Compile Data Set for Download or QSAR
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Found 311 of ki for UniProtKB: P00748
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229873(CHEMBL4088217)
Affinity DataKi:  0.840nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229867(CHEMBL4098389)
Affinity DataKi:  0.890nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229872(CHEMBL4059973)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229738(CHEMBL4087027)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229758(CHEMBL4102962)
Affinity DataKi:  3nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229997(CHEMBL4065450)
Affinity DataKi:  3.70nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22741(1-(3,4-dimethylphenyl)-2-phenylethane-1,2-dione | ...)
Affinity DataKi:  4.10nM ΔG°:  -11.4kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229866(CHEMBL4069650)
Affinity DataKi:  4.5nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22850(1,2-Dione-Based Compound, 7 | 1,2-dicyclohexyletha...)
Affinity DataKi:  5nM ΔG°:  -11.3kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)
Affinity DataKi:  5.60nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)
Affinity DataKi:  5.60nM ΔG°:  -11.2kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229743(CHEMBL4071691)
Affinity DataKi:  6nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229735(CHEMBL4102477)
Affinity DataKi:  6.5nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229744(CHEMBL4104497)
Affinity DataKi:  6.80nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22859(1,2-Dione-Based Compound, 16 | 1,2-dihydroaceanthr...)
Affinity DataKi:  7.70nM ΔG°:  -11.1kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22748(1-(4-methyl-3-nitrophenyl)-2-phenylethane-1,2-dion...)
Affinity DataKi:  7.90nM ΔG°:  -11.0kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22842(1-dodecyl-2,3-dihydro-1H-indole-2,3-dione | CHEMBL...)
Affinity DataKi:  8nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229736(CHEMBL4074219)
Affinity DataKi:  8.80nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22745(1-(2-chlorophenyl)-2-(3,4-dimethoxyphenyl)ethane-1...)
Affinity DataKi:  8.90nM ΔG°:  -11.0kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229734(CHEMBL4064568)
Affinity DataKi:  9nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229987(CHEMBL4095948)
Affinity DataKi:  9.30nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229992(CHEMBL4080261)
Affinity DataKi:  10nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22845(1-{[4-({4-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)me...)
Affinity DataKi:  10nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229996(CHEMBL4066341)
Affinity DataKi:  10nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22742(1-(4-methoxyphenyl)-2-phenylethane-1,2-dione | Ben...)
Affinity DataKi:  10.3nM ΔG°:  -10.9kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22843(1-hexadecyl-2,3-dihydro-1H-indole-2,3-dione | Isat...)
Affinity DataKi:  11nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229874(CHEMBL4074453)
Affinity DataKi:  12nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229980(CHEMBL4101024)
Affinity DataKi:  13nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50230023(CHEMBL4094726)
Affinity DataKi:  14nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Benzil | CHEMBL1898...)
Affinity DataKi:  14.7nM ΔG°:  -10.7kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Benzil | CHEMBL1898...)
Affinity DataKi:  14.7nM ΔG°:  -10.7kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229737(CHEMBL4065597)
Affinity DataKi:  15nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50230018(CHEMBL4084044)
Affinity DataKi:  18nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22737(1-(4-chlorophenyl)-2-phenylethane-1,2-dione | Benz...)
Affinity DataKi:  18.2nM ΔG°:  -10.6kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229976(CHEMBL4098557)
Affinity DataKi:  20nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50369774(SEPIMOSTAT MESYLATE | Sepimostat)
Affinity DataKi:  21nMAssay Description:Non-competitive inhibition of factor 12a (unknown origin) using BQGR as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22746(1-[4-(bromomethyl)phenyl]-2-phenylethane-1,2-dione...)
Affinity DataKi:  21.3nM ΔG°:  -10.5kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22738(1-(4-chlorophenyl)-2-(4-methylphenyl)ethane-1,2-di...)
Affinity DataKi:  22.8nM ΔG°:  -10.4kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22734(1,2-bis(3,5-difluorophenyl)ethane-1,2-dione | Benz...)
Affinity DataKi:  23.4nM ΔG°:  -10.4kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM218840(TATA-FXII618 (14))
Affinity DataKi:  25nMpH: 7.4Assay Description:The inhibition of plasma kallikrein and coagulation factor FXII was assessed by incubating the proteases with bicyclic peptide (twofold dilutions) an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229849(CHEMBL4090666)
Affinity DataKi:  27nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229994(CHEMBL4095870)
Affinity DataKi:  28nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229753(CHEMBL4076870)
Affinity DataKi:  29nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50230020(CHEMBL4062902)
Affinity DataKi:  29nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22749(1-(4-nitrophenyl)-2-phenylethane-1,2-dione | Benzi...)
Affinity DataKi:  30.6nM ΔG°:  -10.2kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229754(CHEMBL4075523)
Affinity DataKi:  31nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22795(1-[(4-chlorophenyl)methyl]-2,3-dihydro-1H-indole-2...)
Affinity DataKi:  32nM ΔG°:  -10.2kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229875(CHEMBL4077847)
Affinity DataKi:  32nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM22739(1-(4-methylphenyl)-2-phenylethane-1,2-dione | Benz...)
Affinity DataKi:  33.3nM ΔG°:  -10.2kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�d�rale de Lausanne (EPFL)

Curated by ChEMBL
LigandPNGBDBM50229989(CHEMBL4084518)
Affinity DataKi:  34nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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