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Compile Data Set for Download or QSAR

Found 150 hits of ic50 for UniProtKB: P19490   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50018845
PNG
(CHEMBL3286869)
Show SMILES NCCCNCCCCNCCCNCCCN(O)CCCNC(=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C26H47N7O2/c27-11-5-14-28-12-3-4-13-29-15-6-16-30-17-7-19-33(35)20-8-18-31-26(34)21-23-22-32-25-10-2-1-9-24(23)25/h1-2,9-10,22,28-30,32,35H,3-8,11-21,27H2,(H,31,34)
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n/an/a 11n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant GluA1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced channel current at holding potential of ...


J Med Chem 57: 4940-9 (2014)


Article DOI: 10.1021/jm5004705
BindingDB Entry DOI: 10.7270/Q29K4CT3
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50018846
PNG
(CHEMBL3286871)
Show SMILES N[C@@H](CCCCNCCCNC(=O)[C@@H](N)CCCNC(N)=N)C(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1c[nH]c2cccc(O)c12
Show InChI InChI=1S/C34H58N12O6/c35-23(9-2-5-13-40-14-8-18-42-32(51)24(36)10-7-17-44-34(38)39)31(50)41-15-3-1-4-16-43-33(52)26(20-28(37)48)46-29(49)19-22-21-45-25-11-6-12-27(47)30(22)25/h6,11-12,21,23-24,26,40,45,47H,1-5,7-10,13-20,35-36H2,(H2,37,48)(H,41,50)(H,42,51)(H,43,52)(H,46,49)(H4,38,39,44)/t23-,24-,26-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant GluA1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced channel current at holding potential of ...


J Med Chem 57: 4940-9 (2014)


Article DOI: 10.1021/jm5004705
BindingDB Entry DOI: 10.7270/Q29K4CT3
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50425996
PNG
(CHEMBL2314718)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCNCCCCCCCNC(=O)[C@@H](NC(=O)Cc1ccc(O)cc1O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C35H53N9O5/c36-28(15-20-42-35(37)38)33(48)40-18-10-4-8-17-39-16-7-2-1-3-9-19-41-34(49)32(27-23-43-29-12-6-5-11-26(27)29)44-31(47)21-24-13-14-25(45)22-30(24)46/h5-6,11-14,22-23,28,32,39,43,45-46H,1-4,7-10,15-21,36H2,(H,40,48)(H,41,49)(H,44,47)(H4,37,38,42)/t28-,32+/m1/s1
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n/an/a 17n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50426005
PNG
(CHEMBL2314933)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCNCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C30H53N9O6/c31-23(10-9-17-38-30(33)34)28(44)36-15-6-4-2-1-3-5-13-35-14-7-8-16-37-29(45)24(20-26(32)42)39-27(43)18-21-11-12-22(40)19-25(21)41/h11-12,19,23-24,35,40-41H,1-10,13-18,20,31H2,(H2,32,42)(H,36,44)(H,37,45)(H,39,43)(H4,33,34,38)/t23-,24-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50399431
PNG
(CHEMBL2178919)
Show SMILES NCCCNCCCCNCCC(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C29H48N8O4/c30-12-8-15-32-13-6-7-14-33-18-11-27(39)34-16-4-1-5-17-35-29(41)25(20-26(31)38)37-28(40)19-22-21-36-24-10-3-2-9-23(22)24/h2-3,9-10,21,25,32-33,36H,1,4-8,11-20,30H2,(H2,31,38)(H,34,39)(H,35,41)(H,37,40)/t25-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat GluA1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...


J Med Chem 55: 10297-301 (2012)


Article DOI: 10.1021/jm301255m
BindingDB Entry DOI: 10.7270/Q27S7PXR
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50425988
PNG
(CHEMBL2314712)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCCCCNCCCCNC(=O)[C@@H](NC(=O)Cc1ccc(O)cc1O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C35H53N9O5/c36-28(15-20-42-35(37)38)33(48)40-18-8-4-2-1-3-7-16-39-17-9-10-19-41-34(49)32(27-23-43-29-12-6-5-11-26(27)29)44-31(47)21-24-13-14-25(45)22-30(24)46/h5-6,11-14,22-23,28,32,39,43,45-46H,1-4,7-10,15-21,36H2,(H,40,48)(H,41,49)(H,44,47)(H4,37,38,42)/t28-,32+/m1/s1
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n/an/a 28n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50425995
PNG
(CHEMBL2314717)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCCCCNCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccccc1O
Show InChI InChI=1S/C29H51N9O5/c30-22(13-18-37-29(32)33)27(42)35-16-8-4-2-1-3-7-14-34-15-9-10-17-36-28(43)23(20-25(31)40)38-26(41)19-21-11-5-6-12-24(21)39/h5-6,11-12,22-23,34,39H,1-4,7-10,13-20,30H2,(H2,31,40)(H,35,42)(H,36,43)(H,38,41)(H4,32,33,37)/t22-,23+/m1/s1
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n/an/a 37n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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n/an/a 40n/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA receptor, using radioligand [3H]- AMPA


