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Found 7667 of ic50 for UniProtKB: P00746
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400274(CHEMBL2180765 | US9085555, 373)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human complement factor D after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400274(CHEMBL2180765 | US9085555, 373)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCobra venom factor/Complement factor B/Complement factor D(Naja kaouthia (Monocled cobra) (Naja siamensis))
Novartis

US Patent
LigandPNGBDBM251420(US9452990, 102)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCobra venom factor/Complement factor B/Complement factor D(Naja kaouthia (Monocled cobra) (Naja siamensis))
Novartis

US Patent
LigandPNGBDBM251408(US9452990, 90)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50446397(CHEMBL3109655)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human factor D expressed in Escherichia coli using Z-Lys-thiobenzyl and 2,4-dinitrobenzenesulfonyl-fluoresceine as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400273(CHEMBL2180764 | US9085555, 375)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400273(CHEMBL2180764 | US9085555, 375)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human complement factor D after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50524347(CHEMBL4535197)
Affinity DataIC50:  3nMAssay Description:Inhibition of 2-((1E,3E,5E)-5-(1-(6-((((3S,5S)-1-((1-carbamoyl-1H-indol-3-yl)carbamoyl)-5-((3-chloro-2-fluorobenzyl)carbamoyl)-3-fluoropyrrolidin-3-y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM171311(US9085555, 741 | US9085555, 757)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400275(CHEMBL2180766 | US9085555, 127)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human complement factor D after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCobra venom factor/Complement factor B/Complement factor D(Naja kaouthia (Monocled cobra) (Naja siamensis))
Novartis

US Patent
LigandPNGBDBM251413(US9452990, 95)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCobra venom factor/Complement factor B/Complement factor D(Naja kaouthia (Monocled cobra) (Naja siamensis))
Novartis

US Patent
LigandPNGBDBM251449(US9452990, 131)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM254483(US9468661, 61)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM254486(US9468661, 64)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM254498(US9468661, 109 | US9468661, 76)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM170864(US9085555, 292)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM170890(US9085555, 318)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM170943(US9085555, 371)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM170945(US9085555, 374)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400275(CHEMBL2180766 | US9085555, 127)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM170738(US9085555, 166)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM171262(US9085555, 692)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM171267(US9085555, 697)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM171305(US9085555, 735)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50446396(CHEMBL3109654)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human factor D expressed in Escherichia coli using Z-Lys-thiobenzyl and 2,4-dinitrobenzenesulfonyl-fluoresceine as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50462108(CHEMBL4246585)
Affinity DataIC50:  4nMAssay Description:Inhibition of human factor D expressed in Escherichia coli using CVF-FB as substrate assessed as decrease in formation of factor B cleavage product B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM171319(US9085555, 749)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM354268((2S,4R)-1-(2-(3-acetyl- 5-(2-methylpyrimidin- 5-yl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of factor D in human serum assessed as decrease in C3 deposition on PNH erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCobra venom factor/Complement factor B/Complement factor D(Naja kaouthia (Monocled cobra) (Naja siamensis))
Novartis

US Patent
LigandPNGBDBM251397(US9452990, 77)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCobra venom factor/Complement factor B/Complement factor D(Naja kaouthia (Monocled cobra) (Naja siamensis))
Novartis

US Patent
LigandPNGBDBM251411(US9452990, 93)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM254471(US9468661, 49)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM254475(US9468661, 53)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM254488(US9468661, 66)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM170953(US9085555, 383)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM170872(US9085555, 300)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM170878(US9085555, 306)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM171334(US9085555, 764)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM170701(US9085555, 129)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM171304(US9085555, 734)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM171314(US9085555, 744)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM171318(US9085555, 748)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM354268((2S,4R)-1-(2-(3-acetyl- 5-(2-methylpyrimidin- 5-yl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of factor D in human serum assessed as decrease in alternative pathway of complement-mediated hemolysis of PNH erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50462108(CHEMBL4246585)
Affinity DataIC50:  5nMAssay Description:Inhibition of 2-((1E,3E,5E)-5-(1-(6-((((3S,5S)-1-((1-carbamoyl-1H-indol-3-yl)carbamoyl)-5-((3-chloro-2-fluorobenzyl)carbamoyl)-3-fluoropyrrolidin-3-y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCobra venom factor/Complement factor B/Complement factor D(Naja kaouthia (Monocled cobra) (Naja siamensis))
Novartis

US Patent
LigandPNGBDBM251348(US9452990, 28)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM254528(US9468661, 106)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM170949(US9085555, 379)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM170866(US9085555, 294)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM170934(US9085555, 362)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM171255(US9085555, 685)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM170734(US9085555, 162)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails US Patent
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