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Compile Data Set for Download or QSAR

Found 90 hits for UniProtKB: P46531   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074796
PNG
(CHEMBL3410169)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2F)C1=O)c1ccccc1
Show InChI InChI=1S/C29H25F5N4O3/c1-38-22-10-6-5-9-19(22)24(16-7-3-2-4-8-16)36-26(28(38)41)37-27(40)20(13-14-29(32,33)34)23(25(35)39)18-12-11-17(30)15-21(18)31/h2-12,15,20,23,26H,13-14H2,1H3,(H2,35,39)(H,37,40)/t20-,23+,26-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Bioorg Med Chem Lett 25: 1905-9 (2015)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074771
PNG
(CHEMBL3410153)
Show SMILES CCC(CC)[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1S/C28H33F3N4O3/c1-4-17(5-2)22(24(32)36)20(15-16-28(29,30)31)26(37)34-25-27(38)35(3)21-14-10-9-13-19(21)23(33-25)18-11-7-6-8-12-18/h6-14,17,20,22,25H,4-5,15-16H2,1-3H3,(H2,32,36)(H,34,37)/t20-,22+,25-/m1/s1
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Bioorg Med Chem Lett 25: 1905-9 (2015)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074818
PNG
(CHEMBL3410163)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cccc(c2)C(F)(F)F)C1=O)c1ccccc1
Show InChI InChI=1S/C30H26F6N4O3/c1-40-22-13-6-5-12-20(22)24(17-8-3-2-4-9-17)38-26(28(40)43)39-27(42)21(14-15-29(31,32)33)23(25(37)41)18-10-7-11-19(16-18)30(34,35)36/h2-13,16,21,23,26H,14-15H2,1H3,(H2,37,41)(H,39,42)/t21-,23+,26-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Bioorg Med Chem Lett 25: 1905-9 (2015)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209895
PNG
(US9273014, 24)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O
Show InChI InChI=1S/C28H28F6N4O3/c29-27(30,31)13-11-18(23(35)39)19(12-14-28(32,33)34)25(40)38-24-26(41)37-22-17(15-9-10-15)7-4-8-20(22)21(36-24)16-5-2-1-3-6-16/h1-8,15,18-19,24H,9-14H2,(H2,35,39)(H,37,41)(H,38,40)/t18-,19+,24+/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209891
PNG
(US9273014, 20)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H25F9N4O3/c1-13-4-2-7-18-19(13)39-24(43)22(38-20(18)14-5-3-6-15(12-14)27(34,35)36)40-23(42)17(9-11-26(31,32)33)16(21(37)41)8-10-25(28,29)30/h2-7,12,16-17,22H,8-11H2,1H3,(H2,37,41)(H,39,43)(H,40,42)/t16-,17+,22+/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242882
PNG
(US9427442, 10)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC2CC(F)(F)C2)C(N)=O)C(=O)Nc2c(Cl)cccc12
Show InChI InChI=1S/C28H28ClF5N4O3/c1-14-4-2-5-16(10-14)21-18-6-3-7-20(29)22(18)37-26(41)24(36-21)38-25(40)17(8-9-28(32,33)34)19(23(35)39)11-15-12-27(30,31)13-15/h2-7,10,15,17,19,24H,8-9,11-13H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t17-,19+,24-/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209896
PNG
(US9273014, 25)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2cccc(c2)C2CC2)c2cccc(Cl)c2NC1=O
Show InChI InChI=1S/C28H27ClF6N4O3/c29-20-6-2-5-19-21(16-4-1-3-15(13-16)14-7-8-14)37-24(26(42)38-22(19)20)39-25(41)18(10-12-28(33,34)35)17(23(36)40)9-11-27(30,31)32/h1-6,13-14,17-18,24H,7-12H2,(H2,36,40)(H,38,42)(H,39,41)/t17-,18+,24+/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209874
PNG
(US9273014, 3)
Show SMILES CC(C)c1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1
Show InChI InChI=1S/C28H29ClF6N4O3/c1-14(2)17-7-4-8-20-21(15-5-3-6-16(29)13-15)37-24(26(42)38-22(17)20)39-25(41)19(10-12-28(33,34)35)18(23(36)40)9-11-27(30,31)32/h3-8,13-14,18-19,24H,9-12H2,1-2H3,(H2,36,40)(H,38,42)(H,39,41)/t18-,19+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074795
PNG
