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Compile Data Set for Download or QSAR

Found 1105 hits for UniProtKB: Q05655   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C delta type


(Homo sapiens (human))
BDBM92596
PNG
(Sapintoxin D)
Show SMILES CCCC(=O)O[C@@]12C(C3CC(=O)C[C@@]4(O)C(C=C(C)C4=O)[C@]3(O)[C@@H](C)[C@H]1OC(=O)c1ccccc1NC)C2(C)C
Show InChI InChI=1S/C31H39NO8/c1-7-10-23(34)40-31-24(28(31,4)5)20-14-18(33)15-29(37)22(13-16(2)25(29)35)30(20,38)17(3)26(31)39-27(36)19-11-8-9-12-21(19)32-6/h8-9,11-13,17,20,22,24,26,32,37-38H,7,10,14-15H2,1-6H3/t17-,20?,22?,24?,26+,29+,30-,31-/m0/s1
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0.140 -54.9n/an/an/an/an/a7.418



National Institutes of Health



Assay Description
[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.


J Biol Chem 283: 10543-9 (2008)


Article DOI: 10.1074/jbc.M707463200
BindingDB Entry DOI: 10.7270/Q2CF9NQ6
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50391386
PNG
(CHEMBL2148106)
Show SMILES CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@@H](OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H](C)O)[C@@H]1C)c1cccc(O)c1
Show InChI InChI=1S/C32H48O10/c1-18(11-12-24(38-7)22-9-8-10-23(34)13-22)29-20(3)26-16-32(41-29)30(5,6)15-19(2)31(37,42-32)17-28(36)39-25(21(4)33)14-27(35)40-26/h8-10,13,18-21,24-26,29,33-34,37H,11-12,14-17H2,1-7H3/t18-,19+,20-,21+,24-,25+,26?,29+,31-,32-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of [3H]PDBu binding to PKCdelta C1B domain


J Med Chem 55: 5614-26 (2012)


Article DOI: 10.1021/jm300566h
BindingDB Entry DOI: 10.7270/Q200036J
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50064089
PNG
(4-hydroxymethyl-7,10-diisopropyl-8,10,13-trimethyl...)
Show SMILES CC(C)[C@@H]1N(C)c2cc3c(c4[nH]cc(C[C@@H](CO)NC1=O)c24)[C@](C)(CC[C@]3(C)C(C)C)C=C
Show InChI InChI=1S/C28H41N3O2/c1-9-27(6)10-11-28(7,17(4)5)20-13-21-22-18(14-29-24(22)23(20)27)12-19(15-32)30-26(33)25(16(2)3)31(21)8/h9,13-14,16-17,19,25,29,32H,1,10-12,15H2,2-8H3,(H,30,33)/t19-,25-,27-,28+/m0/s1
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0.320n/an/an/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Displacement of [3H]-PDBu from recombinant Protein kinase C delta


J Med Chem 41: 1476-96 (1998)


Article DOI: 10.1021/jm970704s
BindingDB Entry DOI: 10.7270/Q2RV0MT8
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50327943
PNG
(Aplysiatoxin | CHEMBL1256416)
Show SMILES CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@@H](OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H](C)O)[C@@H]1C)c1cc(O)ccc1Br
Show InChI InChI=1S/C32H47BrO10/c1-17(8-11-24(39-7)22-12-21(35)9-10-23(22)33)29-19(3)26-15-32(42-29)30(5,6)14-18(2)31(38,43-32)16-28(37)40-25(20(4)34)13-27(36)41-26/h9-10,12,17-20,24-26,29,34-35,38H,8,11,13-16H2,1-7H3/t17-,18+,19-,20+,24-,25+,26?,29+,31-,32-/m0/s1
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0.410n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of [3H]PDBu binding to PKC delta C1B peptide


Bioorg Med Chem Lett 20: 6064-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.051
BindingDB Entry DOI: 10.7270/Q2FJ2H04
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50258529
PNG
(CHEMBL449158 | bryostatin 1)
Show SMILES CCC\C=C\C=C\C(=O)O[C@H]1\C(C[C@H]2C[C@@H](OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C\C(C[C@@H](O4)\C=C\C(C)(C)[C@]1(O)O2)=C\C(=O)OC)O3)[C@@H](C)O)=C\C(=O)OC
Show InChI InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1
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0.440n/an/an/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from human recombinant PKCdelta expressed in Sf9 cells by liquid scintillation counting


J Med Chem 52: 3969-81 (2009)


Article DOI: 10.1021/jm900229p
BindingDB Entry DOI: 10.7270/Q2ZK5GJ1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50229772
PNG
(1-hexylindolactam-V | CHEMBL399981)
Show SMILES CCCCCCn1cc2C[C@@H](CO)NC(=O)[C@H](C(C)C)N(C)c3cccc1c23
Show InChI InChI=1S/C23H35N3O2/c1-5-6-7-8-12-26-14-17-13-18(15-27)24-23(28)22(16(2)3)25(4)19-10-9-11-20(26)21(17)19/h9-11,14,16,18,22,27H,5-8,12-13,15H2,1-4H3,(H,24,28)/t18-,22-/m0/s1
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0.460n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from PKCdelta C1B domain


