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Compile Data Set for Download or QSAR

Found 257 hits of ec50 for UniProtKB: P43405   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015448
PNG
(CHEMBL3265032)
Show SMILES C1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
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n/an/an/an/a 2n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50204291
PNG
(CHEMBL3953104)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(C#N)c3CNC(=O)c23)c1
Show InChI InChI=1S/C21H24N6O/c1-12-5-4-6-13(9-12)25-20-18-15(11-24-21(18)28)14(10-22)19(27-20)26-17-8-3-2-7-16(17)23/h4-6,9,16-17H,2-3,7-8,11,23H2,1H3,(H,24,28)(H2,25,26,27)/t16-,17+/m0/s1
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n/an/an/an/a<3n/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of SYK in TgM-stimulated human Ramos cells expressing RA1/GFP-tagged BLNK assessed as reduction in RA1/GFP-tagged BLNK phosphorylation pre...


Bioorg Med Chem Lett 26: 5947-5950 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.087
BindingDB Entry DOI: 10.7270/Q29888Z2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50204292
PNG
(CHEMBL3916444)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(-c3cn[nH]c3)c3CNC(=O)c23)c1
Show InChI InChI=1S/C23H27N7O/c1-13-5-4-6-15(9-13)28-22-20-16(12-25-23(20)31)19(14-10-26-27-11-14)21(30-22)29-18-8-3-2-7-17(18)24/h4-6,9-11,17-18H,2-3,7-8,12,24H2,1H3,(H,25,31)(H,26,27)(H2,28,29,30)/t17-,18+/m0/s1
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n/an/an/an/a 4n/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of SYK in TgM-stimulated human Ramos cells expressing RA1/GFP-tagged BLNK assessed as reduction in RA1/GFP-tagged BLNK phosphorylation pre...


Bioorg Med Chem Lett 26: 5947-5950 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.087
BindingDB Entry DOI: 10.7270/Q29888Z2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50204289
PNG
(CHEMBL3892927)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)cc3CNC(=O)c23)c1
Show InChI InChI=1S/C20H25N5O/c1-12-5-4-6-14(9-12)23-19-18-13(11-22-20(18)26)10-17(25-19)24-16-8-3-2-7-15(16)21/h4-6,9-10,15-16H,2-3,7-8,11,21H2,1H3,(H,22,26)(H2,23,24,25)/t15-,16+/m0/s1
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n/an/an/an/a 5n/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of SYK in TgM-stimulated human Ramos cells expressing RA1/GFP-tagged BLNK assessed as reduction in RA1/GFP-tagged BLNK phosphorylation pre...


Bioorg Med Chem Lett 26: 5947-5950 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.087
BindingDB Entry DOI: 10.7270/Q29888Z2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50204293
PNG
(CHEMBL3983415)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(F)c3CNC(=O)c23)c1
Show InChI InChI=1S/C20H24FN5O/c1-11-5-4-6-12(9-11)24-18-16-13(10-23-20(16)27)17(21)19(26-18)25-15-8-3-2-7-14(15)22/h4-6,9,14-15H,2-3,7-8,10,22H2,1H3,(H,23,27)(H2,24,25,26)/t14-,15+/m0/s1
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n/an/an/an/a 9n/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of SYK in TgM-stimulated human Ramos cells expressing RA1/GFP-tagged BLNK assessed as reduction in RA1/GFP-tagged BLNK phosphorylation pre...


Bioorg Med Chem Lett 26: 5947-5950 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.087
BindingDB Entry DOI: 10.7270/Q29888Z2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50204295
PNG
(CHEMBL3944381)
Show SMILES N[C@H]1CCCC[C@H]1Nc1nc(-c2cnn3ccccc23)c2C(=O)NCc2c1C#N
Show InChI InChI=1S/C21H21N7O/c22-9-12-13-10-24-21(29)18(13)19(14-11-25-28-8-4-3-7-17(14)28)27-20(12)26-16-6-2-1-5-15(16)23/h3-4,7-8,11,15-16H,1-2,5-6,10,23H2,(H,24,29)(H,26,27)/t15-,16+/m0/s1
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n/an/an/an/a 9n/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of SYK in TgM-stimulated human Ramos cells expressing RA1/GFP-tagged BLNK assessed as reduction in RA1/GFP-tagged BLNK phosphorylation pre...