J Med Chem 46: 2246-9 (2003)


Article DOI: 10.1021/jm020588f
BindingDB Entry DOI: 10.7270/Q26T0M06
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50425997
PNG
(CHEMBL2314719)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCNCCCCCCCNC(=O)[C@@H](NC(=O)Cc1ccc(O)cc1O)c1cnc[nH]1
Show InChI InChI=1S/C30H50N10O5/c31-23(11-16-38-30(32)33)28(44)36-14-8-4-6-13-34-12-5-2-1-3-7-15-37-29(45)27(24-19-35-20-39-24)40-26(43)17-21-9-10-22(41)18-25(21)42/h9-10,18-20,23,27,34,41-42H,1-8,11-17,31H2,(H,35,39)(H,36,44)(H,37,45)(H,40,43)(H4,32,33,38)/t23-,27+/m1/s1
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n/an/a 43n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50426007
PNG
(CHEMBL2314935)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCNCCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C30H53N9O6/c31-23(10-9-17-38-30(33)34)28(44)36-15-7-3-1-5-13-35-14-6-2-4-8-16-37-29(45)24(20-26(32)42)39-27(43)18-21-11-12-22(40)19-25(21)41/h11-12,19,23-24,35,40-41H,1-10,13-18,20,31H2,(H2,32,42)(H,36,44)(H,37,45)(H,39,43)(H4,33,34,38)/t23-,24-/m0/s1
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n/an/a 46n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50399430
PNG
(CHEMBL2178920)
Show SMILES NCCCNCCCCNCCC(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1c[nH]c2cccc(O)c12
Show InChI InChI=1S/C29H48N8O5/c30-11-7-14-32-12-4-5-13-33-17-10-26(40)34-15-2-1-3-16-35-29(42)23(19-25(31)39)37-27(41)18-21-20-36-22-8-6-9-24(38)28(21)22/h6,8-9,20,23,32-33,36,38H,1-5,7,10-19,30H2,(H2,31,39)(H,34,40)(H,35,42)(H,37,41)/t23-/m0/s1
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n/an/a 51n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat GluA1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...


J Med Chem 55: 10297-301 (2012)


Article DOI: 10.1021/jm301255m
BindingDB Entry DOI: 10.7270/Q27S7PXR
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50018844
PNG
(CHEMBL3286866)
Show SMILES CN(CCCC[C@H](N)C(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1c[nH]c2cccc(O)c12)CCCNC(=O)[C@@H](N)CCCNC(N)=N
Show InChI InChI=1S/C35H60N12O6/c1-47(19-9-17-42-33(52)25(37)11-8-16-44-35(39)40)18-6-3-10-24(36)32(51)41-14-4-2-5-15-43-34(53)27(21-29(38)49)46-30(50)20-23-22-45-26-12-7-13-28(48)31(23)26/h7,12-13,22,24-25,27,45,48H,2-6,8-11,14-21,36-37H2,1H3,(H2,38,49)(H,41,51)(H,42,52)(H,43,53)(H,46,50)(H4,39,40,44)/t24-,25-,27-/m0/s1
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n/an/a 52n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant GluA1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced channel current at holding potential of ...


