BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 87 hits of ic50 for UniProtKB: P05696   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM98660
PNG
(US8497385, 18C)
Show SMILES CCCCCCCC(=O)O[C@H]1\C(C[C@H]2C[C@H](CO)OC(=O)C[C@H](O)CCO[C@@H](C[C@@H]3CCO[C@@H](O3)\C=C\C(C)(C)[C@]1(O)O2)c1ccc(Br)cc1)=C\C(=O)OC
Show InChI InChI=1S/C41H59BrO13/c1-5-6-7-8-9-10-35(45)54-39-28(22-36(46)49-4)21-32-24-33(26-43)52-37(47)23-30(44)16-19-50-34(27-11-13-29(42)14-12-27)25-31-17-20-51-38(53-31)15-18-40(2,3)41(39,48)55-32/h11-15,18,22,30-34,38-39,43-44,48H,5-10,16-17,19-21,23-26H2,1-4H3/b18-15+,28-22+/t30-,31+,32+,33-,34+,38+,39+,41-/m1/s1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.60n/an/an/an/an/an/a



The Board of Trustees of the Leland Stanford Junior University

US Patent


Assay Description
Binding affinity of protein kinase C (PKC).


US Patent US8497385 (2013)


BindingDB Entry DOI: 10.7270/Q2H41Q15
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM98659
PNG
(US8497385, 19B.0)
Show SMILES CCCCCCCC(=O)O[C@H]1\C(C[C@H]2C[C@H](CO)OC(=O)C[C@H](O)CCO[C@@H](C[C@@H]3CCO[C@@H](O3)\C=C\C(C)(C)[C@]1(O)O2)c1ccccc1)=C\C(=O)OC
Show InChI InChI=1S/C41H60O13/c1-5-6-7-8-12-15-35(44)53-39-29(23-36(45)48-4)22-32-25-33(27-42)51-37(46)24-30(43)17-20-49-34(28-13-10-9-11-14-28)26-31-18-21-50-38(52-31)16-19-40(2,3)41(39,47)54-32/h9-11,13-14,16,19,23,30-34,38-39,42-43,47H,5-8,12,15,17-18,20-22,24-27H2,1-4H3/b19-16+,29-23+/t30-,31+,32+,33-,34+,38+,39+,41-/m1/s1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.30n/an/an/an/an/an/a



The Board of Trustees of the Leland Stanford Junior University

US Patent


Assay Description
Binding affinity of protein kinase C (PKC).


US Patent US8497385 (2013)


BindingDB Entry DOI: 10.7270/Q2H41Q15
More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.70n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
In vitro inhibition of [32P] incorporation into histones by rat brain partially purified Protein kinase C in the presence of PMA, [Ca2+] and phosphat...


J Med Chem 34: 2928-31 (1991)


Article DOI: 10.1021/jm00113a038
BindingDB Entry DOI: 10.7270/Q2KH0NZG
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50282632
PNG
(3-((3aR,10aR)-2-Methyl-2,3,3a,4,10,10a-hexahydro-1...)
Show SMILES CN1C[C@@H]2Cc3c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c4ccccc4n3C[C@H]2C1
Show InChI InChI=1S/C28H26N4O2/c1-30-12-16-11-23-24(19-8-4-6-10-22(19)32(23)14-17(16)13-30)26-25(27(33)29-28(26)34)20-15-31(2)21-9-5-3-7-18(20)21/h3-10,15-17H,11-14H2,1-2H3,(H,29,33,34)/t16-,17+/m0/s1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 2.85n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C alpha


Bioorg Med Chem Lett 4: 1303-1308 (1994)


Article DOI: 10.1016/S0960-894X(01)80349-8
BindingDB Entry DOI: 10.7270/Q27H1JJ4
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50108296
PNG
(CHEMBL289772 | Indolocarbazole analogue)
Show SMILES COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccc(CO)cc3c3c4CNC(=O)c4c4c5cc(CO)ccc5n2c4c13
Show InChI InChI=1S/C29H25N3O7/c1-28-29(37,27(36)38-2)9-20(39-28)31-18-5-3-13(11-33)7-15(18)22-23-17(10-30-26(23)35)21-16-8-14(12-34)4-6-19(16)32(28)25(21)24(22)31/h3-8,20,33-34,37H,9-12H2,1-2H3,(H,30,35)/t20?,28-,29-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Kyowa-Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor


Bioorg Med Chem Lett 12: 147-50 (2001)


Article DOI: 10.1016/s0960-894x(01)00690-4
BindingDB Entry DOI: 10.7270/Q2571B94
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM98661
PNG
(US8497385, 19B.1)
Show SMILES CCCCCCCC(=O)O[C@H]1\C(C[C@H]2C[C@H](CO)OC(=O)C[C@H](O)CCO[C@@H](C[C@@H]3CCO[C@@H](O3)\C=C\C(C)(C)[C@]1(O)O2)c1ccc(cc1)-c1ccccc1)=C\C(=O)OC
Show InChI InChI=1S/C47H64O13/c1-5-6-7-8-12-15-41(50)59-45-35(27-42(51)54-4)26-38-29-39(31-48)57-43(52)28-36(49)21-24-55-40(34-18-16-33(17-19-34)32-13-10-9-11-14-32)30-37-22-25-56-44(58-37)20-23-46(2,3)47(45,53)60-38/h9-11,13-14,16-20,23,27,36-40,44-45,48-49,53H,5-8,12,15,21-22,24-26,28-31H2,1-4H3/b23-20+,35-27+/t36-,37+,38+,39-,40+,44+,45+,47-/m1/s1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.10n/an/an/an/an/an/a



The Board of Trustees of the Leland Stanford Junior University

US Patent


Assay Description
Binding affinity of protein kinase C (PKC).


US Patent US8497385 (2013)


BindingDB Entry DOI: 10.7270/Q2H41Q15
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM98662
PNG
(US8497385, 19B.2)
Show SMILES CCCCCCCC(=O)O[C@H]1\C(C[C@H]2C[C@H](CO)OC(=O)C[C@H](O)CCO[C@@H](C[C@@H]3CCO[C@@H](O3)\C=C\C(C)(C)[C@]1(O)O2)c1ccc(CCCOCCOCC)cc1)=C\C(=O)OC
Show InChI InChI=1S/C48H74O15/c1-6-8-9-10-11-14-42(51)62-46-36(29-43(52)55-5)28-39-31-40(33-49)60-44(53)30-37(50)20-24-58-41(35-17-15-34(16-18-35)13-12-23-57-27-26-56-7-2)32-38-21-25-59-45(61-38)19-22-47(3,4)48(46,54)63-39/h15-19,22,29,37-41,45-46,49-50,54H,6-14,20-21,23-28,30-33H2,1-5H3/b22-19+,36-29+/t37-,38+,39+,40-,41+,45+,46+,48-/m1/s1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.80n/an/an/an/an/an/a



The Board of Trustees of the Leland Stanford Junior University

US Patent


Assay Description
Binding affinity of protein kinase C (PKC).


US Patent US8497385 (2013)


BindingDB Entry DOI: 10.7270/Q2H41Q15
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM98663
PNG
(US8497385, 19B.3)
Show SMILES CCCCCCCC(=O)O[C@H]1\C(C[C@H]2C[C@H](CO)OC(=O)C[C@H](O)CCO[C@@H](C[C@@H]3CCO[C@@H](O3)\C=C\C(C)(C)[C@]1(O)O2)c1ccc(\C=C\CCCCCC)cc1)=C\C(=O)OC
Show InChI InChI=1S/C49H74O13/c1-6-8-10-12-14-15-17-35-19-21-36(22-20-35)42-33-39-25-28-58-46(60-39)23-26-48(3,4)49(55)47(61-43(52)18-16-13-11-9-7-2)37(30-44(53)56-5)29-40(62-49)32-41(34-50)59-45(54)31-38(51)24-27-57-42/h15,17,19-23,26,30,38-42,46-47,50-51,55H,6-14,16,18,24-25,27-29,31-34H2,1-5H3/b17-15+,26-23+,37-30+/t38-,39+,40+,41-,42+,46+,47+,49-/m1/s1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.60n/an/an/an/an/an/a



The Board of Trustees of the Leland Stanford Junior University

US Patent


Assay Description
Binding affinity of protein kinase C (PKC).


