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Compile Data Set for Download or QSAR

Found 123 hits of ec50 data for polymerid = 6095   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000900
PNG
(CHEMBL90804 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Show SMILES COC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C23H28N4O5/c1-31-21(29)14-27(16-6-3-2-4-7-16)20(28)8-5-11-32-17-9-10-18-15(12-17)13-19-22(24-18)26-23(30)25-19/h9-10,12-13,16H,2-8,11,14H2,1H3,(H2,24,25,26,30)
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n/an/an/an/a 0.700n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000892
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H28N4O3/c1-26(16-7-3-2-4-8-16)20(27)9-5-6-12-29-17-10-11-18-15(13-17)14-19-21(23-18)25-22(28)24-19/h10-11,13-14,16H,2-9,12H2,1H3,(H2,23,24,25,28)
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n/an/an/an/a 1n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000915
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-27(17-8-4-2-3-5-9-17)21(28)10-6-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)26-23(29)25-20/h11-12,14-15,17H,2-10,13H2,1H3,(H2,24,25,26,29)
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n/an/an/an/a 1n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50118223
PNG
(AR-C67085 | Adenosine triphosphate derivative | CH...)
Show SMILES CCCSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C14H22Cl2N5O12P3S/c1-2-3-37-13-19-10(17)7-11(20-13)21(5-18-7)12-9(23)8(22)6(32-12)4-31-36(29,30)33-35(27,28)14(15,16)34(24,25)26/h5-6,8-9,12,22-23H,2-4H2,1H3,(H,27,28)(H,29,30)(H2,17,19,20)(H2,24,25,26)/t6-,8-,9-,12-/m1/s1
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n/an/an/an/a 1.30n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
The compound was evaluated for antagonist activity against platelet P2Y purinoceptor 12 (P2Y12)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50297387
PNG
((5S,6R,7E,9E,11Z,14Z)-6-(cystein-S-yl)-5-hydroxyic...)
Show SMILES CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(O)=O)[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1
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Article
PubMed
n/an/an/an/a 1.30n/an/an/an/a



Amira Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y12 receptor


J Med Chem 52: 5803-15 (2009)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000880
PNG
(7-(2-Hydroxy-ethoxy)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C12H11N3O3/c16-3-4-18-8-1-2-9-7(5-8)6-10-11(13-9)15-12(17)14-10/h1-2,5-6,16H,3-4H2,(H2,13,14,15,17)
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n/an/an/an/a 4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000931
PNG
(CHEMBL91368 | N-Cyclohexyl-N-methyl-4-(2-oxo-2,3-d...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C21H26N4O3/c1-25(15-6-3-2-4-7-15)19(26)8-5-11-28-16-9-10-17-14(12-16)13-18-20(22-17)24-21(27)23-18/h9-10,12-13,15H,2-8,11H2,1H3,(H2,22,23,24,27)
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n/an/an/an/a 5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000915
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-27(17-8-4-2-3-5-9-17)21(28)10-6-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)26-23(29)25-20/h11-12,14-15,17H,2-10,13H2,1H3,(H2,24,25,26,29)
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n/an/an/an/a 5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000900
PNG
(CHEMBL90804 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Show SMILES COC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C23H28N4O5/c1-31-21(29)14-27(16-6-3-2-4-7-16)20(28)8-5-11-32-17-9-10-18-15(12-17)13-19-22(24-18)26-23(30)25-19/h9-10,12-13,16H,2-8,11,14H2,1H3,(H2,24,25,26,30)
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n/an/an/an/a 6n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000931
PNG
(CHEMBL91368 | N-Cyclohexyl-N-methyl-4-(2-oxo-2,3-d...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C21H26N4O3/c1-25(15-6-3-2-4-7-15)19(26)8-5-11-28-16-9-10-17-14(12-16)13-18-20(22-17)24-21(27)23-18/h9-10,12-13,15H,2-8,11H2,1H3,(H2,22,23,24,27)
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n/an/an/an/a 7n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000892
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H28N4O3/c1-26(16-7-3-2-4-8-16)20(27)9-5-6-12-29-17-10-11-18-15(13-17)14-19-21(23-18)25-22(28)24-19/h10-11,13-14,16H,2-9,12H2,1H3,(H2,23,24,25,28)
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n/an/an/an/a 8n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000909
PNG
(7-(4-Benzenesulfonyl-butoxy)-1,3-dihydro-imidazo[4...)
Show SMILES O=c1[nH]c2cc3cc(OCCCCS(=O)(=O)c4ccccc4)ccc3nc2[nH]1
Show InChI InChI=1S/C20H19N3O4S/c24-20-22-18-13-14-12-15(8-9-17(14)21-19(18)23-20)27-10-4-5-11-28(25,26)16-6-2-1-3-7-16/h1-3,6-9,12-13H,4-5,10-11H2,(H2,21,22,23,24)
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n/an/an/an/a 10n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000909
PNG
(7-(4-Benzenesulfonyl-butoxy)-1,3-dihydro-imidazo[4...)