J Med Chem 57: 4940-9 (2014)


Article DOI: 10.1021/jm5004705
BindingDB Entry DOI: 10.7270/Q29K4CT3
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50425989
PNG
(CHEMBL2314713)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCCCCNCCCCNC(=O)[C@@H](NC(=O)Cc1ccc(O)cc1O)c1cnc[nH]1
Show InChI InChI=1S/C30H50N10O5/c31-23(11-16-38-30(32)33)28(44)36-14-6-4-2-1-3-5-12-34-13-7-8-15-37-29(45)27(24-19-35-20-39-24)40-26(43)17-21-9-10-22(41)18-25(21)42/h9-10,18-20,23,27,34,41-42H,1-8,11-17,31H2,(H,35,39)(H,36,44)(H,37,45)(H,40,43)(H4,32,33,38)/t23-,27+/m1/s1
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n/an/a 52n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50426000
PNG
(CHEMBL2311573)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCNCCCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C31H52N10O4/c32-24(13-18-39-31(34)35)29(44)37-16-10-4-8-15-36-14-7-2-1-3-9-17-38-30(45)26(20-27(33)42)41-28(43)19-22-21-40-25-12-6-5-11-23(22)25/h5-6,11-12,21,24,26,36,40H,1-4,7-10,13-20,32H2,(H2,33,42)(H,37,44)(H,38,45)(H,41,43)(H4,34,35,39)/t24-,26+/m1/s1
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n/an/a 57n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50425991
PNG
(CHEMBL2314934)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCCCCNCCCCNC(=O)CNC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C27H48N8O5/c28-22(11-16-34-27(29)30)26(40)33-15-6-4-2-1-3-5-12-31-13-7-8-14-32-25(39)19-35-24(38)17-20-9-10-21(36)18-23(20)37/h9-10,18,22,31,36-37H,1-8,11-17,19,28H2,(H,32,39)(H,33,40)(H,35,38)(H4,29,30,34)/t22-/m1/s1
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n/an/a 62n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50105843
PNG
(2-Amino-N-{3-[4-(3-amino-propylamino)-butylamino]-...)
Show SMILES NCCCNCCCCNCCC(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C27H47N7O6/c28-10-6-13-30-11-4-5-12-31-16-9-25(38)32-14-2-1-3-15-33-27(40)22(19-24(29)37)34-26(39)17-20-7-8-21(35)18-23(20)36/h7-8,18,22,30-31,35-36H,1-6,9-17,19,28H2,(H2,29,37)(H,32,38)(H,33,40)(H,34,39)/t22-/m0/s1
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n/an/a 65n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat GluA1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...


J Med Chem 55: 10297-301 (2012)


Article DOI: 10.1021/jm301255m
BindingDB Entry DOI: 10.7270/Q27S7PXR
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50316373
PNG
(Argiotoxin-636 | CHEMBL1098240)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)NCCCNCCCNCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C29H52N10O6/c30-22(7-4-15-38-29(32)33)27(44)36-16-6-13-35-12-5-11-34-10-2-1-3-14-37-28(45)23(19-25(31)42)39-26(43)17-20-8-9-21(40)18-24(20)41/h8-9,18,22-23,34-35,40-41H,1-7,10-17,19,30H2,(H2,31,42)(H,36,44)(H,37,45)(H,39,43)(H4,32,33,38)/t22-,23-/m0/s1
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n/an/a 77n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50426003
PNG
(CHEMBL2314931)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCNCCCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccccc1O
Show InChI InChI=1S/C29H51N9O5/c30-22(13-18-37-29(32)33)27(42)35-16-10-4-8-15-34-14-7-2-1-3-9-17-36-28(43)23(20-25(31)40)38-26(41)19-21-11-5-6-12-24(21)39/h5-6,11-12,22-23,34,39H,1-4,7-10,13-20,30H2,(H2,31,40)(H,35,42)(H,36,43)(H,38,41)(H4,32,33,37)/t22-,23+/m1/s1
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n/an/a 77n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50316373
PNG
(Argiotoxin-636 | CHEMBL1098240)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)NCCCNCCCNCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C29H52N10O6/c30-22(7-4-15-38-29(32)33)27(44)36-16-6-13-35-12-5-11-34-10-2-1-3-14-37-28(45)23(19-25(31)42)39-26(43)17-20-8-9-21(40)18-24(20)41/h8-9,18,22-23,34-35,40-41H,1-7,10-17,19,30H2,(H2,31,42)(H,36,44)(H,37,45)(H,39,43)(H4,32,33,38)/t22-,23-/m0/s1
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n/an/a 77n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 expressed in xenopus laevis oocytes assessed as inhibition of glutamate-evoked current at membrane potential of -60 mV by vol...