US Patent US8497385 (2013)


BindingDB Entry DOI: 10.7270/Q2H41Q15
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50282633
PNG
((S)-3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydr...)
Show SMILES CN(C)C[C@H]1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(C)c3ccccc13)c1ccccc21
Show InChI InChI=1S/C28H28N4O2/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34)/t17-/m0/s1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
n/an/a 8.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C alpha


Bioorg Med Chem Lett 4: 1303-1308 (1994)


Article DOI: 10.1016/S0960-894X(01)80349-8
BindingDB Entry DOI: 10.7270/Q27H1JJ4
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents


Similars

Article
n/an/a 9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM3033
PNG
(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Show SMILES Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCC#N)c3c12
Show InChI InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50280871
PNG
(12-(3-azidopropyl)-13-methyl-6,7,12,13-tetrahydro-...)
Show SMILES Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCCN=[N+]=[N-])c3c12
Show InChI InChI=1S/C24H20N6O/c1-29-17-9-4-2-7-14(17)20-21-16(13-26-24(21)31)19-15-8-3-5-10-18(15)30(23(19)22(20)29)12-6-11-27-28-25/h2-5,7-10H,6,11-13H2,1H3,(H,26,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 25n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50280873
PNG
(2-(13-ethyl-5-oxo-6,7,12,13-tetrahydro-5H-indolo[2...)
Show SMILES CCn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCC#N)c3c12
Show InChI InChI=1S/C25H20N4O/c1-2-28-18-10-5-4-9-16(18)21-22-17(14-27-25(22)30)20-15-8-3-6-11-19(15)29(13-7-12-26)23(20)24(21)28/h3-6,8-11H,2,7,13-14H2,1H3,(H,27,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 27n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM98664
PNG
(US8497385, 19B.4)
Show SMILES CCCCCCCCCCCC\C=C\c1ccc(cc1)[C@@H]1C[C@@H]2CCO[C@@H](O2)\C=C\C(C)(C)[C@]2(O)O[C@@H](C\C(=C/C(=O)OC)[C@@H]2OC(=O)CCCCCCC)C[C@H](CO)OC(=O)C[C@H](O)CCO1
Show InChI InChI=1S/C55H86O13/c1-6-8-10-12-13-14-15-16-17-18-20-21-23-41-25-27-42(28-26-41)48-39-45-31-34-64-52(66-45)29-32-54(3,4)55(61)53(67-49(58)24-22-19-11-9-7-2)43(36-50(59)62-5)35-46(68-55)38-47(40-56)65-51(60)37-44(57)30-33-63-48/h21,23,25-29,32,36,44-48,52-53,56-57,61H,6-20,22,24,30-31,33-35,37-40H2,1-5H3/b23-21+,32-29+,43-36+/t44-,45+,46+,47-,48+,52+,53+,55-/m1/s1
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 30n/an/an/an/an/an/a



The Board of Trustees of the Leland Stanford Junior University

US Patent


Assay Description
Binding affinity of protein kinase C (PKC).


US Patent US8497385 (2013)


