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Compile Data Set for Download or QSAR

Found 24 hits of ic50 data for polymerid = 50006195   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402568
PNG
(CHEMBL2205566)
Show SMILES CCCCc1sc(Nc2ccc(OCCCN(CC)CC)cc2)nc1-c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C32H38ClN3O2S/c1-4-7-9-30-31(24-10-16-28(17-11-24)38-29-18-12-25(33)13-19-29)35-32(39-30)34-26-14-20-27(21-15-26)37-23-8-22-36(5-2)6-3/h10-21H,4-9,22-23H2,1-3H3,(H,34,35)
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n/an/a 550n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402572
PNG
(CHEMBL2205559)
Show SMILES CCCCc1sc(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)-c1ccc(OCC2CCCN(CC)C2)cc1
Show InChI InChI=1S/C33H37ClN2O2S/c1-3-5-8-31-32(25-9-17-29(18-10-25)38-30-19-13-27(34)14-20-30)35-33(39-31)26-11-15-28(16-12-26)37-23-24-7-6-21-36(4-2)22-24/h9-20,24H,3-8,21-23H2,1-2H3
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n/an/a 660n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402565
PNG
(CHEMBL2205572)
Show SMILES CCCCc1sc(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)-c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C31H33ClN2O2S/c1-2-3-6-29-30(23-7-15-27(16-8-23)36-28-17-11-25(32)12-18-28)33-31(37-29)24-9-13-26(14-10-24)35-22-21-34-19-4-5-20-34/h7-18H,2-6,19-22H2,1H3
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n/an/a 910n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402564
PNG
(CHEMBL2205549)
Show SMILES CCCCc1sc(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C32H35ClN2O2S/c1-2-3-7-30-31(24-8-16-28(17-9-24)37-29-18-12-26(33)13-19-29)34-32(38-30)25-10-14-27(15-11-25)36-23-22-35-20-5-4-6-21-35/h8-19H,2-7,20-23H2,1H3
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n/an/a 1.04E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402575
PNG
(CHEMBL2205556)
Show SMILES CCCCc1sc(nc1-c1ccc(OCCCN(CC)CC)cc1)-c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C32H37ClN2O2S/c1-4-7-9-30-31(24-10-16-27(17-11-24)36-23-8-22-35(5-2)6-3)34-32(38-30)25-12-18-28(19-13-25)37-29-20-14-26(33)15-21-29/h10-21H,4-9,22-23H2,1-3H3
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n/an/a 1.12E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402570
PNG
(CHEMBL2205561)
Show SMILES CCCCc1nc(sc1-c1ccc(OCC2CCCN(CC)C2)cc1)-c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C33H37ClN2O2S/c1-3-5-8-31-32(25-9-15-28(16-10-25)37-23-24-7-6-21-36(4-2)22-24)39-33(35-31)26-11-17-29(18-12-26)38-30-19-13-27(34)14-20-30/h9-20,24H,3-8,21-23H2,1-2H3
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n/an/a 1.14E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402563
PNG
(CHEMBL2205550)
Show SMILES CCCCc1sc(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)-c1ccc(OCCN2CCN(C)CC2)cc1
Show InChI InChI=1S/C32H36ClN3O2S/c1-3-4-5-30-31(24-6-14-28(15-7-24)38-29-16-10-26(33)11-17-29)34-32(39-30)25-8-12-27(13-9-25)37-23-22-36-20-18-35(2)19-21-36/h6-17H,3-5,18-23H2,1-2H3
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n/an/a 1.21E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402566
PNG
(CHEMBL2205569)
Show SMILES CCCCc1sc(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)-c1ccc(OCCCN2CCN(C)CC2)cc1
Show InChI InChI=1S/C33H38ClN3O2S/c1-3-4-6-31-32(25-7-15-29(16-8-25)39-30-17-11-27(34)12-18-30)35-33(40-31)26-9-13-28(14-10-26)38-24-5-19-37-22-20-36(2)21-23-37/h7-18H,3-6,19-24H2,1-2H3
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n/an/a 1.24E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402561
PNG
(CHEMBL2205553)
Show SMILES CCCCc1sc(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)-c1ccc(OCCN(CC)CC)cc1
Show InChI InChI=1S/C31H35ClN2O2S/c1-4-7-8-29-30(23-9-17-27(18-10-23)36-28-19-13-25(32)14-20-28)33-31(37-29)24-11-15-26(16-12-24)35-22-21-34(5-2)6-3/h9-20H,4-8,21-22H2,1-3H3
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n/an/a 1.58E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402573
PNG
(CHEMBL2205558)
Show SMILES CCCCc1sc(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)-c1ccc(OCCCN(CC)CC)cc1
Show InChI InChI=1S/C32H37ClN2O2S/c1-4-7-9-30-31(24-10-18-28(19-11-24)37-29-20-14-26(33)15-21-29)34-32(38-30)25-12-16-27(17-13-25)36-23-8-22-35(5-2)6-3/h10-21H,4-9,22-23H2,1-3H3
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n/an/a 1.72E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402567
PNG
(CHEMBL2205568)
Show SMILES CCCCc1sc(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C33H37ClN2O2S/c1-2-3-8-31-32(25-9-17-29(18-10-25)38-30-19-13-27(34)14-20-30)35-33(39-31)26-11-15-28(16-12-26)37-24-7-23-36-21-5-4-6-22-36/h9-20H,2-8,21-24H2,1H3
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n/an/a 1.84E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50005634
PNG
(CHEMBL3235375)
Show SMILES CCCCOc1cc(OCCCN(CC)CC)ccc1NC(=O)c1cc(nn1C)-c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C34H41FN4O4/c1-5-8-21-42-33-23-29(41-22-9-20-39(6-2)7-3)18-19-30(33)36-34(40)32-24-31(37-38(32)4)25-10-14-27(15-11-25)43-28-16-12-26(35)13-17-28/h10-19,23-24H,5-9,20-22H2,1-4H3,(H,36,40)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Woosuk University

