Compile Data Set for Download or QSAR

Found 289 hits of ec50 data for polymerid = 5868   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50060964 ((R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-...) Show SMILES CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(c1)S(N)(=O)=O Show InChI InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0700	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed...				Bioorg Med Chem 24: 5582-5591 (2016) Article DOI: 10.1016/j.bmc.2016.09.017 BindingDB Entry DOI: 10.7270/Q20K2BJJ
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50000210 (CHEMBL422477) Show SMILES C(Oc1ccccc1-c1ccsc1)C1=NCCN1 Show InChI InChI=1S/C14H14N2OS/c1-2-4-13(17-9-14-15-6-7-16-14)12(3-1)11-5-8-18-10-11/h1-5,8,10H,6-7,9H2,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.25	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL...				Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author Article DOI: 10.1016/s0960-894x(01)00764-8 BindingDB Entry DOI: 10.7270/Q22V2HD6
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50258559 ((S)-6-(2-(pyrimidin-5-yl)phenyl)-6,7-dihydro-5H-py...) Show SMILES C1[C@H](Cn2ccnc12)c1ccccc1-c1cncnc1 Show InChI InChI=1S/C16H14N4/c1-2-4-15(13-8-17-11-18-9-13)14(3-1)12-7-16-19-5-6-20(16)10-12/h1-6,8-9,11-12H,7,10H2/t12-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR				Bioorg Med Chem Lett 19: 3113-7 (2009) Article DOI: 10.1016/j.bmcl.2009.03.166 BindingDB Entry DOI: 10.7270/Q2WS8T5T
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50219169 (CHEMBL152155) Show SMILES C(Nc1ccccc1-c1ccco1)C1=NCCN1 Show InChI InChI=1S/C14H15N3O/c1-2-5-12(17-10-14-15-7-8-16-14)11(4-1)13-6-3-9-18-13/h1-6,9,17H,7-8,10H2,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.468	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function...				Bioorg Med Chem Lett 12: 575-9 (2002) Article DOI: 10.1016/s0960-894x(01)00822-8 BindingDB Entry DOI: 10.7270/Q2Z320ZN
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50000195 (CHEMBL142784) Show SMILES C(Oc1ccccc1-c1ccoc1)C1=NCCN1 Show InChI InChI=1S/C14H14N2O2/c1-2-4-13(18-10-14-15-6-7-16-14)12(3-1)11-5-8-17-9-11/h1-5,8-9H,6-7,10H2,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL...				Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author Article DOI: 10.1016/s0960-894x(01)00764-8 BindingDB Entry DOI: 10.7270/Q22V2HD6
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50421599 (CHEMBL155326) Show SMILES C(Nc1ccccc1-c1ncco1)C1=NCCN1 Show InChI InChI=1S/C13H14N4O/c1-2-4-11(17-9-12-14-5-6-15-12)10(3-1)13-16-7-8-18-13/h1-4,7-8,17H,5-6,9H2,(H,14,15)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.661	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function...				Bioorg Med Chem Lett 12: 575-9 (2002) Article DOI: 10.1016/s0960-894x(01)00822-8 BindingDB Entry DOI: 10.7270/Q2Z320ZN
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50219153 (CHEMBL414185) Show SMILES COC(=O)c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C12H15N3O2/c1-17-12(16)9-4-2-3-5-10(9)15-8-11-13-6-7-14-11/h2-5,15H,6-8H2,1H3,(H,13,14)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.794	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.				Bioorg Med Chem Lett 11: 2871-4 (2001) Article DOI: 10.1016/s0960-894x(01)00569-8 BindingDB Entry DOI: 10.7270/Q2CC1201
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50219153 (CHEMBL414185) Show SMILES COC(=O)c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C12H15N3O2/c1-17-12(16)9-4-2-3-5-10(9)15-8-11-13-6-7-14-11/h2-5,15H,6-8H2,1H3,(H,13,14)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.794	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function...				Bioorg Med Chem Lett 12: 575-9 (2002) Article DOI: 10.1016/s0960-894x(01)00822-8 BindingDB Entry DOI: 10.7270/Q2Z320ZN