Bioorg Med Chem Lett 26: 5947-5950 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.087
BindingDB Entry DOI: 10.7270/Q29888Z2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50204290
PNG
(CHEMBL3979920 | US11077111, Compound IIIa)
Show SMILES Cn1cc(cn1)-c1nc(N[C@@H]2CCCC[C@@H]2N)c(F)c2CNC(=O)c12
Show InChI InChI=1S/C17H21FN6O/c1-24-8-9(6-21-24)15-13-10(7-20-17(13)25)14(18)16(23-15)22-12-5-3-2-4-11(12)19/h6,8,11-12H,2-5,7,19H2,1H3,(H,20,25)(H,22,23)/t11-,12+/m0/s1
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n/an/an/an/a 9.80n/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of SYK in TgM-stimulated human Ramos cells expressing RA1/GFP-tagged BLNK assessed as reduction in RA1/GFP-tagged BLNK phosphorylation pre...


Bioorg Med Chem Lett 26: 5947-5950 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.087
BindingDB Entry DOI: 10.7270/Q29888Z2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM60665
PNG
(BDBM50249542 | US9145414, R406 | US9212178, R406)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
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n/an/an/an/a 10n/an/an/an/a



Rigel, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in TNFalpha release


J Med Chem 55: 3614-43 (2012)


Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM60665
PNG
(BDBM50249542 | US9145414, R406 | US9212178, R406)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
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n/an/an/an/a 10n/an/an/an/a



Rigel, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in IL2 release


J Med Chem 55: 3614-43 (2012)


Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM60665
PNG
(BDBM50249542 | US9145414, R406 | US9212178, R406)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
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n/an/an/an/a 10n/an/an/an/a



Rigel, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in IL6 release


J Med Chem 55: 3614-43 (2012)


Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM60665
PNG
(BDBM50249542 | US9145414, R406 | US9212178, R406)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
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n/an/an/an/a 10n/an/an/an/a



Rigel, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in IL13 release


J Med Chem 55: 3614-43 (2012)


Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50538469
PNG
(CHEMBL4643695)
Show SMILES C1OCC1N1CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2cnc3cc[nH]c3n2)cc1
Show InChI InChI=1S/C25H25N9O/c1-3-18(32-9-11-33(12-10-32)19-15-35-16-19)4-2-17(1)29-24-25-27-7-8-34(25)14-22(31-24)21-13-28-20-5-6-26-23(20)30-21/h1-8,13-14,19H,9-12,15-16H2,(H,26,30)(H,29,31)
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n/an/an/an/a 11n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50325991
PNG
(2-(7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-...)
Show SMILES COc1ccc(cc1OC)-c1cc2nccn2c(Nc2ncccc2C(N)=O)n1
Show InChI InChI=1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25)
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n/an/an/an/a 12n/an/an/an/a



Rigel, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in peripheral blood monocytes assessed as reduction FcgammaR-mediated superoxide production


J Med Chem 55: 3614-43 (2012)


Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50538460
PNG
(CHEMBL4634466)
Show SMILES C1OCC1N1CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2cnc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C25H25N9O/c1-3-19(32-7-9-33(10-8-32)20-15-35-16-20)4-2-18(1)29-24-25-26-5-6-34(25)14-23(30-24)17-11-21-22(27-12-17)13-28-31-21/h1-6,11-14,20H,7-10,15-16H2,(H,28,31)(H,29,30)
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n/an/an/an/a 13n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015447
PNG
(CHEMBL3265031)
Show SMILES CC1(O)CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C25H25N7O/c1-25(33)8-11-31(12-9-25)20-6-4-19(5-7-20)28-23-24-26-10-13-32(24)16-22(29-23)17-2-3-18-15-27-30-21(18)14-17/h2-7,10,13-16,33H,8-9,11-12H2,1H3,(H,27,30)(H,28,29)
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n/an/an/an/a 15n/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of Syk in antihuman IgM-stimulated human Ramos cells assessed as decrease in BCR-mediated BLNK phosphorylation by cellular assay


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50235816
PNG
(CHEMBL4069365)
Show SMILES CC1(C)OCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc12
Show InChI InChI=1S/C19H18F3N5O3/c1-18(2)11-4-3-10(7-13(11)25-14(28)8-30-18)24-17-26-12-5-6-29-15(12)16(27-17)23-9-19(20,21)22/h3-7H,8-9H2,1-2H3,(H,25,28)(H2,23,24,26,27)
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n/an/an/an/a 17n/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
BindingDB Entry DOI: 10.7270/Q2WQ061V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50235828
PNG
(CHEMBL4090753)
Show SMILES CC1(C)OCC(=O)Nc2cc(Nc3nc(NC4CC4)c4occc4n3)ccc12
Show InChI InChI=1S/C20H21N5O3/c1-20(2)13-6-5-12(9-15(13)23-16(26)10-28-20)22-19-24-14-7-8-27-17(14)18(25-19)21-11-3-4-11/h5-9,11H,3-4,10H2,1-2H3,(H,23,26)(H2,21,22,24,25)
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n/an/an/an/a 18n/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Syk in human Ramos B cells assessed as decrease in intracellular calcium flux measured for 3.5 mins by calcium-5 dye based FLIPR assay


