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Compile Data Set for Download or QSAR

Found 158 hits of ec50 for UniProtKB: Q9NWZ3   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374367
PNG
(US10246456, Example 520)
Show SMILES CSCC(N)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C21H21N5OS/c1-28-13-17(22)19-6-3-5-18(25-19)14-8-9-15-11-23-26(20(15)10-14)21-7-2-4-16(12-27)24-21/h2-11,17,27H,12-13,22H2,1H3
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374368
PNG
(US10246456, Example 521)
Show SMILES CC(C)C[C@H](N)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C23H25N5O/c1-15(2)11-19(24)21-7-4-6-20(27-21)16-9-10-17-13-25-28(22(17)12-16)23-8-3-5-18(14-29)26-23/h3-10,12-13,15,19,29H,11,14,24H2,1-2H3/t19-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374366
PNG
(US10246456, Example 519)
Show SMILES CCC[C@@H](N)c1cccc(n1)-c1ccc2cnn(-c3cccc(n3)C(F)F)c2c1
Show InChI InChI=1/C22H21F2N5/c1-2-5-16(25)18-7-3-6-17(27-18)14-10-11-15-13-26-29(20(15)12-14)21-9-4-8-19(28-21)22(23)24/h3-4,6-13,16,22H,2,5,25H2,1H3/t16-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374369
PNG
(US10246456, Example 522)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(OCCC2CC2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H31N5O2/c1-2-5-22(28)24-8-4-7-23(31-24)19-14-25-21(26(15-19)34-13-12-18-10-11-18)16-29-32(25)27-9-3-6-20(17-33)30-27/h3-4,6-9,14-16,18,22,33H,2,5,10-13,17,28H2,1H3/t22-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374370
PNG
(US10246456, Example 523)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(OC(F)(F)F)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C23H22F3N5O2/c1-2-5-17(27)19-8-4-7-18(30-19)14-10-20-16(21(11-14)33-23(24,25)26)12-28-31(20)22-9-3-6-15(13-32)29-22/h3-4,6-12,17,32H,2,5,13,27H2,1H3/t17-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374371
PNG
(US10246456, Example 524)
Show SMILES C[C@H](N)c1cccc(n1)-c1cc(C2=NCCO2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C23H22N6O2/c1-14(24)19-5-3-6-20(28-19)15-10-17(23-25-8-9-31-23)18-12-26-29(21(18)11-15)22-7-2-4-16(13-30)27-22/h2-7,10-12,14,30H,8-9,13,24H2,1H3/t14-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374355
PNG
(US10246456, Example 508 | US10246456, Example 525)
Show SMILES CC(O)CC(N)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C22H23N5O2/c1-14(29)10-18(23)20-6-3-5-19(26-20)15-8-9-16-12-24-27(21(16)11-15)22-7-2-4-17(13-28)25-22/h2-9,11-12,14,18,28-29H,10,13,23H2,1H3
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374373
PNG
(US10246456, Example 526)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(OC(F)F)c2cnn(-c3cncc(CO)n3)c2c1
Show InChI InChI=1/C22H22F2N6O2/c1-2-4-16(25)18-6-3-5-17(29-18)13-7-19-15(20(8-13)32-22(23)24)10-27-30(19)21-11-26-9-14(12-31)28-21/h3,5-11,16,22,31H,2,4,12,25H2,1H3/t16-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374374
PNG
(US10246456, Example 527)
Show SMILES CCC[C@H](NC)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C23H25N5O/c1-3-6-20(24-2)21-9-5-8-19(27-21)16-11-12-17-14-25-28(22(17)13-16)23-10-4-7-18(15-29)26-23/h4-5,7-14,20,24,29H,3,6,15H2,1-2H3/t20-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374375
