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Compile Data Set for Download or QSAR

Found 64 hits of ic50 data for polymerid = 7602   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50062351
PNG
((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Show SMILES CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Department of Life Science and National Research Laboratory of Proteolysis

Curated by ChEMBL


Assay Description
In vitro inhibition of A disintegrin and metalloproteinase domain 9 (ADAM9)


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50062351
PNG
((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Show SMILES CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1
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n/an/a 56n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of ADAM9 after 10 to 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM912
PNG
((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CC(C)C)C(C)C)C(C)C)[C@@H](O)CC(O)=O
Show InChI InChI=1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23-,24-,25-,26-,30-,31-/m0/s1
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n/an/a 56n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of ADAM9 after 10 to 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109614
PNG
(CHEMBL353536 | [4-(2-Ethoxy-ethoxy)-phenyl]-(3-hyd...)
Show SMILES CCOCCOc1ccc(cc1)P(=O)(OCC)N1Cc2ccccc2CC1C(=O)NO
Show InChI InChI=1S/C22H29N2O6P/c1-3-28-13-14-29-19-9-11-20(12-10-19)31(27,30-4-2)24-16-18-8-6-5-7-17(18)15-21(24)22(25)23-26/h5-12,21,26H,3-4,13-16H2,1-2H3,(H,23,25)
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n/an/a 70n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109630
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES COc1ccc(cc1)P(=O)(OC)N1Cc2ccccc2CC1C(=O)NO
Show InChI InChI=1S/C18H21N2O5P/c1-24-15-7-9-16(10-8-15)26(23,25-2)20-12-14-6-4-3-5-13(14)11-17(20)18(21)19-22/h3-10,17,22H,11-12H2,1-2H3,(H,19,21)
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n/an/a 70n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50181008
PNG
((S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynyloxy)phenyls...)
Show SMILES CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#CCO)cc1
Show InChI InChI=1S/C17H22N2O6S2/c1-17(2)15(16(21)18-22)19(9-12-26-17)27(23,24)14-7-5-13(6-8-14)25-11-4-3-10-20/h5-8,15,20,22H,9-12H2,1-2H3,(H,18,21)/t15-/m0/s1
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US Patent
n/an/a 85n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The molecules are tested in dose-response studies on the following enzymes MMP1, MMP3, MMP9, ADAM9 and ADAM10 according to the same protocol as that ...


US Patent US9266848 (2016)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM175095
PNG
(US9115102, Apratastat)
Show SMILES CC1(C)SCCN(C1C(=O)NO)S(=O)(=O)c1ccc(OCC#CCO)cc1
Show InChI InChI=1/C17H22N2O6S2/c1-17(2)15(16(21)18-22)19(9-12-26-17)27(23,24)14-7-5-13(6-8-14)25-11-4-3-10-20/h5-8,15,20,22H,9-12H2,1-2H3,(H,18,21)
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n/an/a 85n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The molecules are tested in dose-response studies on the following enzymes MMP1, MMP3, MMP9, ADAMS and ADAM10 according to the same protocol as that ...


US Patent US9115102 (2015)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50181008
PNG
((S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynyloxy)phenyls...)
Show SMILES CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#CCO)cc1
Show InChI InChI=1S/C17H22N2O6S2/c1-17(2)15(16(21)18-22)19(9-12-26-17)27(23,24)14-7-5-13(6-8-14)25-11-4-3-10-20/h5-8,15,20,22H,9-12H2,1-2H3,(H,18,21)/t15-/m0/s1
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n/an/a 85n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


US Patent US9365529 (2016)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109631
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES COc1ccc(cc1)P(=O)(OCCc1ccccn1)N1Cc2ccccc2CC1C(=O)NO
Show InChI InChI=1S/C24H26N3O5P/c1-31-21-9-11-22(12-10-21)33(30,32-15-13-20-8-4-5-14-25-20)27-17-19-7-3-2-6-18(19)16-23(27)24(28)26-29/h2-12,14,23,29H,13,15-17H2,1H3,(H,26,28)
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n/an/a 180n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109610
PNG
((7-Amino-3-hydroxycarbamoyl-3,4-dihydro-1H-isoquin...)
Show SMILES CCOP(=O)(N1Cc2cc(N)ccc2CC1C(=O)NO)c1ccc(OC)cc1
Show InChI InChI=1S/C19H24N3O5P/c1-3-27-28(25,17-8-6-16(26-2)7-9-17)22-12-14-10-15(20)5-4-13(14)11-18(22)19(23)21-24/h4-10,18,24H,3,11-12,20H2,1-2H3,(H,21,23)
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n/an/a 190n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50370191
PNG
(CHEMBL366478)
Show SMILES CCO[P@](=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccc(OC)cc1
Show InChI InChI=1S/C19H23N2O5P/c1-3-26-27(24,17-10-8-16(25-2)9-11-17)21-13-15-7-5-4-6-14(15)12-18(21)19(22)20-23/h4-11,18,23H,3,12-13H2,1-2H3,(H,20,22)/t18?,27-/m0/s1
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n/an/a 230n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109635
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES CCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H25N2O5P/c1-2-30-32(29,22-14-12-21(13-15-22)31-20-10-4-3-5-11-20)26-17-19-9-7-6-8-18(19)16-23(26)24(27)25-28/h3-15,23,28H,2,16-17H2,1H3,(H,25,27)
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n/an/a 260n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109629
PNG
((4-Fluoro-phenyl)-(3-hydroxycarbamoyl-3,4-dihydro-...)
Show SMILES CCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccc(F)cc1
Show InChI InChI=1S/C18H20FN2O4P/c1-2-25-26(24,16-9-7-15(19)8-10-16)21-12-14-6-4-3-5-13(14)11-17(21)18(22)20-23/h3-10,17,23H,2,11-12H2,1H3,(H,20,22)
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n/an/a 300n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109628
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES CCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccccc1
Show InChI InChI=1S/C18H21N2O4P/c1-2-24-25(23,16-10-4-3-5-11-16)20-13-15-9-7-6-8-14(15)12-17(20)18(21)19-22/h3-11,17,22H,2,12-13H2,1H3,(H,19,21)
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n/an/a 370n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109637
PNG
(4-[Ethoxy-(4-methoxy-phenyl)-phosphinoyl]-3-hydrox...)
Show SMILES CCOP(=O)(N1CCN(CC1C(=O)NO)C(=O)OCc1ccccc1)c1ccc(OC)cc1
Show InChI InChI=1S/C22H28N3O7P/c1-3-32-33(29,19-11-9-18(30-2)10-12-19)25-14-13-24(15-20(25)21(26)23-28)22(27)31-16-17-7-5-4-6-8-17/h4-12,20,28H,3,13-16H2,1-2H3,(H,23,26)
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Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109634
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES CCOCCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccc(OC)cc1
Show InChI InChI=1S/C21H27N2O6P/c1-3-28-12-13-29-30(26,19-10-8-18(27-2)9-11-19)23-15-17-7-5-4-6-16(17)14-20(23)21(24)22-25/h4-11,20,25H,3,12-15H2,1-2H3,(H,22,24)
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Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109624
PNG
((6-Hydroxycarbamoyl-6,7-dihydro-4H-thieno[3,2-c]py...)
Show SMILES CCOP(=O)(N1Cc2ccsc2CC1C(=O)NO)c1ccc(OC)cc1
Show InChI InChI=1S/C17H21N2O5PS/c1-3-24-25(22,14-6-4-13(23-2)5-7-14)19-11-12-8-9-26-16(12)10-15(19)17(20)18-21/h4-9,15,21H,3,10-11H2,1-2H3,(H,18,20)
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n/an/a 520n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109616
PNG
((7-Hydroxycarbamoyl-7,8-dihydro-5H-pyrido[3,4-b]py...)
Show SMILES CCOP(=O)(N1Cc2nccnc2CC1C(=O)NO)c1ccc(OC)cc1
Show InChI InChI=1S/C17H21N4O5P/c1-3-26-27(24,13-6-4-12(25-2)5-7-13)21-11-15-14(18-8-9-19-15)10-16(21)17(22)20-23/h4-9,16,23H,3,10-11H2,1-2H3,(H,20,22)
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n/an/a 560n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109623
PNG
((4-Amino-phenyl)-(3-hydroxycarbamoyl-3,4-dihydro-1...)
Show SMILES CCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccc(N)cc1
Show InChI InChI=1S/C18H22N3O4P/c1-2-25-26(24,16-9-7-15(19)8-10-16)21-12-14-6-4-3-5-13(14)11-17(21)18(22)20-23/h3-10,17,23H,2,11-12,19H2,1H3,(H,20,22)
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n/an/a 660n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109625
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES CCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccc(Oc2ccncc2)cc1
Show InChI InChI=1S/C23H24N3O5P/c1-2-30-32(29,21-9-7-19(8-10-21)31-20-11-13-24-14-12-20)26-16-18-6-4-3-5-17(18)15-22(26)23(27)25-28/h3-14,22,28H,2,15-16H2,1H3,(H,25,27)
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Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109613
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES CCOP(=O)(CCc1ccccc1)N1Cc2ccccc2CC1C(=O)NO
Show InChI InChI=1S/C20H25N2O4P/c1-2-26-27(25,13-12-16-8-4-3-5-9-16)22-15-18-11-7-6-10-17(18)14-19(22)20(23)21-24/h3-11,19,24H,2,12-15H2,1H3,(H,21,23)
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n/an/a 700n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109633
PNG
((3-Hydroxycarbamoyl-1,3,4,9-tetrahydro-beta-carbol...)
Show SMILES CCOP(=O)(N1Cc2[nH]c3ccccc3c2CC1C(=O)NO)c1ccc(OC)cc1
Show InChI InChI=1S/C21H24N3O5P/c1-3-29-30(27,15-10-8-14(28-2)9-11-15)24-13-19-17(12-20(24)21(25)23-26)16-6-4-5-7-18(16)22-19/h4-11,20,22,26H,3,12-13H2,1-2H3,(H,23,25)
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n/an/a 800n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109627
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES CCCCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccc(OC)cc1
Show InChI InChI=1S/C21H27N2O5P/c1-3-4-13-28-29(26,19-11-9-18(27-2)10-12-19)23-15-17-8-6-5-7-16(17)14-20(23)21(24)22-25/h5-12,20,25H,3-4,13-15H2,1-2H3,(H,22,24)
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n/an/a 810n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109632
PNG
((3-Fluoro-phenyl)-(3-hydroxycarbamoyl-3,4-dihydro-...)
Show SMILES CCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1cccc(F)c1
Show InChI InChI=1S/C18H20FN2O4P/c1-2-25-26(24,16-9-5-8-15(19)11-16)21-12-14-7-4-3-6-13(14)10-17(21)18(22)20-23/h3-9,11,17,23H,2,10,12H2,1H3,(H,20,22)
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n/an/a 830n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109640
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES CCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1cccs1
Show InChI InChI=1S/C16H19N2O4PS/c1-2-22-23(21,15-8-5-9-24-15)18-11-13-7-4-3-6-12(13)10-14(18)16(19)17-20/h3-9,14,20H,2,10-11H2,1H3,(H,17,19)
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n/an/a 890n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109611
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES CCOP(=O)(\C=C\c1ccccc1)N1Cc2ccccc2CC1C(=O)NO
Show InChI InChI=1S/C20H23N2O4P/c1-2-26-27(25,13-12-16-8-4-3-5-9-16)22-15-18-11-7-6-10-17(18)14-19(22)20(23)21-24/h3-13,19,24H,2,14-15H2,1H3,(H,21,23)/b13-12+
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n/an/a 910n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109612
PNG
((2-Fluoro-phenyl)-(3-hydroxycarbamoyl-3,4-dihydro-...)
Show SMILES CCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccccc1F
Show InChI InChI=1S/C18H20FN2O4P/c1-2-25-26(24,17-10-6-5-9-15(17)19)21-12-14-8-4-3-7-13(14)11-16(21)18(22)20-23/h3-10,16,23H,2,11-12H2,1H3,(H,20,22)
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n/an/a 1.06E+3n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109615
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES CCN(CC)CCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccc(OC)cc1
Show InChI InChI=1S/C23H32N3O5P/c1-4-25(5-2)14-15-31-32(29,21-12-10-20(30-3)11-13-21)26-17-19-9-7-6-8-18(19)16-22(26)23(27)24-28/h6-13,22,28H,4-5,14-17H2,1-3H3,(H,24,27)
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n/an/a 1.14E+3n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109622
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES COc1ccc(cc1)P(=O)(OCC1CCCCC1)N1Cc2ccccc2CC1C(=O)NO
Show InChI InChI=1S/C24H31N2O5P/c1-30-21-11-13-22(14-12-21)32(29,31-17-18-7-3-2-4-8-18)26-16-20-10-6-5-9-19(20)15-23(26)24(27)25-28/h5-6,9-14,18,23,28H,2-4,7-8,15-17H2,1H3,(H,25,27)
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n/an/a 1.34E+3n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109639
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES CCCCCCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccc(OC)cc1
Show InChI InChI=1S/C23H31N2O5P/c1-3-4-5-8-15-30-31(28,21-13-11-20(29-2)12-14-21)25-17-19-10-7-6-9-18(19)16-22(25)23(26)24-27/h6-7,9-14,22,27H,3-5,8,15-17H2,1-2H3,(H,24,26)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109621
PNG
(CHEMBL425316 | [4-(4-Amino-phenoxy)-phenyl]-(3-hyd...)
Show SMILES CCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccc(Oc2ccc(N)cc2)cc1
Show InChI InChI=1S/C24H26N3O5P/c1-2-31-33(30,22-13-11-21(12-14-22)32-20-9-7-19(25)8-10-20)27-16-18-6-4-3-5-17(18)15-23(27)24(28)26-29/h3-14,23,29H,2,15-16,25H2,1H3,(H,26,28)
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n/an/a 1.67E+3n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109636
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES CCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccc(C)cc1
Show InChI InChI=1S/C19H23N2O4P/c1-3-25-26(24,17-10-8-14(2)9-11-17)21-13-16-7-5-4-6-15(16)12-18(21)19(22)20-23/h4-11,18,23H,3,12-13H2,1-2H3,(H,20,22)
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n/an/a 1.89E+3n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109626
PNG
(Biphenyl-4-yl-(3-hydroxycarbamoyl-3,4-dihydro-1H-i...)
Show SMILES CCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C24H25N2O4P/c1-2-30-31(29,22-14-12-19(13-15-22)18-8-4-3-5-9-18)26-17-21-11-7-6-10-20(21)16-23(26)24(27)25-28/h3-15,23,28H,2,16-17H2,1H3,(H,25,27)
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n/an/a 1.96E+3n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109620
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES COc1ccc(cc1)P(=O)(OC(C)C)N1Cc2ccccc2CC1C(=O)NO
Show InChI InChI=1S/C20H25N2O5P/c1-14(2)27-28(25,18-10-8-17(26-3)9-11-18)22-13-16-7-5-4-6-15(16)12-19(22)20(23)21-24/h4-11,14,19,24H,12-13H2,1-3H3,(H,21,23)
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n/an/a 2.24E+3n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109638
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES CCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccncc1
Show InChI InChI=1S/C17H20N3O4P/c1-2-24-25(23,15-7-9-18-10-8-15)20-12-14-6-4-3-5-13(14)11-16(20)17(21)19-22/h3-10,16,22H,2,11-12H2,1H3,(H,19,21)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM113589
PNG
(US8633196, 19 | US9365529, 19)
Show SMILES CCN1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C26H33N5O5S/c1-3-30-12-14-31(15-13-30)25(26(32)29-33)17-27-37(34,35)22-10-8-21(9-11-22)36-18-20-16-19(2)28-24-7-5-4-6-23(20)24/h4-11,16,25,27,33H,3,12-15,17-18H2,1-2H3,(H,29,32)/t25-/m0/s1
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US Patent
n/an/a 3.05E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


