Compile Data Set for Download or QSAR
maximum 50k data
Found 4121 of ic50 for UniProtKB: P04150
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  0.00800nMAssay Description:Inhibition of CHO-K1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50250114(CHEMBL4104286)
Affinity DataIC50:  0.0200nMAssay Description:Transrepression of glucocorticoid receptor in human PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50250125(CHEMBL4061359)
Affinity DataIC50:  0.0290nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50203432(CHEMBL3911831)
Affinity DataIC50:  0.0300nMAssay Description:Agonist activity at glucocorticoid receptor in human ChaGoK1 cells assessed as inhibition of AP1-mediated transcriptional activity by measuring reduc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50206900(CHEMBL3895181)
Affinity DataIC50:  0.0300nMAssay Description:Antagonist activity at GR in human HepG2 cells assessed as inhibition of protein mediated-transcriptional activity by MMTV-promoter driven luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50250115(CHEMBL4086388)
Affinity DataIC50:  0.0320nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM141378(US8916600, 12 | US9738632, Example 12)
Affinity DataIC50:  0.0370nMAssay Description:Displacement of fluormone labelled GS Red from human recombinant glucocorticoid receptor after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50354851(FLUTICASONE FUROATE | Veramyst)
Affinity DataIC50:  0.0398nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50203441(CHEMBL3973775)
Affinity DataIC50:  0.0400nMAssay Description:Agonist activity at glucocorticoid receptor in human ChaGoK1 cells assessed as inhibition of AP1-mediated transcriptional activity by measuring reduc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50354849(CCI-18781 | Cutivate | FLUTICASONE PROPIONATE | Fl...)
Affinity DataIC50:  0.0400nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50203418(CHEMBL3902818)
Affinity DataIC50:  0.0400nMAssay Description:Agonist activity at glucocorticoid receptor in human ChaGoK1 cells assessed as inhibition of AP1-mediated transcriptional activity by measuring reduc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50354849(CCI-18781 | Cutivate | FLUTICASONE PROPIONATE | Fl...)
Affinity DataIC50:  0.0440nMAssay Description:Displacement of fluormone labelled GS Red from human recombinant glucocorticoid receptor after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50250112(CHEMBL4072756)
Affinity DataIC50:  0.0490nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50203413(CHEMBL3920760)
Affinity DataIC50:  0.0500nMAssay Description:Agonist activity at glucocorticoid receptor in human ChaGoK1 cells assessed as inhibition of AP1-mediated transcriptional activity by measuring reduc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM141371(US8916600, 5 | US9738632, Example 5)
Affinity DataIC50:  0.0510nMAssay Description:Displacement of fluormone labelled GS Red from human recombinant glucocorticoid receptor after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM141372(US8916600, 6 | US9738632, Example 6)
Affinity DataIC50:  0.0560nMAssay Description:Displacement of fluormone labelled GS Red from human recombinant glucocorticoid receptor after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM141379(US8916600, 13 | US9738632, Example 13)
Affinity DataIC50:  0.0620nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50250126(CHEMBL4094154)
Affinity DataIC50:  0.0660nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50206950(CHEMBL3933702)
Affinity DataIC50:  0.0700nMAssay Description:Antagonist activity at GR in human HepG2 cells assessed as inhibition of protein mediated-transcriptional activity by MMTV-promoter driven luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50250125(CHEMBL4061359)
Affinity DataIC50:  0.0730nMAssay Description:Transrepression of glucocorticoid receptor in human PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50354849(CCI-18781 | Cutivate | FLUTICASONE PROPIONATE | Fl...)