PNG
(US10246456, Example 528)
Show SMILES C[C@H](N)c1cccc(n1)-c1cc(C2=NC(C)CO2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C24H24N6O2/c1-14-13-32-24(27-14)18-9-16(21-7-4-6-20(29-21)15(2)25)10-22-19(18)11-26-30(22)23-8-3-5-17(12-31)28-23/h3-11,14-15,31H,12-13,25H2,1-2H3/t14?,15-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374376
PNG
(US10246456, Example 529)
Show SMILES C[C@@H](N)c1cccc(n1)-c1ccc2cnn(-c3cccc(n3)C(F)F)c2c1
Show InChI InChI=1/C20H17F2N5/c1-12(23)15-4-2-5-16(25-15)13-8-9-14-11-24-27(18(14)10-13)19-7-3-6-17(26-19)20(21)22/h2-12,20H,23H2,1H3/t12-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374501
PNG
(US10246456, Example 530)
Show SMILES NC(CO)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C20H19N5O2/c21-16(12-27)18-5-2-4-17(24-18)13-7-8-14-10-22-25(19(14)9-13)20-6-1-3-15(11-26)23-20/h1-10,16,26-27H,11-12,21H2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374377
PNG
(US10246456, Example 531)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1ccc2cnn(-c3nccc(n3)C(F)(F)F)c2c1
Show InChI InChI=1/C21H19F3N6/c1-2-4-15(25)17-6-3-5-16(28-17)13-7-8-14-12-27-30(18(14)11-13)20-26-10-9-19(29-20)21(22,23)24/h3,5-12,15H,2,4,25H2,1H3/t15-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374378
PNG
(US10246456, Example 532)
Show SMILES CS(=O)(=O)CC(N)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C21H21N5O3S/c1-30(28,29)13-17(22)19-6-3-5-18(25-19)14-8-9-15-11-23-26(20(15)10-14)21-7-2-4-16(12-27)24-21/h2-11,17,27H,12-13,22H2,1H3
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374379
PNG
(US10246456, Example 533)
Show SMILES CC[C@H](N)c1cccc(n1)-c1cc(C#N)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C22H20N6O/c1-2-18(24)20-7-4-6-19(27-20)14-9-15(11-23)17-12-25-28(21(17)10-14)22-8-3-5-16(13-29)26-22/h3-10,12,18,29H,2,13,24H2,1H3/t18-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374380
PNG
(US10246456, Example 535)
Show SMILES NC(CC1CC1)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C23H23N5O/c24-19(11-15-7-8-15)21-5-2-4-20(27-21)16-9-10-17-13-25-28(22(17)12-16)23-6-1-3-18(14-29)26-23/h1-6,9-10,12-13,15,19,29H,7-8,11,14,24H2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374381
PNG
(US10246456, Example 536)
Show SMILES CC(N)c1cccc(n1)-c1cc(-c2cnco2)c2cnn(-c3cccc(C)n3)c2c1
Show InChI InChI=1/C23H20N6O/c1-14-5-3-8-23(27-14)29-21-10-16(20-7-4-6-19(28-20)15(2)24)9-17(18(21)11-26-29)22-12-25-13-30-22/h3-13,15H,24H2,1-2H3
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374382
PNG
(US10246456, Example 537)
Show SMILES C[C@H](N)c1cccc(n1)-c1cc(C#N)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C21H18N6O/c1-13(23)18-5-3-6-19(26-18)14-8-15(10-22)17-11-24-27(20(17)9-14)21-7-2-4-16(12-28)25-21/h2-9,11,13,28H,12,23H2,1H3/t13-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374383
PNG
(US10246456, Example 538)
Show SMILES NC(C1CC1)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C22H21N5O/c23-22(14-7-8-14)19-5-2-4-18(26-19)15-9-10-16-12-24-27(20(16)11-15)21-6-1-3-17(13-28)25-21/h1-6,9-12,14,22,28H,7-8,13,23H2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374184
PNG
((R)-N-((S)-1-(6-(1-(6-(((tert-butyldimethylsilyl)o...)
