Compile Data Set for Download or QSAR
maximum 50k data
Found 884 of ic50 data for polymerid = 6624
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM165905(US9067922, 247)
Affinity DataIC50:  1nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM165898(US9067922, 239)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50239134(CHEMBL4087516)
Affinity DataIC50:  2nMAssay Description:Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM165900(US9067922, 241)
Affinity DataIC50:  3nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM165745(US9067922, 235 | US9067922, 79)
Affinity DataIC50:  7nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290450(2{[4-(4-Cyanonaphthalen)isoquinolin-6-yl]thio}-2-m...)
Affinity DataIC50:  8nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM165896(US9067922, 237)
Affinity DataIC50:  8nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290480(US10100016, Compound 45B)
Affinity DataIC50:  10nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM152051(US8987473, 137)
Affinity DataIC50:  10nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM152041(US8987473, 122)
Affinity DataIC50:  10nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50239146(CHEMBL4088988)
Affinity DataIC50:  10nMAssay Description:Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290470(US10100016, Compound 43A)
Affinity DataIC50:  11nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290481(3-[4-(4-Cyanonaphthalen-1-yl)isoquinolin-6-yl]-2,2...)
Affinity DataIC50:  12nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM165893(US9067922, 232)
Affinity DataIC50:  12nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM318948(2-Methyl-2-[[7-(4-nitrophenyl)benzo[d]isothiazol-6...)
Affinity DataIC50:  12nMAssay Description:URAT1 stably expressed HEK293 cells (HEK-URAT1) or HEK293 cells transfected with empty vector (HEK-mock) were cultured in DMEM culture medium supplem...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290489(3-[4-(4-Cyanophenyl)thieno[2,3-c]pyridin-2-yl]-2,2...)
Affinity DataIC50:  12nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM165745(US9067922, 235 | US9067922, 79)
Affinity DataIC50:  13nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM165667(US9067922, 1)
Affinity DataIC50:  13nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM152048(US8987473, 134)
Affinity DataIC50:  13nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377700(US10266496, Example 27)
Affinity DataIC50:  14nMAssay Description:a. Construction of a Cell Line Stably Expressing hURAT1hURAT1 plasmid was transfected into HEK293T cell, and a cell line stably expressing hURAT1 was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290479(3-[4-(4-Cyanonaphthalen-1-yl)isoquinolin-6-yl]-2-m...)
Affinity DataIC50:  15nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377703(US10266496, Example 30)
Affinity DataIC50:  15nMAssay Description:a. Construction of a Cell Line Stably Expressing hURAT1hURAT1 plasmid was transfected into HEK293T cell, and a cell line stably expressing hURAT1 was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM152079(US8987473, 183)
Affinity DataIC50:  15nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290448(2{[4-(4-Cyanophenyl)isoquinolin-6-yl]thio-2-methyl...)
Affinity DataIC50:  15nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM152017(US8987473, 82)
Affinity DataIC50:  15nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM165769(US9067922, 104)
Affinity DataIC50:  15nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM152047(US8987473, 133)
Affinity DataIC50:  16nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM152080(US8987473, 185)
Affinity DataIC50:  17nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290487(3-[4-(4-Cyanonaphthalen-1-yl)thieno[2,3-c]pyridin-...)
Affinity DataIC50:  18nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290488(2-{[4-(2-Chloro-4-cyanophenyl)isoquinolin-6-yl]thi...)
Affinity DataIC50:  18nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM152026(US8987473, 97)
Affinity DataIC50:  18nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM152016(US8987473, 80)
Affinity DataIC50:  18nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290490(1-{[4-(4-cyanonaphthalen-1-yl)isoquinolin-6-yl]thi...)
Affinity DataIC50:  18nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290467(2{[4-(5-Cyanonaphthalen-1-yl)isoquinolin-6-yl]thio...)
Affinity DataIC50:  19nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290515(3-[4-(4-Cyanophenyl)isoquinolin-6-yl]-2,2-dimethyl...)
Affinity DataIC50:  19nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM165744(US9067922, 78)
Affinity DataIC50:  19nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377690(US10266496, Example 2)
Affinity DataIC50:  19nMAssay Description:a. Construction of a Cell Line Stably Expressing hURAT1hURAT1 plasmid was transfected into HEK293T cell, and a cell line stably expressing hURAT1 was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50134635(CHEMBL3746329 | US9637484, 3)
Affinity DataIC50:  19nMAssay Description:In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM318954(2-[[7-(4-Cyanophenyl)benzo[d]isothiazol-6-yl]thio]...)
Affinity DataIC50:  21nMAssay Description:URAT1 stably expressed HEK293 cells (HEK-URAT1) or HEK293 cells transfected with empty vector (HEK-mock) were cultured in DMEM culture medium supplem...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM60431(US9067922, 249)
Affinity DataIC50:  21nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM318946(1-[[7-(4-Cyanophenyl)benzo[d]isothiazol-6-yl]thio]...)
Affinity DataIC50:  21.5nMAssay Description:URAT1 stably expressed HEK293 cells (HEK-URAT1) or HEK293 cells transfected with empty vector (HEK-mock) were cultured in DMEM culture medium supplem...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM152011(US8987473, 64)
Affinity DataIC50:  22nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290431(CAS No.:1352792-74-5 | RDEA3170 | US10100016, Veri...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human URAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM152049(US8987473, 135)
Affinity DataIC50:  23nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM152023(US8987473, 89)
Affinity DataIC50:  23nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290468(3-[4-(4-Cyanonaphthalen-1-yl)thieno[2,3-c]pyridin-...)
Affinity DataIC50:  24nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM290477(3-[4-(4-Cyanonaphthalen-1-yl)isoquinolin-6-yl]buty...)
Affinity DataIC50:  24nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM152054(US8987473, 140)
Affinity DataIC50:  24nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM152015(US8987473, 78)
Affinity DataIC50:  24nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM165780(US9067922, 115)
Affinity DataIC50:  24nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
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