Curated by ChEMBL


Assay Description
Inhibition of biotinylated human RAGE assessed as bound amyloid beta level after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50005633
PNG
(CHEMBL3235374)
Show SMILES CCCCOc1cc(OCCCN(CC)CC)ccc1NC(=O)c1cc(nn1C)-c1ccc(Oc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C35H41F3N4O4/c1-5-8-21-45-33-23-29(44-22-9-20-42(6-2)7-3)18-19-30(33)39-34(43)32-24-31(40-41(32)4)25-10-14-27(15-11-25)46-28-16-12-26(13-17-28)35(36,37)38/h10-19,23-24H,5-9,20-22H2,1-4H3,(H,39,43)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Woosuk University

Curated by ChEMBL


Assay Description
Inhibition of biotinylated human RAGE assessed as bound amyloid beta level after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402574
PNG
(CHEMBL2205557)
Show SMILES CCCCc1sc(nc1-c1ccc(OCC2CCCN(CC)C2)cc1)-c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C33H37ClN2O2S/c1-3-5-8-31-32(25-9-15-28(16-10-25)37-23-24-7-6-21-36(4-2)22-24)35-33(39-31)26-11-17-29(18-12-26)38-30-19-13-27(34)14-20-30/h9-20,24H,3-8,21-23H2,1-2H3
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n/an/a 1.91E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402571
PNG
(CHEMBL2205560)
Show SMILES CCCCc1nc(sc1-c1ccc(OCCCN(CC)CC)cc1)-c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C32H37ClN2O2S/c1-4-7-9-30-31(24-10-16-27(17-11-24)36-23-8-22-35(5-2)6-3)38-32(34-30)25-12-18-28(19-13-25)37-29-20-14-26(33)15-21-29/h10-21H,4-9,22-23H2,1-3H3
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n/an/a 2.01E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50005629
PNG
(CHEMBL3235049)
Show SMILES CCCCOc1cc(OCCCN(CC)CC)ccc1NC(=O)c1cc(nn1C)-c1ccc(OC2CCCCC2)cc1
Show InChI InChI=1S/C34H48N4O4/c1-5-8-22-41-33-24-29(40-23-12-21-38(6-2)7-3)19-20-30(33)35-34(39)32-25-31(36-37(32)4)26-15-17-28(18-16-26)42-27-13-10-9-11-14-27/h15-20,24-25,27H,5-14,21-23H2,1-4H3,(H,35,39)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Woosuk University

Curated by ChEMBL


Assay Description
Inhibition of biotinylated human RAGE assessed as bound amyloid beta level after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402562
PNG
(CHEMBL2205552)
Show SMILES CCCCc1sc(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)-c1ccc(OCCN(C)C)cc1
Show InChI InChI=1S/C29H31ClN2O2S/c1-4-5-6-27-28(21-7-15-25(16-8-21)34-26-17-11-23(30)12-18-26)31-29(35-27)22-9-13-24(14-10-22)33-20-19-32(2)3/h7-18H,4-6,19-20H2,1-3H3
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n/an/a 3.18E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50397837
PNG
(CHEMBL2179074)
Show SMILES CCN(CC)CCOc1ccccc1Nc1nc(cc(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C28H28Cl2N4O/c1-3-34(4-2)17-18-35-27-8-6-5-7-24(27)31-28-32-25(20-9-13-22(29)14-10-20)19-26(33-28)21-11-15-23(30)16-12-21/h5-16,19H,3-4,17-18H2,1-2H3,(H,31,32,33)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant biotinylated receptor for advanced glycation end product expressed in Escherichia coli DE3 assessed as inhibition of ...