Show SMILES CCC[C@H](N[S@](=O)C(C)(C)C)c1cccc(n1)-c1cc(N2CCCCC2)c2cnn(-c3cccc(CO[Si](C)(C)C(C)(C)C)n3)c2c1
Show InChI InChI=1S/C37H54N6O2SSi/c1-10-16-32(41-46(44)36(2,3)4)31-19-15-18-30(40-31)27-23-33(42-21-12-11-13-22-42)29-25-38-43(34(29)24-27)35-20-14-17-28(39-35)26-45-47(8,9)37(5,6)7/h14-15,17-20,23-25,32,41H,10-13,16,21-22,26H2,1-9H3/t32-,46+/m0/s1
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374185
PNG
(US10246456, Example 325)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCC(O)C2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C26H30N6O2/c1-2-5-21(27)23-8-4-7-22(30-23)17-12-24(31-11-10-19(34)15-31)20-14-28-32(25(20)13-17)26-9-3-6-18(16-33)29-26/h3-4,6-9,12-14,19,21,33-34H,2,5,10-11,15-16,27H2,1H3/t19?,21-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374186
PNG
(US10246456, Example 326)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCCC2CO)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H32N6O2/c1-2-6-22(28)24-10-4-9-23(31-24)18-13-25(32-12-5-8-20(32)17-35)21-15-29-33(26(21)14-18)27-11-3-7-19(16-34)30-27/h3-4,7,9-11,13-15,20,22,34-35H,2,5-6,8,12,16-17,28H2,1H3/t20?,22-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374187
PNG
(US10246456, Example 327)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(NC)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C23H26N6O/c1-3-6-18(24)20-9-5-8-19(28-20)15-11-21(25-2)17-13-26-29(22(17)12-15)23-10-4-7-16(14-30)27-23/h4-5,7-13,18,25,30H,3,6,14,24H2,1-2H3/t18-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374188
PNG
(US10246456, Example 328)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(NCC)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C24H28N6O/c1-3-7-19(25)21-10-6-9-20(29-21)16-12-22(26-4-2)18-14-27-30(23(18)13-16)24-11-5-8-17(15-31)28-24/h5-6,8-14,19,26,31H,3-4,7,15,25H2,1-2H3/t19-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374189
PNG
(US10246456, Example 329)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCC(O)CC2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H32N6O2/c1-2-5-22(28)24-8-4-7-23(31-24)18-14-25(32-12-10-20(35)11-13-32)21-16-29-33(26(21)15-18)27-9-3-6-19(17-34)30-27/h3-4,6-9,14-16,20,22,34-35H,2,5,10-13,17,28H2,1H3/t22-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374190
PNG
(US10246456, Example 330)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCCC(O)C2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H32N6O2/c1-2-6-22(28)24-10-4-9-23(31-24)18-13-25(32-12-5-8-20(35)16-32)21-15-29-33(26(21)14-18)27-11-3-7-19(17-34)30-27/h3-4,7,9-11,13-15,20,22,34-35H,2,5-6,8,12,16-17,28H2,1H3/t20?,22-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374191
PNG
(US10246456, Example 331)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CC(F)(F)C2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C25H26F2N6O/c1-2-5-19(28)21-8-4-7-20(31-21)16-10-22(32-14-25(26,27)15-32)18-12-29-33(23(18)11-16)24-9-3-6-17(13-34)30-24/h3-4,6-12,19,34H,2,5,13-15,28H2,1H3/t19-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374192
PNG
(US10246456, Example 332)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CC(CO)(CCl)C2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H31ClN6O2/c1-2-5-21(29)23-8-4-7-22(32-23)18-10-24(33-15-27(14-28,16-33)17-36)20-12-30-34(25(20)11-18)26-9-3-6-19(13-35)31-26/h3-4,6-12,21,35-36H,2,5,13-17,29H2,1H3/t21-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374193
PNG
(US10246456, Example 333)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCC(F)(F)C2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C26H28F2N6O/c1-2-5-20(29)22-8-4-7-21(32-22)17-12-23(33-11-10-26(27,28)16-33)19-14-30-34(24(19)13-17)25-9-3-6-18(15-35)31-25/h3-4,6-9,12-14,20,35H,2,5,10-11,15-16,29H2,1H3/t20-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374194
PNG
