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Compile Data Set for Download or QSAR

Found 739 hits of ki data for polymerid = 9126   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM?mit=repeat
Kd
nM
EC50/IC50
nM?mit=repeat
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM84979
PNG
(Isoquercitrin)
Show SMILES OCC1OC(O)C(Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)C(O)C1O
Show InChI InChI=1S/C21H20O12/c22-6-13-15(27)17(29)20(21(30)32-13)33-19-16(28)14-11(26)4-8(23)5-12(14)31-18(19)7-1-2-9(24)10(25)3-7/h1-5,13,15,17,20-25,27-30H,6H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Westfälische Wilhelms-Universitä Muenster,

Curated by PDSP Ki Database




Psychopharmacology (Berl) 162: 193-202 (2002)


Article DOI: 10.1007/s00213-002-1073-7
BindingDB Entry DOI: 10.7270/Q25D8QDD
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50333880
PNG
(CHEMBL1614664 | Hypericin | Pseudohypericin)
Show SMILES Cc1cc(O)c2c3c1c1c(CO)cc(O)c4c1c1c5c(c(O)cc(O)c5c4=O)c4c(O)cc(O)c(c4c31)c2=O
Show InChI InChI=1S/C30H16O9/c1-7-2-9(32)19-23-15(7)16-8(6-31)3-10(33)20-24(16)28-26-18(12(35)5-14(37)22(26)30(20)39)17-11(34)4-13(36)21(29(19)38)25(17)27(23)28/h2-5,31-37H,6H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Westfälische Wilhelms-Universitä Muenster,

Curated by PDSP Ki Database




Psychopharmacology (Berl) 162: 193-202 (2002)


Article DOI: 10.1007/s00213-002-1073-7
BindingDB Entry DOI: 10.7270/Q25D8QDD
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
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>1.00E+4n/an/an/an/an/an/an/an/a



Westfälische Wilhelms-Universitä Muenster,

Curated by PDSP Ki Database




Psychopharmacology (Berl) 162: 193-202 (2002)


Article DOI: 10.1007/s00213-002-1073-7
BindingDB Entry DOI: 10.7270/Q25D8QDD
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM84978
PNG
(Quercitrin | cid_5280459)
Show SMILES C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C21H20O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-18,21-24,26-29H,1H3/t7-,15-,17+,18+,21-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Westfälische Wilhelms-Universitä Muenster,

Curated by PDSP Ki Database




Psychopharmacology (Berl) 162: 193-202 (2002)


Article DOI: 10.1007/s00213-002-1073-7
BindingDB Entry DOI: 10.7270/Q25D8QDD
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50122872
PNG
(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Show SMILES COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(N)c2CCOc12
Show InChI InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
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>1.00E+4n/an/an/an/an/an/an/an/a



Janssen Research Foundation

Curated by PDSP Ki Database




Eur J Pharmacol 423: 71-83 (2001)


BindingDB Entry DOI: 10.7270/Q23T9FSX
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM26739
PNG
(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



McGill University

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 102: 18620-5 (2005)


Article DOI: 10.1073/pnas.0509591102
BindingDB Entry DOI: 10.7270/Q2F47MQJ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50055828
PNG
((5-Bromo-quinoxalin-6-yl)-(1H-imidazol-2-yl)-amine...)
Show SMILES Brc1c(Nc2ncc[nH]2)ccc2nccnc12
Show InChI InChI=1S/C11H8BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-6H,(H2,15,16,17)
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>1.00E+4n/an/an/an/an/an/an/an/a



Allergan Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cells


J Med Chem 40: 18-23 (1997)


Article DOI: 10.1021/jm9605142
BindingDB Entry DOI: 10.7270/Q2RV0MST
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50094968
PNG
(3-(1-Methyl-4,5-dihydro-1H-imidazol-2-ylmethyl)-py...)
Show SMILES CN1CCN=C1Cc1cccnc1
Show InChI InChI=1S/C10H13N3/c1-13-6-5-12-10(13)7-9-3-2-4-11-8-9/h2-4,8H,5-7H2,1H3
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Universita di Camerino

Curated by ChEMBL


Assay Description
The binding affinity towards the Alpha-2C adrenergic receptor; No affinity


J Med Chem 45: 4724-31 (2002)


