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Found 649 of ic50 for UniProtKB: P00735
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228863((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  8.90nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029498(1N-[2-{2-[4-amino(imino)methylamino-1-formyl-(1S)-...)
Affinity DataIC50:  9.60nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029510(1N-[2-{2-[4-amino(imino)methylamino-1-formyl-(1S)-...)
Affinity DataIC50:  13nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50269544(CHEMBL510512 | tellimagrandin II)
Affinity DataIC50:  14nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029506(CHEMBL318998 | tert-butyloxy carbonyl-D-ethylpheny...)
Affinity DataIC50:  16nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029515(CHEMBL141584 | tert-butyloxy carbonyl-D-Phe-azetid...)
Affinity DataIC50:  18nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029501(5N-[4-amino(imino)methylamino-1-formyl-(1S)-butyl]...)
Affinity DataIC50:  19nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029514((S)-1-((R)-2-Acetylamino-2-phenyl-propionyl)-azeti...)
Affinity DataIC50:  19nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029500((S)-1-((S)-1,2,3,4-Tetrahydro-isoquinoline-3-carbo...)
Affinity DataIC50:  19nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50280654((S)-5-Guanidino-2-{[(S)-1-((S)-2-methylamino-2-phe...)
Affinity DataIC50:  20nMAssay Description:In vitro concentration of compound required to inhibit 50% of 6 nM thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029507(CHEMBL2370860 | {(R)-2-[2-((S)-1-Formyl-4-guanidin...)
Affinity DataIC50:  22nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50269547(5-desgalloylstachyurin | CHEMBL488110)
Affinity DataIC50:  26nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50280655(3-Isobutyryloxy-benzo[4,5]thieno[3,2-b]furan-2-car...)
Affinity DataIC50:  30nMAssay Description:In vitro concentration of compound required to inhibit 50% of 6 nM thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029511(CHEMBL104472 | tert-butyloxy carbonyl-D-Phe-pro-Ar...)
Affinity DataIC50:  45nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50241052(1,2,3,4,6-Pgg | 1,2,3,4,6-pentakis-O-(3,4,5-trihyd...)
Affinity DataIC50:  50nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50269546(CHEMBL509562 | casuariin)
Affinity DataIC50:  59nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029502(1N-[2-[5-[4-amino(imino)methylamino-1-formyl-(1S)-...)
Affinity DataIC50:  64nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50269544(CHEMBL510512 | tellimagrandin II)
Affinity DataIC50:  70nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029499(CHEMBL141834 | tert-butyloxy carbonyl-D-Phe-thiazo...)
Affinity DataIC50:  88nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50241052(1,2,3,4,6-Pgg | 1,2,3,4,6-pentakis-O-(3,4,5-trihyd...)
Affinity DataIC50:  110nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM83506((5Z)-5-[[2-(3-isopropoxypropylamino)-4-keto-9-meth...)
Affinity DataIC50:  148nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50242262(CHEMBL506204 | PEDUNCULAGIN)
Affinity DataIC50:  150nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50404562(CHEMBL353809)
Affinity DataIC50:  150nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50242262(CHEMBL506204 | PEDUNCULAGIN)
Affinity DataIC50:  180nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50269547(5-desgalloylstachyurin | CHEMBL488110)
Affinity DataIC50:  190nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50404544(CHEMBL355327)
Affinity DataIC50:  200nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50269546(CHEMBL509562 | casuariin)
Affinity DataIC50:  280nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029512(CHEMBL139910 | tert-butyloxy carbonyl-D-Phe-DL-Pro...)
Affinity DataIC50:  290nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50404567(CHEMBL168621)
Affinity DataIC50:  300nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50404563(CHEMBL352975)
Affinity DataIC50:  300nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM52848(MLS000333673 | Methanesulfonic acid 3-oxo-2-[1-(2,...)
Affinity DataIC50:  468nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM39775((5E)-5-[(E)-3-[4-(dimethylamino)phenyl]prop-2-enyl...)
Affinity DataIC50:  529nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM88892(MLS000401485 | N-(2-chlorophenyl)-2-[(2E)-2-[(2-mo...)
Affinity DataIC50:  564nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50404623(CHEMBL168547)
Affinity DataIC50:  670nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50404564(CHEMBL353701)
Affinity DataIC50:  1.00E+3nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029505(5N-[4-amino(imino)methylamino-1-formyl-1-methyl-(1...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50046896(2-Acetylamino-4-methyl-pentanoic acid [1-(1-formyl...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of thrombin with benzoyl-Phe-Val-arginine- p-nitroanilide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM60483((5Z)-5-(4-hydroxy-3,5-dimethoxy-benzylidene)-2-(p-...)
Affinity DataIC50:  1.37E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50046887(2-(2-Acetylamino-3-phenyl-propionylamino)-4-methyl...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of thrombin with benzoyl-Phe-Val-arginine- p-nitroanilide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50024617(N-acetylhirudin45-65)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of plasma fibrin clot formation by thrombin in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM88918(MLS001006760 | N-[(E)-1-(1-benzofuran-2-yl)ethylid...)
Affinity DataIC50:  1.62E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029504(CHEMBL139490 | {(S)-1-Benzyl-2-[(S)-2-((S)-1-formy...)
Affinity DataIC50:  1.70E+3nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50404530(CHEMBL166995)
Affinity DataIC50:  2.00E+3nMAssay Description:Concentration at which the clotting time was prolonged by twice the control was determined using topical bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50404531(CHEMBL166822)
Affinity DataIC50:  2.00E+3nMAssay Description:Concentration at which the clotting time was prolonged by twice the control was determined using topical bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50404506(CHEMBL355622)
Affinity DataIC50:  2.00E+3nMAssay Description:Concentration at which the clotting time was prolonged by twice the control was determined using topical bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM83218(1-[(Z)-3-indolylidenemethyl]-2-(4-nitrophenyl)hydr...)
Affinity DataIC50:  2.05E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM45037((2Z)-2-[(2-hydroxy-5-nitro-anilino)methylene]benzo...)
Affinity DataIC50:  2.57E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM66127((5E)-3-benzyl-5-(4-hydroxy-3,5-dimethoxy-benzylide...)
Affinity DataIC50:  2.90E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM237191(Rutin palmitate)
Affinity DataIC50:  3.00E+3nMpH: 8.0Assay Description:The rate of hydrolysis of the substrates (0.3 mM) by trypsin (18 U/ml), thrombin (12.5 NIH U/ml), urokinase (62500 IU/ml) and elastase (8.4 U/ml) was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50024619([Tyr56] Hirudin55-65)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of plasma fibrin clot formation by thrombin in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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