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Compile Data Set for Download or QSAR

Found 844 hits of affinity data for UniProtKB/TrEMBL: P08473   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neprilysin


(Homo sapiens (Human))
BDBM50411736
PNG
(CHEMBL271225)
Show SMILES CC(C)C[C@H](S)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H25NO3S/c1-14(2)12-19(26)20(23)22-18(21(24)25)13-15-8-10-17(11-9-15)16-6-4-3-5-7-16/h3-11,14,18-19,26H,12-13H2,1-2H3,(H,22,23)(H,24,25)/t18-,19-/m0/s1
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0.280n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NEP by fluorescence assay


Bioorg Med Chem Lett 18: 732-7 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.048
BindingDB Entry DOI: 10.7270/Q2GT5PCB
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50024101
PNG
((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...)
Show SMILES C[C@H](NC(=O)[C@@H](CS)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C13H17NO3S/c1-9(13(16)17)14-12(15)11(8-18)7-10-5-3-2-4-6-10/h2-6,9,11,18H,7-8H2,1H3,(H,14,15)(H,16,17)/t9-,11+/m0/s1
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0.700n/an/an/an/an/an/an/an/a



Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry


J Med Chem 57: 5748-63 (2014)


Article DOI: 10.1021/jm500602h
BindingDB Entry DOI: 10.7270/Q2Q241TH
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50411731
PNG
(CHEMBL257726)
Show SMILES CC[C@H](S)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C19H21NO3S/c1-2-17(24)18(21)20-16(19(22)23)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11,16-17,24H,2,12H2,1H3,(H,20,21)(H,22,23)/t16-,17-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NEP by fluorescence assay