BindingDB Entry DOI: 10.7270/Q2H41Q15
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50280870
PNG
(12-(2,2-difluoroethyl)-13-methyl-6,7,12,13-tetrahy...)
Show SMILES Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CC(F)F)c3c12
Show InChI InChI=1S/C23H17F2N3O/c1-27-15-8-4-2-6-12(15)19-20-14(10-26-23(20)29)18-13-7-3-5-9-16(13)28(11-17(24)25)22(18)21(19)27/h2-9,17H,10-11H2,1H3,(H,26,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 32n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50280877
PNG
(2-(5-oxo-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrr...)
Show SMILES O=C1NCc2c1c1c3ccccc3[nH]c1c1n(CCC#N)c3ccccc3c21
Show InChI InChI=1S/C23H16N4O/c24-10-5-11-27-17-9-4-2-7-14(17)18-15-12-25-23(28)20(15)19-13-6-1-3-8-16(13)26-21(19)22(18)27/h1-4,6-9,26H,5,11-12H2,(H,25,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
n/an/a 75n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50280868
PNG
(12-(2,3-dihydroxypropyl)-6,7,12,13-tetrahydro-5H-i...)
Show SMILES OCC(O)Cn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4[nH]c3c12
Show InChI InChI=1S/C23H19N3O3/c27-11-12(28)10-26-17-8-4-2-6-14(17)18-15-9-24-23(29)20(15)19-13-5-1-3-7-16(13)25-21(19)22(18)26/h1-8,12,25,27-28H,9-11H2,(H,24,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 99n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50280869
PNG
(13-methyl-12-propyl-6,7,12,13-tetrahydro-5H-indolo...)
Show SMILES CCCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4n(C)c3c12
Show InChI InChI=1S/C24H21N3O/c1-3-12-27-18-11-7-5-9-15(18)19-16-13-25-24(28)21(16)20-14-8-4-6-10-17(14)26(2)22(20)23(19)27/h4-11H,3,12-13H2,1-2H3,(H,25,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50280875
PNG
(3-(5-oxo-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrr...)
Show SMILES NC(=O)CCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4[nH]c3c12
Show InChI InChI=1S/C23H18N4O2/c24-17(28)9-10-27-16-8-4-2-6-13(16)18-14-11-25-23(29)20(14)19-12-5-1-3-7-15(12)26-21(19)22(18)27/h1-8,26H,9-11H2,(H2,24,28)(H,25,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 110n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C beta 1


Bioorg Med Chem Lett 13: 1857-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00286-5
BindingDB Entry DOI: 10.7270/Q2319V87
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50128287
PNG
(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-methyl-piperidi...)
Show SMILES CN1CCC(CC1)n1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-29-13-11-17(12-14-29)31-16-21(19-8-4-6-10-23(19)31)25-24(26(32)28-27(25)33)20-15-30(2)22-9-5-3-7-18(20)22/h3-10,15-17H,11-14H2,1-2H3,(H,28,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of purified rat brain protein kinase C (RB-PKC)


Bioorg Med Chem Lett 13: 1857-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00286-5
BindingDB Entry DOI: 10.7270/Q2319V87
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50128282
PNG
(3-(1H-Indol-3-yl)-4-[1-(1-methyl-piperidin-4-yl)-1...)
Show SMILES CN1CCC(CC1)n1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-12-10-16(11-13-29)30-15-20(18-7-3-5-9-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-4-2-6-17(19)21/h2-9,14-16,27H,10-13H2,1H3,(H,28,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C beta 1


Bioorg Med Chem Lett 13: 1857-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00286-5
BindingDB Entry DOI: 10.7270/Q2319V87
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50128280
PNG
(3-[1-(1-Ethyl-piperidin-4-yl)-1H-indol-3-yl]-4-(1-...)
Show SMILES CCN1CCC(CC1)n1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C28H28N4O2/c1-3-31-14-12-18(13-15-31)32-17-22(20-9-5-7-11-24(20)32)26-25(27(33)29-28(26)34)21-16-30(2)23-10-6-4-8-19(21)23/h4-11,16-18H,3,12-15H2,1-2H3,(H,29,33,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C beta 1


Bioorg Med Chem Lett 13: 1857-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00286-5
BindingDB Entry DOI: 10.7270/Q2319V87
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50280879
PNG
(12,13-diethyl-6,7,12,13-tetrahydro-5H-indolo[2,3-a...)
Show SMILES CCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4n(CC)c3c12
Show InChI InChI=1S/C24H21N3O/c1-3-26-17-11-7-5-9-14(17)19-16-13-25-24(28)21(16)20-15-10-6-8-12-18(15)27(4-2)23(20)22(19)26/h5-12H,3-4,13H2,1-2H3,(H,25,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50108291
PNG
(CHEMBL36891 | Indolocarbazole analogue)
Show SMILES CCSCc1ccc2n3[C@H]4C[C@](O)(C(=O)OC)[C@](C)(O4)n4c5ccccc5c5c6CNC(=O)c6c(c2c1)c3c45
Show InChI InChI=1S/C30H27N3O5S/c1-4-39-14-15-9-10-19-17(11-15)23-24-18(13-31-27(24)34)22-16-7-5-6-8-20(16)33-26(22)25(23)32(19)21-12-30(36,28(35)37-3)29(33,2)38-21/h5-11,21,36H,4,12-14H2,1-3H3,(H,31,34)/t21?,29-,30-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 222n/an/an/an/an/an/a