J Nat Prod 74: 483-6 (2011)


Article DOI: 10.1021/np100746w
BindingDB Entry DOI: 10.7270/Q2KK9CWC
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50426006
PNG
(CHEMBL2314936)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCNCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C30H53N9O6/c31-23(10-9-17-38-30(33)34)28(44)36-15-7-3-1-2-5-13-35-14-6-4-8-16-37-29(45)24(20-26(32)42)39-27(43)18-21-11-12-22(40)19-25(21)41/h11-12,19,23-24,35,40-41H,1-10,13-18,20,31H2,(H2,32,42)(H,36,44)(H,37,45)(H,39,43)(H4,33,34,38)/t23-,24-/m0/s1
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n/an/a 78n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50425992
PNG
(CHEMBL2314940)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCCCCNCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C31H52N10O4/c32-24(13-18-39-31(34)35)29(44)37-16-8-4-2-1-3-7-14-36-15-9-10-17-38-30(45)26(20-27(33)42)41-28(43)19-22-21-40-25-12-6-5-11-23(22)25/h5-6,11-12,21,24,26,36,40H,1-4,7-10,13-20,32H2,(H2,33,42)(H,37,44)(H,38,45)(H,41,43)(H4,34,35,39)/t24-,26+/m1/s1
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n/an/a 81n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50426009
PNG
(CHEMBL2314938)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)NCCCCNCCCCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C30H53N9O6/c31-23(10-9-17-38-30(33)34)28(44)36-16-8-7-14-35-13-5-3-1-2-4-6-15-37-29(45)24(20-26(32)42)39-27(43)18-21-11-12-22(40)19-25(21)41/h11-12,19,23-24,35,40-41H,1-10,13-18,20,31H2,(H2,32,42)(H,36,44)(H,37,45)(H,39,43)(H4,33,34,38)/t23-,24-/m0/s1
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n/an/a 83n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50425994
PNG
(CHEMBL2314716)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCCCCNCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1
Show InChI InChI=1S/C29H51N9O5/c30-23(13-18-37-29(32)33)27(42)35-16-6-4-2-1-3-5-14-34-15-7-8-17-36-28(43)24(20-25(31)40)38-26(41)19-21-9-11-22(39)12-10-21/h9-12,23-24,34,39H,1-8,13-20,30H2,(H2,31,40)(H,35,42)(H,36,43)(H,38,41)(H4,32,33,37)/t23-,24+/m1/s1
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n/an/a 84n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50425993
PNG
(CHEMBL2314715)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCCCCNCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C29H51N9O4/c30-23(14-19-37-29(32)33)27(41)35-17-9-4-2-1-3-8-15-34-16-10-11-18-36-28(42)24(21-25(31)39)38-26(40)20-22-12-6-5-7-13-22/h5-7,12-13,23-24,34H,1-4,8-11,14-21,30H2,(H2,31,39)(H,35,41)(H,36,42)(H,38,40)(H4,32,33,37)/t23-,24+/m1/s1
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n/an/a 94n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50426002
PNG
(CHEMBL2314929)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCNCCCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1
Show InChI InChI=1S/C29H51N9O5/c30-23(13-18-37-29(32)33)27(42)35-16-8-4-6-15-34-14-5-2-1-3-7-17-36-28(43)24(20-25(31)40)38-26(41)19-21-9-11-22(39)12-10-21/h9-12,23-24,34,39H,1-8,13-20,30H2,(H2,31,40)(H,35,42)(H,36,43)(H,38,41)(H4,32,33,37)/t23-,24+/m1/s1
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n/an/a 96n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50425999
PNG
(CHEMBL2314928)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCNCCCCCCCNC(=O)CNC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C27H48N8O5/c28-22(11-16-34-27(29)30)26(40)33-15-8-4-6-13-31-12-5-2-1-3-7-14-32-25(39)19-35-24(38)17-20-9-10-21(36)18-23(20)37/h9-10,18,22,31,36-37H,1-8,11-17,19,28H2,(H,32,39)(H,33,40)(H,35,38)(H4,29,30,34)/t22-/m1/s1
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n/an/a 105n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50426008
PNG
(CHEMBL2314937)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)NCCCCCNCCCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C30H53N9O6/c31-23(10-9-17-38-30(33)34)28(44)36-15-8-4-6-14-35-13-5-2-1-3-7-16-37-29(45)24(20-26(32)42)39-27(43)18-21-11-12-22(40)19-25(21)41/h11-12,19,23-24,35,40-41H,1-10,13-18,20,31H2,(H2,32,42)(H,36,44)(H,37,45)(H,39,43)(H4,33,34,38)/t23-,24-/m0/s1
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n/an/a 118n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50018843
PNG
(CHEMBL3286865)
Show SMILES C[N+](C)(CCCC[C@H](N)C(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1c[nH]c2cccc(O)c12)CCCNC(=O)[C@@H](N)CCCNC(N)=N
Show InChI InChI=1S/C36H62N12O6/c1-48(2,20-10-18-43-34(53)26(38)12-9-17-45-36(40)41)19-7-4-11-25(37)33(52)42-15-5-3-6-16-44-35(54)28(22-30(39)50)47-31(51)21-24-23-46-27-13-8-14-29(49)32(24)27/h8,13-14,23,25-26,28,46H,3-7,9-12,15-22,37-38H2,1-2H3,(H10-,39,40,41,42,43,44,45,47,49,50,51,52,53,54)/p+1/t25-,26-,28-/m0/s1
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n/an/a 123n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant GluA1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced channel current at holding potential of ...


