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Compile Data Set for Download or QSAR

Found 4 hits of ec50 for UniProtKB: P54760   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ephrin type-B receptor 4


(Homo sapiens (Human))
BDBM50242740
PNG
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)
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Article
PubMed
n/an/an/an/a 4n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of EphB4 by cellular assay


Proc Natl Acad Sci U S A 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4


(Homo sapiens (Human))
BDBM50553180
PNG
(CHEMBL4792853)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(cc1)-n1c(N)c(C(N)=O)c2nc3ccccc3nc12)C(C)(C)C
Show InChI InChI=1S/C32H31N9O2/c1-18-9-13-21(14-10-18)41-25(17-24(39-41)32(2,3)4)38-31(43)35-19-11-15-20(16-12-19)40-28(33)26(29(34)42)27-30(40)37-23-8-6-5-7-22(23)36-27/h5-17H,33H2,1-4H3,(H2,34,42)(H2,35,38,43)
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n/an/an/an/a 360n/an/an/an/a



University of Zurich

Curated by ChEMBL


Assay Description
Inhibition of full-length human EPHB4 expressed in MEF cells assessed as autophosphorylation by sandwitch-ELISA


RSC Med Chem 11: 665-675 (2020)

More data for this
Ligand-Target Pair
Ephrin type-B receptor 4


(Homo sapiens (Human))
BDBM482158
PNG
(BDBM50242742 | TAE684)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
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Article
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n/an/an/an/a>1.00E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of EphB4 by cellular assay


Proc Natl Acad Sci U S A 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4


(Homo sapiens (Human))
BDBM50553181
PNG
(CHEMBL4784484)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-n2c(N)c(C(N)=O)c3nc4ccccc4nc23)n(n1)-c1ccc2ncccc2c1
Show InChI InChI=1S/C34H30N10O2/c1-34(2,3)26-18-27(44(42-26)22-14-15-23-19(17-22)7-6-16-37-23)41-33(46)38-20-10-12-21(13-11-20)43-30(35)28(31(36)45)29-32(43)40-25-9-5-4-8-24(25)39-29/h4-18H,35H2,1-3H3,(H2,36,45)(H2,38,41,46)
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n/an/an/an/a 1.10E+3n/an/an/an/a



University of Zurich

Curated by ChEMBL


Assay Description
Inhibition of full-length human EPHB4 expressed in MEF cells assessed as autophosphorylation by sandwitch-ELISA


RSC Med Chem 11: 665-675 (2020)

More data for this
Ligand-Target Pair