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Compile Data Set for Download or QSAR

Found 117 hits of ec50 data for polymerid = 9126   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50019646
PNG
(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Show SMILES CC(Oc1c(Cl)cccc1Cl)C1=NCCN1
Show InChI InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15)
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n/an/an/an/a 1.40n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...

Bioorg Med Chem 20: 2082-90 (2012)


Article DOI: 10.1016/j.bmc.2012.01.035
BindingDB Entry DOI: 10.7270/Q2TD9ZKT
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50420342
PNG
(CHEMBL2089156)
Show SMILES C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1
Show InChI InChI=1S/C15H20N2O/c1-11(15-16-8-9-17-15)18-14-5-3-2-4-13(14)10-12-6-7-12/h2-5,11-12H,6-10H2,1H3,(H,16,17)/t11-/m0/s1
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n/an/an/an/a 2n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2C adrenoreceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor m...

ACS Med Chem Lett 3: 535-539 (2012)


Article DOI: 10.1021/ml300064v
BindingDB Entry DOI: 10.7270/Q28W3FK6
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50419878
PNG
(CHEMBL1956195)
Show SMILES CC(Oc1ccccc1CC1CC1)C1=NCCN1
Show InChI InChI=1S/C15H20N2O/c1-11(15-16-8-9-17-15)18-14-5-3-2-4-13(14)10-12-6-7-12/h2-5,11-12H,6-10H2,1H3,(H,16,17)
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TBA

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2C adrenoreceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor m...

ACS Med Chem Lett 3: 535-539 (2012)


Article DOI: 10.1021/ml300064v
BindingDB Entry DOI: 10.7270/Q28W3FK6
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50419878
PNG
(CHEMBL1956195)
Show SMILES CC(Oc1ccccc1CC1CC1)C1=NCCN1
Show InChI InChI=1S/C15H20N2O/c1-11(15-16-8-9-17-15)18-14-5-3-2-4-13(14)10-12-6-7-12/h2-5,11-12H,6-10H2,1H3,(H,16,17)
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n/an/an/an/a 2n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...

Bioorg Med Chem 20: 2082-90 (2012)


Article DOI: 10.1016/j.bmc.2012.01.035
BindingDB Entry DOI: 10.7270/Q2TD9ZKT
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50212995
PNG
(CHEMBL75030)
Show SMILES C1CN=C(NC2CCCc3ccccc23)O1
Show InChI InChI=1S/C13H16N2O/c1-2-6-11-10(4-1)5-3-7-12(11)15-13-14-8-9-16-13/h1-2,4,6,12H,3,5,7-9H2,(H,14,15)
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n/an/an/an/a 2.20n/an/an/an/a


TBA

Assay Description
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...

Citation and Details
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM34572
PNG
(BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...)
Show SMILES Brc1c(NC2=NCCN2)ccc2nccnc12
Show InChI InChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
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n/an/an/an/a 3.40n/an/an/an/a



Allergan Pharmaceuticals

Curated by ChEMBL


Assay Description
Effective concentration at Alpha-2C adrenergic receptor from CHO-C4 cells

J Med Chem 40: 18-23 (1997)


Article DOI: 10.1021/jm9605142
BindingDB Entry DOI: 10.7270/Q2RV0MST
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50212997
PNG
(CHEMBL310335)
Show SMILES CCC[C@H]1CCCCC1NC1=NCCO1
Show InChI InChI=1S/C12H22N2O/c1-2-5-10-6-3-4-7-11(10)14-12-13-8-9-15-12/h10-11H,2-9H2,1H3,(H,13,14)/t10-,11?/m0/s1
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n/an/an/an/a 4.10n/an/an/an/a


TBA

Assay Description
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...