Kyowa-Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor


Bioorg Med Chem Lett 12: 147-50 (2001)


Article DOI: 10.1016/s0960-894x(01)00690-4
BindingDB Entry DOI: 10.7270/Q2571B94
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50128286
PNG
(3-[1-(1-Isopropyl-piperidin-4-yl)-1H-indol-3-yl]-4...)
Show SMILES CC(C)N1CCC(CC1)n1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C29H30N4O2/c1-18(2)32-14-12-19(13-15-32)33-17-23(21-9-5-7-11-25(21)33)27-26(28(34)30-29(27)35)22-16-31(3)24-10-6-4-8-20(22)24/h4-11,16-19H,12-15H2,1-3H3,(H,30,34,35)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C beta 1


Bioorg Med Chem Lett 13: 1857-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00286-5
BindingDB Entry DOI: 10.7270/Q2319V87
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50128290
PNG
(3-[1-(1-Cyclopropylmethyl-piperidin-4-yl)-1H-indol...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(CC4CC4)CC3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C30H30N4O2/c1-32-17-23(21-6-2-4-8-25(21)32)27-28(30(36)31-29(27)35)24-18-34(26-9-5-3-7-22(24)26)20-12-14-33(15-13-20)16-19-10-11-19/h2-9,17-20H,10-16H2,1H3,(H,31,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of purified rat brain protein kinase C (RB-PKC)


Bioorg Med Chem Lett 13: 1857-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00286-5
BindingDB Entry DOI: 10.7270/Q2319V87
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50128281
PNG
(18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...)
Show SMILES CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21
Show InChI InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 320n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of purified rat brain protein kinase C (RB-PKC)


Bioorg Med Chem Lett 13: 1857-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00286-5
BindingDB Entry DOI: 10.7270/Q2319V87
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50128288
PNG
(3-(1-Methyl-1H-indol-3-yl)-4-(1-piperidin-4-yl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCNCC3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-19(17-6-2-4-8-21(17)29)23-24(26(32)28-25(23)31)20-15-30(16-10-12-27-13-11-16)22-9-5-3-7-18(20)22/h2-9,14-16,27H,10-13H2,1H3,(H,28,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 400n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of purified rat brain protein kinase C (RB-PKC)


Bioorg Med Chem Lett 13: 1857-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00286-5
BindingDB Entry DOI: 10.7270/Q2319V87
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50108299
PNG
(CHEMBL288229 | Indolocarbazole analogue)
Show SMILES CCSCc1ccc2n3c4c(c5CNC(=O)c5c5c6ccccc6n([C@H]6C[C@](O)(C(=O)OC)[C@]3(C)O6)c45)c2c1
Show InChI InChI=1S/C30H27N3O5S/c1-4-39-14-15-9-10-20-17(11-15)22-18-13-31-27(34)24(18)23-16-7-5-6-8-19(16)32-21-12-30(36,28(35)37-3)29(2,38-21)33(20)26(22)25(23)32/h5-11,21,36H,4,12-14H2,1-3H3,(H,31,34)/t21?,29-,30-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 400n/an/an/an/an/an/a



Kyowa-Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor


Bioorg Med Chem Lett 12: 147-50 (2001)


Article DOI: 10.1016/s0960-894x(01)00690-4
BindingDB Entry DOI: 10.7270/Q2571B94
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50280878
PNG
(12,13-dimethyl-6,7,12,13-tetrahydro-5H-indolo[2,3-...)
Show SMILES Cn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4n(C)c3c12
Show InChI InChI=1S/C22H17N3O/c1-24-15-9-5-3-7-12(15)17-14-11-23-22(26)19(14)18-13-8-4-6-10-16(13)25(2)21(18)20(17)24/h3-10H,11H2,1-2H3,(H,23,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 450n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50108295
PNG
(CHEMBL288817 | Indolocarbazole analogue)
Show SMILES COCc1ccc2n3[C@H]4C[C@](O)(C(=O)OC)[C@](C)(O4)n4c5ccc(COC)cc5c5c6CNC(=O)c6c(c2c1)c3c45
Show InChI InChI=1S/C31H29N3O7/c1-30-31(37,29(36)40-4)11-22(41-30)33-20-7-5-15(13-38-2)9-17(20)24-25-19(12-32-28(25)35)23-18-10-16(14-39-3)6-8-21(18)34(30)27(23)26(24)33/h5-10,22,37H,11-14H2,1-4H3,(H,32,35)/t22?,30-,31-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 450n/an/an/an/an/an/a