(CHEMBL3410170)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cc(F)cc(F)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C29H25F5N4O3/c1-38-22-10-6-5-9-20(22)24(16-7-3-2-4-8-16)36-26(28(38)41)37-27(40)21(11-12-29(32,33)34)23(25(35)39)17-13-18(30)15-19(31)14-17/h2-10,13-15,21,23,26H,11-12H2,1H3,(H2,35,39)(H,37,40)/t21-,23+,26-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Bioorg Med Chem Lett 25: 1905-9 (2015)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074798
PNG
(CHEMBL3410168)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)c(F)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C29H25F5N4O3/c1-38-22-10-6-5-9-18(22)24(16-7-3-2-4-8-16)36-26(28(38)41)37-27(40)19(13-14-29(32,33)34)23(25(35)39)17-11-12-20(30)21(31)15-17/h2-12,15,19,23,26H,13-14H2,1H3,(H2,35,39)(H,37,40)/t19-,23+,26-/m1/s1
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Bioorg Med Chem Lett 25: 1905-9 (2015)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074799
PNG
(CHEMBL3410167)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2)C1=O)c1ccccc1
Show InChI InChI=1S/C29H26F4N4O3/c1-37-22-10-6-5-9-20(22)24(18-7-3-2-4-8-18)35-26(28(37)40)36-27(39)21(15-16-29(31,32)33)23(25(34)38)17-11-13-19(30)14-12-17/h2-14,21,23,26H,15-16H2,1H3,(H2,34,38)(H,36,39)/t21-,23+,26-/m1/s1
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Bioorg Med Chem Lett 25: 1905-9 (2015)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074784
PNG
(CHEMBL3410151)
Show SMILES CCC(CC)[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1S/C29H38N4O3/c1-6-19(7-2)24(26(30)34)22(17-18(3)4)28(35)32-27-29(36)33(5)23-16-12-11-15-21(23)25(31-27)20-13-9-8-10-14-20/h8-16,18-19,22,24,27H,6-7,17H2,1-5H3,(H2,30,34)(H,32,35)/t22-,24+,27-/m1/s1
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Bioorg Med Chem Lett 25: 1905-9 (2015)

More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242883
PNG
(US9427442, 11)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC2CC(F)(F)C2)C(N)=O)C(=O)Nc2c(F)cccc12
Show InChI InChI=1S/C28H28F6N4O3/c1-14-4-2-5-16(10-14)21-18-6-3-7-20(29)22(18)37-26(41)24(36-21)38-25(40)17(8-9-28(32,33)34)19(23(35)39)11-15-12-27(30,31)13-15/h2-7,10,15,17,19,24H,8-9,11-13H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t17-,19+,24-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209876
PNG
(US9273014, 5)
Show SMILES Cc1cc(C)cc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12
Show InChI InChI=1S/C28H29ClF6N4O3/c1-14-11-15(2)13-16(12-14)21-19-5-3-7-20(29)22(19)38-26(42)24(37-21)39-25(41)18(8-10-28(33,34)35)17(23(36)40)6-4-9-27(30,31)32/h3,5,7,11-13,17-18,24H,4,6,8-10H2,1-2H3,(H2,36,40)(H,38,42)(H,39,41)/t17-,18+,24+/m0/s1
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n/an/a 2.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209881
PNG
(US9273014, 10)
Show SMILES Cc1cc(C)cc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12
Show InChI InChI=1S/C27H27ClF6N4O3/c1-13-10-14(2)12-15(11-13)20-18-4-3-5-19(28)21(18)37-25(41)23(36-20)38-24(40)17(7-9-27(32,33)34)16(22(35)39)6-8-26(29,30)31/h3-5,10-12,16-17,23H,6-9H2,1-2H3,(H2,35,39)(H,37,41)(H,38,40)/t16-,17+,23+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242890
PNG
(US9427442, 18)
Show SMILES CC(F)(F)C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O)C(N)=O
Show InChI InChI=1S/C25H25F5N4O3/c1-24(26,27)13-17(20(31)35)15(11-12-25(28,29)30)22(36)34-21-23(37)32-18-10-6-5-9-16(18)19(33-21)14-7-3-2-4-8-14/h2-10,15,17,21H,11-13H2,1H3,(H2,31,35)(H,32,37)(H,34,36)/t15-,17+,21-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209902
PNG
(US9273014, 31)
Show SMILES Cc1ccccc1C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2ccccc12