Bioorg Med Chem Lett 18: 732-7 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.048
BindingDB Entry DOI: 10.7270/Q2GT5PCB
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300752
PNG
(US10130642, Example 6-4)
Show SMILES CC(CO)(CC(Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cn(O)nn1)C(O)=O
Show InChI InChI=1S/C22H24N4O5/c1-22(14-27,21(29)30)12-18(23-20(28)19-13-26(31)25-24-19)11-15-7-9-17(10-8-15)16-5-3-2-4-6-16/h2-10,13,18,27,31H,11-12,14H2,1H3,(H,23,28)(H,29,30)
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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300755
PNG
(US10130642, Example 6-15)
Show SMILES CC(CO)(CC(Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cc(n[nH]1)C(O)=O)C(O)=O
Show InChI InChI=1S/C24H25N3O6/c1-24(14-28,23(32)33)13-18(25-21(29)19-12-20(22(30)31)27-26-19)11-15-7-9-17(10-8-15)16-5-3-2-4-6-16/h2-10,12,18,28H,11,13-14H2,1H3,(H,25,29)(H,26,27)(H,30,31)(H,32,33)
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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300758
PNG
(US10130642, Example 6-18)
Show SMILES CC(CO)(CC(Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cnc(O)nc1)C(O)=O
Show InChI InChI=1S/C24H25N3O5/c1-24(15-28,22(30)31)12-20(27-21(29)19-13-25-23(32)26-14-19)11-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,13-14,20,28H,11-12,15H2,1H3,(H,27,29)(H,30,31)(H,25,26,32)
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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300759
PNG
(US10130642, Example 6-19)
Show SMILES CC(CO)(CC(Cc1ccc(cc1)-c1ccccc1)NC(=O)C1CC(O)=NO1)C(O)=O
Show InChI InChI=1S/C23H26N2O6/c1-23(14-26,22(29)30)13-18(24-21(28)19-12-20(27)25-31-19)11-15-7-9-17(10-8-15)16-5-3-2-4-6-16/h2-10,18-19,26H,11-14H2,1H3,(H,24,28)(H,25,27)(H,29,30)
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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300760
PNG
(5-[(1R,3S)-3-Carboxy-1-(3′-fluorobiphenyl-4-...)
Show SMILES C[C@@](CO)(C[C@@H](Cc1ccc(cc1)-c1cccc(F)c1)NC(=O)c1cc(n[nH]1)C(O)=O)C(O)=O
Show InChI InChI=1S/C24H24FN3O6/c1-24(13-29,23(33)34)12-18(26-21(30)19-11-20(22(31)32)28-27-19)9-14-5-7-15(8-6-14)16-3-2-4-17(25)10-16/h2-8,10-11,18,29H,9,12-13H2,1H3,(H,26,30)(H,27,28)(H,31,32)(H,33,34)/t18-,24+/m1/s1
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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300761
PNG
(US10130642, Example 8-1)
Show SMILES CC(CO)(CC(Cc1ccc(cc1)-c1cccc(F)c1)NC(=O)c1cnn[nH]1)C(O)=O
Show InChI InChI=1S/C22H23FN4O4/c1-22(13-28,21(30)31)11-18(25-20(29)19-12-24-27-26-19)9-14-5-7-15(8-6-14)16-3-2-4-17(23)10-16/h2-8,10,12,18,28H,9,11,13H2,1H3,(H,25,29)(H,30,31)(H,24,26,27)
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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300762
PNG
(US10130642, Example 8-2)
Show SMILES CC(CO)(CC(Cc1ccc(cc1)-c1ccccc1F)NC(=O)c1cnn[nH]1)C(O)=O
Show InChI InChI=1S/C22H23FN4O4/c1-22(13-28,21(30)31)11-16(25-20(29)19-12-24-27-26-19)10-14-6-8-15(9-7-14)17-4-2-3-5-18(17)23/h2-9,12,16,28H,10-11,13H2,1H3,(H,25,29)(H,30,31)(H,24,26,27)
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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300764
PNG
(US10130642, Example 8-4)
Show SMILES CC(CO)(CC(Cc1ccc(cc1)-c1ccccc1F)NC(=O)c1cn(O)nn1)C(O)=O
Show InChI InChI=1S/C22H23FN4O5/c1-22(13-28,21(30)31)11-16(24-20(29)19-12-27(32)26-25-19)10-14-6-8-15(9-7-14)17-4-2-3-5-18(17)23/h2-9,12,16,28,32H,10-11,13H2,1H3,(H,24,29)(H,30,31)
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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300765
PNG
(US10130642, Example 8-5)
Show SMILES CC(CO)(CC(Cc1ccc(cc1)-c1ccccc1F)NC(=O)c1coc(=O)[nH]1)C(O)=O
Show InChI InChI=1S/C23H23FN2O6/c1-23(13-27,21(29)30)11-16(25-20(28)19-12-32-22(31)26-19)10-14-6-8-15(9-7-14)17-4-2-3-5-18(17)24/h2-9,12,16,27H,10-11,13H2,1H3,(H,25,28)(H,26,31)(H,29,30)
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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300766
PNG
(US10130642, Example 8-6)
Show SMILES CC(CO)(CC(Cc1ccc(cc1)-c1ccccc1F)NC(=O)C1CNC(=O)O1)C(O)=O
Show InChI InChI=1S/C23H25FN2O6/c1-23(13-27,21(29)30)11-16(26-20(28)19-12-25-22(31)32-19)10-14-6-8-15(9-7-14)17-4-2-3-5-18(17)24/h2-9,16,19,27H,10-13H2,1H3,(H,25,31)(H,26,28)(H,29,30)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300767
PNG
((2S,4S)-5-Biphenyl-4-yl-4-[(3-hydroxy-isoxazole-5-...)
Show SMILES CC(C)([C@H](C[C@@H](CO)C(O)=O)NC(=O)c1cn(O)nn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H26N4O5/c1-23(2,18-10-8-16(9-11-18)15-6-4-3-5-7-15)20(12-17(14-28)22(30)31)24-21(29)19-13-27(32)26-25-19/h3-11,13,17,20,28,32H,12,14H2,1-2H3,(H,24,29)(H,30,31)/t17-,20-/m0/s1
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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300768
PNG
(US10130642, Example 10-1)
Show SMILES CC(C)(C(CC(CO)C(O)=O)Cc1ccc(cc1)-c1ccccc1)C(=O)c1cn(O)nn1
Show InChI InChI=1S/C24H27N3O5/c1-24(2,22(29)21-14-27(32)26-25-21)20(13-19(15-28)23(30)31)12-16-8-10-18(11-9-16)17-6-4-3-5-7-17/h3-11,14,19-20,28,32H,12-13,15H2,1-2H3,(H,30,31)
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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300769
PNG
(US10130642, Example 10-2)
Show SMILES CC(C)(C(CC(CO)C(O)=O)Cc1ccc(cc1)-c1ccccc1)C(=O)c1cnn[nH]1
Show InChI InChI=1S/C24H27N3O4/c1-24(2,22(29)21-14-25-27-26-21)20(13-19(15-28)23(30)31)12-16-8-10-18(11-9-16)17-6-4-3-5-7-17/h3-11,14,19-20,28H,12-13,15H2,1-2H3,(H,30,31)(H,25,26,27)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM298317
PNG
(US10123984, Example 11-2)
Show SMILES C[C@@](CO)(C[C@@H](Cc1ccc(cc1)-c1cc(Cl)c(cc1F)-c1cc(Cl)ccc1F)NC(=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C27H23Cl2F2NO6/c1-27(13-33,26(37)38)12-17(32-24(34)25(35)36)8-14-2-4-15(5-3-14)18-10-21(29)19(11-23(18)31)20-9-16(28)6-7-22(20)30/h2-7,9-11,17,33H,8,12-13H2,1H3,(H,32,34)(H,35,36)(H,37,38)/t17-,27+/m1/s1
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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
The assays were performed in 384-well white opaque plates at 37 C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...


