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Compile Data Set for Download or QSAR

Found 66 hits for UniProtKB: Q06330   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242886
PNG
(US9427442, 14)
Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O
Show InChI InChI=1S/C27H26F6N4O3/c28-19-8-4-7-17-20(15-5-2-1-3-6-15)35-23(25(40)36-21(17)19)37-24(39)16(9-10-27(31,32)33)18(22(34)38)11-14-12-26(29,30)13-14/h1-8,14,16,18,23H,9-13H2,(H2,34,38)(H,36,40)(H,37,39)/t16-,18+,23-/m1/s1
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US Patent
n/an/a 1.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242882
PNG
(US9427442, 10)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC2CC(F)(F)C2)C(N)=O)C(=O)Nc2c(Cl)cccc12
Show InChI InChI=1S/C28H28ClF5N4O3/c1-14-4-2-5-16(10-14)21-18-6-3-7-20(29)22(18)37-26(41)24(36-21)38-25(40)17(8-9-28(32,33)34)19(23(35)39)11-15-12-27(30,31)13-15/h2-7,10,15,17,19,24H,8-9,11-13H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t17-,19+,24-/m1/s1
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PC sid
UniChem
US Patent
n/an/a 1.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242879
PNG
(US9427442, 7)
Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O
Show InChI InChI=1S/C30H31F5N4O4/c31-29(32)14-16(15-29)13-21(25(36)40)19(11-12-30(33,34)35)27(41)39-26-28(42)38-24-20(7-4-8-22(24)43-18-9-10-18)23(37-26)17-5-2-1-3-6-17/h1-8,16,18-19,21,26H,9-15H2,(H2,36,40)(H,38,42)(H,39,41)/t19-,21+,26-/m1/s1
PDB

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US Patent
n/an/a 2.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242883
PNG
(US9427442, 11)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC2CC(F)(F)C2)C(N)=O)C(=O)Nc2c(F)cccc12
Show InChI InChI=1S/C28H28F6N4O3/c1-14-4-2-5-16(10-14)21-18-6-3-7-20(29)22(18)37-26(41)24(36-21)38-25(40)17(8-9-28(32,33)34)19(23(35)39)11-15-12-27(30,31)13-15/h2-7,10,15,17,19,24H,8-9,11-13H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t17-,19+,24-/m1/s1
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US Patent
n/an/a 2.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242883
PNG
(US9427442, 11)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC2CC(F)(F)C2)C(N)=O)C(=O)Nc2c(F)cccc12
Show InChI InChI=1S/C28H28F6N4O3/c1-14-4-2-5-16(10-14)21-18-6-3-7-20(29)22(18)37-26(41)24(36-21)38-25(40)17(8-9-28(32,33)34)19(23(35)39)11-15-12-27(30,31)13-15/h2-7,10,15,17,19,24H,8-9,11-13H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t17-,19+,24-/m1/s1
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US Patent
n/an/a 2.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242873
PNG
(US9427442, 1)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1ccccc1
Show InChI InChI=1S/C28H29F5N4O3/c1-15-6-5-9-19-21(15)36-26(40)24(35-22(19)17-7-3-2-4-8-17)37-25(39)18(10-11-28(31,32)33)20(23(34)38)12-16-13-27(29,30)14-16/h2-9,16,18,20,24H,10-14H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t18-,20+,24-/m1/s1
PDB

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US Patent
n/an/a 2.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242891
PNG
(US9427442, 19)
Show SMILES C[C@@H](C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O)C(N)=O)C(F)(F)F
Show InChI InChI=1S/C26H25F7N4O3/c1-13(26(31,32)33)12-17(21(34)38)15(10-11-25(28,29)30)23(39)37-22-24(40)36-20-16(8-5-9-18(20)27)19(35-22)14-6-3-2-4-7-14/h2-9,13,15,17,22H,10-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t13-,15+,17-,22+/m0/s1
PDB