Show InChI InChI=1S/C26H26F6N4O3/c1-14-6-2-3-7-15(14)20-18-8-4-5-9-19(18)34-24(39)22(35-20)36-23(38)17(11-13-26(30,31)32)16(21(33)37)10-12-25(27,28)29/h2-9,16-17,22H,10-13H2,1H3,(H2,33,37)(H,34,39)(H,36,38)/t16-,17+,22+/m0/s1
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n/an/a 2.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242885
PNG
(US9427442, 13)
Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O
Show InChI InChI=1S/C27H26ClF5N4O3/c28-19-8-4-7-17-20(15-5-2-1-3-6-15)35-23(25(40)36-21(17)19)37-24(39)16(9-10-27(31,32)33)18(22(34)38)11-14-12-26(29,30)13-14/h1-8,14,16,18,23H,9-13H2,(H2,34,38)(H,36,40)(H,37,39)/t16-,18+,23-/m1/s1
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n/an/a 2.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209898
PNG
(US9273014, 27)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(Cl)cc1
Show InChI InChI=1S/C26H25ClF6N4O4/c1-41-18-4-2-3-17-19(13-5-7-14(27)8-6-13)35-22(24(40)36-20(17)18)37-23(39)16(10-12-26(31,32)33)15(21(34)38)9-11-25(28,29)30/h2-8,15-16,22H,9-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t15-,16+,22+/m0/s1
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n/an/a 2.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242880
PNG
(US9427442, 8)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1ccccc1
Show InChI InChI=1S/C28H29F5N4O4/c1-41-20-9-5-8-18-21(16-6-3-2-4-7-16)35-24(26(40)36-22(18)20)37-25(39)17(10-11-28(31,32)33)19(23(34)38)12-15-13-27(29,30)14-15/h2-9,15,17,19,24H,10-14H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t17-,19+,24-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242891
PNG
(US9427442, 19)
Show SMILES C[C@@H](C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O)C(N)=O)C(F)(F)F
Show InChI InChI=1S/C26H25F7N4O3/c1-13(26(31,32)33)12-17(21(34)38)15(10-11-25(28,29)30)23(39)37-22-24(40)36-20-16(8-5-9-18(20)27)19(35-22)14-6-3-2-4-7-14/h2-9,13,15,17,22H,10-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t13-,15+,17-,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209880
PNG
(US9273014, 11 | US9273014, 9)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c1cccc2C(F)(F)F
Show InChI InChI=1S/C27H25F9N4O3/c1-13-4-2-5-14(12-13)19-17-6-3-7-18(27(34,35)36)20(17)39-24(43)22(38-19)40-23(42)16(9-11-26(31,32)33)15(21(37)41)8-10-25(28,29)30/h2-7,12,15-16,22H,8-11H2,1H3,(H2,37,41)(H,39,43)(H,40,42)/t15-,16+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242873
PNG
(US9427442, 1)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1ccccc1
Show InChI InChI=1S/C28H29F5N4O3/c1-15-6-5-9-19-21(15)36-26(40)24(35-22(19)17-7-3-2-4-8-17)37-25(39)18(10-11-28(31,32)33)20(23(34)38)12-16-13-27(29,30)14-16/h2-9,16,18,20,24H,10-14H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t18-,20+,24-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074695
PNG
(CHEMBL3410160)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2conc2C)C1=O)c1ccccc1
Show InChI InChI=1S/C27H26F3N5O4/c1-15-19(14-39-34-15)21(23(31)36)18(12-13-27(28,29)30)25(37)33-24-26(38)35(2)20-11-7-6-10-17(20)22(32-24)16-8-4-3-5-9-16/h3-11,14,18,21,24H,12-13H2,1-2H3,(H2,31,36)(H,33,37)/t18-,21-,24-/m1/s1
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Bioorg Med Chem Lett 25: 1905-9 (2015)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074693
PNG
(CHEMBL3410162)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cccc(C)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C30H29F3N4O3/c1-18-9-8-12-20(17-18)24(26(34)38)22(15-16-30(31,32)33)28(39)36-27-29(40)37(2)23-14-7-6-13-21(23)25(35-27)19-10-4-3-5-11-19/h3-14,17,22,24,27H,15-16H2,1-2H3,(H2,34,38)(H,36,39)/t22-,24+,27-/m1/s1
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Bioorg Med Chem Lett 25: 1905-9 (2015)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209883