(US10246456, Example 334)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCOC(C)C2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H32N6O2/c1-3-6-22(28)24-9-5-8-23(31-24)19-13-25(32-11-12-35-18(2)16-32)21-15-29-33(26(21)14-19)27-10-4-7-20(17-34)30-27/h4-5,7-10,13-15,18,22,34H,3,6,11-12,16-17,28H2,1-2H3/t18?,22-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374195
PNG
(US10246456, Example 335)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CC(C)OC(C)C2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C28H34N6O2/c1-4-7-23(29)25-10-6-9-24(32-25)20-12-26(33-15-18(2)36-19(3)16-33)22-14-30-34(27(22)13-20)28-11-5-8-21(17-35)31-28/h5-6,8-14,18-19,23,35H,4,7,15-17,29H2,1-3H3/t18?,19?,23-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374196
PNG
(US10246456, Example 336)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(NCC(CCl)C(O)=O)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C26H29ClN6O3/c1-2-5-20(28)22-8-4-7-21(32-22)16-10-23(29-13-17(12-27)26(35)36)19-14-30-33(24(19)11-16)25-9-3-6-18(15-34)31-25/h3-4,6-11,14,17,20,29,34H,2,5,12-13,15,28H2,1H3,(H,35,36)/t17?,20-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374197
PNG
(US10246456, Example 337)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCS(=O)(=O)CC2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C26H30N6O3S/c1-2-5-21(27)23-8-4-7-22(30-23)18-14-24(31-10-12-36(34,35)13-11-31)20-16-28-32(25(20)15-18)26-9-3-6-19(17-33)29-26/h3-4,6-9,14-16,21,33H,2,5,10-13,17,27H2,1H3/t21-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374198
PNG
(US10246456, Example 338)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCSCC2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C26H30N6OS/c1-2-5-21(27)23-8-4-7-22(30-23)18-14-24(31-10-12-34-13-11-31)20-16-28-32(25(20)15-18)26-9-3-6-19(17-33)29-26/h3-4,6-9,14-16,21,33H,2,5,10-13,17,27H2,1H3/t21-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374199
PNG
(US10246456, Example 339)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCOCC2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C26H30N6O2/c1-2-5-21(27)23-8-4-7-22(30-23)18-14-24(31-10-12-34-13-11-31)20-16-28-32(25(20)15-18)26-9-3-6-19(17-33)29-26/h3-4,6-9,14-16,21,33H,2,5,10-13,17,27H2,1H3/t21-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374200
PNG
(US10246456, Example 340)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CC(C)(C)C2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H32N6O/c1-4-7-21(28)23-10-6-9-22(31-23)18-12-24(32-16-27(2,3)17-32)20-14-29-33(25(20)13-18)26-11-5-8-19(15-34)30-26/h5-6,8-14,21,34H,4,7,15-17,28H2,1-3H3/t21-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374201
PNG
(US10246456, Example 341)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCC(C2)C(O)=O)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H30N6O3/c1-2-5-21(28)23-8-4-7-22(31-23)18-12-24(32-11-10-17(15-32)27(35)36)20-14-29-33(25(20)13-18)26-9-3-6-19(16-34)30-26/h3-4,6-9,12-14,17,21,34H,2,5,10-11,15-16,28H2,1H3,(H,35,36)/t17?,21-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374202
PNG
(US10246456, Example 342)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCCC2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C26H30N6O/c1-2-7-21(27)23-10-6-9-22(30-23)18-14-24(31-12-3-4-13-31)20-16-28-32(25(20)15-18)26-11-5-8-19(17-33)29-26/h5-6,8-11,14-16,21,33H,2-4,7,12-13,17,27H2,1H3/t21-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374203
PNG
(US10246456, Example 343)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCN(C)CC2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H33N7O/c1-3-6-22(28)24-9-5-8-23(31-24)19-15-25(33-13-11-32(2)12-14-33)21-17-29-34(26(21)16-19)27-10-4-7-20(18-35)30-27/h4-5,7-10,15-17,22,35H,3,6,11-14,18,28H2,1-2H3/t22-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374204
PNG
(US10246456, Example 344)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(NCC(C)(C)CCl)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H33ClN6O/c1-4-7-21(29)23-10-6-9-22(33-23)18-12-24(30-17-27(2,3)16-28)20-14-31-34(25(20)13-18)26-11-5-8-19(15-35)32-26/h5-6,8-14,21,30,35H,4,7,15-17,29H2,1-3H3/t21-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374205
PNG
(US10246456, Example 345)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCC2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C25H28N6O/c1-2-6-20(26)22-9-4-8-21(29-22)17-13-23(30-11-5-12-30)19-15-27-31(24(19)14-17)25-10-3-7-18(16-32)28-25/h3-4,7-10,13-15,20,32H,2,5-6,11-12,16,26H2,1H3/t20-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374206
PNG
(US10246456, Example 346)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCC(F)(F)CC2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H30F2N6O/c1-2-5-21(30)23-8-4-7-22(33-23)18-14-24(34-12-10-27(28,29)11-13-34)20-16-31-35(25(20)15-18)26-9-3-6-19(17-36)32-26/h3-4,6-9,14-16,21,36H,2,5,10-13,17,30H2,1H3/t21-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374207
PNG
(US10246456, Example 347)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCCC(F)(F)C2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H30F2N6O/c1-2-6-21(30)23-9-4-8-22(33-23)18-13-24(34-12-5-11-27(28,29)17-34)20-15-31-35(25(20)14-18)26-10-3-7-19(16-36)32-26/h3-4,7-10,13-15,21,36H,2,5-6,11-12,16-17,30H2,1H3/t21-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374208
PNG
(US10246456, Example 348)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CC(C2)C(O)=O)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C26H28N6O3/c1-2-5-20(27)22-8-4-7-21(30-22)16-10-23(31-13-17(14-31)26(34)35)19-12-28-32(24(19)11-16)25-9-3-6-18(15-33)29-25/h3-4,6-12,17,20,33H,2,5,13-15,27H2,1H3,(H,34,35)/t20-/s2
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n/an/an/an/a<1.00E+3n/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374209
PNG
(US10246456, Example 349)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCCC(C2)C(O)=O)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C28H32N6O3/c1-2-6-22(29)24-10-4-9-23(32-24)19-13-25(33-12-5-7-18(16-33)28(36)37)21-15-30-34(26(21)14-19)27-11-3-8-20(17-35)31-27/h3-4,8-11,13-15,18,22,35H,2,5-7,12,16-17,29H2,1H3,(H,36,37)/t18?,22-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374213
PNG
(US10246456, Example 354)
Show SMILES C[C@H](N)c1cccc(n1)-c1cc(-n2ccnc2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C23H21N7O/c1-15(24)19-5-3-6-20(28-19)16-10-21(29-9-8-25-14-29)18-12-26-30(22(18)11-16)23-7-2-4-17(13-31)27-23/h2-12,14-15,31H,13,24H2,1H3/t15-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374214
PNG
(US10246456, Example 355)
Show SMILES C[C@H](N)c1cccc(n1)-c1cc(-n2cncn2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C22H20N8O/c1-14(23)18-5-3-6-19(28-18)15-8-20(29-13-24-12-26-29)17-10-25-30(21(17)9-15)22-7-2-4-16(11-31)27-22/h2-10,12-14,31H,11,23H2,1H3/t14-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374216
PNG
((S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-meth...)
Show SMILES C[C@H](N)c1cccc(n1)-c1cc(-c2ccn(C)n2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C24H23N7O/c1-15(25)20-6-4-7-21(28-20)16-11-18(22-9-10-30(2)29-22)19-13-26-31(23(19)12-16)24-8-3-5-17(14-32)27-24/h3-13,15,32H,14,25H2,1-2H3/t15-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374217
PNG
(US10246456, Example 358)
Show SMILES CCc1cccc(n1)-c1cc(-c2nnc(C)o2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C23H20N6O2/c1-3-16-6-4-8-20(25-16)15-10-18(23-28-27-14(2)31-23)19-12-24-29(21(19)11-15)22-9-5-7-17(13-30)26-22/h4-12,30H,3,13H2,1-2H3
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374218
PNG
(US10246456, Example 359)
Show SMILES C[C@H](N)c1cccc(n1)-c1cc(-c2ncco2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C23H20N6O2/c1-14(24)19-5-3-6-20(28-19)15-10-17(23-25-8-9-31-23)18-12-26-29(21(18)11-15)22-7-2-4-16(13-30)27-22/h2-12,14,30H,13,24H2,1H3/t14-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
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