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50222910 (CHEMBL17491) Show SMILES C(Nc1ccccc1-c1nc[nH]n1)C1=NCCN1 Show InChI InChI=1S/C12H14N6/c1-2-4-10(15-7-11-13-5-6-14-11)9(3-1)12-16-8-17-18-12/h1-4,8,15H,5-7H2,(H,13,14)(H,16,17,18)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.794	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells				Bioorg Med Chem Lett 13: 1183-6 (2003) Article DOI: 10.1016/s0960-894x(03)00050-7 BindingDB Entry DOI: 10.7270/Q21V5G8T
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50219153 (CHEMBL414185) Show SMILES COC(=O)c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C12H15N3O2/c1-17-12(16)9-4-2-3-5-10(9)15-8-11-13-6-7-14-11/h2-5,15H,6-8H2,1H3,(H,13,14)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.794	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Effective concentration showing agonistic activity towards Human alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cells was determined				Bioorg Med Chem Lett 13: 1183-6 (2003) Article DOI: 10.1016/s0960-894x(03)00050-7 BindingDB Entry DOI: 10.7270/Q21V5G8T
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50421597 (CHEMBL155327) Show SMILES C(Nc1ccccc1-c1ccno1)C1=NCCN1 Show InChI InChI=1S/C13H14N4O/c1-2-4-11(16-9-13-14-7-8-15-13)10(3-1)12-5-6-17-18-12/h1-6,16H,7-9H2,(H,14,15)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.794	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function...				Bioorg Med Chem Lett 12: 575-9 (2002) Article DOI: 10.1016/s0960-894x(01)00822-8 BindingDB Entry DOI: 10.7270/Q2Z320ZN
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50219080 (CHEMBL152693) Show SMILES Cc1ccsc1-c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C15H17N3S/c1-11-6-9-19-15(11)12-4-2-3-5-13(12)18-10-14-16-7-8-17-14/h2-6,9,18H,7-8,10H2,1H3,(H,16,17)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.851	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function...				Bioorg Med Chem Lett 12: 575-9 (2002) Article DOI: 10.1016/s0960-894x(01)00822-8 BindingDB Entry DOI: 10.7270/Q2Z320ZN
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50258563 ((S)-6-(2-(pyridin-3-yl)phenyl)-6,7-dihydro-5H-pyrr...) Show SMILES C1[C@H](Cn2ccnc12)c1ccccc1-c1cccnc1 Show InChI InChI=1S/C17H15N3/c1-2-6-16(14-10-17-19-8-9-20(17)12-14)15(5-1)13-4-3-7-18-11-13/h1-9,11,14H,10,12H2/t14-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR				Bioorg Med Chem Lett 19: 3113-7 (2009) Article DOI: 10.1016/j.bmcl.2009.03.166 BindingDB Entry DOI: 10.7270/Q2WS8T5T
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50421641 (CHEMBL277375) Show SMILES C(Nc1ccccc1-c1cc[nH]n1)C1=NCCN1 Show InChI InChI=1S/C13H15N5/c1-2-4-11(16-9-13-14-7-8-15-13)10(3-1)12-5-6-17-18-12/h1-6,16H,7-9H2,(H,14,15)(H,17,18)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells				Bioorg Med Chem Lett 13: 1183-6 (2003) Article DOI: 10.1016/s0960-894x(03)00050-7 BindingDB Entry DOI: 10.7270/Q21V5G8T
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50000216 (CHEMBL143801) Show SMILES C(Oc1ccccc1-c1cccs1)C1=NCCN1 Show InChI InChI=1S/C14H14N2OS/c1-2-5-12(17-10-14-15-7-8-16-14)11(4-1)13-6-3-9-18-13/h1-6,9H,7-8,10H2,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL...				Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author Article DOI: 10.1016/s0960-894x(01)00764-8 BindingDB Entry DOI: 10.7270/Q22V2HD6
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50258594 (6-(5-fluoro-2-(pyrimidin-5-yl)phenyl)-6,7-dihydro-...) Show SMILES Fc1ccc(-c2cncnc2)c(c1)C1Cc2nccn2C1 Show InChI InChI=1S/C16H13FN4/c17-13-1-2-14(12-7-18-10-19-8-12)15(6-13)11-5-16-20-3-4-21(16)9-11/h1-4,6-8,10-11H,5,9H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR				Bioorg Med Chem Lett 19: 3113-7 (2009) Article DOI: 10.1016/j.bmcl.2009.03.166 BindingDB Entry DOI: 10.7270/Q2WS8T5T
