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Found 594 of ic50 for UniProtKB: P07308
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50257967(CHEMBL494748 | N-(2-(7-(4-chloro-3-(trifluoromethy...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of SCD in rat microsomesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50257967(CHEMBL494748 | N-(2-(7-(4-chloro-3-(trifluoromethy...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of stearoyl-CoA delta9 desaturase in rat microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50425256(CHEMBL2315179)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat SCD1 by rat microsomal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50312702((3-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-y...)
Affinity DataIC50:  1nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50354672(CHEMBL1834453)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50354682(CHEMBL1834455)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50298907(CHEMBL572876 | N-(2-(6-(3,4-dichlorobenzylamino)-3...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of stearoyl-CoA delta9 desaturase in rat microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50298904(2-hydroxy-N-(2-(2-oxo-3-(trifluoromethyl)-7-(3-(tr...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of stearoyl-CoA delta9 desaturase in rat microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50364041(CHEMBL1950551)
Affinity DataIC50:  2nMAssay Description:Inhibition of rat liver microsome SCD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50354677(CHEMBL1834443)
Affinity DataIC50:  2nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50:  2nMAssay Description:Inhibition of SCD-1 activity in Sprague-Dawley rat microsome assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50:  2nMAssay Description:Inhibition of rat SCD by rat microsomal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50305767((5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-y...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50425258(CHEMBL2315181)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat SCD1 by rat microsomal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50425259(CHEMBL2315473)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat SCD1 by rat microsomal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50312684(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)th...)
Affinity DataIC50:  3nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50312688(5-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)-1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50362592(CHEMBL1938870)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat SCD-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50354671(CHEMBL1834452)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50362592(CHEMBL1938870)
Affinity DataIC50:  3nMAssay Description:Inhibition of SCD-1 activity in Sprague-Dawley rat microsome assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50305773((5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-y...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50305764(2-isopropyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)pi...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50425257(CHEMBL2315472)
Affinity DataIC50:  4nMAssay Description:Inhibition of rat SCD1 by rat microsomal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50425266(CHEMBL2315480)
Affinity DataIC50:  4nMAssay Description:Inhibition of rat SCD1 by rat microsomal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50312700(3-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM174861(US9102669, 24)
Affinity DataIC50:  4nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50305750(3-(4-(2-ethylphenoxy)piperidin-1-yl)-6-(1H-imidazo...)
Affinity DataIC50:  4nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50305760(3-(1H-imidazol-1-yl)-6-(4-(2-(trifluoromethyl)phen...)
Affinity DataIC50:  4nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50312683(2-(4-(2-(trifluoromethyl)phenylthio)piperidin-1-yl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50354674(CHEMBL1834457)
Affinity DataIC50:  4nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50305758(3-(4-(2-bromophenoxy)piperidin-1-yl)-6-(1H-imidazo...)
Affinity DataIC50:  5nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50364040(CHEMBL1950550)
Affinity DataIC50:  5nMAssay Description:Inhibition of rat liver microsome SCD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM174891(US9102669, 83)
Affinity DataIC50:  6nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50305774(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50:  6nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50356891(CHEMBL1915541)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat SCD by rat microsomal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM60550(BDBM50448682 | US9102669, 53)
Affinity DataIC50:  6nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50305772(5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl...)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of SCD1 in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50467582(CHEMBL4276719)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of rat liver microsome SCD assessed as reduction in [3H]H2O production using stearoyl [9,10-3H]CoA as substrate in presence of NADH incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50448659(CHEMBL3127654)
Affinity DataIC50:  7nMAssay Description:Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using stearoyl-[9,10-3H]-CoA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50354676(CHEMBL1834262)
Affinity DataIC50:  7nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50354667(CHEMBL1834456)
Affinity DataIC50:  7nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM174867(US9102669, 33)
Affinity DataIC50:  7nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50393166(CHEMBL2153601)
Affinity DataIC50:  7nMAssay Description:Inhibition of SCD-1 activity in Sprague-Dawley rat microsome assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50448657(CHEMBL3127530 | US9102669, 29)
Affinity DataIC50:  7nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50443712(CHEMBL3093861 | US9238658, 33)
Affinity DataIC50:  7nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 uL using 10 ug of RLM (prepared as described above) in a 96-well polypropylene plate (enzyme reac...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50312692(3-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)is...)
Affinity DataIC50:  8nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50443716(CHEMBL3093874 | US9238658, 50)
Affinity DataIC50:  8nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 uL using 10 ug of RLM (prepared as described above) in a 96-well polypropylene plate (enzyme reac...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50364013(CHEMBL1950401)
Affinity DataIC50:  8nMAssay Description:Inhibition of rat SCD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Central South University

Curated by ChEMBL
LigandPNGBDBM50448667(CHEMBL3127646)
Affinity DataIC50:  8nMAssay Description:Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using stearoyl-[9,10-3H]-CoA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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