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50005635
PNG
(CHEMBL3235378)
Show SMILES CCCCOc1cc(OCCCN(CC)CC)ccc1NC(=O)c1cc(nn1C)-c1ccc(Oc2ccc(Cl)c(OC)c2)cc1
Show InChI InChI=1S/C35H43ClN4O5/c1-6-9-20-44-34-22-27(43-21-10-19-40(7-2)8-3)16-18-30(34)37-35(41)32-24-31(38-39(32)4)25-11-13-26(14-12-25)45-28-15-17-29(36)33(23-28)42-5/h11-18,22-24H,6-10,19-21H2,1-5H3,(H,37,41)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Woosuk University

Curated by ChEMBL


Assay Description
Inhibition of biotinylated human RAGE assessed as bound amyloid beta level after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50005630
PNG
(CHEMBL3235050)
Show SMILES CCCCOc1cc(OCCCN(CC)CC)ccc1NC(=O)c1cc(nn1C)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C34H42N4O4/c1-5-8-22-41-33-24-29(40-23-12-21-38(6-2)7-3)19-20-30(33)35-34(39)32-25-31(36-37(32)4)26-15-17-28(18-16-26)42-27-13-10-9-11-14-27/h9-11,13-20,24-25H,5-8,12,21-23H2,1-4H3,(H,35,39)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Woosuk University

Curated by ChEMBL


Assay Description
Inhibition of biotinylated human RAGE assessed as bound amyloid beta level after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402569
PNG
(CHEMBL2205565)
Show SMILES CCCCc1sc(NC(=O)c2ccc(OCCCN(CC)CC)cc2)nc1-c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C33H38ClN3O3S/c1-4-7-9-30-31(24-10-18-28(19-11-24)40-29-20-14-26(34)15-21-29)35-33(41-30)36-32(38)25-12-16-27(17-13-25)39-23-8-22-37(5-2)6-3/h10-21H,4-9,22-23H2,1-3H3,(H,35,36,38)
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n/an/a 5.59E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


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Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50005632
PNG
(CHEMBL3235052)
Show SMILES CCCCOc1cc(OCCCN(CC)CC)ccc1NC(=O)c1cc(nn1C)-c1ccc(Oc2ccc(OC)cc2)cc1
Show InChI InChI=1S/C35H44N4O5/c1-6-9-22-43-34-24-30(42-23-10-21-39(7-2)8-3)19-20-31(34)36-35(40)33-25-32(37-38(33)4)26-11-13-28(14-12-26)44-29-17-15-27(41-5)16-18-29/h11-20,24-25H,6-10,21-23H2,1-5H3,(H,36,40)
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n/an/a 7.80E+3n/an/an/an/an/an/a



Woosuk University

Curated by ChEMBL


Assay Description
Inhibition of biotinylated human RAGE assessed as bound amyloid beta level after 60 mins by ELISA


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More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50397836
PNG
(CHEMBL2179073)
Show SMILES CCN(CC)CCOc1cccc(Nc2nc(cc(n2)-c2ccc(Cl)cc2)-c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C28H28Cl2N4O/c1-3-34(4-2)16-17-35-25-7-5-6-24(18-25)31-28-32-26(20-8-12-22(29)13-9-20)19-27(33-28)21-10-14-23(30)15-11-21/h5-15,18-19H,3-4,16-17H2,1-2H3,(H,31,32,33)
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n/an/a 1.65E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant biotinylated receptor for advanced glycation end product expressed in Escherichia coli DE3 assessed as inhibition of ...


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More data for this
Ligand-Target Pair
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50005631
PNG
(CHEMBL3235051)
Show SMILES CCCCOc1cc(OCCCN(CC)CC)ccc1NC(=O)c1cc(nn1C)-c1ccc(Oc2ccccn2)cc1
Show InChI InChI=1S/C33H41N5O4/c1-5-8-21-41-31-23-27(40-22-11-20-38(6-2)7-3)17-18-28(31)35-33(39)30-24-29(36-37(30)4)25-13-15-26(16-14-25)42-32-12-9-10-19-34-32/h9-10,12-19,23-24H,5-8,11,20-22H2,1-4H3,(H,35,39)
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n/an/a 1.89E+4n/an/an/an/an/an/a



Woosuk University

Curated by ChEMBL


Assay Description
Inhibition of biotinylated human RAGE assessed as bound amyloid beta level after 60 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair