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Compile Data Set for Download or QSAR

Found 10 hits of ic50 data for polymerid = 50006952   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sialic acid-binding Ig-like lectin 7


(Homo sapiens)
BDBM50230647
PNG
(CHEMBL4096201)
Show SMILES [Na+].CCS(=O)(=O)NC[C@@H](O)[C@@H](O)[C@@H]1O[C@@](C[C@H](O)[C@H]1NC(C)=O)(OCCCn1cc(nn1)-c1ccc(cc1)-c1ccccc1)C([O-])=O
Show InChI InChI=1S/C30H39N5O10S.Na/c1-3-46(42,43)31-17-25(38)27(39)28-26(32-19(2)36)24(37)16-30(45-28,29(40)41)44-15-7-14-35-18-23(33-34-35)22-12-10-21(11-13-22)20-8-5-4-6-9-20;/h4-6,8-13,18,24-28,31,37-39H,3,7,14-17H2,1-2H3,(H,32,36)(H,40,41);/q;+1/p-1/t24-,25+,26+,27+,28+,30+;/m0./s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



G3-BioTec

Curated by ChEMBL


Assay Description
Binding affinity to human IgG1-fused Siglec-7-Fc assessed as inhibition of Siglec-7-Fc binding to RBC preincubated for 10 mins followed by RBC additi...


J Med Chem 60: 941-956 (2017)

More data for this
Ligand-Target Pair
Sialic acid-binding Ig-like lectin 7


(Homo sapiens)
BDBM50230646
PNG
(CHEMBL4060254)
Show SMILES [Na+].CC(=O)N[C@@H]1[C@@H](O)C[C@@](OCCCn2cc(nn2)-c2ccc(cc2)-c2ccccc2)(O[C@H]1[C@H](O)[C@H](O)CNS(C)(=O)=O)C([O-])=O
Show InChI InChI=1S/C29H37N5O10S.Na/c1-18(35)31-25-23(36)15-29(28(39)40,44-27(25)26(38)24(37)16-30-45(2,41)42)43-14-6-13-34-17-22(32-33-34)21-11-9-20(10-12-21)19-7-4-3-5-8-19;/h3-5,7-12,17,23-27,30,36-38H,6,13-16H2,1-2H3,(H,31,35)(H,39,40);/q;+1/p-1/t23-,24+,25+,26+,27+,29+;/m0./s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



G3-BioTec

Curated by ChEMBL


Assay Description
Binding affinity to human IgG1-fused Siglec-7-Fc assessed as inhibition of Siglec-7-Fc binding to RBC preincubated for 10 mins followed by RBC additi...


J Med Chem 60: 941-956 (2017)

More data for this
Ligand-Target Pair
Sialic acid-binding Ig-like lectin 7


(Homo sapiens)
BDBM50230580
PNG
(CHEMBL4094130)
Show SMILES [Na+].CC(=O)N[C@@H]1[C@@H](O)C[C@@](OCCCn2cc(nn2)-c2ccc(cc2)-c2ccccc2)(O[C@H]1[C@H](O)[C@H](O)CO)C([O-])=O
Show InChI InChI=1S/C28H34N4O9.Na/c1-17(34)29-24-22(35)14-28(27(38)39,41-26(24)25(37)23(36)16-33)40-13-5-12-32-15-21(30-31-32)20-10-8-19(9-11-20)18-6-3-2-4-7-18;/h2-4,6-11,15,22-26,33,35-37H,5,12-14,16H2,1H3,(H,29,34)(H,38,39);/q;+1/p-1/t22-,23+,24+,25+,26+,28+;/m0./s1
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n/an/a 5.30E+4n/an/an/an/an/an/a



G3-BioTec

Curated by ChEMBL


Assay Description
Binding affinity to human IgG1-fused Siglec-7-Fc assessed as inhibition of Siglec-7-Fc binding to RBC preincubated for 10 mins followed by RBC additi...


J Med Chem 60: 941-956 (2017)

More data for this
Ligand-Target Pair
Sialic acid-binding Ig-like lectin 7


(Homo sapiens)
BDBM50230647
PNG
(CHEMBL4096201)
Show SMILES [Na+].CCS(=O)(=O)NC[C@@H](O)[C@@H](O)[C@@H]1O[C@@](C[C@H](O)[C@H]1NC(C)=O)(OCCCn1cc(nn1)-c1ccc(cc1)-c1ccccc1)C([O-])=O
Show InChI InChI=1S/C30H39N5O10S.Na/c1-3-46(42,43)31-17-25(38)27(39)28-26(32-19(2)36)24(37)16-30(45-28,29(40)41)44-15-7-14-35-18-23(33-34-35)22-12-10-21(11-13-22)20-8-5-4-6-9-20;/h4-6,8-13,18,24-28,31,37-39H,3,7,14-17H2,1-2H3,(H,32,36)(H,40,41);/q;+1/p-1/t24-,25+,26+,27+,28+,30+;/m0./s1
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n/an/a 2.30E+5n/an/an/an/an/an/a



G3-BioTec

Curated by ChEMBL


Assay Description
Binding affinity to human IgG1-fused Siglec-7-Fc measured after 2.5 hrs by ELISA


J Med Chem 60: 941-956 (2017)

More data for this
Ligand-Target Pair
Sialic acid-binding Ig-like lectin 7


(Homo sapiens)
BDBM50230646
PNG
(CHEMBL4060254)
Show SMILES [Na+].CC(=O)N[C@@H]1[C@@H](O)C[C@@](OCCCn2cc(nn2)-c2ccc(cc2)-c2ccccc2)(O[C@H]1[C@H](O)[C@H](O)CNS(C)(=O)=O)C([O-])=O
Show InChI InChI=1S/C29H37N5O10S.Na/c1-18(35)31-25-23(36)15-29(28(39)40,44-27(25)26(38)24(37)16-30-45(2,41)42)43-14-6-13-34-17-22(32-33-34)21-11-9-20(10-12-21)19-7-4-3-5-8-19;/h3-5,7-12,17,23-27,30,36-38H,6,13-16H2,1-2H3,(H,31,35)(H,39,40);/q;+1/p-1/t23-,24+,25+,26+,27+,29+;/m0./s1
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n/an/a 2.60E+5n/an/an/an/an/an/a



G3-BioTec

Curated by ChEMBL


Assay Description
Binding affinity to human IgG1-fused Siglec-7-Fc measured after 2.5 hrs by ELISA


J Med Chem 60: 941-956 (2017)

More data for this
Ligand-Target Pair
Sialic acid-binding Ig-like lectin 7


(Homo sapiens)
BDBM50114355
PNG
(CHEMBL3604070)
Show SMILES [Na+].CO[C@@]1(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O1)[C@H](O)[C@H](O)CNC(=O)C(N)=O)C([O-])=O
Show InChI InChI=1S/C14H23N3O10.Na/c1-5(18)17-8-6(19)3-14(26-2,13(24)25)27-10(8)9(21)7(20)4-16-12(23)11(15)22;/h6-10,19-21H,3-4H2,1-2H3,(H2,15,22)(H,16,23)(H,17,18)(H,24,25);/q;+1/p-1/t6-,7+,8+,9+,10+,14+;/m0./s1
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n/an/a 1.64E+6n/an/an/an/an/an/a



G3-BioTec

Curated by ChEMBL


Assay Description
Binding affinity to human IgG1-fused human Siglec-7-FC (Gln19 to Gly357 residues) assessed as inhibition Siglec-7-Fc binding to to RBC pre-incubated ...


Bioorg Med Chem 23: 5915-21 (2015)


Article DOI: 10.1016/j.bmc.2015.06.069
BindingDB Entry DOI: 10.7270/Q2FB54RH
More data for this
Ligand-Target Pair
Sialic acid-binding Ig-like lectin 7


(Homo sapiens)
BDBM50230579
PNG
(CHEMBL4077460)
Show SMILES [Na+].COC1(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O1)[C@H](O)[C@H](O)CO)C([O-])=O
Show InChI InChI=1S/C12H21NO9.Na/c1-5(15)13-8-6(16)3-12(21-2,11(19)20)22-10(8)9(18)7(17)4-14;/h6-10,14,16-18H,3-4H2,1-2H3,(H,13,15)(H,19,20);/q;+1/p-1/t6-,7+,8+,9+,10+,12?;/m0./s1
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n/an/a 8.08E+6n/an/an/an/an/an/a



G3-BioTec

Curated by ChEMBL


Assay Description
Binding affinity to human IgG1-fused Siglec-7-Fc assessed as inhibition of Siglec-7-Fc binding to RBC preincubated for 10 mins followed by RBC additi...


J Med Chem 60: 941-956 (2017)

More data for this
Ligand-Target Pair
Sialic acid-binding Ig-like lectin 7


(Homo sapiens)
BDBM50114356
PNG
(CHEMBL3604069)
Show SMILES [Na+].CO[C@@]1(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O1)[C@H](O)[C@H](O)CO)C([O-])=O
Show InChI InChI=1S/C12H21NO9.Na/c1-5(15)13-8-6(16)3-12(21-2,11(19)20)22-10(8)9(18)7(17)4-14;/h6-10,14,16-18H,3-4H2,1-2H3,(H,13,15)(H,19,20);/q;+1/p-1/t6-,7+,8+,9+,10+,12+;/m0./s1
PDB

UniProtKB/SwissProt

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Article
PubMed
n/an/a 8.08E+6n/an/an/an/an/an/a



G3-BioTec

Curated by ChEMBL


Assay Description
Binding affinity to human IgG1-fused human Siglec-7-FC (Gln19 to Gly357 residues) assessed as inhibition Siglec-7-Fc binding to to RBC pre-incubated ...


Bioorg Med Chem 23: 5915-21 (2015)


Article DOI: 10.1016/j.bmc.2015.06.069
BindingDB Entry DOI: 10.7270/Q2FB54RH
More data for this
Ligand-Target Pair
Sialic acid-binding Ig-like lectin 7


(Homo sapiens)
BDBM50230649
PNG
(CHEMBL3764071)
Show SMILES CC(=O)N[C@@H]1[C@@H](O)C[C@@](OC[C@H]2O[C@@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@@H](O)[C@H]2O)(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O
Show InChI InChI=1S/C23H39NO19/c1-6(27)24-11-7(28)2-23(22(37)38,43-19(11)12(30)8(29)3-25)39-5-10-13(31)14(32)17(35)21(41-10)42-18-9(4-26)40-20(36)16(34)15(18)33/h7-21,25-26,28-36H,2-5H2,1H3,(H,24,27)(H,37,38)/t7-,8+,9+,10+,11+,12+,13-,14-,15+,16+,17+,18+,19+,20+,21-,23+/m0/s1
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n/an/a 2.56E+7n/an/an/an/an/an/a



G3-BioTec

Curated by ChEMBL


Assay Description
Binding affinity to human IgG1-fused Siglec-7-Fc measured after 2.5 hrs by ELISA


J Med Chem 60: 941-956 (2017)

More data for this
Ligand-Target Pair
Sialic acid-binding Ig-like lectin 7


(Homo sapiens)
BDBM50230648
PNG
(CHEMBL3764379)
Show SMILES CC(=O)N[C@@H]1[C@@H](O)C[C@@](O[C@H]2[C@@H](O)[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O
Show InChI InChI=1S/C23H39NO19/c1-6(28)24-11-7(29)2-23(22(37)38,42-18(11)12(31)8(30)3-25)43-19-13(32)9(4-26)40-21(16(19)35)41-17-10(5-27)39-20(36)15(34)14(17)33/h7-21,25-27,29-36H,2-5H2,1H3,(H,24,28)(H,37,38)/t7-,8+,9+,10+,11+,12+,13-,14+,15+,16+,17+,18+,19-,20+,21-,23-/m0/s1
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n/an/a 3.69E+7n/an/an/an/an/an/a



G3-BioTec

Curated by ChEMBL


Assay Description
Binding affinity to human IgG1-fused Siglec-7-Fc measured after 2.5 hrs by ELISA


J Med Chem 60: 941-956 (2017)

More data for this
Ligand-Target Pair