PNG
(US9273014, 12)
Show SMILES CC(C)c1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1
Show InChI InChI=1S/C29H32F6N4O3/c1-15(2)18-8-5-9-21-22(17-7-4-6-16(3)14-17)37-25(27(42)38-23(18)21)39-26(41)20(11-13-29(33,34)35)19(24(36)40)10-12-28(30,31)32/h4-9,14-15,19-20,25H,10-13H2,1-3H3,(H2,36,40)(H,38,42)(H,39,41)/t19-,20+,25+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074777
PNG
(CHEMBL3410152)
Show SMILES CCC(CC)[C@@H]([C@@H](CC(C)(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1S/C30H40N4O3/c1-7-19(8-2)24(26(31)35)22(18-30(3,4)5)28(36)33-27-29(37)34(6)23-17-13-12-16-21(23)25(32-27)20-14-10-9-11-15-20/h9-17,19,22,24,27H,7-8,18H2,1-6H3,(H2,31,35)(H,33,36)/t22-,24+,27-/m1/s1
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Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Bioorg Med Chem Lett 25: 1905-9 (2015)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074813
PNG
(CHEMBL3410164)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cccc(OC(F)(F)F)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C30H26F6N4O4/c1-40-22-13-6-5-12-20(22)24(17-8-3-2-4-9-17)38-26(28(40)43)39-27(42)21(14-15-29(31,32)33)23(25(37)41)18-10-7-11-19(16-18)44-30(34,35)36/h2-13,16,21,23,26H,14-15H2,1H3,(H2,37,41)(H,39,42)/t21-,23+,26-/m1/s1
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Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Bioorg Med Chem Lett 25: 1905-9 (2015)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209893
PNG
(US9273014, 22)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(F)cc1
Show InChI InChI=1S/C26H25F7N4O3/c1-13-3-2-4-18-19(13)36-24(40)22(35-20(18)14-5-7-15(27)8-6-14)37-23(39)17(10-12-26(31,32)33)16(21(34)38)9-11-25(28,29)30/h2-8,16-17,22H,9-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242894
PNG
(US9427442, 22)
Show SMILES C[C@H](C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C(N)=O)C(F)(F)F
Show InChI InChI=1S/C26H25ClF6N4O3/c1-13(26(31,32)33)12-17(21(34)38)15(10-11-25(28,29)30)23(39)37-22-24(40)36-20-16(8-5-9-18(20)27)19(35-22)14-6-3-2-4-7-14/h2-9,13,15,17,22H,10-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t13-,15-,17+,22-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209892
PNG
(US9273014, 21)
Show SMILES Cc1ccccc1C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12
Show InChI InChI=1S/C26H25ClF6N4O3/c1-13-5-2-3-6-14(13)19-17-7-4-8-18(27)20(17)36-24(40)22(35-19)37-23(39)16(10-12-26(31,32)33)15(21(34)38)9-11-25(28,29)30/h2-8,15-16,22H,9-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t15-,16+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209884
PNG
(US9273014, 13)
Show SMILES CC(C)c1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccccc1
Show InChI InChI=1S/C28H30F6N4O3/c1-15(2)17-9-6-10-20-21(16-7-4-3-5-8-16)36-24(26(41)37-22(17)20)38-25(40)19(12-14-28(32,33)34)18(23(35)39)11-13-27(29,30)31/h3-10,15,18-19,24H,11-14H2,1-2H3,(H2,35,39)(H,37,41)(H,38,40)/t18-,19+,24+/m0/s1
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Bristol-Myers Squibb Company

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Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242881
PNG
(US9427442, 9)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1cccc(F)c1
Show InChI InChI=1S/C28H28F6N4O3/c1-14-4-2-7-19-21(14)37-26(41)24(36-22(19)16-5-3-6-17(29)11-16)38-25(40)18(8-9-28(32,33)34)20(23(35)39)10-15-12-27(30,31)13-15/h2-7,11,15,18,20,24H,8-10,12-13H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t18-,20+,24-/m1/s1
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Bristol-Myers Squibb Company