J Med Chem 57: 4940-9 (2014)


Article DOI: 10.1021/jm5004705
BindingDB Entry DOI: 10.7270/Q29K4CT3
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50426001
PNG
(CHEMBL2314930)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCNCCCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C29H51N9O4/c30-23(14-19-37-29(32)33)27(41)35-17-11-5-9-16-34-15-8-2-1-3-10-18-36-28(42)24(21-25(31)39)38-26(40)20-22-12-6-4-7-13-22/h4,6-7,12-13,23-24,34H,1-3,5,8-11,14-21,30H2,(H2,31,39)(H,35,41)(H,36,42)(H,38,40)(H4,32,33,37)/t23-,24+/m1/s1
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n/an/a 124n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50316373
PNG
(Argiotoxin-636 | CHEMBL1098240)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)NCCCNCCCNCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C29H52N10O6/c30-22(7-4-15-38-29(32)33)27(44)36-16-6-13-35-12-5-11-34-10-2-1-3-14-37-28(45)23(19-25(31)42)39-26(43)17-20-8-9-21(40)18-24(20)41/h8-9,18,22-23,34-35,40-41H,1-7,10-17,19,30H2,(H2,31,42)(H,36,44)(H,37,45)(H,39,43)(H4,32,33,38)/t22-,23-/m0/s1
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n/an/a 135n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat GluA1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...


J Med Chem 55: 10297-301 (2012)


Article DOI: 10.1021/jm301255m
BindingDB Entry DOI: 10.7270/Q27S7PXR
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50399433
PNG
(CHEMBL2178917)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)NCCCCNCCC(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C30H52N10O7/c31-22(7-6-15-39-30(33)34)28(46)37-14-5-4-11-35-16-10-26(44)36-12-2-1-3-13-38-29(47)23(19-25(32)43)40-27(45)17-20-8-9-21(41)18-24(20)42/h8-9,18,22-23,35,41-42H,1-7,10-17,19,31H2,(H2,32,43)(H,36,44)(H,37,46)(H,38,47)(H,40,45)(H4,33,34,39)/t22-,23-/m0/s1
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n/an/a 137n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat GluA1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...


J Med Chem 55: 10297-301 (2012)


Article DOI: 10.1021/jm301255m
BindingDB Entry DOI: 10.7270/Q27S7PXR
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50425998
PNG
(CHEMBL2314927)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCNCCCCCCCNC(=O)[C@H](CC(O)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C29H50N8O7/c30-22(11-16-36-29(31)32)27(43)34-14-8-4-6-13-33-12-5-2-1-3-7-15-35-28(44)23(19-26(41)42)37-25(40)17-20-9-10-21(38)18-24(20)39/h9-10,18,22-23,33,38-39H,1-8,11-17,19,30H2,(H,34,43)(H,35,44)(H,37,40)(H,41,42)(H4,31,32,36)/t22-,23+/m1/s1
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n/an/a 167n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50426004
PNG
(CHEMBL2314932)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCNCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C30H53N9O6/c31-23(10-8-16-38-30(33)34)28(44)36-15-7-5-3-1-2-4-6-13-35-14-9-17-37-29(45)24(20-26(32)42)39-27(43)18-21-11-12-22(40)19-25(21)41/h11-12,19,23-24,35,40-41H,1-10,13-18,20,31H2,(H2,32,42)(H,36,44)(H,37,45)(H,39,43)(H4,33,34,38)/t23-,24-/m0/s1
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n/an/a 171n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50128264
PNG
((R,S)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)p...)
Show SMILES NC(Cc1o[nH]c(=O)c1Cl)C(O)=O
Show InChI InChI=1S/C6H7ClN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)
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n/an/a 220n/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA receptor, using radioligand [3H]- AMPA