Citation and Details
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50417349
PNG
(CHEMBL1276248)
Show SMILES C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1
Show InChI InChI=1S/C15H16N2OS/c1-11(15-16-7-8-17-15)18-14-5-3-2-4-13(14)12-6-9-19-10-12/h2-6,9-11H,7-8H2,1H3,(H,16,17)/t11-/m0/s1
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n/an/an/an/a 6.30n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry

J Med Chem 53: 7825-35 (2010)


Article DOI: 10.1021/jm100977d
BindingDB Entry DOI: 10.7270/Q24B32JF
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50055832
PNG
((1H-Imidazol-2-yl)-(5-methyl-2,3-dihydro-benzo[1,4...)
Show SMILES Cc1c(Nc2ncc[nH]2)ccc2OCCOc12
Show InChI InChI=1S/C12H13N3O2/c1-8-9(15-12-13-4-5-14-12)2-3-10-11(8)17-7-6-16-10/h2-5H,6-7H2,1H3,(H2,13,14,15)
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n/an/an/an/a 6.60n/an/an/an/a



Allergan Pharmaceuticals

Curated by ChEMBL


Assay Description
Effective concentration at Alpha-2C adrenergic receptor from CHO-C4 cells

J Med Chem 40: 18-23 (1997)


Article DOI: 10.1021/jm9605142
BindingDB Entry DOI: 10.7270/Q2RV0MST
More data for this
Ligand-Target Pair
Adrenergic receptor alpha


(Homo sapiens (Human))		BDBM34572
PNG
(BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...)
Show SMILES Brc1c(NC2=NCCN2)ccc2nccnc12
Show InChI InChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
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n/an/an/an/a 9.5n/an/an/an/a


TBA

Assay Description
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis

Citation and Details
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50218115
PNG
((R)-2-[1-(3'-nitrobiphenyl-2-yloxy)ethyl]-4,5-dihy...)
Show SMILES C[C@@H](Oc1ccccc1-c1cccc(c1)[N+]([O-])=O)C1=NCCN1
Show InChI InChI=1S/C17H17N3O3/c1-12(17-18-9-10-19-17)23-16-8-3-2-7-15(16)13-5-4-6-14(11-13)20(21)22/h2-8,11-12H,9-10H2,1H3,(H,18,19)/t12-/m1/s1
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Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonistic potency at human adrenergic alpha2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation

J Med Chem 50: 3964-8 (2007)

Checked by Author
Article DOI: 10.1021/jm061487a
BindingDB Entry DOI: 10.7270/Q2W095NP
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50218115
PNG
((R)-2-[1-(3'-nitrobiphenyl-2-yloxy)ethyl]-4,5-dihy...)
Show SMILES C[C@@H](Oc1ccccc1-c1cccc(c1)[N+]([O-])=O)C1=NCCN1
Show InChI InChI=1S/C17H17N3O3/c1-12(17-18-9-10-19-17)23-16-8-3-2-7-15(16)13-5-4-6-14(11-13)20(21)22/h2-8,11-12H,9-10H2,1H3,(H,18,19)/t12-/m1/s1
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Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry

J Med Chem 53: 7825-35 (2010)


Article DOI: 10.1021/jm100977d
BindingDB Entry DOI: 10.7270/Q24B32JF
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50412244
PNG
(CHEMBL495096)
Show SMILES CC(Oc1ccccc1C1CCCC1)C1=NCCN1
Show InChI InChI=1S/C16H22N2O/c1-12(16-17-10-11-18-16)19-15-9-5-4-8-14(15)13-6-2-3-7-13/h4-5,8-9,12-13H,2-3,6-7,10-11H2,1H3,(H,17,18)
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Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification

J Med Chem 51: 4289-99 (2008)


Article DOI: 10.1021/jm800250z
BindingDB Entry DOI: 10.7270/Q2HQ4147
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50419874
PNG
(CHEMBL1956192)
Show SMILES CC(Oc1ccccc1Br)C1=NCCN1
Show InChI InChI=1S/C11H13BrN2O/c1-8(11-13-6-7-14-11)15-10-5-3-2-4-9(10)12/h2-5,8H,6-7H2,1H3,(H,13,14)
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Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...