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50000197 (CHEMBL279136) Show SMILES C(Oc1ccccc1-c1ccco1)C1=NCCN1 Show InChI InChI=1S/C14H14N2O2/c1-2-5-13(18-10-14-15-7-8-16-14)11(4-1)12-6-3-9-17-12/h1-6,9H,7-8,10H2,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL...				Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author Article DOI: 10.1016/s0960-894x(01)00764-8 BindingDB Entry DOI: 10.7270/Q22V2HD6
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50219156 (CHEMBL97859) Show SMILES CCC(C)OC(=O)c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C15H21N3O2/c1-3-11(2)20-15(19)12-6-4-5-7-13(12)18-10-14-16-8-9-17-14/h4-7,11,18H,3,8-10H2,1-2H3,(H,16,17)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.				Bioorg Med Chem Lett 11: 2871-4 (2001) Article DOI: 10.1016/s0960-894x(01)00569-8 BindingDB Entry DOI: 10.7270/Q2CC1201
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50222908 (CHEMBL273316) Show SMILES CCn1ncnc1-c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C14H18N6/c1-2-20-14(18-10-19-20)11-5-3-4-6-12(11)17-9-13-15-7-8-16-13/h3-6,10,17H,2,7-9H2,1H3,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells				Bioorg Med Chem Lett 13: 1183-6 (2003) Article DOI: 10.1016/s0960-894x(03)00050-7 BindingDB Entry DOI: 10.7270/Q21V5G8T
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50421593 (CHEMBL357129) Show SMILES C(Oc1ccccc1-c1ccc[nH]1)C1=NCCN1 Show InChI InChI=1S/C14H15N3O/c1-2-6-13(18-10-14-16-8-9-17-14)11(4-1)12-5-3-7-15-12/h1-7,15H,8-10H2,(H,16,17)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL...				Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author Article DOI: 10.1016/s0960-894x(01)00764-8 BindingDB Entry DOI: 10.7270/Q22V2HD6
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50222935 (CHEMBL275844) Show SMILES C(Nc1ccccc1-c1cn[nH]c1)C1=NCCN1 Show InChI InChI=1S/C13H15N5/c1-2-4-12(16-9-13-14-5-6-15-13)11(3-1)10-7-17-18-8-10/h1-4,7-8,16H,5-6,9H2,(H,14,15)(H,17,18)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells				Bioorg Med Chem Lett 13: 1183-6 (2003) Article DOI: 10.1016/s0960-894x(03)00050-7 BindingDB Entry DOI: 10.7270/Q21V5G8T
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50222905 (CHEMBL18069) Show SMILES Cn1ncnc1-c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C13H16N6/c1-19-13(17-9-18-19)10-4-2-3-5-11(10)16-8-12-14-6-7-15-12/h2-5,9,16H,6-8H2,1H3,(H,14,15)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells				Bioorg Med Chem Lett 13: 1183-6 (2003) Article DOI: 10.1016/s0960-894x(03)00050-7 BindingDB Entry DOI: 10.7270/Q21V5G8T
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50421594 (CHEMBL356605) Show SMILES C(Oc1ccccc1-c1cccnc1)C1=NCCN1 Show InChI InChI=1S/C15H15N3O/c1-2-6-14(19-11-15-17-8-9-18-15)13(5-1)12-4-3-7-16-10-12/h1-7,10H,8-9,11H2,(H,17,18)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL...				Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author Article DOI: 10.1016/s0960-894x(01)00764-8 BindingDB Entry DOI: 10.7270/Q22V2HD6
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50258560 ((S)-2-(2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-...) Show SMILES C1[C@H](Cn2ccnc12)c1ccccc1-c1ncco1 Show InChI InChI=1S/C15H13N3O/c1-2-4-13(15-17-6-8-19-15)12(3-1)11-9-14-16-5-7-18(14)10-11/h1-8,11H,9-10H2/t11-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR				Bioorg Med Chem Lett 19: 3113-7 (2009) Article DOI: 10.1016/j.bmcl.2009.03.166 BindingDB Entry DOI: 10.7270/Q2WS8T5T
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50219165 (CHEMBL346380) Show SMILES C(Nc1ccccc1-c1cccs1)C1=NCCN1 Show InChI InChI=1S/C14H15N3S/c1-2-5-12(17-10-14-15-7-8-16-14)11(4-1)13-6-3-9-18-13/h1-6,9,17H,7-8,10H2,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.20	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function...				Bioorg Med Chem Lett 12: 575-9 (2002) Article DOI: 10.1016/s0960-894x(01)00822-8 BindingDB Entry DOI: 10.7270/Q2Z320ZN