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US Patent
n/an/a 2.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242885
PNG
(US9427442, 13)
Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O
Show InChI InChI=1S/C27H26ClF5N4O3/c28-19-8-4-7-17-20(15-5-2-1-3-6-15)35-23(25(40)36-21(17)19)37-24(39)16(9-10-27(31,32)33)18(22(34)38)11-14-12-26(29,30)13-14/h1-8,14,16,18,23H,9-13H2,(H2,34,38)(H,36,40)(H,37,39)/t16-,18+,23-/m1/s1
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US Patent
n/an/a 2.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242890
PNG
(US9427442, 18)
Show SMILES CC(F)(F)C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O)C(N)=O
Show InChI InChI=1S/C25H25F5N4O3/c1-24(26,27)13-17(20(31)35)15(11-12-25(28,29)30)22(36)34-21-23(37)32-18-10-6-5-9-16(18)19(33-21)14-7-3-2-4-8-14/h2-10,15,17,21H,11-13H2,1H3,(H2,31,35)(H,32,37)(H,34,36)/t15-,17+,21-/m1/s1
PDB

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US Patent
n/an/a 2.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242885
PNG
(US9427442, 13)
Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O
Show InChI InChI=1S/C27H26ClF5N4O3/c28-19-8-4-7-17-20(15-5-2-1-3-6-15)35-23(25(40)36-21(17)19)37-24(39)16(9-10-27(31,32)33)18(22(34)38)11-14-12-26(29,30)13-14/h1-8,14,16,18,23H,9-13H2,(H2,34,38)(H,36,40)(H,37,39)/t16-,18+,23-/m1/s1
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 2.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242880
PNG
(US9427442, 8)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1ccccc1
Show InChI InChI=1S/C28H29F5N4O4/c1-41-20-9-5-8-18-21(16-6-3-2-4-7-16)35-24(26(40)36-22(18)20)37-25(39)17(10-11-28(31,32)33)19(23(34)38)12-15-13-27(29,30)14-15/h2-9,15,17,19,24H,10-14H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t17-,19+,24-/m1/s1
PDB

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US Patent
n/an/a 2.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242891
PNG
(US9427442, 19)
Show SMILES C[C@@H](C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O)C(N)=O)C(F)(F)F
Show InChI InChI=1S/C26H25F7N4O3/c1-13(26(31,32)33)12-17(21(34)38)15(10-11-25(28,29)30)23(39)37-22-24(40)36-20-16(8-5-9-18(20)27)19(35-22)14-6-3-2-4-7-14/h2-9,13,15,17,22H,10-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t13-,15+,17-,22+/m0/s1
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 2.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242873
PNG
(US9427442, 1)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1ccccc1
Show InChI InChI=1S/C28H29F5N4O3/c1-15-6-5-9-19-21(15)36-26(40)24(35-22(19)17-7-3-2-4-8-17)37-25(39)18(10-11-28(31,32)33)20(23(34)38)12-16-13-27(29,30)14-16/h2-9,16,18,20,24H,10-14H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t18-,20+,24-/m1/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242894
PNG
(US9427442, 22)
Show SMILES C[C@H](C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C(N)=O)C(F)(F)F
Show InChI InChI=1S/C26H25ClF6N4O3/c1-13(26(31,32)33)12-17(21(34)38)15(10-11-25(28,29)30)23(39)37-22-24(40)36-20-16(8-5-9-18(20)27)19(35-22)14-6-3-2-4-7-14/h2-9,13,15,17,22H,10-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t13-,15-,17+,22-/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 3.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242881
PNG
(US9427442, 9)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1cccc(F)c1
Show InChI InChI=1S/C28H28F6N4O3/c1-14-4-2-7-19-21(14)37-26(41)24(36-22(19)16-5-3-6-17(29)11-16)38-25(40)18(8-9-28(32,33)34)20(23(35)39)10-15-12-27(30,31)13-15/h2-7,11,15,18,20,24H,8-10,12-13H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t18-,20+,24-/m1/s1
PDB