Kyowa-Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor


Bioorg Med Chem Lett 12: 147-50 (2001)


Article DOI: 10.1016/s0960-894x(01)00690-4
BindingDB Entry DOI: 10.7270/Q2571B94
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50280876
PNG
(12-methyl-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyr...)
Show SMILES Cn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4[nH]c3c12
Show InChI InChI=1S/C21H15N3O/c1-24-15-9-5-3-7-12(15)16-13-10-22-21(25)18(13)17-11-6-2-4-8-14(11)23-19(17)20(16)24/h2-9,23H,10H2,1H3,(H,22,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
n/an/a 520n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50052039
PNG
(18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...)
Show SMILES OC[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21
Show InChI InChI=1S/C26H23N3O4/c30-15-16-9-10-28-13-19(17-5-1-3-7-21(17)28)23-24(26(32)27-25(23)31)20-14-29(11-12-33-16)22-8-4-2-6-18(20)22/h1-8,13-14,16,30H,9-12,15H2,(H,27,31,32)/t16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 550n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of rat brain PKC


Bioorg Med Chem Lett 5: 2093-2096 (1995)


Article DOI: 10.1016/0960-894X(95)00350-3
BindingDB Entry DOI: 10.7270/Q2D50MXM
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50280874
PNG
(3-(5-oxo-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrr...)
Show SMILES OC(=O)CCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4[nH]c3c12
Show InChI InChI=1S/C23H17N3O3/c27-17(28)9-10-26-16-8-4-2-6-13(16)18-14-11-24-23(29)20(14)19-12-5-1-3-7-15(12)25-21(19)22(18)26/h1-8,25H,9-11H2,(H,24,29)(H,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
n/an/a 590n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM2581
PNG
(3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...)
Show SMILES O=C1NCc2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21
Show InChI InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
n/an/a 680n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50128285
PNG
(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmet...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccn4)CC3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 700n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C beta 1


Bioorg Med Chem Lett 13: 1857-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00286-5
BindingDB Entry DOI: 10.7270/Q2319V87
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50108297
PNG
(CHEMBL288816 | Indolocarbazole analogue)
Show SMILES COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccc(CSC(C)C)cc3c3c4CNC(=O)c4c4c5cc(CSC(C)C)ccc5n2c4c13
Show InChI InChI=1S/C35H37N3O5S2/c1-17(2)44-15-19-7-9-24-21(11-19)28-29-23(14-36-32(29)39)27-22-12-20(16-45-18(3)4)8-10-25(22)38-31(27)30(28)37(24)26-13-35(41,33(40)42-6)34(38,5)43-26/h7-12,17-18,26,41H,13-16H2,1-6H3,(H,36,39)/t26?,34-,35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 980n/an/an/an/an/an/a



Kyowa-Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor


Bioorg Med Chem Lett 12: 147-50 (2001)


Article DOI: 10.1016/s0960-894x(01)00690-4
BindingDB Entry DOI: 10.7270/Q2571B94
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50108300
PNG
(CHEMBL38338 | Indolocarbazole analogue)
Show SMILES COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccc(CSCCN(C)C)cc3c3c4CNC(=O)c4c4c5cc(CSCCN(C)C)ccc5n2c4c13
Show InChI InChI=1S/C37H43N5O5S2/c1-36-37(45,35(44)46-6)17-28(47-36)41-26-9-7-21(19-48-13-11-39(2)3)15-23(26)30-31-25(18-38-34(31)43)29-24-16-22(20-49-14-12-40(4)5)8-10-27(24)42(36)33(29)32(30)41/h7-10,15-16,28,45H,11-14,17-20H2,1-6H3,(H,38,43)/t28?,36-,37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