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50421512 (CHEMBL95523) Show SMILES CNC(=O)c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C12H16N4O/c1-13-12(17)9-4-2-3-5-10(9)16-8-11-14-6-7-15-11/h2-5,16H,6-8H2,1H3,(H,13,17)(H,14,15)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.				Bioorg Med Chem Lett 11: 2871-4 (2001) Article DOI: 10.1016/s0960-894x(01)00569-8 BindingDB Entry DOI: 10.7270/Q2CC1201
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50222929 (CHEMBL275902) Show SMILES CCn1cccc1-c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C16H20N4/c1-2-20-11-5-8-15(20)13-6-3-4-7-14(13)19-12-16-17-9-10-18-16/h3-8,11,19H,2,9-10,12H2,1H3,(H,17,18)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells				Bioorg Med Chem Lett 13: 1183-6 (2003) Article DOI: 10.1016/s0960-894x(03)00050-7 BindingDB Entry DOI: 10.7270/Q21V5G8T
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50000208 (CHEMBL142871) Show SMILES C(Oc1ccccc1-c1nccs1)C1=NCCN1 Show InChI InChI=1S/C13H13N3OS/c1-2-4-11(17-9-12-14-5-6-15-12)10(3-1)13-16-7-8-18-13/h1-4,7-8H,5-6,9H2,(H,14,15)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL...				Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author Article DOI: 10.1016/s0960-894x(01)00764-8 BindingDB Entry DOI: 10.7270/Q22V2HD6
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50000218 (CHEMBL143973) Show SMILES C(Oc1ccccc1-c1cnccn1)C1=NCCN1 Show InChI InChI=1S/C14H14N4O/c1-2-4-13(19-10-14-17-7-8-18-14)11(3-1)12-9-15-5-6-16-12/h1-6,9H,7-8,10H2,(H,17,18)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL...				Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author Article DOI: 10.1016/s0960-894x(01)00764-8 BindingDB Entry DOI: 10.7270/Q22V2HD6
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50219298 (CHEMBL152725) Show SMILES Cc1ccc(o1)-c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C15H17N3O/c1-11-6-7-14(19-11)12-4-2-3-5-13(12)18-10-15-16-8-9-17-15/h2-7,18H,8-10H2,1H3,(H,16,17)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.70	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function...				Bioorg Med Chem Lett 12: 575-9 (2002) Article DOI: 10.1016/s0960-894x(01)00822-8 BindingDB Entry DOI: 10.7270/Q2Z320ZN
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50377387 (CHEMBL260720) Show SMILES Cc1[nH]ncc1-c1cccc2C(CCc12)c1ncc[nH]1 Show InChI InChI=1S/C16H16N4/c1-10-15(9-19-20-10)12-4-2-3-11-13(12)5-6-14(11)16-17-7-8-18-16/h2-4,7-9,14H,5-6H2,1H3,(H,17,18)(H,19,20)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR				Bioorg Med Chem Lett 18: 2930-4 (2008) Article DOI: 10.1016/j.bmcl.2008.03.070 BindingDB Entry DOI: 10.7270/Q2VQ33KM
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50258642 (6-(5-fluoro-2-(1H-pyrazol-5-yl)phenyl)-6,7-dihydro...) Show SMILES Fc1ccc(-c2cc[nH]n2)c(c1)C1Cc2nccn2C1 Show InChI InChI=1S/C15H13FN4/c16-11-1-2-12(14-3-4-18-19-14)13(8-11)10-7-15-17-5-6-20(15)9-10/h1-6,8,10H,7,9H2,(H,18,19)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR				Bioorg Med Chem Lett 19: 3113-7 (2009) Article DOI: 10.1016/j.bmcl.2009.03.166 BindingDB Entry DOI: 10.7270/Q2WS8T5T
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50258640 (2-(2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-yl)-...) Show SMILES Fc1ccc(-c2ncco2)c(c1)C1Cc2nccn2C1 Show InChI InChI=1S/C15H12FN3O/c16-11-1-2-12(15-18-4-6-20-15)13(8-11)10-7-14-17-3-5-19(14)9-10/h1-6,8,10H,7,9H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR				Bioorg Med Chem Lett 19: 3113-7 (2009) Article DOI: 10.1016/j.bmcl.2009.03.166 BindingDB Entry DOI: 10.7270/Q2WS8T5T
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50258562 ((S)-2-(2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-...) Show SMILES C1[C@H](Cn2ccnc12)c1ccccc1-c1nccs1 Show InChI InChI=1S/C15H13N3S/c1-2-4-13(15-17-6-8-19-15)12(3-1)11-9-14-16-5-7-18(14)10-11/h1-8,11H,9-10H2/t11-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR				Bioorg Med Chem Lett 19: 3113-7 (2009) Article DOI: 10.1016/j.bmcl.2009.03.166 BindingDB Entry DOI: 10.7270/Q2WS8T5T