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US Patent
n/an/a 3.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242895
PNG
(US9427442, 23)
Show SMILES C[C@@H](C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C(N)=O)C(F)(F)F
Show InChI InChI=1S/C26H25ClF6N4O3/c1-13(26(31,32)33)12-17(21(34)38)15(10-11-25(28,29)30)23(39)37-22-24(40)36-20-16(8-5-9-18(20)27)19(35-22)14-6-3-2-4-7-14/h2-9,13,15,17,22H,10-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t13-,15+,17-,22+/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 3.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242881
PNG
(US9427442, 9)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1cccc(F)c1
Show InChI InChI=1S/C28H28F6N4O3/c1-14-4-2-7-19-21(14)37-26(41)24(36-22(19)16-5-3-6-17(29)11-16)38-25(40)18(8-9-28(32,33)34)20(23(35)39)10-15-12-27(30,31)13-15/h2-7,11,15,18,20,24H,8-10,12-13H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t18-,20+,24-/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 3.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242897
PNG
(US9427442, 25)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1(F)CCC1)C(N)=O)N=C2c1ccccc1
Show InChI InChI=1S/C28H30F4N4O3/c1-16-7-5-10-19-21(16)35-26(39)24(34-22(19)17-8-3-2-4-9-17)36-25(38)18(11-14-28(30,31)32)20(23(33)37)15-27(29)12-6-13-27/h2-5,7-10,18,20,24H,6,11-15H2,1H3,(H2,33,37)(H,35,39)(H,36,38)/t18-,20+,24-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242887
PNG
(US9427442, 15)
Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O
Show InChI InChI=1S/C27H27F5N4O3/c28-26(29)13-15(14-26)12-19(22(33)37)17(10-11-27(30,31)32)24(38)36-23-25(39)34-20-9-5-4-8-18(20)21(35-23)16-6-2-1-3-7-16/h1-9,15,17,19,23H,10-14H2,(H2,33,37)(H,34,39)(H,36,38)/t17-,19+,23-/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


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More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242879
PNG
(US9427442, 7)
Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O
Show InChI InChI=1S/C30H31F5N4O4/c31-29(32)14-16(15-29)13-21(25(36)40)19(11-12-30(33,34)35)27(41)39-26-28(42)38-24-20(7-4-8-22(24)43-18-9-10-18)23(37-26)17-5-2-1-3-6-17/h1-8,16,18-19,21,26H,9-15H2,(H2,36,40)(H,38,42)(H,39,41)/t19-,21+,26-/m1/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