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
BindingDB Entry DOI: 10.7270/Q2WQ061V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50235831
PNG
(CHEMBL4093260)
Show SMILES CCNc1nc(Nc2ccc3c(NC(=O)COC3(C)C)c2)nc2ccoc12
Show InChI InChI=1S/C19H21N5O3/c1-4-20-17-16-13(7-8-26-16)23-18(24-17)21-11-5-6-12-14(9-11)22-15(25)10-27-19(12,2)3/h5-9H,4,10H2,1-3H3,(H,22,25)(H2,20,21,23,24)
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n/an/an/an/a 18n/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
BindingDB Entry DOI: 10.7270/Q2WQ061V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50538467
PNG
(CHEMBL4641358)
Show SMILES C1OCC1N1CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cc[nH]c3n2)cc1
Show InChI InChI=1S/C26H26N8O/c1-6-22(30-24-18(1)7-8-27-24)23-15-34-10-9-28-26(34)25(31-23)29-19-2-4-20(5-3-19)32-11-13-33(14-12-32)21-16-35-17-21/h1-10,15,21H,11-14,16-17H2,(H,27,30)(H,29,31)
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n/an/an/an/a 18n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015453
PNG
(CHEMBL3265037)
Show SMILES COc1cc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)ccc1N1CCOCC1
Show InChI InChI=1S/C24H23N7O2/c1-32-22-13-18(4-5-21(22)30-8-10-33-11-9-30)27-23-24-25-6-7-31(24)15-20(28-23)16-2-3-17-14-26-29-19(17)12-16/h2-7,12-15H,8-11H2,1H3,(H,26,29)(H,27,28)
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n/an/an/an/a 20n/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of Syk in antihuman IgM-stimulated human Ramos cells assessed as decrease in BCR-mediated BLNK phosphorylation by cellular assay


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50538457
PNG
(CHEMBL4638089)
Show SMILES COCCN1CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C26H28N8O/c1-35-15-14-32-10-12-33(13-11-32)22-6-4-21(5-7-22)29-25-26-27-8-9-34(26)18-24(30-25)19-2-3-20-17-28-31-23(20)16-19/h2-9,16-18H,10-15H2,1H3,(H,28,31)(H,29,30)
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n/an/an/an/a 23n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50538459
PNG
(CHEMBL4644977)
Show SMILES C1OCC1N1CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3n2)cc1
Show InChI InChI=1S/C25H25N9O/c1-6-21(29-23-17(1)13-27-31-23)22-14-34-8-7-26-25(34)24(30-22)28-18-2-4-19(5-3-18)32-9-11-33(12-10-32)20-15-35-16-20/h1-8,13-14,20H,9-12,15-16H2,(H,28,30)(H,27,29,31)
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n/an/an/an/a 23n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM212271
PNG
(6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...)
Show SMILES Nc1cncc(n1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCN(CC2)C2COC2)n1
Show InChI InChI=1S/C23H25N9O/c24-21-12-25-11-19(28-21)20-13-32-6-5-26-23(32)22(29-20)27-16-1-3-17(4-2-16)30-7-9-31(10-8-30)18-14-33-15-18/h1-6,11-13,18H,7-10,14-15H2,(H2,24,28)(H,27,29)
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n/an/an/an/a 24n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015427
PNG
(CHEMBL3265017)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1OC
Show InChI InChI=1S/C21H18N6O2/c1-28-18-6-5-15(10-19(18)29-2)24-20-21-22-7-8-27(21)12-17(25-20)13-3-4-14-11-23-26-16(14)9-13/h3-12H,1-2H3,(H,23,26)(H,24,25)
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n/an/an/an/a 24n/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of Syk in antihuman IgM-stimulated human Ramos cells assessed as decrease in BCR-mediated BLNK phosphorylation by cellular assay


