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Compile Data Set for Download or QSAR

Found 8 hits of ec50 for UniProtKB: P19020   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50090828
PNG
((-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4-oxa-9-...)
Show SMILES CCCN1CCO[C@H]2[C@H]1CSc1ccc(O)cc21
Show InChI InChI=1S/C14H19NO2S/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15/h3-4,8,12,14,16H,2,5-7,9H2,1H3/t12-,14-/m1/s1
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PubMed
n/an/an/an/a 0.00700n/an/an/an/a



University Centre for Pharmacy

Curated by ChEMBL


Assay Description
Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from rat


J Med Chem 43: 2871-82 (2000)


Article DOI: 10.1021/jm0000113
BindingDB Entry DOI: 10.7270/Q2X067R1
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50010586
PNG
((+)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-diox...)
Show SMILES CCCN1CCO[C@H]2[C@H]1COc1ccc(O)cc21
Show InChI InChI=1S/C14H19NO3/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15/h3-4,8,12,14,16H,2,5-7,9H2,1H3/t12-,14-/m1/s1
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n/an/an/an/a 0.360n/an/an/an/a



University Centre for Pharmacy

Curated by ChEMBL


Assay Description
Agonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from rat


J Med Chem 43: 2871-82 (2000)


Article DOI: 10.1021/jm0000113
BindingDB Entry DOI: 10.7270/Q2X067R1
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM84637
PNG
(CAS_85760-74-3 | CHEMBL240773 | NSC_54562 | QUINPI...)
Show SMILES CCCN1CCC[C@@H]2Cc3[nH]ncc3C[C@@H]12
Show InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1
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n/an/an/an/a 1.70n/an/an/an/a



University Centre for Pharmacy

Curated by ChEMBL


Assay Description
Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from rat


J Med Chem 43: 2871-82 (2000)


Article DOI: 10.1021/jm0000113
BindingDB Entry DOI: 10.7270/Q2X067R1
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50090832
PNG
((cis)1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4-oxa-9...)
Show SMILES CCCN1CCO[C@H]2[C@@H]1CSc1ccc(O)cc21
Show InChI InChI=1S/C14H19NO2S/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15/h3-4,8,12,14,16H,2,5-7,9H2,1H3/t12-,14+/m0/s1
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n/an/an/an/a 36n/an/an/an/a



University Centre for Pharmacy

Curated by ChEMBL


Assay Description
Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from rat


J Med Chem 43: 2871-82 (2000)


Article DOI: 10.1021/jm0000113
BindingDB Entry DOI: 10.7270/Q2X067R1
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM84637
PNG
(CAS_85760-74-3 | CHEMBL240773 | NSC_54562 | QUINPI...)
Show SMILES CCCN1CCC[C@@H]2Cc3[nH]ncc3C[C@@H]12
Show InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1
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n/an/an/an/a 80n/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Basal binding towards Dopamine receptor D3 was evaluated using [35S]- GTP-gamma S radioligand


J Med Chem 46: 3822-39 (2003)


Article DOI: 10.1021/jm0211220
BindingDB Entry DOI: 10.7270/Q2H132RF
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50092169
PNG
(CHEMBL118636 | N*7*,N*7*-Dipropyl-7,8-dihydro-6H-1...)
Show SMILES CCCN(CCC)C1Cc2ccc3nc(N)sc3c2C1
Show InChI InChI=1S/C16H23N3S/c1-3-7-19(8-4-2)12-9-11-5-6-14-15(13(11)10-12)20-16(17)18-14/h5-6,12H,3-4,7-10H2,1-2H3,(H2,17,18)
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Maastricht

Curated by ChEMBL


Assay Description
Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay (intrin...


J Med Chem 43: 3549-57 (2000)


Article DOI: 10.1021/jm000087z
BindingDB Entry DOI: 10.7270/Q2B27W0T
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50092170
PNG
(CHEMBL116372 | N*8*,N*8*-Dipropyl-8,9-dihydro-7H-c...)
Show SMILES CCCN(CCC)C1COc2ccc3nc(N)sc3c2C1
Show InChI InChI=1S/C16H23N3OS/c1-3-7-19(8-4-2)11-9-12-14(20-10-11)6-5-13-15(12)21-16(17)18-13/h5-6,11H,3-4,7-10H2,1-2H3,(H2,17,18)
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PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



University of Maastricht

Curated by ChEMBL


Assay Description
Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay


J Med Chem 43: 3549-57 (2000)


Article DOI: 10.1021/jm000087z
BindingDB Entry DOI: 10.7270/Q2B27W0T
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50092173
PNG
(CHEMBL325710 | N*6*,N*6*-Dipropyl-6,7-dihydro-5H-1...)
Show SMILES CCCN(CCC)C1Cc2cc3nc(N)sc3cc2C1
Show InChI InChI=1S/C16H23N3S/c1-3-5-19(6-4-2)13-7-11-9-14-15(10-12(11)8-13)20-16(17)18-14/h9-10,13H,3-8H2,1-2H3,(H2,17,18)
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



University of Maastricht

Curated by ChEMBL


Assay Description
Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay (intrin...


J Med Chem 43: 3549-57 (2000)


Article DOI: 10.1021/jm000087z
BindingDB Entry DOI: 10.7270/Q2B27W0T
More data for this
Ligand-Target Pair