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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209897
PNG
(US9273014, 26)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1
Show InChI InChI=1S/C26H25ClF6N4O4/c1-41-18-7-3-6-17-19(13-4-2-5-14(27)12-13)35-22(24(40)36-20(17)18)37-23(39)16(9-11-26(31,32)33)15(21(34)38)8-10-25(28,29)30/h2-7,12,15-16,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t15-,16+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242897
PNG
(US9427442, 25)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1(F)CCC1)C(N)=O)N=C2c1ccccc1
Show InChI InChI=1S/C28H30F4N4O3/c1-16-7-5-10-19-21(16)35-26(39)24(34-22(19)17-8-3-2-4-9-17)36-25(38)18(11-14-28(30,31)32)20(23(33)37)15-27(29)12-6-13-27/h2-5,7-10,18,20,24H,6,11-15H2,1H3,(H2,33,37)(H,35,39)(H,36,38)/t18-,20+,24-/m1/s1
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Bristol-Myers Squibb Company

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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242896
PNG
(US9427442, 24)
Show SMILES CC(F)(F)CC[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C(N)=O
Show InChI InChI=1S/C26H26ClF5N4O3/c1-25(28,29)12-10-15(21(33)37)16(11-13-26(30,31)32)23(38)36-22-24(39)35-20-17(8-5-9-18(20)27)19(34-22)14-6-3-2-4-7-14/h2-9,15-16,22H,10-13H2,1H3,(H2,33,37)(H,35,39)(H,36,38)/t15-,16+,22+/m0/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242879
PNG
(US9427442, 7)
Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O
Show InChI InChI=1S/C30H31F5N4O4/c31-29(32)14-16(15-29)13-21(25(36)40)19(11-12-30(33,34)35)27(41)39-26-28(42)38-24-20(7-4-8-22(24)43-18-9-10-18)23(37-26)17-5-2-1-3-6-17/h1-8,16,18-19,21,26H,9-15H2,(H2,36,40)(H,38,42)(H,39,41)/t19-,21+,26-/m1/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209900
PNG
(US9273014, 29)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1
Show InChI InChI=1S/C27H28F6N4O4/c1-14-5-3-6-15(13-14)20-18-7-4-8-19(41-2)21(18)36-25(40)23(35-20)37-24(39)17(10-12-27(31,32)33)16(22(34)38)9-11-26(28,29)30/h3-8,13,16-17,23H,9-12H2,1-2H3,(H2,34,38)(H,36,40)(H,37,39)/t16-,17+,23+/m0/s1
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Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074694
PNG
(CHEMBL3410161)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccccc2)C1=O)c1ccccc1
Show InChI InChI=1S/C29H27F3N4O3/c1-36-22-15-9-8-14-20(22)24(19-12-6-3-7-13-19)34-26(28(36)39)35-27(38)21(16-17-29(30,31)32)23(25(33)37)18-10-4-2-5-11-18/h2-15,21,23,26H,16-17H2,1H3,(H2,33,37)(H,35,38)/t21-,23+,26-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Bioorg Med Chem Lett 25: 1905-9 (2015)

More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242875
PNG
(US9427442, 3)
Show SMILES NC(=O)[C@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2cccc(F)c2)c2cccc(OC3CC3)c2NC1=O)C1CCC(F)(F)CC1
Show InChI InChI=1S/C31H32F6N4O4/c32-18-4-1-3-17(15-18)24-21-5-2-6-22(45-19-7-8-19)25(21)40-29(44)27(39-24)41-28(43)20(11-14-31(35,36)37)23(26(38)42)16-9-12-30(33,34)13-10-16/h1-6,15-16,19-20,23,27H,7-14H2,(H2,38,42)(H,40,44)(H,41,43)/t20-,23+,27-/m1/s1
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n/an/a 4.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209904
PNG
(US9273014, 33)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C26H24F9N5O4/c1-44-17-4-2-3-15-18(16-6-5-12(11-37-16)26(33,34)35)38-21(23(43)39-19(15)17)40-22(42)14(8-10-25(30,31)32)13(20(36)41)7-9-24(27,28)29/h2-6,11,13-14,21H,7-10H2,1H3,(H2,36,41)(H,39,43)(H,40,42)/t13-,14+,21+/m0/s1
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n/an/a 4.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209901
PNG