J Med Chem 51: 46-56 (2008)


Article DOI: 10.1021/jm0706719
BindingDB Entry DOI: 10.7270/Q2445M7Q
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50391388
PNG
(CHEMBL2148108)
Show SMILES C[C@@H]1[C@@H](CCCCc2cccc(O)c2)O[C@]23C[C@@H]1OC(=O)C[C@H](CO)OC(=O)C[C@@H](CCC2(C)C)O3
Show InChI InChI=1S/C28H40O8/c1-18-23(10-5-4-7-19-8-6-9-20(30)13-19)36-28-16-24(18)34-26(32)15-22(17-29)33-25(31)14-21(35-28)11-12-27(28,2)3/h6,8-9,13,18,21-24,29-30H,4-5,7,10-12,14-17H2,1-3H3/t18-,21-,22-,23-,24?,28-/m1/s1
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0.460n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of [3H]PDBu binding to PKCdelta C1B domain


J Med Chem 55: 5614-26 (2012)


Article DOI: 10.1021/jm300566h
BindingDB Entry DOI: 10.7270/Q200036J
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50097750
PNG
(Butyric acid (1aR,1bS,4aS,7aR,7bR,8R,9R,9aS)-9-but...)
Show SMILES CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@H]3CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCC
Show InChI InChI=1S/C28H40O7/c1-7-9-21(30)34-25-16(4)27(33)19-11-15(3)23(32)18(19)12-17(14-29)13-20(27)24-26(5,6)28(24,25)35-22(31)10-8-2/h11,13,16,18-20,24-25,29,33H,7-10,12,14H2,1-6H3/t16-,18+,19-,20+,24?,25-,27+,28-/m1/s1
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0.550n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Displacement of 3[H]PDBu from Protein kinase C delta C1a domain


Bioorg Med Chem Lett 11: 719-22 (2001)


Article DOI: 10.1016/s0960-894x(01)00045-2
BindingDB Entry DOI: 10.7270/Q2VM4BHZ
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM86431
PNG
(CAS_4179 | Mezerein | NSC_4179)
Show SMILES CC1C(OC(=O)C=CC=Cc2ccccc2)C2(OC3(OC2C2C4OC4(CO)C(O)C4(O)C(C=C(C)C4=O)C12O3)c1ccccc1)C(C)=C
Show InChI InChI=1S/C38H38O10/c1-21(2)36-30(44-27(40)18-12-11-15-24-13-7-5-8-14-24)23(4)37-26-19-22(3)29(41)35(26,43)33(42)34(20-39)31(45-34)28(37)32(36)46-38(47-36,48-37)25-16-9-6-10-17-25/h5-19,23,26,28,30-33,39,42-43H,1,20H2,2-4H3
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0.550n/an/an/an/an/an/an/an/a



University of Pittsburgh

Curated by PDSP Ki Database




Mol Pharmacol 64: 1342-8 (2003)


Article DOI: 10.1124/mol.64.6.1342
BindingDB Entry DOI: 10.7270/Q270800T
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM86434
PNG
(12-Deoxyphorbol 13-phenylacetate | CAS_105100 | NS...)
Show SMILES CC1CC2(OC(=O)Cc3ccccc3)C(C3C=C(CO)CC4(O)C(C=C(C)C4=O)C13O)C2(C)C
Show InChI InChI=1S/C28H34O6/c1-16-10-21-26(32,24(16)31)14-19(15-29)11-20-23-25(3,4)27(23,13-17(2)28(20,21)33)34-22(30)12-18-8-6-5-7-9-18/h5-11,17,20-21,23,29,32-33H,12-15H2,1-4H3
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0.560n/an/an/an/an/an/an/an/a



University of Pittsburgh

Curated by PDSP Ki Database




Mol Pharmacol 64: 1342-8 (2003)


Article DOI: 10.1124/mol.64.6.1342
BindingDB Entry DOI: 10.7270/Q270800T
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM86432
PNG
((-)-Octylindolactam V | CAS_159320 | NSC_159320)
Show SMILES CCCCCCCCc1ccc2N(C)C(C(C)C)C(=O)NC(CO)Cc3c[nH]c1c23
Show InChI InChI=1S/C25H39N3O2/c1-5-6-7-8-9-10-11-18-12-13-21-22-19(15-26-23(18)22)14-20(16-29)27-25(30)24(17(2)3)28(21)4/h12-13,15,17,20,24,26,29H,5-11,14,16H2,1-4H3,(H,27,30)
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0.770n/an/an/an/an/an/an/an/a



University of Pittsburgh

Curated by PDSP Ki Database




Mol Pharmacol 64: 1342-8 (2003)


Article DOI: 10.1124/mol.64.6.1342
BindingDB Entry DOI: 10.7270/Q270800T
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50057512
PNG
((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Show SMILES CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCC
Show InChI InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22?,24-,26-,27-,28-/m1/s1
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0.800n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PDBu binding to PKC delta wild type


J Med Chem 40: 1316-26 (1997)


