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Found 189 of ic50 for UniProtKB: P26664
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM307515(US10150740, Example 11)
Affinity DataIC50:  39nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM307512(US10150740, Example 8)
Affinity DataIC50:  44nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50158837(4-(3'',5''-Dichloro-2''-cyano-biphenyl-3-yl)-2,4-d...)
Affinity DataIC50:  45nMAssay Description:Inhibitory concentration against hepatitis C virus polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM307518(US10150740, Example 14)
Affinity DataIC50:  47nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM307510(US10150740, Example 6)
Affinity DataIC50:  53nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50125376(CHEMBL275290 | {(S)-3-[(S)-3-Cyclohexyl-2-((2S,3S)...)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration of the compound against HCV NS3 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM35553(1H-benzo[de]isoquinoline-1,3(2H)-dione, 1)
Affinity DataIC50:  64nMAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50158839(4-(5''-Bromo-2''-cyano-biphenyl-3-yl)-2,4-dioxo-bu...)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against hepatitis C virus polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50158845(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against hepatitis C virus polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50158815(4-(3''-Chloro-2''-cyano-biphenyl-3-yl)-2,4-dioxo-b...)
Affinity DataIC50:  110nMAssay Description:Inhibitory concentration against hepatitis C virus polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM307517(US10150740, Example 13)
Affinity DataIC50:  110nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM307511(US10150740, Example 7)
Affinity DataIC50:  172nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM307514(US10150740, Example 10)
Affinity DataIC50:  225nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50125388(CHEMBL13256 | {(S)-3-[(S)-3-Cyclohexyl-2-((2S,3S)-...)
Affinity DataIC50:  230nMAssay Description:Inhibitory concentration of the compound against HCV NS3 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM307509(US10150740, Example 5)
Affinity DataIC50:  248nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50110153((S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-car...)
Affinity DataIC50:  300nMAssay Description:Inhibition to hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50110146((S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-car...)
Affinity DataIC50:  330nMAssay Description:Inhibition to hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50158822(4-[2-(5-Bromo-2-cyano-phenoxy)-phenyl]-2,4-dioxo-b...)
Affinity DataIC50:  350nMAssay Description:Inhibitory concentration against hepatitis C virus polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50110145((S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-2-cyc...)
Affinity DataIC50:  380nMAssay Description:Inhibition to hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50139666(5-(4-Acetyl-phenyl)-3-(2,4-dimethyl-benzenesulfony...)
Affinity DataIC50:  390nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50125392((S)-4-((S)-1-{(S)-1-[(S)-2-((S)-1-Allylaminooxalyl...)
Affinity DataIC50:  420nMAssay Description:Inhibitory concentration of the compound against HCV NS3 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50110143(4-{(S)-1-[(S)-1-((S)-3,3-Difluoro-1-oxalyl-propylc...)
Affinity DataIC50:  440nMAssay Description:Inhibition to hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50110134((S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-met...)
Affinity DataIC50:  460nMAssay Description:Inhibition to hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM307519(US10150740, Example 15)
Affinity DataIC50:  500nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM307513(US10150740, Example 9)
Affinity DataIC50:  624nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM307507(US10150740, Example 3)
Affinity DataIC50:  740nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50139669(3-(4-Chloro-2-methyl-benzenesulfonylamino)-5-pheny...)
Affinity DataIC50:  750nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50410369(CHEMBL363650)
Affinity DataIC50:  794nMAssay Description:Inhibitory concentration against hepatitis C virus NS3 protease (IC50 spans 2.5 log units)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM30406(CHEMBL176058 | benzo[1,2,4]thiadiazine-1,1-dioxide...)
Affinity DataIC50:  800nMAssay Description:Inhibitory concentration against hepatitis C virus polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50144349(4-[2-((S)-4,4-Difluoro-2-{[(2S,4S)-1-(2-isobutoxyc...)
Affinity DataIC50:  900nMAssay Description:Inhibition of Hepatitis C virus NS3 protease in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50110130((S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-met...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition to hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50139657(3-(2,4-Dimethyl-benzenesulfonylamino)-5-phenyl-thi...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of Hepatitis C polymerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50139657(3-(2,4-Dimethyl-benzenesulfonylamino)-5-phenyl-thi...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50139682(3-[(4-Chloro-benzoyl)-methyl-amino]-5-phenyl-thiop...)
Affinity DataIC50:  1.20E+3nMAssay Description:In vitro inhibition of Hepatitis C polymerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50139683(3-[(2,4-DICHLOROBENZOYL)(ISOPROPYL)AMINO]-5-PHENYL...)
Affinity DataIC50:  1.20E+3nMAssay Description:In vitro inhibition of Hepatitis C polymerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50125371((S)-2-{(S)-3-[(S)-3-Cyclohexyl-2-((2S,3S)-3-methyl...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibitory concentration of the compound against HCV NS3 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50110156((S)-3-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-m...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition to hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50139676(3-[(2,4-Dimethyl-benzoyl)-methyl-amino]-5-phenyl-t...)
Affinity DataIC50:  1.40E+3nMAssay Description:In vitro inhibition of Hepatitis C polymerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50139659(5-(4-Acetyl-phenyl)-3-(toluene-2-sulfonylamino)-th...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50125378(CHEMBL274547 | Pyrazine-2-carboxylic acid ((S)-1-{...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibitory concentration of the compound against HCV NS3 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50110148((S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-car...)
Affinity DataIC50:  1.63E+3nMAssay Description:Inhibition to hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50110149(4-{(S)-1-[(S)-1-((S)-3,3-Difluoro-1-oxalyl-propylc...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition to hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50110152((S)-3-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-m...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition to hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50125385(CHEMBL13370 | Pyrazine-2-carboxylic acid ((S)-1-{(...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory concentration of the compound against HCV NS3 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50139658(5-(4-Methanesulfonyl-phenyl)-3-(toluene-2-sulfonyl...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50139673(2-[(2,4-Dichloro-benzoyl)-(3-trifluoromethyl-benzy...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50410376(CHEMBL190689)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory concentration against hepatitis C virus NS3 protease (IC50 spans 2.5 log units)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50139675(3-[Methyl-(4-methyl-benzoyl)-amino]-5-phenyl-thiop...)
Affinity DataIC50:  2.00E+3nMAssay Description:In vitro inhibition of Hepatitis C polymerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50139681(3-[Ethyl-(4-methyl-benzoyl)-amino]-5-phenyl-thioph...)
Affinity DataIC50:  2.00E+3nMAssay Description:In vitro inhibition of Hepatitis C polymerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50110129((S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-car...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition to hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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