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More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242896
PNG
(US9427442, 24)
Show SMILES CC(F)(F)CC[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C(N)=O
Show InChI InChI=1S/C26H26ClF5N4O3/c1-25(28,29)12-10-15(21(33)37)16(11-13-26(30,31)32)23(38)36-22-24(39)35-20-17(8-5-9-18(20)27)19(34-22)14-6-3-2-4-7-14/h2-9,15-16,22H,10-13H2,1H3,(H2,33,37)(H,35,39)(H,36,38)/t15-,16+,22+/m0/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242880
PNG
(US9427442, 8)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1ccccc1
Show InChI InChI=1S/C28H29F5N4O4/c1-41-20-9-5-8-18-21(16-6-3-2-4-7-16)35-24(26(40)36-22(18)20)37-25(39)17(10-11-28(31,32)33)19(23(34)38)12-15-13-27(29,30)14-15/h2-9,15,17,19,24H,10-14H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t17-,19+,24-/m1/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242875
PNG
(US9427442, 3)
Show SMILES NC(=O)[C@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2cccc(F)c2)c2cccc(OC3CC3)c2NC1=O)C1CCC(F)(F)CC1
Show InChI InChI=1S/C31H32F6N4O4/c32-18-4-1-3-17(15-18)24-21-5-2-6-22(45-19-7-8-19)25(21)40-29(44)27(39-24)41-28(43)20(11-14-31(35,36)37)23(26(38)42)16-9-12-30(33,34)13-10-16/h1-6,15-16,19-20,23,27H,7-14H2,(H2,38,42)(H,40,44)(H,41,43)/t20-,23+,27-/m1/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242884
PNG
(US9427442, 12)
Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O
Show InChI InChI=1S/C30H31F5N4O3/c31-29(32)14-16(15-29)13-22(25(36)40)20(11-12-30(33,34)35)27(41)39-26-28(42)38-24-19(17-9-10-17)7-4-8-21(24)23(37-26)18-5-2-1-3-6-18/h1-8,16-17,20,22,26H,9-15H2,(H2,36,40)(H,38,42)(H,39,41)/t20-,22+,26-/m1/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242887
PNG
(US9427442, 15)
Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O
Show InChI InChI=1S/C27H27F5N4O3/c28-26(29)13-15(14-26)12-19(22(33)37)17(10-11-27(30,31)32)24(38)36-23-25(39)34-20-9-5-4-8-18(20)21(35-23)16-6-2-1-3-7-16/h1-9,15,17,19,23H,10-14H2,(H2,33,37)(H,34,39)(H,36,38)/t17-,19+,23-/m1/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242882
PNG
(US9427442, 10)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC2CC(F)(F)C2)C(N)=O)C(=O)Nc2c(Cl)cccc12
Show InChI InChI=1S/C28H28ClF5N4O3/c1-14-4-2-5-16(10-14)21-18-6-3-7-20(29)22(18)37-26(41)24(36-21)38-25(40)17(8-9-28(32,33)34)19(23(35)39)11-15-12-27(30,31)13-15/h2-7,10,15,17,19,24H,8-9,11-13H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t17-,19+,24-/m1/s1
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The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242877
PNG
(US9427442, 5)
Show SMILES NC(=O)[C@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C1CCC(F)(F)CC1
Show InChI InChI=1S/C28H28ClF5N4O3/c29-19-8-4-7-18-21(16-5-2-1-3-6-16)36-24(26(41)37-22(18)19)38-25(40)17(11-14-28(32,33)34)20(23(35)39)15-9-12-27(30,31)13-10-15/h1-8,15,17,20,24H,9-14H2,(H2,35,39)(H,37,41)(H,38,40)/t17-,20+,24-/m1/s1
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The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


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More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242886
PNG
(US9427442, 14)
Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O
Show InChI InChI=1S/C27H26F6N4O3/c28-19-8-4-7-17-20(15-5-2-1-3-6-15)35-23(25(40)36-21(17)19)37-24(39)16(9-10-27(31,32)33)18(22(34)38)11-14-12-26(29,30)13-14/h1-8,14,16,18,23H,9-13H2,(H2,34,38)(H,36,40)(H,37,39)/t16-,18+,23-/m1/s1
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The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242895
PNG
(US9427442, 23)
Show SMILES C[C@@H](C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C(N)=O)C(F)(F)F
Show InChI InChI=1S/C26H25ClF6N4O3/c1-13(26(31,32)33)12-17(21(34)38)15(10-11-25(28,29)30)23(39)37-22-24(40)36-20-16(8-5-9-18(20)27)19(35-22)14-6-3-2-4-7-14/h2-9,13,15,17,22H,10-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t13-,15+,17-,22+/m0/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM209911
PNG
(US9273014, Comparative Compound 47 | US9427442, Co...)
Show SMILES CCCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccc(Cl)cc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1S/C28H35ClN4O3/c1-5-6-9-20(25(30)34)22(16-17(2)3)27(35)32-26-28(36)33(4)23-11-8-7-10-21(23)24(31-26)18-12-14-19(29)15-13-18/h7-8,10-15,17,20,22,26H,5-6,9,16H2,1-4H3,(H2,30,34)(H,32,35)/t20-,22+,26+/m0/s1
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The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