Bioorg Med Chem 20: 2082-90 (2012)


Article DOI: 10.1016/j.bmc.2012.01.035
BindingDB Entry DOI: 10.7270/Q2TD9ZKT
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50218115
PNG
((R)-2-[1-(3'-nitrobiphenyl-2-yloxy)ethyl]-4,5-dihy...)
Show SMILES C[C@@H](Oc1ccccc1-c1cccc(c1)[N+]([O-])=O)C1=NCCN1
Show InChI InChI=1S/C17H17N3O3/c1-12(17-18-9-10-19-17)23-16-8-3-2-7-15(16)13-5-4-6-14(11-13)20(21)22/h2-8,11-12H,9-10H2,1H3,(H,18,19)/t12-/m1/s1
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Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonistic potency at human adrenergic alpha2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation

J Med Chem 50: 3964-8 (2007)

Checked by Author
Article DOI: 10.1021/jm061487a
BindingDB Entry DOI: 10.7270/Q2W095NP
More data for this
Ligand-Target Pair
Adrenergic receptor alpha


(Homo sapiens (Human))		BDBM50052880
PNG
(CHEMBL49137 | Imidazolidin-2-ylidene-(5-methyl-qui...)
Show SMILES Cc1c(ccc2nccnc12)N=C1NCCN1
Show InChI InChI=1S/C12H13N5/c1-8-9(17-12-15-6-7-16-12)2-3-10-11(8)14-5-4-13-10/h2-5H,6-7H2,1H3,(H2,15,16,17)
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TBA

Assay Description
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis

Citation and Details
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50417354
PNG
(CHEMBL396013)
Show SMILES C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)/t13-/m0/s1
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Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonistic potency at human adrenergic alpha2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation

J Med Chem 50: 3964-8 (2007)

Checked by Author
Article DOI: 10.1021/jm061487a
BindingDB Entry DOI: 10.7270/Q2W095NP
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50417354
PNG
(CHEMBL396013)
Show SMILES C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)/t13-/m0/s1
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Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry

J Med Chem 53: 7825-35 (2010)


Article DOI: 10.1021/jm100977d
BindingDB Entry DOI: 10.7270/Q24B32JF
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50412258
PNG
(CHEMBL451229)
Show SMILES CC(Oc1ccccc1C1CCCCC1)C1=NCCN1
Show InChI InChI=1S/C17H24N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h5-6,9-10,13-14H,2-4,7-8,11-12H2,1H3,(H,18,19)
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Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification

J Med Chem 51: 4289-99 (2008)


Article DOI: 10.1021/jm800250z
BindingDB Entry DOI: 10.7270/Q2HQ4147
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50193034
PNG
(CHEMBL3904276)
Show SMILES Cc1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C11H15N3/c1-9-4-2-3-5-10(9)14-8-11-12-6-7-13-11/h2-5,14H,6-8H2,1H3,(H,12,13)
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n/an/an/an/a 22n/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis

ACS Med Chem Lett 7: 956-961 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00290
BindingDB Entry DOI: 10.7270/Q2086784
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50417343
PNG
(CHEMBL1276140)
Show SMILES C[C@H](Oc1ccccc1CC=C)C1=NCCN1
Show InChI InChI=1S/C14H18N2O/c1-3-6-12-7-4-5-8-13(12)17-11(2)14-15-9-10-16-14/h3-5,7-8,11H,1,6,9-10H2,2H3,(H,15,16)/t11-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2C adrenoreceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor m...

ACS Med Chem Lett 3: 535-539 (2012)


Article DOI: 10.1021/ml300064v
BindingDB Entry DOI: 10.7270/Q28W3FK6
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50212996
PNG
(CHEMBL306377)
Show SMILES C1COC(NC2CCCc3ccccc23)=NC1
Show InChI InChI=1S/C14H18N2O/c1-2-7-12-11(5-1)6-3-8-13(12)16-14-15-9-4-10-17-14/h1-2,5,7,13H,3-4,6,8-10H2,(H,15,16)
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n/an/an/an/a 25n/an/an/an/a


TBA

Assay Description
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...

