Compile Data Set for Download or QSAR
maximum 50k data
Found 66 of ic50 data for polymerid = 50006095
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50388144(CHEMBL2058177)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of eIF4A1-mediated protein synthesis in human BJAB cells assessed as inhibition of [35S]Met incorporation after 72 hr by scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50576672(CHEMBL4857096)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50576670(CHEMBL4864162)
Affinity DataIC50:  5nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50576669(CHEMBL4855528)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of eIF4A1 in human HAP1 cells assessed as reduction in cell proliferation incubated for 72 hrs by CellTiter-Glo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50576673(CHEMBL4849769)
Affinity DataIC50:  10nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50576672(CHEMBL4857096)
Affinity DataIC50:  11nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)
Affinity DataIC50:  14nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50388144(CHEMBL2058177)
Affinity DataIC50:  20nMAssay Description:Inhibition of eIF4A1-mediated protein synthesis in human BJAB cells assessed as inhibition of [35S]Met incorporation after 1 hr by scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50576670(CHEMBL4864162)
Affinity DataIC50:  21nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50576669(CHEMBL4855528)
Affinity DataIC50:  22nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50576671(CHEMBL4875109)
Affinity DataIC50:  25nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50576673(CHEMBL4849769)
Affinity DataIC50:  32nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  47nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50080528(3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...)
Affinity DataIC50:  87nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50576671(CHEMBL4875109)
Affinity DataIC50:  89nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)
Affinity DataIC50:  92nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50080528(3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...)
Affinity DataIC50:  101nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  135nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50080528(3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...)
Affinity DataIC50:  142nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)
Affinity DataIC50:  204nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)
Affinity DataIC50:  210nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)
Affinity DataIC50:  218nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50080528(3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...)
Affinity DataIC50:  226nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  231nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)
Affinity DataIC50:  369nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)
Affinity DataIC50:  400nMAssay Description:Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)
Affinity DataIC50:  426nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50482563(CHEMBL449854 | Hippurin-1)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50482552(CHEMBL507260)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50482566(CHEMBL1222376)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50482553(CHEMBL1222377)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)
Affinity DataIC50:  3.10E+3nMAssay Description:Ability to displace radioligand [3H]spiperone from human dopamine D3 receptor transfected chinese hamster ovary cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50482550(CHEMBL1222374 | Hippuristanol 11-One)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50482560(CHEMBL1222308 | Hippuristanol 3-Acetate)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50482559(CHEMBL457151)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50482565(CHEMBL1221511)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50482551(CHEMBL1222375 | Hippuristanol 3,11-Dione)
Affinity DataIC50:  5.20E+4nMAssay Description:Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50482557(CHEMBL506697)
Affinity DataIC50:  5.20E+4nMAssay Description:Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50239861(CHEMBL4092701)
Affinity DataIC50:  5.70E+4nMAssay Description:Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50482562(CHEMBL1222309 | Hippuristanol 3,11-Diacetate)
Affinity DataIC50:  6.40E+4nMAssay Description:Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50482558(Hippuristanohemiacetal)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50482567(22-Epi-Hippuristanol | Epihippuristanol)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50235737(CHEMBL4070102)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50235741(CHEMBL4099717)
Affinity DataIC50: >1.00E+5nMAssay Description:Ability to displace radioligand [3H]spiperone from human dopamine D3 receptor transfected chinese hamster ovary cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50265561(CHEMBL4073833)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of eIF4G-induced full-length human recombinant His6-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50239863(CHEMBL4087449)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50239866(CHEMBL4065018)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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