Article DOI: 10.1021/jm960875h
BindingDB Entry DOI: 10.7270/Q2319TZS
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50084061
PNG
((2S,5S)-5-Hydroxymethyl-1-methyl-2-tetradecyl-1,4,...)
Show SMILES CCCCCCCCCCCCCC[C@@H]1N(C)c2ccccc2C[C@@H](CO)NC1=O
Show InChI InChI=1S/C26H44N2O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-19-25-26(30)27-23(21-29)20-22-17-15-16-18-24(22)28(25)2/h15-18,23,25,29H,3-14,19-21H2,1-2H3,(H,27,30)/t23-,25-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant protein kinase C delta


Bioorg Med Chem Lett 10: 63-6 (2000)


Article DOI: 10.1016/s0960-894x(99)00580-6
BindingDB Entry DOI: 10.7270/Q2R210K4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50084059
PNG
((2S,5S)-2-Dodecyl-5-hydroxymethyl-1-methyl-1,4,5,6...)
Show SMILES CCCCCCCCCCCC[C@@H]1N(C)c2ccccc2C[C@@H](CO)NC1=O
Show InChI InChI=1S/C24H40N2O2/c1-3-4-5-6-7-8-9-10-11-12-17-23-24(28)25-21(19-27)18-20-15-13-14-16-22(20)26(23)2/h13-16,21,23,27H,3-12,17-19H2,1-2H3,(H,25,28)/t21-,23-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant protein kinase C delta


Bioorg Med Chem Lett 10: 63-6 (2000)


Article DOI: 10.1016/s0960-894x(99)00580-6
BindingDB Entry DOI: 10.7270/Q2R210K4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50084058
PNG
((2S,5S)-2-Decyl-5-hydroxymethyl-1-methyl-1,4,5,6-t...)
Show SMILES CCCCCCCCCC[C@@H]1N(C)c2ccccc2C[C@@H](CO)NC1=O
Show InChI InChI=1S/C22H36N2O2/c1-3-4-5-6-7-8-9-10-15-21-22(26)23-19(17-25)16-18-13-11-12-14-20(18)24(21)2/h11-14,19,21,25H,3-10,15-17H2,1-2H3,(H,23,26)/t19-,21-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant protein kinase C delta


Bioorg Med Chem Lett 10: 63-6 (2000)


Article DOI: 10.1016/s0960-894x(99)00580-6
BindingDB Entry DOI: 10.7270/Q2R210K4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50099066
PNG
(CHEMBL279115 | phorbol 13-acetate 12-myristate)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O
Show InChI InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30?,32-,34-,35-,36-/m1/s1
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0.800n/an/an/an/an/an/an/an/a



Georgetotwn University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C delta


Bioorg Med Chem Lett 11: 955-9 (2001)


Article DOI: 10.1016/s0960-894x(01)00097-x
BindingDB Entry DOI: 10.7270/Q2D799PV
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50057514
PNG
((10S,13S)-13-Hydroxymethyl-10-isopropyl-9-methyl-5...)
Show SMILES CCCCCCCCc1ccc2N(C)[C@@H](C(C)C)C(=O)N[C@H](CO)Cc3c[nH]c1c23
Show InChI InChI=1S/C25H39N3O2/c1-5-6-7-8-9-10-11-18-12-13-21-22-19(15-26-23(18)22)14-20(16-29)27-25(30)24(17(2)3)28(21)4/h12-13,15,17,20,24,26,29H,5-11,14,16H2,1-4H3,(H,27,30)/t20-,24-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]- PDBu from recombinant PKC delta expressed in baculovirus


J Med Chem 40: 1316-26 (1997)


Article DOI: 10.1021/jm960875h
BindingDB Entry DOI: 10.7270/Q2319TZS
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50107120
PNG
((E) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Show SMILES CC(C)CC(C\C=C1/CC(CO)(COC(=O)C(C)(C)C)OC1=O)CC(C)C
Show InChI InChI=1S/C22H38O5/c1-15(2)10-17(11-16(3)4)8-9-18-12-22(13-23,27-19(18)24)14-26-20(25)21(5,6)7/h9,15-17,23H,8,10-14H2,1-7H3/b18-9+
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0.900n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Inhibition of [3H]PDBu binding to C1b domain of protein kinase C delta with phosphatidylserine


J Med Chem 48: 5738-48 (2005)


Article DOI: 10.1021/jm050352m
BindingDB Entry DOI: 10.7270/Q27M07G5
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50107120
PNG
((E) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Show SMILES CC(C)CC(C\C=C1/CC(CO)(COC(=O)C(C)(C)C)OC1=O)CC(C)C
Show InChI InChI=1S/C22H38O5/c1-15(2)10-17(11-16(3)4)8-9-18-12-22(13-23,27-19(18)24)14-26-20(25)21(5,6)7/h9,15-17,23H,8,10-14H2,1-7H3/b18-9+
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0.900n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Binding affinity for isolated C1b domain of protein kinase C-delta


J Med Chem 47: 4858-64 (2004)