J Med Chem 46: 2246-9 (2003)


Article DOI: 10.1021/jm020588f
BindingDB Entry DOI: 10.7270/Q26T0M06
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50426010
PNG
(CHEMBL2314939)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)NCCCNCCCCCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C30H53N9O6/c31-23(10-8-16-38-30(33)34)28(44)36-17-9-14-35-13-6-4-2-1-3-5-7-15-37-29(45)24(20-26(32)42)39-27(43)18-21-11-12-22(40)19-25(21)41/h11-12,19,23-24,35,40-41H,1-10,13-18,20,31H2,(H2,32,42)(H,36,44)(H,37,45)(H,39,43)(H4,33,34,38)/t23-,24-/m0/s1
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n/an/a 454n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50316374
PNG
(CHEMBL1096289 | N-(4-hydroxyphenylpropanyl)-spermi...)
Show SMILES NCCCNCCCCNCCCNC(=O)CCc1ccccc1
Show InChI InChI=1S/C19H34N4O/c20-12-6-15-21-13-4-5-14-22-16-7-17-23-19(24)11-10-18-8-2-1-3-9-18/h1-3,8-9,21-22H,4-7,10-17,20H2,(H,23,24)
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n/an/a 460n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant GluA1 receptor expressed in Xenopus oocytes assessed as inhibition of 300 uM kainate-induced current


Bioorg Med Chem 18: 1381-7 (2010)


Article DOI: 10.1016/j.bmc.2009.12.072
BindingDB Entry DOI: 10.7270/Q27W6CB2
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50425990
PNG
(CHEMBL2314714)
Show SMILES N[C@H](CCN=C(N)N)C(=O)NCCCCCCCCNCCCCNC(=O)[C@H](CC(O)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C29H50N8O7/c30-22(11-16-36-29(31)32)27(43)34-14-6-4-2-1-3-5-12-33-13-7-8-15-35-28(44)23(19-26(41)42)37-25(40)17-20-9-10-21(38)18-24(20)39/h9-10,18,22-23,33,38-39H,1-8,11-17,19,30H2,(H,34,43)(H,35,44)(H,37,40)(H,41,42)(H4,31,32,36)/t22-,23+/m1/s1
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n/an/a 466n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...


J Med Chem 56: 1171-81 (2013)


Article DOI: 10.1021/jm301602d
BindingDB Entry DOI: 10.7270/Q2S46T9C
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50017244
PNG
((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O
Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)
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n/an/a 650n/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA receptor, using radioligand [3H]- AMPA


J Med Chem 46: 2246-9 (2003)


Article DOI: 10.1021/jm020588f
BindingDB Entry DOI: 10.7270/Q26T0M06
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50399432
PNG
(CHEMBL2178918)
Show SMILES C[C@H](NC(=O)CNC(=O)[C@@H](N)CCCN=C(N)N)C(=O)NCCCCNCCC(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C35H60N12O9/c1-22(46-31(53)21-45-33(55)25(36)8-7-16-44-35(38)39)32(54)42-15-6-5-12-40-17-11-29(51)41-13-3-2-4-14-43-34(56)26(20-28(37)50)47-30(52)18-23-9-10-24(48)19-27(23)49/h9-10,19,22,25-26,40,48-49H,2-8,11-18,20-21,36H2,1H3,(H2,37,50)(H,41,51)(H,42,54)(H,43,56)(H,45,55)(H,46,53)(H,47,52)(H4,38,39,44)/t22-,25-,26-/m0/s1
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n/an/a 1.08E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat GluA1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...