Citation and Details
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50417351
PNG
(CHEMBL1278084)
Show SMILES C[C@@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-9-10-19-17)21-16-8-3-2-7-15(16)13-5-4-6-14(20)11-13/h2-8,11-12,20H,9-10H2,1H3,(H,18,19)/t12-/m1/s1
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n/an/an/an/a 25n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry

J Med Chem 53: 7825-35 (2010)


Article DOI: 10.1021/jm100977d
BindingDB Entry DOI: 10.7270/Q24B32JF
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50417343
PNG
(CHEMBL1276140)
Show SMILES C[C@H](Oc1ccccc1CC=C)C1=NCCN1
Show InChI InChI=1S/C14H18N2O/c1-3-6-12-7-4-5-8-13(12)17-11(2)14-15-9-10-16-14/h3-5,7-8,11H,1,6,9-10H2,2H3,(H,15,16)/t11-/m0/s1
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n/an/an/an/a 25n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry

J Med Chem 53: 7825-35 (2010)


Article DOI: 10.1021/jm100977d
BindingDB Entry DOI: 10.7270/Q24B32JF
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50415138
PNG
(CHEMBL576078)
Show SMILES CCCc1ccccc1C(C)OC1=NCCN1
Show InChI InChI=1S/C14H20N2O/c1-3-6-12-7-4-5-8-13(12)11(2)17-14-15-9-10-16-14/h4-5,7-8,11H,3,6,9-10H2,1-2H3,(H,15,16)
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n/an/an/an/a 25n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50419884
PNG
(CHEMBL157955)
Show SMILES CCc1cccc(CC)c1OC(C)C1=NCCN1
Show InChI InChI=1S/C15H22N2O/c1-4-12-7-6-8-13(5-2)14(12)18-11(3)15-16-9-10-17-15/h6-8,11H,4-5,9-10H2,1-3H3,(H,16,17)
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n/an/an/an/a 28n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...

Bioorg Med Chem 20: 2082-90 (2012)


Article DOI: 10.1016/j.bmc.2012.01.035
BindingDB Entry DOI: 10.7270/Q2TD9ZKT
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50419889
PNG
(CHEMBL155866)
Show SMILES CC(Oc1c(C)cccc1C)C1=NCCN1
Show InChI InChI=1S/C13H18N2O/c1-9-5-4-6-10(2)12(9)16-11(3)13-14-7-8-15-13/h4-6,11H,7-8H2,1-3H3,(H,14,15)
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n/an/an/an/a 28n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...

Bioorg Med Chem 20: 2082-90 (2012)


Article DOI: 10.1016/j.bmc.2012.01.035
BindingDB Entry DOI: 10.7270/Q2TD9ZKT
More data for this
Ligand-Target Pair
Adrenergic receptor alpha


(Homo sapiens (Human))		BDBM50213348
PNG
(CHEMBL72753)
Show SMILES Clc1c(NC2=NCCN2)ccc2nccnc12
Show InChI InChI=1S/C11H10ClN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
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n/an/an/an/a 31n/an/an/an/a


TBA

Assay Description
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis

Citation and Details
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50417346
PNG
(CHEMBL1276220)
Show SMILES C[C@H](Oc1ccccc1C1CC1)C1=NCCN1
Show InChI InChI=1S/C14H18N2O/c1-10(14-15-8-9-16-14)17-13-5-3-2-4-12(13)11-6-7-11/h2-5,10-11H,6-9H2,1H3,(H,15,16)/t10-/m0/s1
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n/an/an/an/a 35n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry

J Med Chem 53: 7825-35 (2010)


Article DOI: 10.1021/jm100977d
BindingDB Entry DOI: 10.7270/Q24B32JF
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50415139
PNG
(CHEMBL576623)
Show SMILES CC(OC1=NCCN1)c1ccccc1C1CC1
Show InChI InChI=1S/C14H18N2O/c1-10(17-14-15-8-9-16-14)12-4-2-3-5-13(12)11-6-7-11/h2-5,10-11H,6-9H2,1H3,(H,15,16)
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n/an/an/an/a 40n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50417344
PNG
(CHEMBL1276218)
Show SMILES CC(Oc1ccccc1C1CC1)C1=NCCN1
Show InChI InChI=1S/C14H18N2O/c1-10(14-15-8-9-16-14)17-13-5-3-2-4-12(13)11-6-7-11/h2-5,10-11H,6-9H2,1H3,(H,15,16)
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n/an/an/an/a 40n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry

J Med Chem 53: 7825-35 (2010)