US Patent US10123984 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM298322
PNG
(US10123984, Example 14A | US10123984, Example 14C ...)
Show SMILES CCOC(=O)[C@@H](CN(Cc1ccc(Br)cc1)NC(=O)C(=O)OCC)OC(=O)C(=O)OCC
Show InChI InChI=1S/C20H25BrN2O9/c1-4-29-17(25)15(32-20(28)19(27)31-6-3)12-23(22-16(24)18(26)30-5-2)11-13-7-9-14(21)10-8-13/h7-10,15H,4-6,11-12H2,1-3H3,(H,22,24)/t15-/m1/s1
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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
The assays were performed in 384-well white opaque plates at 37 C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...


US Patent US10123984 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300705
PNG
(2S,4S)-5-Biphenyl-4-yl-2-hydroxymethyl-4-[(3H-[1,2...)
Show SMILES OC[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cnn[nH]1)C(O)=O
Show InChI InChI=1S/C21H22N4O4/c26-13-17(21(28)29)11-18(23-20(27)19-12-22-25-24-19)10-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,12,17-18,26H,10-11,13H2,(H,23,27)(H,28,29)(H,22,24,25)/t17-,18+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300707
PNG
((2S,4S)-4-[(5-Chloro-2H-[1,2,4]triazole-3-carbonyl...)
Show SMILES OC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(F)c1)NC(=O)c1nc(Cl)n[nH]1)C(O)=O
Show InChI InChI=1S/C21H20ClFN4O4/c22-21-25-18(26-27-21)19(29)24-17(10-15(11-28)20(30)31)8-12-4-6-13(7-5-12)14-2-1-3-16(23)9-14/h1-7,9,15,17,28H,8,10-11H2,(H,24,29)(H,30,31)(H,25,26,27)/t15-,17+/m0/s1
PDB