Article DOI: 10.1021/jm020188s
BindingDB Entry DOI: 10.7270/Q2ZW1K88
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50419925
PNG
(CHEMBL1956899)
Show SMILES C1CN=C(N1)[C@@H]1CO[C@@H](CO1)c1ccccc1
Show InChI InChI=1S/C13H16N2O2/c1-2-4-10(5-3-1)11-8-17-12(9-16-11)13-14-6-7-15-13/h1-5,11-12H,6-9H2,(H,14,15)/t11-,12-/m0/s1
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<1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human Alpha-2C adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting


Bioorg Med Chem 20: 2259-65 (2012)


Article DOI: 10.1016/j.bmc.2012.02.016
BindingDB Entry DOI: 10.7270/Q2JW8G5M
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50215552
PNG
(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N
Show InChI InChI=1S/C13H6F2N2S/c14-6-13-17-12(8-18-13)2-1-9-3-10(7-16)5-11(15)4-9/h3-5,8H,6H2
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>1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]cholidine from adrenergic alpha-2C receptor


J Med Chem 50: 3256-66 (2007)


Article DOI: 10.1021/jm0701268
BindingDB Entry DOI: 10.7270/Q2FB52NB
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50140058
PNG
(CHEMBL3752576)
Show SMILES C=CCN(CCc1c[nH]c2ccccc12)CC=C
Show InChI InChI=1S/C16H20N2/c1-3-10-18(11-4-2)12-9-14-13-17-16-8-6-5-7-15(14)16/h3-8,13,17H,1-2,9-12H2
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<1.00E+4n/an/an/an/an/an/an/an/a



The Alexander Shulgin Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assay


Bioorg Med Chem Lett 26: 959-64 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.053
BindingDB Entry DOI: 10.7270/Q24F1SKV
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50140054
PNG
(CHEMBL3752900)
Show SMILES Clc1ccc2[nH]cc(CCN(CC=C)CC=C)c2c1
Show InChI InChI=1S/C16H19ClN2/c1-3-8-19(9-4-2)10-7-13-12-18-16-6-5-14(17)11-15(13)16/h3-6,11-12,18H,1-2,7-10H2
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<1.00E+4n/an/an/an/an/an/an/an/a



The Alexander Shulgin Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assay


Bioorg Med Chem Lett 26: 959-64 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.053
BindingDB Entry DOI: 10.7270/Q24F1SKV
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50140055
PNG
(CHEMBL3754166)
Show SMILES Brc1ccc2[nH]cc(CCN(CC=C)CC=C)c2c1
Show InChI InChI=1S/C16H19BrN2/c1-3-8-19(9-4-2)10-7-13-12-18-16-6-5-14(17)11-15(13)16/h3-6,11-12,18H,1-2,7-10H2
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<1.00E+4n/an/an/an/an/an/an/an/a



The Alexander Shulgin Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assay


Bioorg Med Chem Lett 26: 959-64 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.053
BindingDB Entry DOI: 10.7270/Q24F1SKV
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50140056
PNG
(CHEMBL3753318)
Show SMILES Cc1ccc2[nH]cc(CCN(CC=C)CC=C)c2c1
Show InChI InChI=1S/C17H22N2/c1-4-9-19(10-5-2)11-8-15-13-18-17-7-6-14(3)12-16(15)17/h4-7,12-13,18H,1-2,8-11H2,3H3
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<1.00E+4n/an/an/an/an/an/an/an/a



The Alexander Shulgin Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assay


Bioorg Med Chem Lett 26: 959-64 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.053
BindingDB Entry DOI: 10.7270/Q24F1SKV
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50435344
PNG
(CHEMBL2391541)
Show SMILES COc1ccc2[nH]cc(CCN(CC=C)CC=C)c2c1
Show InChI InChI=1S/C17H22N2O/c1-4-9-19(10-5-2)11-8-14-13-18-17-7-6-15(20-3)12-16(14)17/h4-7,12-13,18H,1-2,8-11H2,3H3
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<1.00E+4n/an/an/an/an/an/an/an/a



The Alexander Shulgin Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assay


Bioorg Med Chem Lett 26: 959-64 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.053
BindingDB Entry DOI: 10.7270/Q24F1SKV
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50140053
PNG
(CHEMBL3754496)
Show SMILES Fc1ccc2[nH]cc(CCN(CC=C)CC=C)c2c1
Show InChI InChI=1S/C16H19FN2/c1-3-8-19(9-4-2)10-7-13-12-18-16-6-5-14(17)11-15(13)16/h3-6,11-12,18H,1-2,7-10H2
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<1.00E+4n/an/an/an/an/an/an/an/a