Article DOI: 10.1021/jm100977d
BindingDB Entry DOI: 10.7270/Q24B32JF
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50417350
PNG
(CHEMBL374584)
Show SMILES CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-9-10-19-17)21-16-8-3-2-7-15(16)13-5-4-6-14(20)11-13/h2-8,11-12,20H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 47n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry

J Med Chem 53: 7825-35 (2010)


Article DOI: 10.1021/jm100977d
BindingDB Entry DOI: 10.7270/Q24B32JF
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50417350
PNG
(CHEMBL374584)
Show SMILES CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-9-10-19-17)21-16-8-3-2-7-15(16)13-5-4-6-14(20)11-13/h2-8,11-12,20H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 47n/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonistic potency at human adrenergic alpha2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation

J Med Chem 50: 3964-8 (2007)

Checked by Author
Article DOI: 10.1021/jm061487a
BindingDB Entry DOI: 10.7270/Q2W095NP
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50419880
PNG
(CHEMBL1956197)
Show SMILES CC(Oc1ccccc1OC1CC1)C1=NCCN1
Show InChI InChI=1S/C14H18N2O2/c1-10(14-15-8-9-16-14)17-12-4-2-3-5-13(12)18-11-6-7-11/h2-5,10-11H,6-9H2,1H3,(H,15,16)
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n/an/an/an/a 48n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...

Bioorg Med Chem 20: 2082-90 (2012)


Article DOI: 10.1016/j.bmc.2012.01.035
BindingDB Entry DOI: 10.7270/Q2TD9ZKT
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50412245
PNG
(CHEMBL495095)
Show SMILES CC(Oc1ccccc1CC=C)C1=NCCN1
Show InChI InChI=1S/C14H18N2O/c1-3-6-12-7-4-5-8-13(12)17-11(2)14-15-9-10-16-14/h3-5,7-8,11H,1,6,9-10H2,2H3,(H,15,16)
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n/an/an/an/a 50n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification

J Med Chem 51: 4289-99 (2008)


Article DOI: 10.1021/jm800250z
BindingDB Entry DOI: 10.7270/Q2HQ4147
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50412245
PNG
(CHEMBL495095)
Show SMILES CC(Oc1ccccc1CC=C)C1=NCCN1
Show InChI InChI=1S/C14H18N2O/c1-3-6-12-7-4-5-8-13(12)17-11(2)14-15-9-10-16-14/h3-5,7-8,11H,1,6,9-10H2,2H3,(H,15,16)
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n/an/an/an/a 50n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry

J Med Chem 53: 7825-35 (2010)


Article DOI: 10.1021/jm100977d
BindingDB Entry DOI: 10.7270/Q24B32JF
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50415136
PNG
(CHEMBL570973)
Show SMILES CC(OC1=NCCN1)c1ccccc1CC=C
Show InChI InChI=1S/C14H18N2O/c1-3-6-12-7-4-5-8-13(12)11(2)17-14-15-9-10-16-14/h3-5,7-8,11H,1,6,9-10H2,2H3,(H,15,16)
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n/an/an/an/a 50n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50002905
PNG
(CHEMBL373535)
Show SMILES CC(Oc1ccccc1-c1cccnc1)C1=NCCN1
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-9-10-19-16)20-15-7-3-2-6-14(15)13-5-4-8-17-11-13/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 50n/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonistic potency at human adrenergic alpha2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation

J Med Chem 50: 3964-8 (2007)

Checked by Author
Article DOI: 10.1021/jm061487a
BindingDB Entry DOI: 10.7270/Q2W095NP
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50412245
PNG
(CHEMBL495095)
Show SMILES CC(Oc1ccccc1CC=C)C1=NCCN1
Show InChI InChI=1S/C14H18N2O/c1-3-6-12-7-4-5-8-13(12)17-11(2)14-15-9-10-16-14/h3-5,7-8,11H,1,6,9-10H2,2H3,(H,15,16)
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n/an/an/an/a 50n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2C adrenoreceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor m...

ACS Med Chem Lett 3: 535-539 (2012)


Article DOI: 10.1021/ml300064v
BindingDB Entry DOI: 10.7270/Q28W3FK6
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50001922
PNG
(2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; ...)
Show SMILES C(C1=NCCN1)c1cccc2ccccc12
Show InChI InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)
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n/an/an/an/a 55n/an/an/an/a



Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary.

