Compile Data Set for Download or QSAR
maximum 50k data
Found 89 of ec50 for UniProtKB: P02766
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576397(7-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3-benzothiazole...)
Affinity DataEC50:  14nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576398(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-7- ethyl-1,3-ben...)
Affinity DataEC50:  20nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576403(5-methyl-4-(7-methyl-1,3-benzothiazol-4-yl)-1H-pyr...)
Affinity DataEC50:  20nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576410(4-(3,5-dimethyl-1H-pyrazol-4-yl)-6-fluoro-1,3-benz...)
Affinity DataEC50:  21nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576408(4-(3,5-dimethyl- 1H-pyrazol-4-yl)-6-methyl-1,3-ben...)
Affinity DataEC50:  21nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576409(4-(3,5-dimethyl-1H-pyrazol-4-yl)-6-methoxy-1,3-ben...)
Affinity DataEC50:  25nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576412(4-(3,5-dimethyl-1H-pyrazol-4-yl)-5-fluoro-1,3-benz...)
Affinity DataEC50:  29nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576396(4-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3-benzothiazole...)
Affinity DataEC50:  31nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576406(WO2022112919, Example 11)
Affinity DataEC50:  36nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576404(5-methyl-4-[7-(trifluoromethyl)-1,3-benzothiazol-4...)
Affinity DataEC50:  36nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576407(4-(3,5-di ethyl-1H-pyrazol-4-yl)-7-fluoro-1,3-benz...)
Affinity DataEC50:  37nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576399(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-7-(trifluoro eth...)
Affinity DataEC50:  40nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576400(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-1,3-benzothiazol...)
Affinity DataEC50:  52nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576402(4-(1,3-benzothiazol-4-yl)-5-methyl-1 H-pyrazole-3-...)
Affinity DataEC50:  66nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576413(4-[5- ethyl-3-(trifluoro ethyl)-1 H-pyrazol-4-yl]-...)
Affinity DataEC50:  133nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576411(4-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3-benzothiazole...)
Affinity DataEC50:  159nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576414(7-(3,5-dimethyl-1 H-pyrazol-4-yl)[1,3]thiazolo[5,4...)
Affinity DataEC50:  165nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576405(4-(3,5-dimethyl-1H-pyrazol-4-yl)[1,3]thiazolo[4,5-...)
Affinity DataEC50:  894nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576401(4-(3,5-dimethyl-1 H-pyrazol-4-yl)-2-methyl-1,3-ben...)
Affinity DataEC50:  1.78E+3nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataEC50:  5.60E+3nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM50030892(DIHYDROGUAIARETIC ACID)
Affinity DataEC50:  6.30E+3nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataEC50:  7.30E+3nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM50029216((E)-3-(4-Hydroxy-3-methoxy-phenyl)-acrylic acid ph...)
Affinity DataEC50:  7.90E+3nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataEC50:  8.50E+3nMAssay Description:Inhibition of TTR I84T mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM50029207((E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid phenethy...)
Affinity DataEC50:  8.60E+3nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM50133496((2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydr...)
Affinity DataEC50:  8.60E+3nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM50029215((E)-3-(3-Hydroxy-4-methoxy-phenyl)-acrylic acid ph...)
Affinity DataEC50:  1.10E+4nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataEC50:  1.26E+4nMAssay Description:Inhibition of TTR L55P mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM50029198((E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid benzyl e...)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM50030893(CHEBI:8393 | prenyl caffeate)
Affinity DataEC50:  2.10E+4nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM50029196((E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid ethyl es...)
Affinity DataEC50:  2.30E+4nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM50029206((E)-3-(3,4-Dimethoxy-phenyl)-acrylic acid phenethy...)
Affinity DataEC50:  5.80E+4nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM50029209((E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid methyl e...)
Affinity DataEC50:  6.70E+4nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM4375((2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid | (2...)
Affinity DataEC50:  9.70E+4nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM128202(4-(2-pyridinylthio)benzofuro[3,2-d]pyrimidine | 4-...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM128203((6,7-Dihydro-5H-cyclopenta[d][1,2,4]triazolo[1,5-a...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM128204((4-chloranyl-2-methyl-pyrazol-3-yl)-(2,3-dihydroin...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM128205(6-(1,3-benzodioxol-5-yl)-3-cyclohexyl-7H-[1,2,4]tr...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM128206(2,3-dihydroindol-1-yl-(5-methyl-2-phenyl-3-pyrazol...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM44773(MLS000103167 | N-[4-(3-methoxyphenyl)-1,3-thiazol-...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM128207((Z)-2-(1,3-benzoxazol-2-yl)-3-(2-pyridinylamino)-2...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM128208(1-(2,3-Dimethyl-indol-1-yl)-2-(3,5-dimethyl-pyrazo...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM128209(5-methyl-N'-[(5-methyl-2-furyl)methylene]-3-th...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM128210(1-[(1-methyl-1H-pyrazol-5-yl)carbonyl]indoline | 2...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM128211(7-[(4-hydroxyphenyl)-[(6-methyl-2-pyridinyl)amino]...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM50091(4-(4-ethoxyanilino)-5-[(4-oxo-1-cyclohexa-2,5-dien...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM96956(4-(1,3-benzothiazol-2-yl)-N-(5-methyl-1,3-thiazol-...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM128212(4-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]b...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM50308499(CHEMBL602722 | Ethyl 5-(4-chlorobenzoyl)-4-phenylt...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM128213(MLS000545606 | N'-[(1-ethyl-5-methyl-1H-pyrazo...)
Affinity DataEC50: >1.67E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
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