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More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM209911
PNG
(US9273014, Comparative Compound 47 | US9427442, Co...)
Show SMILES CCCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccc(Cl)cc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1S/C28H35ClN4O3/c1-5-6-9-20(25(30)34)22(16-17(2)3)27(35)32-26-28(36)33(4)23-11-8-7-10-21(23)24(31-26)18-12-14-19(29)15-13-18/h7-8,10-15,17,20,22,26H,5-6,9,16H2,1-4H3,(H2,30,34)(H,32,35)/t20-,22+,26+/m0/s1
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The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242896
PNG
(US9427442, 24)
Show SMILES CC(F)(F)CC[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C(N)=O
Show InChI InChI=1S/C26H26ClF5N4O3/c1-25(28,29)12-10-15(21(33)37)16(11-13-26(30,31)32)23(38)36-22-24(39)35-20-17(8-5-9-18(20)27)19(34-22)14-6-3-2-4-7-14/h2-9,15-16,22H,10-13H2,1H3,(H2,33,37)(H,35,39)(H,36,38)/t15-,16+,22+/m0/s1
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The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242884
PNG
(US9427442, 12)
Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O
Show InChI InChI=1S/C30H31F5N4O3/c31-29(32)14-16(15-29)13-22(25(36)40)20(11-12-30(33,34)35)27(41)39-26-28(42)38-24-19(17-9-10-17)7-4-8-21(24)23(37-26)18-5-2-1-3-6-18/h1-8,16-17,20,22,26H,9-15H2,(H2,36,40)(H,38,42)(H,39,41)/t20-,22+,26-/m1/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242889
PNG
(US9427442, 17)
Show SMILES COc1ccc2c(NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCF)C(N)=O)N=C2c2ccccc2)c1
Show InChI InChI=1S/C26H28F4N4O4/c1-38-16-9-10-19-20(14-16)32-25(37)23(33-21(19)15-6-3-2-4-7-15)34-24(36)18(11-12-26(28,29)30)17(22(31)35)8-5-13-27/h2-4,6-7,9-10,14,17-18,23H,5,8,11-13H2,1H3,(H2,31,35)(H,32,37)(H,34,36)/t17-,18+,23+/m0/s1
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The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242874
PNG
(US9427442, 2)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](C1CCC(F)(F)CC1)C(N)=O)N=C2c1ccccc1
Show InChI InChI=1S/C29H31F5N4O4/c1-42-20-9-5-8-19-22(17-6-3-2-4-7-17)36-25(27(41)37-23(19)20)38-26(40)18(12-15-29(32,33)34)21(24(35)39)16-10-13-28(30,31)14-11-16/h2-9,16,18,21,25H,10-15H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t18-,21+,25-/m1/s1
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The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


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More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242888
PNG
(US9427442, 16)
Show SMILES NOc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCF)C(N)=O)N=C2c1ccccc1
Show InChI InChI=1S/C25H27F4N5O4/c26-13-5-9-15(21(30)35)16(11-12-25(27,28)29)23(36)34-22-24(37)33-20-17(8-4-10-18(20)38-31)19(32-22)14-6-2-1-3-7-14/h1-4,6-8,10,15-16,22H,5,9,11-13,31H2,(H2,30,35)(H,33,37)(H,34,36)/t15-,16+,22+/m0/s1
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The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


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More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242874
PNG
(US9427442, 2)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](C1CCC(F)(F)CC1)C(N)=O)N=C2c1ccccc1
Show InChI InChI=1S/C29H31F5N4O4/c1-42-20-9-5-8-19-22(17-6-3-2-4-7-17)36-25(27(41)37-23(19)20)38-26(40)18(12-15-29(32,33)34)21(24(35)39)16-10-13-28(30,31)14-11-16/h2-9,16,18,21,25H,10-15H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t18-,21+,25-/m1/s1
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The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