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic ca...

Bioorg Med Chem 23: 3991-9 (2015)


Article DOI: 10.1016/j.bmc.2015.01.013
BindingDB Entry DOI: 10.7270/Q2GM892T
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50016897
PNG
(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Show SMILES Clc1cccc(Cl)c1N=C1NCCN1
Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
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TBA

Assay Description
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...

Citation and Details
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50419885
PNG
(CHEMBL157206)
Show SMILES CC(Oc1c(CC=C)cccc1CC=C)C1=NCCN1
Show InChI InChI=1S/C17H22N2O/c1-4-7-14-9-6-10-15(8-5-2)16(14)20-13(3)17-18-11-12-19-17/h4-6,9-10,13H,1-2,7-8,11-12H2,3H3,(H,18,19)
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n/an/an/an/a 56n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...

Bioorg Med Chem 20: 2082-90 (2012)


Article DOI: 10.1016/j.bmc.2012.01.035
BindingDB Entry DOI: 10.7270/Q2TD9ZKT
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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n/an/an/an/a 58n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry

J Med Chem 53: 7825-35 (2010)


Article DOI: 10.1021/jm100977d
BindingDB Entry DOI: 10.7270/Q24B32JF
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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n/an/an/an/a 58n/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonistic potency at human adrenergic alpha2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation

J Med Chem 50: 3964-8 (2007)

Checked by Author
Article DOI: 10.1021/jm061487a
BindingDB Entry DOI: 10.7270/Q2W095NP
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50016897
PNG
(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Show SMILES Clc1cccc(Cl)c1N=C1NCCN1
Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
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n/an/an/an/a 58n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry

J Med Chem 53: 7825-35 (2010)


Article DOI: 10.1021/jm100977d
BindingDB Entry DOI: 10.7270/Q24B32JF
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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n/an/an/an/a 58n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification

J Med Chem 51: 4289-99 (2008)


Article DOI: 10.1021/jm800250z
BindingDB Entry DOI: 10.7270/Q2HQ4147
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50002903
PNG
(CHEMBL223836)
Show SMILES CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1
Show InChI InChI=1S/C17H17FN2O/c1-12(17-19-9-10-20-17)21-16-8-3-2-7-15(16)13-5-4-6-14(18)11-13/h2-8,11-12H,9-10H2,1H3,(H,19,20)
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n/an/an/an/a 60n/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonistic potency at human adrenergic alpha2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation

J Med Chem 50: 3964-8 (2007)

Checked by Author
Article DOI: 10.1021/jm061487a
BindingDB Entry DOI: 10.7270/Q2W095NP
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50415137
PNG
(CHEMBL570863)
Show SMILES CC(OC1=NCCN1)c1ccccc1C
Show InChI InChI=1S/C12H16N2O/c1-9-5-3-4-6-11(9)10(2)15-12-13-7-8-14-12/h3-6,10H,7-8H2,1-2H3,(H,13,14)
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n/an/an/an/a 63n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50212993
PNG
(CHEMBL305928)
Show SMILES C1CN=C(NC2CCCCCC2)O1
Show InChI InChI=1S/C10H18N2O/c1-2-4-6-9(5-3-1)12-10-11-7-8-13-10/h9H,1-8H2,(H,11,12)
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n/an/an/an/a 78n/an/an/an/a


TBA

Assay Description
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...

Citation and Details
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50419873
PNG
(CHEMBL1956203)
Show SMILES CC(Oc1c(cccc1-c1ccccc1)-c1ccccc1)C1=NCCN1
Show InChI InChI=1S/C23H22N2O/c1-17(23-24-15-16-25-23)26-22-20(18-9-4-2-5-10-18)13-8-14-21(22)19-11-6-3-7-12-19/h2-14,17H,15-16H2,1H3,(H,24,25)
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n/an/an/an/a 79n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...

Bioorg Med Chem 20: 2082-90 (2012)


Article DOI: 10.1016/j.bmc.2012.01.035
BindingDB Entry DOI: 10.7270/Q2TD9ZKT
More data for this
Ligand-Target Pair
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