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015448
PNG
(CHEMBL3265032)
Show SMILES C1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
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n/an/an/an/a 26n/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of Syk in antihuman IgM-stimulated human Ramos cells assessed as decrease in BCR-mediated BLNK phosphorylation by cellular assay


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM212271
PNG
(6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...)
Show SMILES Nc1cncc(n1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCN(CC2)C2COC2)n1
Show InChI InChI=1S/C23H25N9O/c24-21-12-25-11-19(28-21)20-13-32-6-5-26-23(32)22(29-20)27-16-1-3-17(4-2-16)30-7-9-31(10-8-30)18-14-33-15-18/h1-6,11-13,18H,7-10,14-15H2,(H2,24,28)(H,27,29)
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n/an/an/an/a 26n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated BTK phosphorylation at Y223 residue


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50538466
PNG
(CHEMBL4648053)
Show SMILES C1OCC1N1CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cc[nH]c3c2)cc1
Show InChI InChI=1S/C27H27N7O/c1-2-20(15-24-19(1)7-8-28-24)25-16-34-10-9-29-27(34)26(31-25)30-21-3-5-22(6-4-21)32-11-13-33(14-12-32)23-17-35-18-23/h1-10,15-16,23,28H,11-14,17-18H2,(H,30,31)
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n/an/an/an/a 26n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50235827
PNG
(CHEMBL4081974)
Show SMILES COC(=O)N[C@@H]1CC(C)(C)c2ccc(Nc3nc(NCC(F)F)c4occc4n3)cc2NC1=O
Show InChI InChI=1S/C22H24F2N6O4/c1-22(2)9-15(29-21(32)33-3)19(31)27-14-8-11(4-5-12(14)22)26-20-28-13-6-7-34-17(13)18(30-20)25-10-16(23)24/h4-8,15-16H,9-10H2,1-3H3,(H,27,31)(H,29,32)(H2,25,26,28,30)/t15-/m1/s1
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n/an/an/an/a 26n/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
BindingDB Entry DOI: 10.7270/Q2WQ061V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50396071
PNG
(CHEMBL2170582 | US10828301, Compound R921303)
Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OC(F)(F)C(=O)Nc4c3)n2)c1
Show InChI InChI=1S/C21H17F3N6O4/c1-25-17(31)10-33-13-4-2-3-11(7-13)28-20-26-9-14(22)18(30-20)27-12-5-6-16-15(8-12)29-19(32)21(23,24)34-16/h2-9H,10H2,1H3,(H,25,31)(H,29,32)(H2,26,27,28,30)
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n/an/an/an/a 27n/an/an/an/a



Rigel, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in cultured human mesangial cells assessed as reduction in tryptase release


J Med Chem 55: 3614-43 (2012)


Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50538454
PNG
(CHEMBL4643354)
Show SMILES OC[C@H]1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
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n/an/an/an/a 29n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50235825
PNG
(CHEMBL4065615)
Show SMILES CCCNc1nc(Nc2ccc3c(NC(=O)COC3(C)C)c2)nc2ccoc12
Show InChI InChI=1S/C20H23N5O3/c1-4-8-21-18-17-14(7-9-27-17)24-19(25-18)22-12-5-6-13-15(10-12)23-16(26)11-28-20(13,2)3/h5-7,9-10H,4,8,11H2,1-3H3,(H,23,26)(H2,21,22,24,25)
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n/an/an/an/a 30n/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of 125I-fibrinogen binding to alpha IIb beta-3 integrin as inhibition of activated platelets


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
BindingDB Entry DOI: 10.7270/Q2WQ061V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50235821
PNG
(CHEMBL4100939)
Show SMILES CC(C)Nc1nc(Nc2ccc3c(NC(=O)COC3(C)C)c2)nc2ccoc12
Show InChI InChI=1S/C20H23N5O3/c1-11(2)21-18-17-14(7-8-27-17)24-19(25-18)22-12-5-6-13-15(9-12)23-16(26)10-28-20(13,3)4/h5-9,11H,10H2,1-4H3,(H,23,26)(H2,21,22,24,25)
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n/an/an/an/a 30n/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 4 expressed in RGT cells.