(US9273014, 30 | US9273014, 35)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O
Show InChI InChI=1S/C26H26F6N4O4/c27-25(28,29)11-9-16(21(33)38)17(10-12-26(30,31)32)23(39)36-22-24(40)34-19-4-2-1-3-18(19)20(35-22)15-7-5-14(13-37)6-8-15/h1-8,16-17,22,37H,9-13H2,(H2,33,38)(H,34,40)(H,36,39)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209878
PNG
(US9273014, 7)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1
Show InChI InChI=1S/C26H25ClF6N4O3/c1-13-4-2-7-18-19(13)36-24(40)22(35-20(18)14-5-3-6-15(27)12-14)37-23(39)17(9-11-26(31,32)33)16(21(34)38)8-10-25(28,29)30/h2-7,12,16-17,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t16-,17+,22+/m0/s1
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n/an/a 4.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209886
PNG
(US9273014, 15)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(OC3CC3)cccc12
Show InChI InChI=1S/C29H30F6N4O4/c1-15-4-2-5-16(14-15)22-20-6-3-7-21(43-17-8-9-17)23(20)38-27(42)25(37-22)39-26(41)19(11-13-29(33,34)35)18(24(36)40)10-12-28(30,31)32/h2-7,14,17-19,25H,8-13H2,1H3,(H2,36,40)(H,38,42)(H,39,41)/t18-,19+,25+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242877
PNG
(US9427442, 5)
Show SMILES NC(=O)[C@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C1CCC(F)(F)CC1
Show InChI InChI=1S/C28H28ClF5N4O3/c29-19-8-4-7-18-21(16-5-2-1-3-6-16)36-24(26(41)37-22(18)19)38-25(40)17(11-14-28(32,33)34)20(23(35)39)15-9-12-27(30,31)13-10-15/h1-8,15,17,20,24H,9-14H2,(H2,35,39)(H,37,41)(H,38,40)/t17-,20+,24-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242887
PNG
(US9427442, 15)
Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O
Show InChI InChI=1S/C27H27F5N4O3/c28-26(29)13-15(14-26)12-19(22(33)37)17(10-11-27(30,31)32)24(38)36-23-25(39)34-20-9-5-4-8-18(20)21(35-23)16-6-2-1-3-7-16/h1-9,15,17,19,23H,10-14H2,(H2,33,37)(H,34,39)(H,36,38)/t17-,19+,23-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242886
PNG
(US9427442, 14)
Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O
Show InChI InChI=1S/C27H26F6N4O3/c28-19-8-4-7-17-20(15-5-2-1-3-6-15)35-23(25(40)36-21(17)19)37-24(39)16(9-10-27(31,32)33)18(22(34)38)11-14-12-26(29,30)13-14/h1-8,14,16,18,23H,9-13H2,(H2,34,38)(H,36,40)(H,37,39)/t16-,18+,23-/m1/s1
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n/an/a 4.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209889
PNG
(US9273014, 18)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)N=C2c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H27F9N4O3/c1-14-5-2-8-19-20(14)40-25(44)23(39-21(19)15-6-3-7-16(13-15)28(35,36)37)41-24(43)18(10-12-27(32,33)34)17(22(38)42)9-4-11-26(29,30)31/h2-3,5-8,13,17-18,23H,4,9-12H2,1H3,(H2,38,42)(H,40,44)(H,41,43)/t17-,18+,23+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209894
PNG
(US9273014, 23)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccccc1
Show InChI InChI=1S/C26H26F6N4O3/c1-14-6-5-9-18-19(14)35-24(39)22(34-20(18)15-7-3-2-4-8-15)36-23(38)17(11-13-26(30,31)32)16(21(33)37)10-12-25(27,28)29/h2-9,16-17,22H,10-13H2,1H3,(H2,33,37)(H,35,39)(H,36,38)/t16-,17+,22+/m0/s1
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n/an/a 4.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209901
PNG
(US9273014, 30 | US9273014, 35)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O
Show InChI InChI=1S/C26H26F6N4O4/c27-25(28,29)11-9-16(21(33)38)17(10-12-26(30,31)32)23(39)36-22-24(40)34-19-4-2-1-3-18(19)20(35-22)15-7-5-14(13-37)6-8-15/h1-8,16-17,22,37H,9-13H2,(H2,33,38)(H,34,40)(H,36,39)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


Citation and Details
More data for this
Ligand-Target Pair
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