Show SMILES O=c1[nH]c2cc3cc(OCCCCS(=O)(=O)c4ccccc4)ccc3nc2[nH]1
Show InChI InChI=1S/C20H19N3O4S/c24-20-22-18-13-14-12-15(8-9-17(14)21-19(18)23-20)27-10-4-5-11-28(25,26)16-6-2-1-3-7-16/h1-3,6-9,12-13H,4-5,10-11H2,(H2,21,22,23,24)
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n/an/an/an/a 10n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000881
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CC(C)OC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-10(2)24-15(21)4-3-7-23-12-5-6-13-11(8-12)9-14-16(18-13)20-17(22)19-14/h5-6,8-10H,3-4,7H2,1-2H3,(H2,18,19,20,22)
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n/an/an/an/a 12n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000899
PNG
(CHEMBL93688 | N-Cycloheptyl-4-(2-oxo-2,3-dihydro-1...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC1CCCCCC1
Show InChI InChI=1S/C21H26N4O3/c26-19(22-15-6-3-1-2-4-7-15)8-5-11-28-16-9-10-17-14(12-16)13-18-20(23-17)25-21(27)24-18/h9-10,12-13,15H,1-8,11H2,(H,22,26)(H2,23,24,25,27)
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n/an/an/an/a 16n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000880
PNG
(7-(2-Hydroxy-ethoxy)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C12H11N3O3/c16-3-4-18-8-1-2-9-7(5-8)6-10-11(13-9)15-12(17)14-10/h1-2,5-6,16H,3-4H2,(H2,13,14,15,17)
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n/an/an/an/a 20n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000933
PNG
(CHEMBL92264 | N-Adamantan-1-yl-4-(2-oxo-2,3-dihydr...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2
Show InChI InChI=1S/C24H28N4O3/c29-21(28-24-11-14-6-15(12-24)8-16(7-14)13-24)2-1-5-31-18-3-4-19-17(9-18)10-20-22(25-19)27-23(30)26-20/h3-4,9-10,14-16H,1-2,5-8,11-13H2,(H,28,29)(H2,25,26,27,30)/t14-,15+,16-,24?
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n/an/an/an/a 20n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000868
PNG
(CHEMBL88444 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Show SMILES CCOC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C24H30N4O5/c1-2-32-22(30)15-28(17-7-4-3-5-8-17)21(29)9-6-12-33-18-10-11-19-16(13-18)14-20-23(25-19)27-24(31)26-20/h10-11,13-14,17H,2-9,12,15H2,1H3,(H2,25,26,27,31)
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n/an/an/an/a 20n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000925
PNG
(7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)
Show SMILES Cc1ccc2nc3[nH]c(=O)[nH]c3cc2c1C
Show InChI InChI=1S/C12H11N3O/c1-6-3-4-9-8(7(6)2)5-10-11(13-9)15-12(16)14-10/h3-5H,1-2H3,(H2,13,14,15,16)
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n/an/an/an/a 20n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000932
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CCOC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-2-22-14(20)4-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(21)18-13/h5-6,8-9H,2-4,7H2,1H3,(H2,17,18,19,21)
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n/an/an/an/a 38n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000920
PNG
(CHEMBL88218 | N-Cyclohexyl-4-(2-oxo-2,3-dihydro-1H...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC1CCCCC1
Show InChI InChI=1S/C20H24N4O3/c25-18(21-14-5-2-1-3-6-14)7-4-10-27-15-8-9-16-13(11-15)12-17-19(22-16)24-20(26)23-17/h8-9,11-12,14H,1-7,10H2,(H,21,25)(H2,22,23,24,26)
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n/an/an/an/a 40n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000908
PNG
(CHEMBL92363 | N-Cyclohexyl-N-methyl-4-(1-methyl-2-...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C22H28N4O3/c1-25(16-7-4-3-5-8-16)20(27)9-6-12-29-17-10-11-18-15(13-17)14-19-21(23-18)24-22(28)26(19)2/h10-11,13-14,16H,3-9,12H2,1-2H3,(H,23,24,28)
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n/an/an/an/a 50n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000918
PNG
(7-(4-Hydroxy-butoxy)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H15N3O3/c18-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(15-11)17-14(19)16-12/h3-4,7-8,18H,1-2,5-6H2,(H2,15,16,17,19)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000918
PNG
(7-(4-Hydroxy-butoxy)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H15N3O3/c18-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(15-11)17-14(19)16-12/h3-4,7-8,18H,1-2,5-6H2,(H2,15,16,17,19)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000877
PNG
(CHEMBL88955 | N-Cycloheptyl-N-methyl-4-(2-oxo-2,3-...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H28N4O3/c1-26(16-7-4-2-3-5-8-16)20(27)9-6-12-29-17-10-11-18-15(13-17)14-19-21(23-18)25-22(28)24-19/h10-11,13-14,16H,2-9,12H2,1H3,(H2,23,24,25,28)
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n/an/an/an/a 60n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000869
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-21-13(19)3-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(20)17-12/h4-5,7-8H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 66n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000903
PNG