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50421578 (CHEMBL13789) Show SMILES C(Oc1ccccc1-c1ccccc1)C1=NCCN1 Show InChI InChI=1S/C16H16N2O/c1-2-6-13(7-3-1)14-8-4-5-9-15(14)19-12-16-17-10-11-18-16/h1-9H,10-12H2,(H,17,18)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.20	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL...				Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author Article DOI: 10.1016/s0960-894x(01)00764-8 BindingDB Entry DOI: 10.7270/Q22V2HD6
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50421595 (CHEMBL143562) Show SMILES Cc1ccoc1-c1ccccc1OCC1=NCCN1 Show InChI InChI=1S/C15H16N2O2/c1-11-6-9-18-15(11)12-4-2-3-5-13(12)19-10-14-16-7-8-17-14/h2-6,9H,7-8,10H2,1H3,(H,16,17)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.20	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL...				Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author Article DOI: 10.1016/s0960-894x(01)00764-8 BindingDB Entry DOI: 10.7270/Q22V2HD6
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50421516 (CHEMBL319553) Show SMILES CC(C)OC(=O)c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C14H19N3O2/c1-10(2)19-14(18)11-5-3-4-6-12(11)17-9-13-15-7-8-16-13/h3-6,10,17H,7-9H2,1-2H3,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.20	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.				Bioorg Med Chem Lett 11: 2871-4 (2001) Article DOI: 10.1016/s0960-894x(01)00569-8 BindingDB Entry DOI: 10.7270/Q2CC1201
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50222907 (CHEMBL17856) Show SMILES Cn1ccc(n1)-c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C14H17N5/c1-19-9-6-13(18-19)11-4-2-3-5-12(11)17-10-14-15-7-8-16-14/h2-6,9,17H,7-8,10H2,1H3,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.20	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells				Bioorg Med Chem Lett 13: 1183-6 (2003) Article DOI: 10.1016/s0960-894x(03)00050-7 BindingDB Entry DOI: 10.7270/Q21V5G8T
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50421578 (CHEMBL13789) Show SMILES C(Oc1ccccc1-c1ccccc1)C1=NCCN1 Show InChI InChI=1S/C16H16N2O/c1-2-6-13(7-3-1)14-8-4-5-9-15(14)19-12-16-17-10-11-18-16/h1-9H,10-12H2,(H,17,18)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.20	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts				Bioorg Med Chem Lett 12: 3449-52 (2002) Article DOI: 10.1016/s0960-894x(02)00753-9 BindingDB Entry DOI: 10.7270/Q2G44RM1
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50219079 (CHEMBL156950) Show SMILES CC\C(=N/OC)c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C14H20N4O/c1-3-12(18-19-2)11-6-4-5-7-13(11)17-10-14-15-8-9-16-14/h4-7,17H,3,8-10H2,1-2H3,(H,15,16)/b18-12+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.30	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function...				Bioorg Med Chem Lett 12: 575-9 (2002) Article DOI: 10.1016/s0960-894x(01)00822-8 BindingDB Entry DOI: 10.7270/Q2Z320ZN
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50258590 ((S)-N-(2'-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6...) Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1ccccc1[C@@H]1Cc2nccn2C1 Show InChI InChI=1S/C19H19N3O2S/c1-25(23,24)21-16-6-4-5-14(11-16)17-7-2-3-8-18(17)15-12-19-20-9-10-22(19)13-15/h2-11,15,21H,12-13H2,1H3/t15-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR				Bioorg Med Chem Lett 19: 3113-7 (2009) Article DOI: 10.1016/j.bmcl.2009.03.166 BindingDB Entry DOI: 10.7270/Q2WS8T5T
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50421576 (CHEMBL325745) Show SMILES CCCNC(=O)c1ccccc1NCc1cnc[nH]1 Show InChI InChI=1S/C14H18N4O/c1-2-7-16-14(19)12-5-3-4-6-13(12)17-9-11-8-15-10-18-11/h3-6,8,10,17H,2,7,9H2,1H3,(H,15,18)(H,16,19)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts				Bioorg Med Chem Lett 12: 3449-52 (2002) Article DOI: 10.1016/s0960-894x(02)00753-9 BindingDB Entry DOI: 10.7270/Q2G44RM1