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
BindingDB Entry DOI: 10.7270/Q2WQ061V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50538446
PNG
(CHEMBL4642075)
Show SMILES C1OC[C@H]2COC[C@@H]1N2c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
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Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015449
PNG
(CHEMBL3265033)
Show SMILES O=S1(=O)CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C23H21N7O2S/c31-33(32)11-9-29(10-12-33)19-5-3-18(4-6-19)26-22-23-24-7-8-30(23)15-21(27-22)16-1-2-17-14-25-28-20(17)13-16/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
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Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50538453
PNG
(CHEMBL4647927)
Show SMILES OC1CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C24H23N7O/c32-20-7-10-30(11-8-20)19-5-3-18(4-6-19)27-23-24-25-9-12-31(24)15-22(28-23)16-1-2-17-14-26-29-21(17)13-16/h1-6,9,12-15,20,32H,7-8,10-11H2,(H,26,29)(H,27,28)
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Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM60665
PNG
(BDBM50249542 | US9145414, R406 | US9212178, R406)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
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n/an/an/an/a 33n/an/an/an/a



Rigel, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human neutrophils cells assessed as reduction in FcepsilonR1/FcgammaR-mediated signaling responses


J Med Chem 55: 3614-43 (2012)


Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50235833
PNG
(CHEMBL4062803)
Show SMILES Cc1n[nH]c2cc(Nc3nc(NC4CC4)c4occc4n3)ccc12
Show InChI InChI=1S/C17H16N6O/c1-9-12-5-4-11(8-14(12)23-22-9)19-17-20-13-6-7-24-15(13)16(21-17)18-10-2-3-10/h4-8,10H,2-3H2,1H3,(H,22,23)(H2,18,19,20,21)
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n/an/an/an/a 34n/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Syk in human Ramos B cells assessed as decrease in intracellular calcium flux measured for 3.5 mins by calcium-5 dye based FLIPR assay


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
BindingDB Entry DOI: 10.7270/Q2WQ061V
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM212271
PNG
(6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...)
Show SMILES Nc1cncc(n1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCN(CC2)C2COC2)n1
Show InChI InChI=1S/C23H25N9O/c24-21-12-25-11-19(28-21)20-13-32-6-5-26-23(32)22(29-20)27-16-1-3-17(4-2-16)30-7-9-31(10-8-30)18-14-33-15-18/h1-6,11-13,18H,7-10,14-15H2,(H2,24,28)(H,27,29)
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n/an/an/an/a 34n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated AKT phosphorylation at S473 residue


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50204294
PNG
(CHEMBL3943295)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nc3CNC(=O)c23)c1
Show InChI InChI=1S/C19H24N6O/c1-11-5-4-6-12(9-11)22-17-16-15(10-21-18(16)26)24-19(25-17)23-14-8-3-2-7-13(14)20/h4-6,9,13-14H,2-3,7-8,10,20H2,1H3,(H,21,26)(H2,22,23,24,25)/t13-,14+/m0/s1
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n/an/an/an/a 35n/an/an/an/a



Takeda California Inc

Curated by ChEMBL


Assay Description
Inhibition of SYK in TgM-stimulated human Ramos cells expressing RA1/GFP-tagged BLNK assessed as reduction in RA1/GFP-tagged BLNK phosphorylation pre...


Bioorg Med Chem Lett 26: 5947-5950 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.087
BindingDB Entry DOI: 10.7270/Q29888Z2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50235829
PNG
(CHEMBL4098474)
Show SMILES CC1(C)CCC(=O)Nc2cc(Nc3nc(NC4CC4)c4occc4n3)ccc12
Show InChI InChI=1S/C21H23N5O2/c1-21(2)9-7-17(27)24-16-11-13(5-6-14(16)21)23-20-25-15-8-10-28-18(15)19(26-20)22-12-3-4-12/h5-6,8,10-12H,3-4,7,9H2,1-2H3,(H,24,27)(H2,22,23,25,26)
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n/an/an/an/a 35n/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Syk in human Ramos B cells assessed as decrease in intracellular calcium flux measured for 3.5 mins by calcium-5 dye based FLIPR assay


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
BindingDB Entry DOI: 10.7270/Q2WQ061V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50538456
PNG
(CHEMBL4649800)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C25H26N8/c1-2-31-11-13-32(14-12-31)21-7-5-20(6-8-21)28-24-25-26-9-10-33(25)17-23(29-24)18-3-4-19-16-27-30-22(19)15-18/h3-10,15-17H,2,11-14H2,1H3,(H,27,30)(H,28,29)
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n/an/an/an/a 36n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50538461
PNG
(CHEMBL4637326)
Show SMILES C1OCC1N1CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2cnc3cn[nH]c3n2)cc1
Show InChI InChI=1S/C24H24N10O/c1-3-17(32-7-9-33(10-8-32)18-14-35-15-18)4-2-16(1)28-23-24-25-5-6-34(24)13-21(30-23)19-11-26-20-12-27-31-22(20)29-19/h1-6,11-13,18H,7-10,14-15H2,(H,28,30)(H,27,29,31)
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n/an/an/an/a 37n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM212271
PNG
(6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...)
Show SMILES Nc1cncc(n1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCN(CC2)C2COC2)n1
Show InChI InChI=1S/C23H25N9O/c24-21-12-25-11-19(28-21)20-13-32-6-5-26-23(32)22(29-20)27-16-1-3-17(4-2-16)30-7-9-31(10-8-30)18-14-33-15-18/h1-6,11-13,18H,7-10,14-15H2,(H2,24,28)(H,27,29)
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n/an/an/an/a 37n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated ERK phosphorylation at T202/Y204 residue