Affinity DataIC50:  0.0750nMAssay Description:Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-stimulated IL-6 cytokine synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50414604(CHEMBL551816)
Affinity DataIC50:  0.0790nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50417875(CHEMBL1668063)
Affinity DataIC50:  0.0794nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50203430(CHEMBL3901719)
Affinity DataIC50:  0.0800nMAssay Description:Agonist activity at glucocorticoid receptor in human ChaGoK1 cells assessed as inhibition of AP1-mediated transcriptional activity by measuring reduc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50250114(CHEMBL4104286)
Affinity DataIC50:  0.0800nMAssay Description:Transrepression of glucocorticoid receptor in human PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50203435(CHEMBL3940724)
Affinity DataIC50:  0.0900nMAssay Description:Agonist activity at glucocorticoid receptor in human ChaGoK1 cells assessed as inhibition of AP1-mediated transcriptional activity by measuring reduc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50203423(CHEMBL3960682)
Affinity DataIC50:  0.0900nMAssay Description:Agonist activity at glucocorticoid receptor in human ChaGoK1 cells assessed as inhibition of AP1-mediated transcriptional activity by measuring reduc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM476583(US10869929, Compound 18 | US11554172, Compound 18)
Affinity DataIC50:  0.100nMAssay Description:The potency of binding to gucocorticoid receptor by small molecule compounds was measured with the PolarScreen™ Glucocorticoid Receptor Competitor As...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50214935(5-fluoro-2-((Z)-(9-hydroxy-10-methoxy-2,2,4-trimet...)
Affinity DataIC50:  0.100nMAssay Description:Antagonist activity at GR assessed as inhibition of dexamethasone-induced GRE activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50195157((8S,11R,13S,14S,17S)-17-hydroxy-11-(4-methoxy-3-me...)
Affinity DataIC50:  0.100nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50250115(CHEMBL4086388)
Affinity DataIC50:  0.101nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50250118(CHEMBL4070346)
Affinity DataIC50:  0.120nMAssay Description:Transrepression of glucocorticoid receptor in human PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50417887(CHEMBL1668077)
Affinity DataIC50:  0.126nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50414609(CHEMBL550730)
Affinity DataIC50:  0.126nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50203419(CHEMBL3915997)
Affinity DataIC50:  0.130nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50203419(CHEMBL3915997)
Affinity DataIC50:  0.130nMAssay Description:Agonist activity at glucocorticoid receptor in human ChaGoK1 cells assessed as inhibition of AP1-mediated transcriptional activity by measuring reduc...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50250126(CHEMBL4094154)
Affinity DataIC50:  0.132nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM589245(US11554172, Compound 19)
Affinity DataIC50:  0.140nMAssay Description:The potency of binding to gucocorticoid receptor by small molecule compounds was measured with the PolarScreen™ Glucocorticoid Receptor Competitor As...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50250119(CHEMBL4098641)
Affinity DataIC50:  0.150nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM589230(US11554172, Compound Fluticasone-Propionate)
Affinity DataIC50:  0.150nMAssay Description:The potency of binding to gucocorticoid receptor by small molecule compounds was measured with the PolarScreen™ Glucocorticoid Receptor Competitor As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50250116(CHEMBL4066614)
Affinity DataIC50:  0.156nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50203424(CHEMBL3893393)
Affinity DataIC50:  0.158nMAssay Description:Binding affinity to recombinant human glucocorticoid receptor expressed in baculovirus infected sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50203424(CHEMBL3893393)
Affinity DataIC50:  0.158nMAssay Description:Transrepression activity at glucocorticoid receptor in human THP1 cells assessed as receptor-mediated anti-inflammatory activity by measuring inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50250112(CHEMBL4072756)
Affinity DataIC50:  0.160nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM141368(US8916600, 2 | US8916600, 3 | US9738632, Example 2)
Affinity DataIC50:  0.170nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM141378(US8916600, 12 | US9738632, Example 12)
Affinity DataIC50:  0.170nMAssay Description:Transrepression of glucocorticoid receptor in human PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM141375(US8916600, 9 | US9738632, Example 9)
Affinity DataIC50:  0.190nMAssay Description:Transrepression of glucocorticoid receptor in human PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18617((18Z)-12-methoxy-18-{[3-(methoxymethyl)thiophen-2-...)
Affinity DataKi:  0.200nM ΔG°:  -12.3kcal/mole IC50:  0.200nM EC50:  0.200nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18616((18Z)-18-{[3-(hydroxymethyl)thiophen-2-yl]methylid...)
Affinity DataKi:  0.700nM ΔG°:  -11.6kcal/mole IC50:  0.200nM EC50:  0.200nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18623((18Z)-12-methoxy-18-({3-[(1E)-1-(methoxyimino)ethy...)
Affinity DataKi:  1.10nM ΔG°:  -11.4kcal/mole IC50:  0.200nM EC50:  0.100nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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