US Patent US9365529 (2016)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109618
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES COc1ccc(cc1)P(=O)(OCCc1ccccc1)N1Cc2ccccc2CC1C(=O)NO
Show InChI InChI=1S/C25H27N2O5P/c1-31-22-11-13-23(14-12-22)33(30,32-16-15-19-7-3-2-4-8-19)27-18-21-10-6-5-9-20(21)17-24(27)25(28)26-29/h2-14,24,29H,15-18H2,1H3,(H,26,28)
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n/an/a 3.11E+3n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM175076
PNG
(US9115102, Ex2)
Show SMILES CC#CCOc1ccc(cc1)C(=O)NC[C@H](N1CCN(CC1)S(C)(=O)=O)C(=O)NO
Show InChI InChI=1S/C19H26N4O6S/c1-3-4-13-29-16-7-5-15(6-8-16)18(24)20-14-17(19(25)21-26)22-9-11-23(12-10-22)30(2,27)28/h5-8,17,26H,9-14H2,1-2H3,(H,20,24)(H,21,25)/t17-/m0/s1
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n/an/a 3.25E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The molecules are tested in dose-response studies on the following enzymes MMP1, MMP3, MMP9, ADAMS and ADAM10 according to the same protocol as that ...


US Patent US9115102 (2015)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50109617
PNG
((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Show SMILES COc1ccc(cc1)P(=O)(OCCc1ccc(cc1)-c1ccccc1)N1Cc2ccccc2CC1C(=O)NO
Show InChI InChI=1S/C31H31N2O5P/c1-37-28-15-17-29(18-16-28)39(36,33-22-27-10-6-5-9-26(27)21-30(33)31(34)32-35)38-20-19-23-11-13-25(14-12-23)24-7-3-2-4-8-24/h2-18,30,35H,19-22H2,1H3,(H,32,34)
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n/an/a 3.56E+3n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50265157
PNG
((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Show SMILES CN1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)NO
Show InChI InChI=1S/C20H26F3N5O3/c1-26-12-19(4-5-19)10-14(17(29)25-31)16(26)18(30)28-8-6-27(7-9-28)15-3-2-13(11-24-15)20(21,22)23/h2-3,11,14,16,31H,4-10,12H2,1H3,(H,25,29)/t14-,16-/m0/s1
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Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of ADAM9