Article DOI: 10.1021/jm049723+
BindingDB Entry DOI: 10.7270/Q25D8SMX
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50057512
PNG
((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Show SMILES CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCC
Show InChI InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22?,24-,26-,27-,28-/m1/s1
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1n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Displacement of 3[H]PDBu from Protein kinase C delta C1a domain


Bioorg Med Chem Lett 11: 719-22 (2001)


Article DOI: 10.1016/s0960-894x(01)00045-2
BindingDB Entry DOI: 10.7270/Q2VM4BHZ
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50107112
PNG
((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Show SMILES CC(C)CC(C\C=C1\CC(CO)(COC(=O)C(C)(C)C)OC1=O)CC(C)C
Show InChI InChI=1S/C22H38O5/c1-15(2)10-17(11-16(3)4)8-9-18-12-22(13-23,27-19(18)24)14-26-20(25)21(5,6)7/h9,15-17,23H,8,10-14H2,1-7H3/b18-9-
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1.16 -49.8n/an/an/an/an/a7.418



National Institutes of Health



Assay Description
[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.


J Biol Chem 283: 10543-9 (2008)


Article DOI: 10.1074/jbc.M707463200
BindingDB Entry DOI: 10.7270/Q2CF9NQ6
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50107112
PNG
((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Show SMILES CC(C)CC(C\C=C1\CC(CO)(COC(=O)C(C)(C)C)OC1=O)CC(C)C
Show InChI InChI=1S/C22H38O5/c1-15(2)10-17(11-16(3)4)8-9-18-12-22(13-23,27-19(18)24)14-26-20(25)21(5,6)7/h9,15-17,23H,8,10-14H2,1-7H3/b18-9-
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1.20n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Binding affinity for isolated C1b domain of protein kinase C-delta


J Med Chem 47: 4858-64 (2004)


Article DOI: 10.1021/jm049723+
BindingDB Entry DOI: 10.7270/Q25D8SMX
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50107112
PNG
((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Show SMILES CC(C)CC(C\C=C1\CC(CO)(COC(=O)C(C)(C)C)OC1=O)CC(C)C
Show InChI InChI=1S/C22H38O5/c1-15(2)10-17(11-16(3)4)8-9-18-12-22(13-23,27-19(18)24)14-26-20(25)21(5,6)7/h9,15-17,23H,8,10-14H2,1-7H3/b18-9-
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1.20n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PDBu binding to C1b domain of protein kinase C delta


J Med Chem 48: 5738-48 (2005)


Article DOI: 10.1021/jm050352m
BindingDB Entry DOI: 10.7270/Q27M07G5
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM86429
PNG
(CAS_6437389 | NSC_6437389 | Thymeleatoxin | Thymel...)
Show SMILES CC1C(OC(=O)C=Cc2ccccc2)C2(OC3(OC2C2C4OC4(CO)C(O)C4(O)C(C=C(C)C4=O)C12O3)c1ccccc1)C(C)=C
Show InChI InChI=1S/C36H36O10/c1-19(2)34-28(42-25(38)16-15-22-11-7-5-8-12-22)21(4)35-24-17-20(3)27(39)33(24,41)31(40)32(18-37)29(43-32)26(35)30(34)44-36(45-34,46-35)23-13-9-6-10-14-23/h5-17,21,24,26,28-31,37,40-41H,1,18H2,2-4H3
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1.31n/an/an/an/an/an/an/an/a



University of Pittsburgh

Curated by PDSP Ki Database




Mol Pharmacol 64: 1342-8 (2003)


Article DOI: 10.1124/mol.64.6.1342
BindingDB Entry DOI: 10.7270/Q270800T
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50187521
PNG
((E)-{2-(hydroxymethyl)-4-[(4-hydroxyphenyl)methyle...)
Show SMILES CC(C)C(CC(=O)OCC1(CO)C\C(=C/c2ccc(O)cc2)C(=O)O1)C(C)C
Show InChI InChI=1S/C22H30O6/c1-14(2)19(15(3)4)10-20(25)27-13-22(12-23)11-17(21(26)28-22)9-16-5-7-18(24)8-6-16/h5-9,14-15,19,23-24H,10-13H2,1-4H3/b17-9+
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1.40n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Binding affinity to PKCdeltaC1b in presence of phospholipid


J Med Chem 49: 3185-203 (2006)


Article DOI: 10.1021/jm060011o
BindingDB Entry DOI: 10.7270/Q2Z89C1G
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50081077
PNG
(CHEMBL216658 | Dicarba-Closo-Dodecaborane analogue)
Show SMILES CCCC[C]1234[B]567[B]89%10[B]%11%12%13[B]585[B]%118%11[B]%12%12%14[B]9%139[B]16%10[B]2%129[C]38%14(c1ccc2C[C@@H](CO)NC(=O)[C@H](C(C)C)N(C)c2c1)[B]475%11
Show InChI InChI=1S/C21H30B10N2O2/c1-5-6-9-20-21(15-8-7-14-10-16(12-34)32-19(35)18(13(2)3)33(4)17(14)11-15)22(20)24(20)25(20)23(20,21)27(21)26(21,22)28(22,24)30(24,25)29(23,25,27)31(26,27,28)30/h7-8,11,13,16,18,34H,5-6,9-10,12H2,1-4H3,(H,32,35)/t16-,18-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Displacement of [3H]-PDBu from human recombinant Protein kinase C delta