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US Patent
<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300709
PNG
(US10130642, Example 4-2)
Show SMILES OCC(CC(Cc1ccc(cc1)-c1ccccc1F)NC(=O)c1cnn[nH]1)C(O)=O
Show InChI InChI=1S/C21H21FN4O4/c22-18-4-2-1-3-17(18)14-7-5-13(6-8-14)9-16(10-15(12-27)21(29)30)24-20(28)19-11-23-26-25-19/h1-8,11,15-16,27H,9-10,12H2,(H,24,28)(H,29,30)(H,23,25,26)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300710
PNG
(US10130642, Example 4-3)
Show SMILES OCC(CC(Cc1ccc(cc1)-c1cccc(F)c1)NC(=O)c1cnn[nH]1)C(O)=O
Show InChI InChI=1S/C21H21FN4O4/c22-17-3-1-2-15(9-17)14-6-4-13(5-7-14)8-18(10-16(12-27)21(29)30)24-20(28)19-11-23-26-25-19/h1-7,9,11,16,18,27H,8,10,12H2,(H,24,28)(H,29,30)(H,23,25,26)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300711
PNG
(US10130642, Example 4-7)
Show SMILES OCC(CC(Cc1ccccc1)NC(=O)c1cn(O)nn1)C(O)=O
Show InChI InChI=1S/C15H18N4O5/c20-9-11(15(22)23)7-12(6-10-4-2-1-3-5-10)16-14(21)13-8-19(24)18-17-13/h1-5,8,11-12,20,24H,6-7,9H2,(H,16,21)(H,22,23)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300712
PNG
(US10130642, Example 4-8)
Show SMILES OCC(CC(Cc1ccc(cc1)-c1ccccc1F)NC(=O)c1cn(O)nn1)C(O)=O
Show InChI InChI=1S/C21H21FN4O5/c22-18-4-2-1-3-17(18)14-7-5-13(6-8-14)9-16(10-15(12-27)21(29)30)23-20(28)19-11-26(31)25-24-19/h1-8,11,15-16,27,31H,9-10,12H2,(H,23,28)(H,29,30)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300713
PNG
(US10130642, Example 4-9)
Show SMILES OCC(CC(Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1c[nH]nn1)C(O)=O
Show InChI InChI=1S/C21H21ClN4O4/c22-17-3-1-2-15(9-17)14-6-4-13(5-7-14)8-18(10-16(12-27)21(29)30)24-20(28)19-11-23-26-25-19/h1-7,9,11,16,18,27H,8,10,12H2,(H,24,28)(H,29,30)(H,23,25,26)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300714
PNG
(US10130642, Example 4-10)
Show SMILES OCC(CC(Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cn(O)nn1)C(O)=O
Show InChI InChI=1S/C21H21ClN4O5/c22-17-3-1-2-15(9-17)14-6-4-13(5-7-14)8-18(10-16(12-27)21(29)30)23-20(28)19-11-26(31)25-24-19/h1-7,9,11,16,18,27,31H,8,10,12H2,(H,23,28)(H,29,30)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300718
PNG
(US10130642, Example 4-14)
Show SMILES OCC(CC(Cc1ccccc1)NC(=O)c1nc(O)n[nH]1)C(O)=O
Show InChI InChI=1S/C15H18N4O5/c20-8-10(14(22)23)7-11(6-9-4-2-1-3-5-9)16-13(21)12-17-15(24)19-18-12/h1-5,10-11,20H,6-8H2,(H,16,21)(H,22,23)(H2,17,18,19,24)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300720
PNG
(US10130642, Example 4-16)
Show SMILES OCC(CC(Cc1ccc(cc1)-c1ccccc1F)NC(=O)c1nc(Cl)n[nH]1)C(O)=O
Show InChI InChI=1S/C21H20ClFN4O4/c22-21-25-18(26-27-21)19(29)24-15(10-14(11-28)20(30)31)9-12-5-7-13(8-6-12)16-3-1-2-4-17(16)23/h1-8,14-15,28H,9-11H2,(H,24,29)(H,30,31)(H,25,26,27)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300721
PNG
(US10130642, Example 4-17)
Show SMILES OCC(CC(Cc1ccccc1)NC(=O)c1cc(O)n[nH]1)C(O)=O
Show InChI InChI=1S/C16H19N3O5/c20-9-11(16(23)24)7-12(6-10-4-2-1-3-5-10)17-15(22)13-8-14(21)19-18-13/h1-5,8,11-12,20H,6-7,9H2,(H,17,22)(H,23,24)(H2,18,19,21)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300722
PNG
(US10130642, Example 4-18)
Show SMILES OCC(CC(Cc1ccccc1)NC(=O)c1cc(n[nH]1)C(O)=O)C(O)=O
Show InChI InChI=1S/C17H19N3O6/c21-9-11(16(23)24)7-12(6-10-4-2-1-3-5-10)18-15(22)13-8-14(17(25)26)20-19-13/h1-5,8,11-12,21H,6-7,9H2,(H,18,22)(H,19,20)(H,23,24)(H,25,26)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300728
PNG
(US10130642, Example 4-24)
Show SMILES OCC(CC(Cc1ccccc1)NC(=O)c1cc(n[nH]1)C(=O)N1CCC1)C(O)=O