(CHEMBL91422 | N-Cycloheptyl-N-methyl-4-(1-methyl-2...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-26(17-8-5-3-4-6-9-17)21(28)10-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)25-23(29)27(20)2/h11-12,14-15,17H,3-10,13H2,1-2H3,(H,24,25,29)
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n/an/an/an/a 70n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000903
PNG
(CHEMBL91422 | N-Cycloheptyl-N-methyl-4-(1-methyl-2...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-26(17-8-5-3-4-6-9-17)21(28)10-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)25-23(29)27(20)2/h11-12,14-15,17H,3-10,13H2,1-2H3,(H,24,25,29)
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n/an/an/an/a 70n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000868
PNG
(CHEMBL88444 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Show SMILES CCOC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C24H30N4O5/c1-2-32-22(30)15-28(17-7-4-3-5-8-17)21(29)9-6-12-33-18-10-11-19-16(13-18)14-20-23(25-19)27-24(31)26-20/h10-11,13-14,17H,2-9,12,15H2,1H3,(H2,25,26,27,31)
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n/an/an/an/a 80n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000869
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-21-13(19)3-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(20)17-12/h4-5,7-8H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 83n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma PRP


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000875
PNG
(1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-...)
Show SMILES CCOC(=O)C1CCN(CC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H26N4O5/c1-2-30-21(28)14-7-9-26(10-8-14)19(27)4-3-11-31-16-5-6-17-15(12-16)13-18-20(23-17)25-22(29)24-18/h5-6,12-14H,2-4,7-11H2,1H3,(H2,23,24,25,29)
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n/an/an/an/a 90n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000890
PNG
(6-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-23-15(21)5-3-2-4-8-24-12-6-7-13-11(9-12)10-14-16(18-13)20-17(22)19-14/h6-7,9-10H,2-5,8H2,1H3,(H2,18,19,20,22)
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n/an/an/an/a 90n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000867
PNG
(7-(4-Hydroxy-pentyloxy)-1,3-dihydro-imidazo[4,5-b]...)
Show SMILES CC(O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H17N3O3/c1-9(19)3-2-6-21-11-4-5-12-10(7-11)8-13-14(16-12)18-15(20)17-13/h4-5,7-9,19H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 100n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000897
PNG
(7-(4-Oxo-4-piperidin-1-yl-butoxy)-1,3-dihydro-imid...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)N1CCCCC1
Show InChI InChI=1S/C19H22N4O3/c24-17(23-8-2-1-3-9-23)5-4-10-26-14-6-7-15-13(11-14)12-16-18(20-15)22-19(25)21-16/h6-7,11-12H,1-5,8-10H2,(H2,20,21,22,25)
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n/an/an/an/a 110n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000933
PNG
(CHEMBL92264 | N-Adamantan-1-yl-4-(2-oxo-2,3-dihydr...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2
Show InChI InChI=1S/C24H28N4O3/c29-21(28-24-11-14-6-15(12-24)8-16(7-14)13-24)2-1-5-31-18-3-4-19-17(9-18)10-20-22(25-19)27-23(30)26-20/h3-4,9-10,14-16H,1-2,5-8,11-13H2,(H,28,29)(H2,25,26,27,30)/t14-,15+,16-,24?
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n/an/an/an/a 120n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000897
PNG
(7-(4-Oxo-4-piperidin-1-yl-butoxy)-1,3-dihydro-imid...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)N1CCCCC1
Show InChI InChI=1S/C19H22N4O3/c24-17(23-8-2-1-3-9-23)5-4-10-26-14-6-7-15-13(11-14)12-16-18(20-15)22-19(25)21-16/h6-7,11-12H,1-5,8-10H2,(H2,20,21,22,25)
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n/an/an/an/a 130n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000891
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C24H32N4O3/c1-27(18-9-5-3-4-6-10-18)22(29)11-7-8-14-31-19-12-13-20-17(15-19)16-21-23(25-20)26-24(30)28(21)2/h12-13,15-16,18H,3-11,14H2,1-2H3,(H,25,26,30)
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n/an/an/an/a 140n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000928
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES CN(C1CCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-26(17-8-4-3-5-9-17)21(28)10-6-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)25-23(29)27(20)2/h11-12,14-15,17H,3-10,13H2,1-2H3,(H,24,25,29)
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n/an/an/an/a 150n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000907
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES O=c1[nH]c2cc3cc(OCCCC#N)ccc3nc2[nH]1
Show InChI InChI=1S/C14H12N4O2/c15-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(16-11)18-14(19)17-12/h3-4,7-8H,1-2,6H2,(H2,16,17,18,19)
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n/an/an/an/a 180n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000893
PNG
(CHEMBL91356 | N-Cyclohexyl-4-(1-methyl-2-oxo-2,3-d...)
Show SMILES Cn1c2cc3cc(OCCCC(=O)NC4CCCCC4)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C21H26N4O3/c1-25-18-13-14-12-16(9-10-17(14)23-20(18)24-21(25)27)28-11-5-8-19(26)22-15-6-3-2-4-7-15/h9-10,12-13,15H,2-8,11H2,1H3,(H,22,26)(H,23,24,27)
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n/an/an/an/a 180n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000912
PNG
(CHEMBL90958 | N,N-Dimethyl-4-(2-oxo-2,3-dihydro-1H...)
Show SMILES CN(C)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H18N4O3/c1-20(2)14(21)4-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(22)18-13/h5-6,8-9H,3-4,7H2,1-2H3,(H2,17,18,19,22)
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n/an/an/an/a 190n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000872
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCC1)C(=O)CCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H28N4O2/c1-26(17-8-3-2-4-9-17)20(27)10-6-5-7-15-11-12-18-16(13-15)14-19-21(23-18)25-22(28)24-19/h11-14,17H,2-10H2,1H3,(H2,23,24,25,28)
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n/an/an/an/a 210n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000875
PNG
(1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-...)
Show SMILES CCOC(=O)C1CCN(CC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H26N4O5/c1-2-30-21(28)14-7-9-26(10-8-14)19(27)4-3-11-31-16-5-6-17-15(12-16)13-18-20(23-17)25-22(29)24-18/h5-6,12-14H,2-4,7-11H2,1H3,(H2,23,24,25,29)
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n/an/an/an/a 210n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000879
PNG
(7-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-1,3-d...)
Show SMILES O=c1[nH]c2cc3cc(OCCCCc4nnnn4C4CCCCC4)ccc3nc2[nH]1
Show InChI InChI=1S/C21H25N7O2/c29-21-23-18-13-14-12-16(9-10-17(14)22-20(18)24-21)30-11-5-4-8-19-25-26-27-28(19)15-6-2-1-3-7-15/h9-10,12-13,15H,1-8,11H2,(H2,22,23,24,29)
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n/an/an/an/a 250n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000913
PNG
(7-(2,3-Dihydroxy-propoxy)-1,3-dihydro-imidazo[4,5-...)
Show SMILES OCC(O)COc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C13H13N3O4/c17-5-8(18)6-20-9-1-2-10-7(3-9)4-11-12(14-10)16-13(19)15-11/h1-4,8,17-18H,5-6H2,(H2,14,15,16,19)
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n/an/an/an/a 260n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000913
PNG
(7-(2,3-Dihydroxy-propoxy)-1,3-dihydro-imidazo[4,5-...)
Show SMILES OCC(O)COc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C13H13N3O4/c17-5-8(18)6-20-9-1-2-10-7(3-9)4-11-12(14-10)16-13(19)15-11/h1-4,8,17-18H,5-6H2,(H2,14,15,16,19)
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n/an/an/an/a 260n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000906
PNG
(7-(4-Morpholin-4-yl-4-oxo-butoxy)-1,3-dihydro-imid...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)N1CCOCC1
Show InChI InChI=1S/C18H20N4O4/c23-16(22-5-8-25-9-6-22)2-1-7-26-13-3-4-14-12(10-13)11-15-17(19-14)21-18(24)20-15/h3-4,10-11H,1-2,5-9H2,(H2,19,20,21,24)
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n/an/an/an/a 280n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000941
PNG
(Acetic acid 3-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]...)
Show SMILES CC(=O)OCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-9(19)21-5-2-6-22-11-3-4-12-10(7-11)8-13-14(16-12)18-15(20)17-13/h3-4,7-8H,2,5-6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 330n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000916
PNG
(4-(3-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCOc1ccc2nc3n(C)c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-19-15-13(18-16(19)21)9-10-8-11(5-6-12(10)17-15)23-7-3-4-14(20)22-2/h5-6,8-9H,3-4,7H2,1-2H3,(H,18,21)
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n/an/an/an/a 360n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000939
PNG
(1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-...)
Show SMILES OC(=O)C1CCN(CC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C20H22N4O5/c25-17(24-7-5-12(6-8-24)19(26)27)2-1-9-29-14-3-4-15-13(10-14)11-16-18(21-15)23-20(28)22-16/h3-4,10-12H,1-2,5-9H2,(H,26,27)(H2,21,22,23,28)
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n/an/an/an/a 380n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
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