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50235818
PNG
(CHEMBL4071441)
Show SMILES COC(=O)N[C@@H]1CC(C)(C)c2ccc(Nc3nc(NC4CC4)c4occc4n3)cc2NC1=O
Show InChI InChI=1S/C23H26N6O4/c1-23(2)11-17(28-22(31)32-3)20(30)26-16-10-13(6-7-14(16)23)25-21-27-15-8-9-33-18(15)19(29-21)24-12-4-5-12/h6-10,12,17H,4-5,11H2,1-3H3,(H,26,30)(H,28,31)(H2,24,25,27,29)/t17-/m1/s1
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n/an/an/an/a 39n/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Syk in human Ramos B cells assessed as decrease in intracellular calcium flux measured for 3.5 mins by calcium-5 dye based FLIPR assay


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
BindingDB Entry DOI: 10.7270/Q2WQ061V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015449
PNG
(CHEMBL3265033)
Show SMILES O=S1(=O)CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C23H21N7O2S/c31-33(32)11-9-29(10-12-33)19-5-3-18(4-6-19)26-22-23-24-7-8-30(23)15-21(27-22)16-1-2-17-14-25-28-20(17)13-16/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
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n/an/an/an/a 40n/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of Syk in antihuman IgM-stimulated human Ramos cells assessed as decrease in BCR-mediated BLNK phosphorylation by cellular assay


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015448
PNG
(CHEMBL3265032)
Show SMILES C1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
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n/an/an/an/a 41n/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of Syk in alphaIgM-stimulated human B cells assessed as cell proliferation after 1 hr incubation by flow cytometry


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015451
PNG
(CHEMBL3265035)
Show SMILES CN(CCO)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C22H21N7O/c1-28(10-11-30)18-6-4-17(5-7-18)25-21-22-23-8-9-29(22)14-20(26-21)15-2-3-16-13-24-27-19(16)12-15/h2-9,12-14,30H,10-11H2,1H3,(H,24,27)(H,25,26)
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n/an/an/an/a 42n/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of Syk in antihuman IgM-stimulated human Ramos cells assessed as decrease in BCR-mediated BLNK phosphorylation by cellular assay


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50235824
PNG
(CHEMBL4082961)
Show SMILES CC(C)CNc1nc(Nc2ccc3c(NC(=O)COC3(C)C)c2)nc2ccoc12
Show InChI InChI=1S/C21H25N5O3/c1-12(2)10-22-19-18-15(7-8-28-18)25-20(26-19)23-13-5-6-14-16(9-13)24-17(27)11-29-21(14,3)4/h5-9,12H,10-11H2,1-4H3,(H,24,27)(H2,22,23,25,26)
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n/an/an/an/a 43n/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Syk in human Ramos B cells assessed as decrease in intracellular calcium flux measured for 3.5 mins by calcium-5 dye based FLIPR assay


Bioorg Med Chem Lett 26: 5562-5567 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.077
BindingDB Entry DOI: 10.7270/Q2WQ061V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50538451
PNG
(CHEMBL4642016)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
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n/an/an/an/a 45n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50538468
PNG
(CHEMBL4640138)
Show SMILES C1OCC1N1CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2cnc3cc[nH]c3c2)cc1
Show InChI InChI=1S/C26H26N8O/c1-3-20(32-9-11-33(12-10-32)21-16-35-17-21)4-2-19(1)30-25-26-28-7-8-34(26)15-24(31-25)18-13-23-22(29-14-18)5-6-27-23/h1-8,13-15,21,27H,9-12,16-17H2,(H,30,31)
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n/an/an/an/a 46n/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...


ACS Med Chem Lett 11: 506-513 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00621
More data for this
Ligand-Target Pair
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