852(CHEMBL4849098)
Affinity DataIC50:  16nMAssay Description:Inhibition of IKKalpha (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396923(US9981963, Compound 14)
Affinity DataIC50:  18nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396915(US9981963, Compound 6)
Affinity DataIC50:  19nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396917(US9981963, Compound 8)
Affinity DataIC50:  21nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50294686(CHEMBL562370 | N1-(3-(1-methyl-4-(methylamino)-1,6...)
Affinity DataIC50:  22nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50294683(2-hydroxy-N-(3-(1-methyl-4-(methylamino)-1,6-dihyd...)
Affinity DataIC50:  25nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50149806(2''-Amino-6''-(2-hydroxy-phenyl)-1,2,3,4,5,6-hexah...)
Affinity DataIC50:  25nMAssay Description:Inhibition of I-kappa-B-kinase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50395535(CHEMBL2164413)
Affinity DataIC50:  25.1nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396913(US9981963, Compound 4)
Affinity DataIC50:  28nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396929(US9981963, Compound 20)
Affinity DataIC50:  29nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396935(US9981963, Compound 30)
Affinity DataIC50:  29nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50175701((4-(4-(5-(3-amino-3-methylbutyl)thiophen-2-yl)pyri...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50175690((4-(4-(5-(3-amino-3-ethylpentyl)thiophen-2-yl)pyri...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175690((4-(4-(5-(3-amino-3-ethylpentyl)thiophen-2-yl)pyri...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50395533(CHEMBL2164415)
Affinity DataIC50:  31.6nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50271752(CHEMBL4128114)
Affinity DataIC50:  32nMAssay Description:Inhibition of IKK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50293532(1-(3-(5-(4-(aminomethyl)phenyl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  32nMAssay Description:Inhibition of IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50413877(CHEMBL482540)
Affinity DataIC50:  32nMAssay Description:Inhibition of human recombinant IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50:  33nMAssay Description:Inhibition of IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50294684(CHEMBL560708 | N-(3-(1-methyl-4-(methylamino)-1,6-...)
Affinity DataIC50:  39nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human recombinant IKK-alpha expressed in insect Sf21 cells using phospho-Ulight-IkappaB-alpha as substrate at 30 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50294675(CHEMBL565076 | N,1-dimethyl-7-phenyl-1,6-dihydroim...)
Affinity DataIC50:  40nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175701((4-(4-(5-(3-amino-3-methylbutyl)thiophen-2-yl)pyri...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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