Bioorg Med Chem Lett 9: 2561-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00436-9
BindingDB Entry DOI: 10.7270/Q2G44PHV
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM92595
PNG
(DAG-lactone (130C045))
Show SMILES CN(C)c1ccc(\C=C2\CC(CO)(COC(=O)c3ccc(cc3)N(=O)=O)OC2=O)cc1
Show InChI InChI=1S/C22H22N2O7/c1-23(2)18-7-3-15(4-8-18)11-17-12-22(13-25,31-21(17)27)14-30-20(26)16-5-9-19(10-6-16)24(28)29/h3-11,25H,12-14H2,1-2H3/b17-11-
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1.54 -49.1n/an/an/an/an/a7.418



National Institutes of Health



Assay Description
[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.


J Biol Chem 283: 10543-9 (2008)


Article DOI: 10.1074/jbc.M707463200
BindingDB Entry DOI: 10.7270/Q2CF9NQ6
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50081078
PNG
(CHEMBL374446 | Dicarba-Closo-Dodecaborane analogue)
Show SMILES CCCCCCCC[C]1234[B]567[B]89%10[B]%11%12%13[B]585[B]%118%11[B]%12%12%14[B]9%139[B]16%10[B]2%129[C]38%14(c1ccc2C[C@@H](CO)NC(=O)[C@H](C(C)C)N(C)c2c1)[B]475%11
Show InChI InChI=1S/C25H38B10N2O2/c1-5-6-7-8-9-10-13-24-25(19-12-11-18-14-20(16-38)36-23(39)22(17(2)3)37(4)21(18)15-19)26(24)28(24)29(24)27(24,25)31(25)30(25,26)32(26,28)34(28,29)33(27,29,31)35(30,31,32)34/h11-12,15,17,20,22,38H,5-10,13-14,16H2,1-4H3,(H,36,39)/t20-,22-/m0/s1
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1.80n/an/an/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Displacement of [3H]-PDBu from human recombinant Protein kinase C delta


Bioorg Med Chem Lett 9: 2561-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00436-9
BindingDB Entry DOI: 10.7270/Q2G44PHV
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50064091
PNG
((2S,5S)-9-Decyl-5-hydroxymethyl-2-isopropyl-1-meth...)
Show SMILES CCCCCCCCCCc1ccc2C[C@@H](CO)NC(=O)[C@H](C(C)C)N(C)c2c1
Show InChI InChI=1S/C25H42N2O2/c1-5-6-7-8-9-10-11-12-13-20-14-15-21-17-22(18-28)26-25(29)24(19(2)3)27(4)23(21)16-20/h14-16,19,22,24,28H,5-13,17-18H2,1-4H3,(H,26,29)/t22-,24-/m0/s1
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1.80n/an/an/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Displacement of [3H]-PDBu from human recombinant Protein kinase C delta


Bioorg Med Chem Lett 9: 2561-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00436-9
BindingDB Entry DOI: 10.7270/Q2G44PHV
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50081076
PNG
(CHEMBL414278 | Dicarba-Closo-Dodecaborane analogue)
Show SMILES CC(C)[C@@H]1N(C)c2cc(ccc2C[C@@H](CO)NC1=O)[C]1234[B]567[B]89%10[B]%11%12%13[B]585[B]%118%11[B]%12%12%14[B]9%139[B]16%10[B]2%129[C]38%14[B]475%11
Show InChI InChI=1S/C17H21B10N2O2/c1-9(2)14-15(31)28-12(8-30)6-10-4-5-11(7-13(10)29(14)3)17-16-18(17)20(16)21(16)19(16,17)23(17)22(17,18)24(18,20)26(20,21)25(19,21,23)27(22,23,24)26/h4-5,7,9,12,14,30H,6,8H2,1-3H3,(H,28,31)/t12-,14-/m0/s1
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2n/an/an/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Displacement of [3H]-PDBu from human recombinant Protein kinase C delta


Bioorg Med Chem Lett 9: 2561-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00436-9
BindingDB Entry DOI: 10.7270/Q2G44PHV
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50133236
PNG
(CHEMBL337834 | Tetradecanedioic acid ((S)-5-hydrox...)
Show SMILES CC(C)[C@@H]1N(C)c2ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc3ccc4C[C@@H](CO)NC(=O)[C@H](C(C)C)N(C)c4c3)cc2C[C@@H](CO)NC1=O
Show InChI InChI=1S/C44H68N6O6/c1-29(2)41-43(55)48-36(28-52)25-32-24-33(21-22-37(32)49(41)5)45-39(53)17-15-13-11-9-7-8-10-12-14-16-18-40(54)46-34-20-19-31-23-35(27-51)47-44(56)42(30(3)4)50(6)38(31)26-34/h19-22,24,26,29-30,35-36,41-42,51-52H,7-18,23,25,27-28H2,1-6H3,(H,45,53)(H,46,54)(H,47,56)(H,48,55)/t35-,36-,41-,42-/m0/s1
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2.10n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human Protein kinase C delta


