Compile Data Set for Download or QSAR
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Found 186 of ic50 for UniProtKB: P06746
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50408425(CHEMBL2092835)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound was evaluated for the inhibition of cellular DNA polymerase (beta)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50408425(CHEMBL2092835)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound was evaluated for the inhibition of cellular DNA polymerase (beta)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50241922(CHEMBL486991 | ddCTP SODIUM | sodium ((2S,5R)-5-(4...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human recombinant DNA polymerase beta assessed as fluorescein-12-dCTP incorporation by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50164648(2'-deoxythymidine triphosphate | 5'-TTP | CHEMBL36...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human DNA polymerase-betaMore data for this Ligand-Target Pair
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50335554(({[({[2-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)e...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human DNA polymerase beta by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50184757((3aR,4R,7S,7aS)-7-ethyl 2,4-dimethyl 3,5-dihexadec...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50408426(CHEMBL2092833)
Affinity DataIC50:  2.20E+3nMAssay Description:Compound was evaluated for the inhibition of cellular DNA polymerase (beta)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50292441(1beta-hydroxyaleuritolic acid 3-p-hydroxybenzoate ...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50184758((3aS,4S,7R,7aR)-1,6-didodecyl-2,7-bis(methoxycarbo...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50184756((3aR,4S,7S,7aS)-7-ethyl 2,4-dimethyl 3,5-dihexadec...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50346601(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50184755((3aS,4S,7R,7aR)-1,6-dihexadecyl-2,7-bis(methoxycar...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50184752((3aS,4S,7R,7aR)-1,6-dihexadecyl-2,7-bis(isopropoxy...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50250356((+)-protolichesterinic acid | CHEMBL490329 | proto...)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50184761((3aR,4R,7S,7aS)-dimethyl 3,5-dihexadecyl-1-oxo-7-(...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50184748((2S,3S,4R)-methyl 2-ethyl-4-hydroxy-5-(2-oxononade...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50184750((2R,3S,4R)-4-hydroxy-5-[2-oxo-nonadec-ylidene]-1-p...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50079577((4aS,6aS,6bR,10S,12aR,14bS)-10-Hydroxy-2,2,6a,6b,9...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of DNA polymerase beta (unknown origin) lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50346601(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50184754((E)-methyl-3,6-dioxo-4-docosenoate | CHEMBL425779)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of DNA polymerase beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50181922(2-(4-(bis(3-fluorophenyl)methoxy)phenyl)-1-cyclohe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50184759((2R,3S,4R)-methyl 1-(2-(1H-indol-3-yl)ethyl)-4-hyd...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50181929(1-cyclohexyl-2-(4-(dip-tolylmethoxy)phenyl)-1H-ben...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50181923(2-(4-(benzhydryloxy)phenyl)-1-cyclohexyl-1H-benzo[...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50181933(2-(4-(bis(4-fluorophenyl)methoxy)phenyl)-1-cyclohe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50181926(2-{4-[Bis-(4-dimethylcarbamoyl-phenyl)-methoxy]-2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50181941(2-(4-(benzhydryloxy)-2-fluorophenyl)-1-cyclohexyl-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50181935(1-Cyclohexyl-2-[4-(di-pyridin-3-yl-methoxy)-2-fluo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50181932(2-(4-(bis(4-chlorophenyl)methoxy)phenyl)-1-cyclohe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50181938(1-Cyclohexyl-2-[2-fluoro-4-(phenyl-pyridin-3-yl-me...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50181927(2-(4-(bis(4-fluorophenyl)methoxy)-2-fluorophenyl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50241929(CHEMBL520861 | Mahureone D)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human recombinant DNA polymerase beta assessed as fluorescein-12-dCTP incorporation by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50242105(CHEMBL470873 | armenin-B)
Affinity DataIC50:  1.23E+4nMAssay Description:Inhibition of DNA polymerase beta (unknown origin) lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50184753((1R,1bR,2R,5S,5aS)-1a,3-dihexadecyl-6-oxo-1a,1b,2,...)
Affinity DataIC50: >1.25E+4nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50:  1.26E+4nMAssay Description:Inhibition of DNA polymerase beta (unknown origin) lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50250720(3beta,16beta,23-triacetoxyolean-12-en-28-oic acid ...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50335553(CHEMBL1652466 | [({[2-(2-amino-6-oxo-6,9-dihydro-3...)
Affinity DataIC50:  1.35E+4nMAssay Description:Inhibition of human DNA polymerase beta by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50242088((7S,8R,1'S,5'S,6'R)-delta 2',8'-5',6'-Dihydroxy-3'...)
Affinity DataIC50:  1.53E+4nMAssay Description:Inhibition of DNA polymerase beta (unknown origin) lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50370476(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM104089((Z)-5-(3-Nitro-4-(o-tolylthio)benzylidene)-2-thiox...)
Affinity DataIC50:  1.82E+4nMpH: 7.9Assay Description:Pol β reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.9, 20mM KCl, 5% (v/v) glycerol, 1mM DTT, 2mM MnCl2, 250nM puri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50242090(2,4-Dimethoxy-5,6-methylenedioxy-1-(2-propenyl)ben...)
Affinity DataIC50:  1.86E+4nMAssay Description:Inhibition of DNA polymerase beta (unknown origin) lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50148911((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)
Affinity DataIC50:  1.86E+4nMAssay Description:Inhibition of DNA polymerase beta (unknown origin) lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50020676(CHEBI:41846 | CHEMBL566812)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human DNA polymerase beta using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50300195(4-Fluoro-2-[3-(1-naphthalen-2-ylmethyl-1H-pyrazol-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50300194(2-[3-(1-Benzyl-1H-pyrazol-3-yl)-benzenesulfonylami...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50300193(2-[3-(1-Benzyl-1H-pyrazol-3-yl)-benzenesulfonylami...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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