Show InChI InChI=1S/C20H24N4O5/c25-12-14(20(28)29)10-15(9-13-5-2-1-3-6-13)21-18(26)16-11-17(23-22-16)19(27)24-7-4-8-24/h1-3,5-6,11,14-15,25H,4,7-10,12H2,(H,21,26)(H,22,23)(H,28,29)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300729
PNG
(US10130642, Example 4-25)
Show SMILES OCC(CC(Cc1ccccc1)NC(=O)c1cc(n[nH]1)C(=O)N1CCCC1)C(O)=O
Show InChI InChI=1S/C21H26N4O5/c26-13-15(21(29)30)11-16(10-14-6-2-1-3-7-14)22-19(27)17-12-18(24-23-17)20(28)25-8-4-5-9-25/h1-3,6-7,12,15-16,26H,4-5,8-11,13H2,(H,22,27)(H,23,24)(H,29,30)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300731
PNG
(US10130642, Example 4-27)
Show SMILES OCC(CC(Cc1ccccc1)NC(=O)c1cc(n[nH]1)-c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C22H22ClN3O4/c23-18-9-5-4-8-17(18)19-12-20(26-25-19)21(28)24-16(11-15(13-27)22(29)30)10-14-6-2-1-3-7-14/h1-9,12,15-16,27H,10-11,13H2,(H,24,28)(H,25,26)(H,29,30)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300732
PNG
(US10130642, Example 4-28)
Show SMILES CCCCc1cc([nH]n1)C(=O)NC(CC(CO)C(O)=O)Cc1ccccc1
Show InChI InChI=1S/C20H27N3O4/c1-2-3-9-16-12-18(23-22-16)19(25)21-17(11-15(13-24)20(26)27)10-14-7-5-4-6-8-14/h4-8,12,15,17,24H,2-3,9-11,13H2,1H3,(H,21,25)(H,22,23)(H,26,27)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300733
PNG
(US10130642, Example 4-29)
Show SMILES OCC(CC(Cc1ccc(cc1)-c1cccc(F)c1)NC(=O)c1cc(n[nH]1)-c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C28H25ClFN3O4/c29-24-7-2-1-6-23(24)25-15-26(33-32-25)27(35)31-22(14-20(16-34)28(36)37)12-17-8-10-18(11-9-17)19-4-3-5-21(30)13-19/h1-11,13,15,20,22,34H,12,14,16H2,(H,31,35)(H,32,33)(H,36,37)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300734
PNG
(US10130642, Example 4-30)
Show SMILES OCC(CC(Cc1ccc(cc1)-c1cccc(F)c1)NC(=O)c1cc(n[nH]1)-c1ccccn1)C(O)=O
Show InChI InChI=1S/C27H25FN4O4/c28-21-5-3-4-19(13-21)18-9-7-17(8-10-18)12-22(14-20(16-33)27(35)36)30-26(34)25-15-24(31-32-25)23-6-1-2-11-29-23/h1-11,13,15,20,22,33H,12,14,16H2,(H,30,34)(H,31,32)(H,35,36)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300737
PNG
(US10130642, Example 4-33)
Show SMILES OCC(CC(Cc1ccccc1)NC(=O)c1cc(F)c2nn[nH]c2c1)C(O)=O
Show InChI InChI=1S/C19H19FN4O4/c20-15-8-12(9-16-17(15)23-24-22-16)18(26)21-14(7-13(10-25)19(27)28)6-11-4-2-1-3-5-11/h1-5,8-9,13-14,25H,6-7,10H2,(H,21,26)(H,27,28)(H,22,23,24)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300738
PNG
(US10130642, Example 4-34)
Show SMILES OCC(CC(Cc1ccc(cc1)-c1cccc(F)c1)NC(=O)c1ccc2nnn(O)c2c1)C(O)=O
Show InChI InChI=1S/C25H23FN4O5/c26-20-3-1-2-17(11-20)16-6-4-15(5-7-16)10-21(12-19(14-31)25(33)34)27-24(32)18-8-9-22-23(13-18)30(35)29-28-22/h1-9,11,13,19,21,31,35H,10,12,14H2,(H,27,32)(H,33,34)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300744
PNG
(US10130642, Example 4-45)
Show SMILES OCC(CC(Cc1ccccc1)NC(=O)c1cc(O)no1)C(O)=O
Show InChI InChI=1S/C16H18N2O6/c19-9-11(16(22)23)7-12(6-10-4-2-1-3-5-10)17-15(21)13-8-14(20)18-24-13/h1-5,8,11-12,19H,6-7,9H2,(H,17,21)(H,18,20)(H,22,23)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300745
PNG
(US10130642, Example 4-47)
Show SMILES OCC(CC(Cc1ccccc1)NC(=O)c1cnc(O)nc1)C(O)=O
Show InChI InChI=1S/C17H19N3O5/c21-10-12(16(23)24)7-14(6-11-4-2-1-3-5-11)20-15(22)13-8-18-17(25)19-9-13/h1-5,8-9,12,14,21H,6-7,10H2,(H,20,22)(H,23,24)(H,18,19,25)
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300748
PNG
(US10130642, Example 5-A)
Show SMILES C[C@@](CO)(C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cnnn1)C(O)=O
PDB