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50203527
PNG
((6S,7S)-methyl 7-(hydroxycarbamoyl)-6-(4-phenyl-1,...)
Show SMILES COC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(=CC1)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C22H27N3O5/c1-30-21(28)25-14-22(9-10-22)13-17(19(26)23-29)18(25)20(27)24-11-7-16(8-12-24)15-5-3-2-4-6-15/h2-7,17-18,29H,8-14H2,1H3,(H,23,26)/t17-,18-/m0/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of ADAM9


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM113588
PNG
(US8633196, 18 | US9365529, 18)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(Cc3ccc(F)cc3)CC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C31H34FN5O5S/c1-22-18-24(28-4-2-3-5-29(28)34-22)21-42-26-10-12-27(13-11-26)43(40,41)33-19-30(31(38)35-39)37-16-14-36(15-17-37)20-23-6-8-25(32)9-7-23/h2-13,18,30,33,39H,14-17,19-21H2,1H3,(H,35,38)/t30-/m0/s1
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n/an/a 9.25E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


US Patent US9365529 (2016)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM207973
PNG
(US9266848, 11)
Show SMILES CCN(CC)[C@@H](CNC(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C25H30N4O4/c1-4-29(5-2)23(25(31)28-32)15-26-24(30)18-10-12-20(13-11-18)33-16-19-14-17(3)27-22-9-7-6-8-21(19)22/h6-14,23,32H,4-5,15-16H2,1-3H3,(H,26,30)(H,28,31)/t23-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The molecules are tested in dose-response studies on the following enzymes MMP1, MMP3, MMP9, ADAM9 and ADAM10 according to the same protocol as that ...


US Patent US9266848 (2016)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM207964
PNG
(US9266848, 2)
Show SMILES Cc1cc(COc2ccc(cc2)C(=O)NC[C@H](N2CCCCC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C26H30N4O4/c1-18-15-20(22-7-3-4-8-23(22)28-18)17-34-21-11-9-19(10-12-21)25(31)27-16-24(26(32)29-33)30-13-5-2-6-14-30/h3-4,7-12,15,24,33H,2,5-6,13-14,16-17H2,1H3,(H,27,31)(H,29,32)/t24-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The molecules are tested in dose-response studies on the following enzymes MMP1, MMP3, MMP9, ADAM9 and ADAM10 according to the same protocol as that ...