J Med Chem 55: 10297-301 (2012)


Article DOI: 10.1021/jm301255m
BindingDB Entry DOI: 10.7270/Q27S7PXR
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50094298
PNG
(CHEMBL16117 | N-[(S)-1-{3-[4-(3-Amino-propylamino)...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCNCCCCNCCCN
Show InChI InChI=1S/C23H41N5O3/c1-2-7-22(30)28-21(18-19-8-10-20(29)11-9-19)23(31)27-17-6-16-26-14-4-3-13-25-15-5-12-24/h8-11,21,25-26,29H,2-7,12-18,24H2,1H3,(H,27,31)(H,28,30)/t21-/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current


Bioorg Med Chem 18: 1381-7 (2010)


Article DOI: 10.1016/j.bmc.2009.12.072
BindingDB Entry DOI: 10.7270/Q27W6CB2
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50316373
PNG
(Argiotoxin-636 | CHEMBL1098240)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)NCCCNCCCNCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C29H52N10O6/c30-22(7-4-15-38-29(32)33)27(44)36-16-6-13-35-12-5-11-34-10-2-1-3-14-37-28(45)23(19-25(31)42)39-26(43)17-20-8-9-21(40)18-24(20)41/h8-9,18,22-23,34-35,40-41H,1-7,10-17,19,30H2,(H2,31,42)(H,36,44)(H,37,45)(H,39,43)(H4,32,33,38)/t22-,23-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current


Bioorg Med Chem 18: 1381-7 (2010)


Article DOI: 10.1016/j.bmc.2009.12.072
BindingDB Entry DOI: 10.7270/Q27W6CB2
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50324405
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxobenzo[g]quinazolin-3...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2cc3ccccc3cc2c1=O
Show InChI InChI=1S/C27H17N3O5/c31-26-23-15-19-5-1-2-6-20(19)16-24(23)28-25(13-8-17-4-3-7-22(14-17)30(34)35)29(26)21-11-9-18(10-12-21)27(32)33/h1-16H,(H,32,33)/b13-8+
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n/an/a 4.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50324463
PNG
((E)-3-(2-(2-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)...)
Show SMILES OC(=O)c1cccc(c1)-n1c(\C=C\c2ccccc2[N+]([O-])=O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H15N3O5/c27-22-18-9-2-3-10-19(18)24-21(13-12-15-6-1-4-11-20(15)26(30)31)25(22)17-8-5-7-16(14-17)23(28)29/h1-14H,(H,28,29)/b13-12+
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n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50324404
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxo-6-phenylquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(cc2c1=O)-c1ccccc1
Show InChI InChI=1S/C29H19N3O5/c33-28-25-18-22(20-6-2-1-3-7-20)12-15-26(25)30-27(16-9-19-5-4-8-24(17-19)32(36)37)31(28)23-13-10-21(11-14-23)29(34)35/h1-18H,(H,34,35)/b16-9+
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n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50324461
PNG
((E)-4-(2-(2-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccccc2[N+]([O-])=O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H15N3O5/c27-22-18-6-2-3-7-19(18)24-21(14-11-15-5-1-4-8-20(15)26(30)31)25(22)17-12-9-16(10-13-17)23(28)29/h1-14H,(H,28,29)/b14-11+
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n/an/a 6.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50324397
PNG
((E)-4-(6-Fluoro-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(F)cc2c1=O
Show InChI InChI=1S/C23H14FN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
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n/an/a 7.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50324392
PNG
((E)-4-(6-Chloro-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(Cl)cc2c1=O
Show InChI InChI=1S/C23H14ClN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
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n/an/a 7.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50031702
PNG
((2R,4S)-2-Amino-4-methyl-pentanedioic acid | (4S)-...)
Show SMILES C[C@@H](C[C@@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m0/s1
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n/an/a>7.00E+3n/an/an/an/an/an/a



Symphony Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability of the compound to inhibit [3H]-CGS-19,755 binding to Ionotropic glutamate receptor AMPA


J Med Chem 38: 2518-20 (1995)


Article DOI: 10.1021/jm00014a002
BindingDB Entry DOI: 10.7270/Q2R210DW
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50324398
PNG
((E)-4-(6-Bromo-2-(3-nitrostyryl)-4-oxoquinazolin-3...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(Br)cc2c1=O
Show InChI InChI=1S/C23H14BrN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
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n/an/a 8.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50031703
PNG
((2S,4S)-2-Amino-4-methyl-pentanedioic acid | 2-Ami...)
Show SMILES C[C@@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Symphony Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability of the compound to inhibit [3H]-AMPA binding to Ionotropic glutamate receptor AMPA


J Med Chem 38: 2518-20 (1995)


Article DOI: 10.1021/jm00014a002
BindingDB Entry DOI: 10.7270/Q2R210DW
More data for this
Ligand-Target Pair
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