J Med Chem 46: 4196-204 (2003)


Article DOI: 10.1021/jm0302041
BindingDB Entry DOI: 10.7270/Q2GF0SX2
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50078562
PNG
(11,21-dihydroxy-17-[1-hydroxy-(1R)-ethyl]-10,10-di...)
Show SMILES CCCCCCCC(=O)O[C@H]1\C(CC2C[C@@H](OC(=O)C[C@H](O)C[C@@H]3CCC[C@H](C[C@@H]4CCO[C@@H](O4)\C=C\C(C)(C)[C@]1(O)O2)O3)[C@@H](C)O)=C\C(=O)OC
Show InChI InChI=1S/C39H62O13/c1-6-7-8-9-10-14-33(42)51-37-26(20-34(43)46-5)19-31-24-32(25(2)40)50-35(44)22-27(41)21-28-12-11-13-29(48-28)23-30-16-18-47-36(49-30)15-17-38(3,4)39(37,45)52-31/h15,17,20,25,27-32,36-37,40-41,45H,6-14,16,18-19,21-24H2,1-5H3/b17-15+,26-20+/t25-,27-,28+,29-,30+,31?,32-,36+,37+,39-/m1/s1
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2.5n/an/an/an/an/an/an/an/a



Stanford University

Curated by ChEMBL


Assay Description
Displacement of [3H]-PDBu from protein kinase C delta C1b domain


Bioorg Med Chem Lett 9: 1687-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00263-2
BindingDB Entry DOI: 10.7270/Q2M907VD
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50249959
PNG
(CHEMBL522428 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES CC(C)=C1CC(CO)(COC(=O)c2ccc(cc2)C#Cc2ccc(C)cc2)OC1=O
Show InChI InChI=1S/C25H24O5/c1-17(2)22-14-25(15-26,30-24(22)28)16-29-23(27)21-12-10-20(11-13-21)9-8-19-6-4-18(3)5-7-19/h4-7,10-13,26H,14-16H2,1-3H3
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2.70n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCdelta in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)


Article DOI: 10.1021/jm900186m
BindingDB Entry DOI: 10.7270/Q2862GB6
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50064090
PNG
((S)-2-Decyl-5-hydroxymethyl-1-methyl-1,4,5,6-tetra...)
Show SMILES CCCCCCCCCCC1N(C)c2ccccc2C[C@@H](CO)NC1=O
Show InChI InChI=1S/C22H36N2O2/c1-3-4-5-6-7-8-9-10-15-21-22(26)23-19(17-25)16-18-13-11-12-14-20(18)24(21)2/h11-14,19,21,25H,3-10,15-17H2,1-2H3,(H,23,26)/t19-,21?/m0/s1
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3n/an/an/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Displacement of [3H]-PDBu from recombinant Protein kinase C delta


J Med Chem 41: 1476-96 (1998)


Article DOI: 10.1021/jm970704s
BindingDB Entry DOI: 10.7270/Q2RV0MT8
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50172488
PNG
(2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-[3-i...)
Show SMILES CC(C)CC(C\C=C1/CC(CO)(COC(=O)C(C)(C)C)OC1=S)CC(C)C
Show InChI InChI=1S/C22H38O4S/c1-15(2)10-17(11-16(3)4)8-9-18-12-22(13-23,26-19(18)27)14-25-20(24)21(5,6)7/h9,15-17,23H,8,10-14H2,1-7H3/b18-9+
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3.10n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Inhibition of [3H]PDBu binding to C1b domain of protein kinase C delta with phosphatidylserine


J Med Chem 48: 5738-48 (2005)


Article DOI: 10.1021/jm050352m
BindingDB Entry DOI: 10.7270/Q27M07G5
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50391387
PNG
(CHEMBL2148107)
Show SMILES C[C@@H]1CC(C)(C)[C@@]23C[C@@H](C[C@@H](CCCCc4cccc(O)c4)O2)OC(=O)C[C@H](CO)OC(=O)C[C@@H]1O3
Show InChI InChI=1S/C28H40O8/c1-18-15-27(2,3)28-16-22(33-25(31)13-23(17-29)34-26(32)14-24(18)36-28)12-21(35-28)10-5-4-7-19-8-6-9-20(30)11-19/h6,8-9,11,18,21-24,29-30H,4-5,7,10,12-17H2,1-3H3/t18-,21-,22?,23-,24+,28+/m1/s1
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3.30n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of [3H]PDBu binding to PKCdelta C1B domain


J Med Chem 55: 5614-26 (2012)


Article DOI: 10.1021/jm300566h
BindingDB Entry DOI: 10.7270/Q200036J
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50249959
PNG
(CHEMBL522428 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES CC(C)=C1CC(CO)(COC(=O)c2ccc(cc2)C#Cc2ccc(C)cc2)OC1=O
Show InChI InChI=1S/C25H24O5/c1-17(2)22-14-25(15-26,30-24(22)28)16-29-23(27)21-12-10-20(11-13-21)9-8-19-6-4-18(3)5-7-19/h4-7,10-13,26H,14-16H2,1-3H3
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5.40n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCdelta in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)