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More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242877
PNG
(US9427442, 5)
Show SMILES NC(=O)[C@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C1CCC(F)(F)CC1
Show InChI InChI=1S/C28H28ClF5N4O3/c29-19-8-4-7-18-21(16-5-2-1-3-6-16)36-24(26(41)37-22(18)19)38-25(40)17(11-14-28(32,33)34)20(23(35)39)15-9-12-27(30,31)13-10-15/h1-8,15,17,20,24H,9-14H2,(H2,35,39)(H,37,41)(H,38,40)/t17-,20+,24-/m1/s1
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The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


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Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242893
PNG
(US9427442, 21)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(C)(F)F)C(N)=O)N=C2c1ccccc1
Show InChI InChI=1S/C27H29F5N4O4/c1-26(28,29)13-11-16(22(33)37)17(12-14-27(30,31)32)24(38)36-23-25(39)35-21-18(9-6-10-19(21)40-2)20(34-23)15-7-4-3-5-8-15/h3-10,16-17,23H,11-14H2,1-2H3,(H2,33,37)(H,35,39)(H,36,38)/t16-,17+,23+/m0/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


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More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242875
PNG
(US9427442, 3)
Show SMILES NC(=O)[C@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2cccc(F)c2)c2cccc(OC3CC3)c2NC1=O)C1CCC(F)(F)CC1
Show InChI InChI=1S/C31H32F6N4O4/c32-18-4-1-3-17(15-18)24-21-5-2-6-22(45-19-7-8-19)25(21)40-29(44)27(39-24)41-28(43)20(11-14-31(35,36)37)23(26(38)42)16-9-12-30(33,34)13-10-16/h1-6,15-16,19-20,23,27H,7-14H2,(H2,38,42)(H,40,44)(H,41,43)/t20-,23+,27-/m1/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


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More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242894
PNG
(US9427442, 22)
Show SMILES C[C@H](C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C(N)=O)C(F)(F)F
Show InChI InChI=1S/C26H25ClF6N4O3/c1-13(26(31,32)33)12-17(21(34)38)15(10-11-25(28,29)30)23(39)37-22-24(40)36-20-16(8-5-9-18(20)27)19(35-22)14-6-3-2-4-7-14/h2-9,13,15,17,22H,10-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t13-,15-,17+,22-/m1/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242892
PNG
(US9427442, 20)
Show SMILES NC(=O)[C@@H](CCCF)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O
Show InChI InChI=1S/C25H25ClF4N4O3/c26-18-10-4-8-17-19(14-6-2-1-3-7-14)32-22(24(37)33-20(17)18)34-23(36)16(11-12-25(28,29)30)15(21(31)35)9-5-13-27/h1-4,6-8,10,15-16,22H,5,9,11-13H2,(H2,31,35)(H,33,37)(H,34,36)/t15-,16+,22+/m0/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242890
PNG
(US9427442, 18)
Show SMILES CC(F)(F)C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O)C(N)=O
Show InChI InChI=1S/C25H25F5N4O3/c1-24(26,27)13-17(20(31)35)15(11-12-25(28,29)30)22(36)34-21-23(37)32-18-10-6-5-9-16(18)19(33-21)14-7-3-2-4-8-14/h2-10,15,17,21H,11-13H2,1H3,(H2,31,35)(H,32,37)(H,34,36)/t15-,17+,21-/m1/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM242889
PNG
(US9427442, 17)
Show SMILES COc1ccc2c(NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCF)C(N)=O)N=C2c2ccccc2)c1
Show InChI InChI=1S/C26H28F4N4O4/c1-38-16-9-10-19-20(14-16)32-25(37)23(33-21(19)15-6-3-2-4-7-15)34-24(36)18(11-12-26(28,29)30)17(22(31)35)8-5-13-27/h2-4,6-7,9-10,14,17-18,23H,5,8,11-13H2,1H3,(H2,31,35)(H,32,37)(H,34,36)/t17-,18+,23+/m0/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM242876
PNG
(US9427442, 4)
Show SMILES NC(=O)[C@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C1CCC(CC1)C(F)(F)F
Show InChI InChI=1S/C29H29ClF6N4O3/c30-20-8-4-7-19-22(16-5-2-1-3-6-16)38-25(27(43)39-23(19)20)40-26(42)18(13-14-28(31,32)33)21(24(37)41)15-9-11-17(12-10-15)29(34,35)36/h1-8,15,17-18,21,25H,9-14H2,(H2,37,41)(H,39,43)(H,40,42)/t15?,17?,18-,21+,25-/m1/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM209912
PNG
(US9273014, Comparative Compound 48 | US9427442, Co...)
Show SMILES CCCN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CC(C)C)[C@H](CC=C)C(N)=O)C1=O)c1ccccc1
Show InChI InChI=1S/C29H36N4O3/c1-5-12-21(26(30)34)23(18-19(3)4)28(35)32-27-29(36)33(17-6-2)24-16-11-10-15-22(24)25(31-27)20-13-8-7-9-14-20/h5,7-11,13-16,19,21,23,27H,1,6,12,17-18H2,2-4H3,(H2,30,34)(H,32,35)/t21-,23+,27+/m0/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1-CBF1