US Patent US9266848 (2016)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM207967
PNG
(US9266848, 5)
Show SMILES ONC(=O)[C@H](CNC(=O)c1ccc(OCc2ccncc2)cc1)N1CCCCC1
Show InChI InChI=1S/C21H26N4O4/c26-20(23-14-19(21(27)24-28)25-12-2-1-3-13-25)17-4-6-18(7-5-17)29-15-16-8-10-22-11-9-16/h4-11,19,28H,1-3,12-15H2,(H,23,26)(H,24,27)/t19-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The molecules are tested in dose-response studies on the following enzymes MMP1, MMP3, MMP9, ADAM9 and ADAM10 according to the same protocol as that ...


US Patent US9266848 (2016)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM207966
PNG
(US9266848, 4)
Show SMILES ONC(=O)[C@H](CNC(=O)c1ccc(OCc2ccnc(c2)-c2ccccc2)cc1)N1CCCCC1
Show InChI InChI=1S/C27H30N4O4/c32-26(29-18-25(27(33)30-34)31-15-5-2-6-16-31)22-9-11-23(12-10-22)35-19-20-13-14-28-24(17-20)21-7-3-1-4-8-21/h1,3-4,7-14,17,25,34H,2,5-6,15-16,18-19H2,(H,29,32)(H,30,33)/t25-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The molecules are tested in dose-response studies on the following enzymes MMP1, MMP3, MMP9, ADAM9 and ADAM10 according to the same protocol as that ...


US Patent US9266848 (2016)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM113593
PNG
(US8633196, 26 | US9365529, 26)
Show SMILES CC(C)S(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C27H35N5O7S2/c1-19(2)41(37,38)32-14-12-31(13-15-32)26(27(33)30-34)17-28-40(35,36)23-10-8-22(9-11-23)39-18-21-16-20(3)29-25-7-5-4-6-24(21)25/h4-11,16,19,26,28,34H,12-15,17-18H2,1-3H3,(H,30,33)/t26-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


US Patent US9365529 (2016)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM113592
PNG
(US8633196, 24 | US9365529, 24)
Show SMILES CC(C)CS(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C28H37N5O7S2/c1-20(2)19-41(36,37)33-14-12-32(13-15-33)27(28(34)31-35)17-29-42(38,39)24-10-8-23(9-11-24)40-18-22-16-21(3)30-26-7-5-4-6-25(22)26/h4-11,16,20,27,29,35H,12-15,17-19H2,1-3H3,(H,31,34)/t27-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


US Patent US9365529 (2016)

More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50302107
PNG
(CHEMBL567893 | Grassystatin A)
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](OC(=O)[C@@H](OC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C)[C@@H](C)O
Show InChI InChI=1S/C58H95N9O16/c1-30(2)25-38(43(69)29-45(71)64-46(36(12)68)52(74)60-35(11)54(76)66(15)42(27-37-21-18-17-19-22-37)55(77)67-24-20-23-41(67)56(78)81-16)61-51(73)40(28-44(59)70)62-50(72)39(26-31(3)4)63-53(75)48(33(7)8)82-58(80)49(34(9)10)83-57(79)47(32(5)6)65(13)14/h17-19,21-22,30-36,38-43,46-49,68-69H,20,23-29H2,1-16H3,(H2,59,70)(H,60,74)(H,61,73)(H,62,72)(H,63,75)(H,64,71)/t35-,36+,38-,39-,40-,41-,42+,43-,46-,47-,48+,49-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of ADAM9 after 10 to 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50370192
PNG
(CHEMBL418655)
Show SMILES CCO[P@](=O)(N1Cc2ccccc2C[C@H]1C(=O)NO)c1ccc(OC)cc1
Show InChI InChI=1S/C19H23N2O5P/c1-3-26-27(24,17-10-8-16(25-2)9-11-17)21-13-15-7-5-4-6-14(15)12-18(21)19(22)20-23/h4-11,18,23H,3,12-13H2,1-2H3,(H,20,22)/t18-,27-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Nippon Organon K.K.

Curated by ChEMBL


Assay Description
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...


J Med Chem 45: 919-29 (2002)

More data for this
Ligand-Target Pair
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