Article DOI: 10.1021/jm900186m
BindingDB Entry DOI: 10.7270/Q2862GB6
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50064091
PNG
((2S,5S)-9-Decyl-5-hydroxymethyl-2-isopropyl-1-meth...)
Show SMILES CCCCCCCCCCc1ccc2C[C@@H](CO)NC(=O)[C@H](C(C)C)N(C)c2c1
Show InChI InChI=1S/C25H42N2O2/c1-5-6-7-8-9-10-11-12-13-20-14-15-21-17-22(18-28)26-25(29)24(19(2)3)27(4)23(21)16-20/h14-16,19,22,24,28H,5-13,17-18H2,1-4H3,(H,26,29)/t22-,24-/m0/s1
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5.90n/an/an/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Displacement of [3H]-PDBu from recombinant Protein kinase C delta


J Med Chem 41: 1476-96 (1998)


Article DOI: 10.1021/jm970704s
BindingDB Entry DOI: 10.7270/Q2RV0MT8
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50078564
PNG
(CHEMBL45053 | Octanoic acid (E)-(1S,5S,9S,11S,15R,...)
Show SMILES CCCCCCCC(=O)O[C@H]1\C(CC2C[C@@H](OC(=O)C[C@H](O)CCO[C@@H](C[C@@H]3CCO[C@@H](O3)\C=C\C(C)(C)[C@]1(O)O2)C(C)(C)C)[C@@H](C)O)=C\C(=O)OC
Show InChI InChI=1S/C40H66O13/c1-9-10-11-12-13-14-33(43)52-37-27(22-34(44)47-8)21-30-24-31(26(2)41)51-35(45)23-28(42)16-19-48-32(38(3,4)5)25-29-17-20-49-36(50-29)15-18-39(6,7)40(37,46)53-30/h15,18,22,26,28-32,36-37,41-42,46H,9-14,16-17,19-21,23-25H2,1-8H3/b18-15+,27-22+/t26-,28-,29+,30?,31-,32+,36+,37+,40-/m1/s1
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6.30n/an/an/an/an/an/an/an/a



Stanford University

Curated by ChEMBL


Assay Description
Displacement of [3H]-PDBu from protein kinase C delta C1b domain


Bioorg Med Chem Lett 9: 1687-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00263-2
BindingDB Entry DOI: 10.7270/Q2M907VD
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50015677
PNG
((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester | 1,...)
Show SMILES CCCCCCCC(=O)OC[C@H](CO)OC(=O)CCCCCCC
Show InChI InChI=1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3/t17-/m0/s1
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6.80 -45.5n/an/an/an/an/a7.418



National Institutes of Health



Assay Description
[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.


J Biol Chem 283: 10543-9 (2008)


Article DOI: 10.1074/jbc.M707463200
BindingDB Entry DOI: 10.7270/Q2CF9NQ6
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50327946
PNG
(1S,3R,5R,9R,13R)-9-Hydroxymethyl-3-[4-(3-hydroxy-p...)
Show SMILES CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4cccc(O)c4)O[C@@]1(C3)O2
Show InChI InChI=1S/C27H38O8/c1-26(2)11-10-21-14-24(30)33-23(17-28)15-25(31)32-22-13-20(34-27(26,16-22)35-21)9-4-3-6-18-7-5-8-19(29)12-18/h5,7-8,12,20-23,28-29H,3-4,6,9-11,13-17H2,1-2H3/t20-,21-,22?,23-,27+/m1/s1
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7.40n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of [3H]PDBu binding to PKCdelta C1B domain


J Med Chem 55: 5614-26 (2012)


Article DOI: 10.1021/jm300566h
BindingDB Entry DOI: 10.7270/Q200036J
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50327946
PNG
(1S,3R,5R,9R,13R)-9-Hydroxymethyl-3-[4-(3-hydroxy-p...)
Show SMILES CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4cccc(O)c4)O[C@@]1(C3)O2
Show InChI InChI=1S/C27H38O8/c1-26(2)11-10-21-14-24(30)33-23(17-28)15-25(31)32-22-13-20(34-27(26,16-22)35-21)9-4-3-6-18-7-5-8-19(29)12-18/h5,7-8,12,20-23,28-29H,3-4,6,9-11,13-17H2,1-2H3/t20-,21-,22?,23-,27+/m1/s1
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7.40n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of [3H]PDBu binding to PKC delta C1B peptide


Bioorg Med Chem Lett 20: 6064-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.051
BindingDB Entry DOI: 10.7270/Q2FJ2H04
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50402020
PNG
(CHEMBL2205426)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O
Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-13-25-22(28-17)26-16-6-4-14(5-7-16)15-8-11-24-12-9-15/h4-13,29H,1-3H3,(H2,25,26,27,28)
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7.90n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant PKCdelta after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATP


Bioorg Med Chem Lett 22: 7615-22 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.009
BindingDB Entry DOI: 10.7270/Q2XK8GQ3
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM86430
PNG
((-)-Indolactam V | (-)-Indolactam V (low PS) | CAS...)
Show SMILES CC(C)C1N(C)c2cccc3[nH]cc(CC(CO)NC1=O)c23
Show InChI InChI=1S/C17H23N3O2/c1-10(2)16-17(22)19-12(9-21)7-11-8-18-13-5-4-6-14(15(11)13)20(16)3/h4-6,8,10,12,16,18,21H,7,9H2,1-3H3,(H,19,22)
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8.16n/an/an/an/an/an/an/an/a



University of Pittsburgh

Curated by PDSP Ki Database




Mol Pharmacol 64: 1342-8 (2003)


Article DOI: 10.1124/mol.64.6.1342
BindingDB Entry DOI: 10.7270/Q270800T
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50057511
PNG
((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Show SMILES CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23
Show InChI InChI=1S/C17H23N3O2/c1-10(2)16-17(22)19-12(9-21)7-11-8-18-13-5-4-6-14(15(11)13)20(16)3/h4-6,8,10,12,16,18,21H,7,9H2,1-3H3,(H,19,22)/t12-,16-/m0/s1
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8.20n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]- PDBu from recombinant PKC delta expressed in baculovirus


J Med Chem 40: 1316-26 (1997)


Article DOI: 10.1021/jm960875h
BindingDB Entry DOI: 10.7270/Q2319TZS
More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical/novel


(Homo sapiens (human))
BDBM50057511
PNG
((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Show SMILES CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23
Show InChI InChI=1S/C17H23N3O2/c1-10(2)16-17(22)19-12(9-21)7-11-8-18-13-5-4-6-14(15(11)13)20(16)3/h4-6,8,10,12,16,18,21H,7,9H2,1-3H3,(H,19,22)/t12-,16-/m0/s1
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8.30n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to Protein kinase C epsilon C1b domain


Bioorg Med Chem Lett 11: 723-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00047-6
BindingDB Entry DOI: 10.7270/Q2QV3KRS
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50057511
PNG
((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Show SMILES CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23
Show InChI InChI=1S/C17H23N3O2/c1-10(2)16-17(22)19-12(9-21)7-11-8-18-13-5-4-6-14(15(11)13)20(16)3/h4-6,8,10,12,16,18,21H,7,9H2,1-3H3,(H,19,22)/t12-,16-/m0/s1
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8.30n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Displacement of [3H]- PDBu from Protein kinase C delta C1b domain


Bioorg Med Chem Lett 10: 2087-90 (2000)


Article DOI: 10.1016/s0960-894x(00)00411-x
BindingDB Entry DOI: 10.7270/Q22F7NZS
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50327944
PNG
((1S,3R,5R,9R,13R)-9-Hydroxymethyl-16,16-dimethyl-3...)
Show SMILES CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4ccccc4)O[C@@]1(C3)O2
Show InChI InChI=1S/C27H38O7/c1-26(2)13-12-21-15-24(29)32-23(18-28)16-25(30)31-22-14-20(33-27(26,17-22)34-21)11-7-6-10-19-8-4-3-5-9-19/h3-5,8-9,20-23,28H,6-7,10-18H2,1-2H3/t20-,21-,22?,23-,27+/m1/s1
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9.80n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of [3H]PDBu binding to PKC delta C1B peptide


Bioorg Med Chem Lett 20: 6064-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.051
BindingDB Entry DOI: 10.7270/Q2FJ2H04
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50427365
PNG
(CHEMBL2326000)
Show SMILES CC(C)[C@@](C)(O)[C@@H]1CN(CCN1)c1nc(-c2n[nH]c3ncccc23)c(F)cc1CO
Show InChI InChI=1S/C21H27FN6O2/c1-12(2)21(3,30)16-10-28(8-7-23-16)20-13(11-29)9-15(22)18(25-20)17-14-5-4-6-24-19(14)27-26-17/h4-6,9,12,16,23,29-30H,7-8,10-11H2,1-3H3,(H,24,26,27)/t16-,21+/m0/s1
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<10n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PKC delta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 15 mins by spectrophotometry in presence of ATP


J Med Chem 56: 1799-810 (2013)


Article DOI: 10.1021/jm301465a
BindingDB Entry DOI: 10.7270/Q2M046R2
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50427367
PNG
(CHEMBL2325998)
Show SMILES CC(C)[C@@](C)(O)[C@@H]1CN(CCN1)c1nc(-c2n[nH]c3ncccc23)c(F)cc1O
Show InChI InChI=1S/C20H25FN6O2/c1-11(2)20(3,29)15-10-27(8-7-22-15)19-14(28)9-13(21)17(24-19)16-12-5-4-6-23-18(12)26-25-16/h4-6,9,11,15,22,28-29H,7-8,10H2,1-3H3,(H,23,25,26)/t15-,20+/m0/s1
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<10n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PKC delta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 15 mins by spectrophotometry in presence of ATP


J Med Chem 56: 1799-810 (2013)


Article DOI: 10.1021/jm301465a
BindingDB Entry DOI: 10.7270/Q2M046R2
More data for this
Ligand-Target Pair
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