Kyowa-Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor


Bioorg Med Chem Lett 12: 147-50 (2001)


Article DOI: 10.1016/s0960-894x(01)00690-4
BindingDB Entry DOI: 10.7270/Q2571B94
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50108293
PNG
(CHEMBL277817 | Indolocarbazole analogue)
Show SMILES CCOCc1ccc2n3[C@H]4C[C@](O)(C(=O)OC)[C@](C)(O4)n4c5ccc(COCC)cc5c5c6CNC(=O)c6c(c2c1)c3c45
Show InChI InChI=1S/C33H33N3O7/c1-5-41-15-17-7-9-22-19(11-17)26-27-21(14-34-30(27)37)25-20-12-18(16-42-6-2)8-10-23(20)36-29(25)28(26)35(22)24-13-33(39,31(38)40-4)32(36,3)43-24/h7-12,24,39H,5-6,13-16H2,1-4H3,(H,34,37)/t24?,32-,33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



Kyowa-Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor


Bioorg Med Chem Lett 12: 147-50 (2001)


Article DOI: 10.1016/s0960-894x(01)00690-4
BindingDB Entry DOI: 10.7270/Q2571B94
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50128283
PNG
(3-[1-(1-Benzyl-pyrrolidin-3-yl)-1H-indol-3-yl]-4-(...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccc4)C3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C32H28N4O2/c1-34-19-25(23-11-5-7-13-27(23)34)29-30(32(38)33-31(29)37)26-20-36(28-14-8-6-12-24(26)28)22-15-16-35(18-22)17-21-9-3-2-4-10-21/h2-14,19-20,22H,15-18H2,1H3,(H,33,37,38)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.80E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of purified rat brain protein kinase C (RB-PKC)


Bioorg Med Chem Lett 13: 1857-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00286-5
BindingDB Entry DOI: 10.7270/Q2319V87
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50212623
PNG
(CHEMBL299248)
Show SMILES CC(C)=CCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4[nH]c3c12
Show InChI InChI=1S/C25H21N3O/c1-14(2)11-12-28-19-10-6-4-8-16(19)20-17-13-26-25(29)22(17)21-15-7-3-5-9-18(15)27-23(21)24(20)28/h3-11,27H,12-13H2,1-2H3,(H,26,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
n/an/a 3.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50128284
PNG
(3-(1-(1-benzylpiperidin-4-yl)-1H-indol-3-yl)-4-(1-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccc4)CC3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C33H30N4O2/c1-35-20-26(24-11-5-7-13-28(24)35)30-31(33(39)34-32(30)38)27-21-37(29-14-8-6-12-25(27)29)23-15-17-36(18-16-23)19-22-9-3-2-4-10-22/h2-14,20-21,23H,15-19H2,1H3,(H,34,38,39)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of purified rat brain protein kinase C (RB-PKC)


Bioorg Med Chem Lett 13: 1857-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00286-5
BindingDB Entry DOI: 10.7270/Q2319V87
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50285193
PNG
(17-hydroxymethyl-18-oxa-4,14,22-triazahexacyclo[20...)
Show SMILES OCC1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCCO1)c1ccccc31)c1ccccc21
Show InChI InChI=1S/C27H25N3O4/c31-16-17-10-12-30-15-21(19-7-2-4-9-23(19)30)25-24(26(32)28-27(25)33)20-14-29(11-5-13-34-17)22-8-3-1-6-18(20)22/h1-4,6-9,14-15,17,31H,5,10-13,16H2,(H,28,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
n/an/a 6.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of rat brain PKC


Bioorg Med Chem Lett 5: 2093-2096 (1995)


Article DOI: 10.1016/0960-894X(95)00350-3
BindingDB Entry DOI: 10.7270/Q2D50MXM
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50108298
PNG
(CHEMBL29709 | Indolocarbazole analogue)
Show SMILES CCCCSCc1ccc2n3[C@H]4C[C@](O)(C(=O)OC)[C@](C)(O4)n4c5ccc(CSCCCC)cc5c5c6CNC(=O)c6c(c2c1)c3c45
Show InChI InChI=1S/C37H41N3O5S2/c1-5-7-13-46-19-21-9-11-26-23(15-21)30-31-25(18-38-34(31)41)29-24-16-22(20-47-14-8-6-2)10-12-27(24)40-33(29)32(30)39(26)28-17-37(43,35(42)44-4)36(40,3)45-28/h9-12,15-16,28,43H,5-8,13-14,17-20H2,1-4H3,(H,38,41)/t28?,36-,37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>7.60E+3n/an/an/an/an/an/a