(Homo sapiens (Human))
BDBM209912
PNG
(US9273014, Comparative Compound 48 | US9427442, Co...)
Show SMILES CCCN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CC(C)C)[C@H](CC=C)C(N)=O)C1=O)c1ccccc1
Show InChI InChI=1S/C29H36N4O3/c1-5-12-21(26(30)34)23(18-19(3)4)28(35)32-27-29(36)33(17-6-2)24-16-11-10-15-22(24)25(31-27)20-13-8-7-9-14-20/h5,7-11,13-16,19,21,23,27H,1,6,12,17-18H2,2-4H3,(H2,30,34)(H,32,35)/t21-,23+,27+/m0/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM209912
PNG
(US9273014, Comparative Compound 48 | US9427442, Co...)
Show SMILES CCCN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CC(C)C)[C@H](CC=C)C(N)=O)C1=O)c1ccccc1
Show InChI InChI=1S/C29H36N4O3/c1-5-12-21(26(30)34)23(18-19(3)4)28(35)32-27-29(36)33(17-6-2)24-16-11-10-15-22(24)25(31-27)20-13-8-7-9-14-20/h5,7-11,13-16,19,21,23,27H,1,6,12,17-18H2,2-4H3,(H2,30,34)(H,32,35)/t21-,23+,27+/m0/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM209912
PNG
(US9273014, Comparative Compound 48 | US9427442, Co...)
Show SMILES CCCN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CC(C)C)[C@H](CC=C)C(N)=O)C1=O)c1ccccc1
Show InChI InChI=1S/C29H36N4O3/c1-5-12-21(26(30)34)23(18-19(3)4)28(35)32-27-29(36)33(17-6-2)24-16-11-10-15-22(24)25(31-27)20-13-8-7-9-14-20/h5,7-11,13-16,19,21,23,27H,1,6,12,17-18H2,2-4H3,(H2,30,34)(H,32,35)/t21-,23+,27+/m0/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3-CBF1


(Homo sapiens (Human))
BDBM209911
PNG
(US9273014, Comparative Compound 47 | US9427442, Co...)
Show SMILES CCCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccc(Cl)cc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1S/C28H35ClN4O3/c1-5-6-9-20(25(30)34)22(16-17(2)3)27(35)32-26-28(36)33(4)23-11-8-7-10-21(23)24(31-26)18-12-14-19(29)15-13-18/h7-8,10-15,17,20,22,26H,5-6,9,16H2,1-4H3,(H2,30,34)(H,32,35)/t20-,22+,26+/m0/s1
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Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...


Citation and Details
More data for this
Ligand-Target Pair
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