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<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300321
PNG
(US9593110, 30-10)
Show SMILES COC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1c[nH]c(=O)o1)C(O)=O
Show InChI InChI=1S/C23H21ClFN3O7/c1-34-23(33)28-18(21(30)31)10-15(27-20(29)19-11-26-22(32)35-19)8-12-2-4-13(5-3-12)16-9-14(24)6-7-17(16)25/h2-7,9,11,15,18H,8,10H2,1H3,(H,26,32)(H,27,29)(H,28,33)(H,30,31)/t15-,18-/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300322
PNG
(US9593110, 30-11)
Show SMILES COC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1coc(=O)[nH]1)C(O)=O
Show InChI InChI=1S/C23H21ClFN3O7/c1-34-22(32)27-18(21(30)31)10-15(26-20(29)19-11-35-23(33)28-19)8-12-2-4-13(5-3-12)16-9-14(24)6-7-17(16)25/h2-7,9,11,15,18H,8,10H2,1H3,(H,26,29)(H,27,32)(H,28,33)(H,30,31)/t15-,18-/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300324
PNG
(US9593110, 30-12)
Show SMILES COC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ccc(Cl)cn1)C(O)=O
Show InChI InChI=1S/C25H22Cl2FN3O5/c1-36-25(35)31-22(24(33)34)12-18(30-23(32)21-9-7-17(27)13-29-21)10-14-2-4-15(5-3-14)19-11-16(26)6-8-20(19)28/h2-9,11,13,18,22H,10,12H2,1H3,(H,30,32)(H,31,35)(H,33,34)/t18-,22-/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300334
PNG
(US9593110, 16-9)
Show SMILES CC(=O)c1cc([nH]n1)C(=O)N[C@@H](C[C@@H](N)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C23H22ClFN4O4/c1-12(30)20-11-21(29-28-20)22(31)27-16(10-19(26)23(32)33)8-13-2-4-14(5-3-13)17-9-15(24)6-7-18(17)25/h2-7,9,11,16,19H,8,10,26H2,1H3,(H,27,31)(H,28,29)(H,32,33)/t16-,19-/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300335
PNG
(US9593110, 37-1)
Show SMILES C[C@H](N)C(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cnn[nH]1)C(O)=O
Show InChI InChI=1S/C23H24ClFN6O4/c1-12(26)21(32)29-19(23(34)35)10-16(28-22(33)20-11-27-31-30-20)8-13-2-4-14(5-3-13)17-9-15(24)6-7-18(17)25/h2-7,9,11-12,16,19H,8,10,26H2,1H3,(H,28,33)(H,29,32)(H,34,35)(H,27,30,31)/t12-,16+,19+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300338
PNG
(US9593110, 39-1)
Show SMILES CC(C)[C@H](N)C(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cnn[nH]1)C(O)=O
Show InChI InChI=1S/C25H28ClFN6O4/c1-13(2)22(28)24(35)31-20(25(36)37)11-17(30-23(34)21-12-29-33-32-21)9-14-3-5-15(6-4-14)18-10-16(26)7-8-19(18)27/h3-8,10,12-13,17,20,22H,9,11,28H2,1-2H3,(H,30,34)(H,31,35)(H,36,37)(H,29,32,33)/t17-,20-,22+/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300339
PNG
(US9593110, 41)
Show SMILES NCCC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cnn[nH]1)C(O)=O
Show InChI InChI=1S/C23H24ClFN6O4/c24-15-5-6-18(25)17(10-15)14-3-1-13(2-4-14)9-16(28-22(33)20-12-27-31-30-20)11-19(23(34)35)29-21(32)7-8-26/h1-6,10,12,16,19H,7-9,11,26H2,(H,28,33)(H,29,32)(H,34,35)(H,27,30,31)/t16-,19-/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300341
PNG
(US9593110, 16-16)
Show SMILES N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1noc(=O)[nH]1)C(O)=O
Show InChI InChI=1S/C20H18ClFN4O5/c21-12-5-6-15(22)14(8-12)11-3-1-10(2-4-11)7-13(9-16(23)19(28)29)24-18(27)17-25-20(30)31-26-17/h1-6,8,13,16H,7,9,23H2,(H,24,27)(H,28,29)(H,25,26,30)/t13-,16-/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300342
PNG
(US9593110, 16-18)
Show SMILES CN(C)C(=O)c1cc([nH]n1)C(=O)N[C@@H](C[C@@H](N)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C24H25ClFN5O4/c1-31(2)23(33)21-12-20(29-30-21)22(32)28-16(11-19(27)24(34)35)9-13-3-5-14(6-4-13)17-10-15(25)7-8-18(17)26/h3-8,10,12,16,19H,9,11,27H2,1-2H3,(H,28,32)(H,29,30)(H,34,35)/t16-,19-/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
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