Kyowa-Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor


Bioorg Med Chem Lett 12: 147-50 (2001)


Article DOI: 10.1016/s0960-894x(01)00690-4
BindingDB Entry DOI: 10.7270/Q2571B94
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50212624
PNG
(CHEMBL294684)
Show SMILES CCCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4n(CCC)c3c12
Show InChI InChI=1S/C26H25N3O/c1-3-13-28-19-11-7-5-9-16(19)21-18-15-27-26(30)23(18)22-17-10-6-8-12-20(17)29(14-4-2)25(22)24(21)28/h5-12H,3-4,13-15H2,1-2H3,(H,27,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
n/an/a 8.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain


Bioorg Med Chem Lett 3: 1959-1964 (1993)


Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50108294
PNG
(CHEMBL288818 | Indolocarbazole analogue)
Show SMILES COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccc(CSCC=C)cc3c3c4CNC(=O)c4c4c5cc(CSCC=C)ccc5n2c4c13
Show InChI InChI=1S/C35H33N3O5S2/c1-5-11-44-17-19-7-9-24-21(13-19)28-29-23(16-36-32(29)39)27-22-14-20(18-45-12-6-2)8-10-25(22)38-31(27)30(28)37(24)26-15-35(41,33(40)42-4)34(38,3)43-26/h5-10,13-14,26,41H,1-2,11-12,15-18H2,3-4H3,(H,36,39)/t26?,34-,35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Kyowa-Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor


Bioorg Med Chem Lett 12: 147-50 (2001)


Article DOI: 10.1016/s0960-894x(01)00690-4
BindingDB Entry DOI: 10.7270/Q2571B94
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM24942
PNG
(CEP-1347 | CHEMBL290352 | methyl (15S,16R,18R)-10,...)
Show SMILES CCSCc1ccc2n3[C@H]4C[C@](O)(C(=O)OC)[C@](C)(O4)n4c5ccc(CSCC)cc5c5c6CNC(=O)c6c(c2c1)c3c45
Show InChI InChI=1S/C33H33N3O5S2/c1-5-42-15-17-7-9-22-19(11-17)26-27-21(14-34-30(27)37)25-20-12-18(16-43-6-2)8-10-23(20)36-29(25)28(26)35(22)24-13-33(39,31(38)40-4)32(36,3)41-24/h7-12,24,39H,5-6,13-16H2,1-4H3,(H,34,37)/t24-,32+,33+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Kyowa-Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity for Growth factor receptor bound protein 2 SH2 domain


Bioorg Med Chem Lett 12: 147-50 (2001)


Article DOI: 10.1016/s0960-894x(01)00690-4
BindingDB Entry DOI: 10.7270/Q2571B94
More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of rat brain Protein kinase C


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)
BDBM50108292
PNG
(CHEMBL37529 | Indolocarbazole analogue)
Show SMILES CCCSCc1ccc2n3[C@H]4C[C@](O)(C(=O)OC)[C@](C)(O4)n4c5ccc(CSCCC)cc5c5c6CNC(=O)c6c(c2c1)c3c45
Show InChI InChI=1S/C35H37N3O5S2/c1-5-11-44-17-19-7-9-24-21(13-19)28-29-23(16-36-32(29)39)27-22-14-20(18-45-12-6-2)8-10-25(22)38-31(27)30(28)37(24)26-15-35(41,33(40)42-4)34(38,3)43-26/h7-10,13-14,26,41H,5-6,11-12,15-18H2,1-4H3,(H,36,39)/t26?,34-,35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Kyowa-Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor


Bioorg Med Chem Lett 12: 147-50 (2001)


Article DOI: 10.1016/s0960-894x(01)00690-4
BindingDB Entry DOI: 10.7270/Q2571B94
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 87 total )  |  Next  |  Last  >>
Jump to: