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Compile Data Set for Download or QSAR

Found 1 hit of ec50 data for polymerid = 5758   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50436423
PNG
(CHEMBL2397014)
Show SMILES COc1cc(ccc1Nc1ncc(F)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1
Show InChI InChI=1S/C22H25FN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27)
PDB

KEGG

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 4n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of LRRK2 G2019S mutant-induced neuronal toxicity in human cortical neurons


J Med Chem 58: 6733-46 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00261
BindingDB Entry DOI: 10.7270/Q20K2BC9
More data for this
Ligand-Target Pair