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50219255 (CHEMBL434074) Show SMILES Cc1nc(cs1)-c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C14H16N4S/c1-10-18-13(9-19-10)11-4-2-3-5-12(11)17-8-14-15-6-7-16-14/h2-5,9,17H,6-8H2,1H3,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function...				Bioorg Med Chem Lett 12: 575-9 (2002) Article DOI: 10.1016/s0960-894x(01)00822-8 BindingDB Entry DOI: 10.7270/Q2Z320ZN
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50219297 (CHEMBL349082) Show SMILES C(Nc1ccccc1-c1cnccn1)C1=NCCN1 Show InChI InChI=1S/C14H15N5/c1-2-4-12(19-10-14-17-7-8-18-14)11(3-1)13-9-15-5-6-16-13/h1-6,9,19H,7-8,10H2,(H,17,18)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.60	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function...				Bioorg Med Chem Lett 12: 575-9 (2002) Article DOI: 10.1016/s0960-894x(01)00822-8 BindingDB Entry DOI: 10.7270/Q2Z320ZN
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50258643 (6-(5-fluoro-2-(1H-pyrazol-1-yl)phenyl)-6,7-dihydro...) Show SMILES Fc1ccc(c(c1)C1Cc2nccn2C1)-n1cccn1 Show InChI InChI=1S/C15H13FN4/c16-12-2-3-14(20-6-1-4-18-20)13(9-12)11-8-15-17-5-7-19(15)10-11/h1-7,9,11H,8,10H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR				Bioorg Med Chem Lett 19: 3113-7 (2009) Article DOI: 10.1016/j.bmcl.2009.03.166 BindingDB Entry DOI: 10.7270/Q2WS8T5T
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50421580 (CHEMBL117248) Show SMILES CSc1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C11H15N3S/c1-15-10-5-3-2-4-9(10)14-8-11-12-6-7-13-11/h2-5,14H,6-8H2,1H3,(H,12,13)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts				Bioorg Med Chem Lett 12: 3449-52 (2002) Article DOI: 10.1016/s0960-894x(02)00753-9 BindingDB Entry DOI: 10.7270/Q2G44RM1
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50000207 (CHEMBL142387) Show SMILES C(Oc1ccccc1-c1ccns1)C1=NCCN1 Show InChI InChI=1S/C13H13N3OS/c1-2-4-11(17-9-13-14-7-8-15-13)10(3-1)12-5-6-16-18-12/h1-6H,7-9H2,(H,14,15)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL...				Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author Article DOI: 10.1016/s0960-894x(01)00764-8 BindingDB Entry DOI: 10.7270/Q22V2HD6
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50000205 (CHEMBL344551) Show SMILES C(Oc1ccccc1-c1cc[nH]n1)C1=NCCN1 Show InChI InChI=1S/C13H14N4O/c1-2-4-12(18-9-13-14-7-8-15-13)10(3-1)11-5-6-16-17-11/h1-6H,7-9H2,(H,14,15)(H,16,17)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL...				Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author Article DOI: 10.1016/s0960-894x(01)00764-8 BindingDB Entry DOI: 10.7270/Q22V2HD6
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50258589 ((S)-6-(2-(1H-pyrazol-1-yl)phenyl)-6,7-dihydro-5H-p...) Show SMILES C1[C@H](Cn2ccnc12)c1ccccc1-n1cccn1 Show InChI InChI=1S/C15H14N4/c1-2-5-14(19-8-3-6-17-19)13(4-1)12-10-15-16-7-9-18(15)11-12/h1-9,12H,10-11H2/t12-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR				Bioorg Med Chem Lett 19: 3113-7 (2009) Article DOI: 10.1016/j.bmcl.2009.03.166 BindingDB Entry DOI: 10.7270/Q2WS8T5T
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50222932 (CHEMBL18256) Show SMILES Cn1ccnc1-c1ccccc1NCC1=NCCN1 Show InChI InChI=1S/C14H17N5/c1-19-9-8-17-14(19)11-4-2-3-5-12(11)18-10-13-15-6-7-16-13/h2-5,8-9,18H,6-7,10H2,1H3,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.30	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells				Bioorg Med Chem Lett 13: 1183-6 (2003) Article DOI: 10.1016/s0960-894x(03)00050-7 BindingDB Entry DOI: 10.7270/Q21V5G8T
					More data for this Ligand-Target Pair

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