The Alexander Shulgin Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assay


Bioorg Med Chem Lett 26: 959-64 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.053
BindingDB Entry DOI: 10.7270/Q24F1SKV
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50311076
PNG
(CHEMBL1079079 | [125I]1-(2-iodophenyl)-4-cyano-5-(...)
Show SMILES COc1ccc(cc1)-c1c(C#N)c(nn1-c1ccccc1I)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H22IN5O2/c1-31-17-11-9-16(10-12-17)22-18(15-25)21(23(30)27-28-13-5-2-6-14-28)26-29(22)20-8-4-3-7-19(20)24/h3-4,7-12H,2,5-6,13-14H2,1H3,(H,27,30)
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>1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoclonidine from alpha-2C adrenergic receptor at 10 uM by scintillation counting


Bioorg Med Chem Lett 19: 6209-12 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.092
BindingDB Entry DOI: 10.7270/Q23J3D3H
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50305342
PNG
(4-(3'-Fluorophenethyl)-4-azahexacyclo[5.4.1.02,6.0...)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2CCc1cccc(F)c1
Show InChI InChI=1S/C19H20FNO/c20-9-3-1-2-8(6-9)4-5-21-18-14-10-7-11-13-12(10)15(18)17(13)19(21,22)16(11)14/h1-3,6,10-18,22H,4-5,7H2
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University of Sydney

Curated by ChEMBL


Assay Description
Binding affinity to Alpha2C adrenoceptor receptor


Bioorg Med Chem Lett 20: 145-8 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.019
BindingDB Entry DOI: 10.7270/Q2NS0V0S
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50305343
PNG
(4-(3'-Fluorophenyl)methyl-4-azahexacyclo[5.4.1.02,...)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2Cc1cccc(F)c1
Show InChI InChI=1S/C18H18FNO/c19-8-3-1-2-7(4-8)6-20-17-13-9-5-10-12-11(9)14(17)16(12)18(20,21)15(10)13/h1-4,9-17,21H,5-6H2
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University of Sydney

Curated by ChEMBL


Assay Description
Binding affinity to Alpha2C adrenoceptor receptor


Bioorg Med Chem Lett 20: 145-8 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.019
BindingDB Entry DOI: 10.7270/Q2NS0V0S
More data for this
Ligand-Target Pair
Adrenergic receptor alpha


(Homo sapiens (Human))
BDBM50421506
PNG
(CHEMBL61861 | ORG-24598)
Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O
Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m1/s1
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<1.00E+4n/an/an/an/an/an/an/an/a



Organon Research and Development Group

Curated by ChEMBL


Assay Description
Binding affinity of compound towards Alpha-2C adrenergic receptor was determined


Bioorg Med Chem Lett 11: 2007-9 (2001)


Article DOI: 10.1016/s0960-894x(01)00355-9
BindingDB Entry DOI: 10.7270/Q2X0687Q
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50419925
PNG
(CHEMBL1956899)
Show SMILES C1CN=C(N1)[C@@H]1CO[C@@H](CO1)c1ccccc1
Show InChI InChI=1S/C13H16N2O2/c1-2-4-10(5-3-1)11-8-17-12(9-16-11)13-14-6-7-15-13/h1-5,11-12H,6-9H2,(H,14,15)/t11-,12-/m0/s1
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<1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human Alpha-2C adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting


Bioorg Med Chem 20: 2259-65 (2012)


Article DOI: 10.1016/j.bmc.2012.02.016
BindingDB Entry DOI: 10.7270/Q2JW8G5M
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50419926
PNG
(CHEMBL1956901)
Show SMILES C1CN=C(N1)[C@@H]1CO[C@H](CO1)c1ccccc1
Show InChI InChI=1S/C13H16N2O2/c1-2-4-10(5-3-1)11-8-17-12(9-16-11)13-14-6-7-15-13/h1-5,11-12H,6-9H2,(H,14,15)/t11-,12+/m1/s1
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<1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human Alpha-2C adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting


Bioorg Med Chem 20: 2259-65 (2012)


Article DOI: 10.1016/j.bmc.2012.02.016
BindingDB Entry DOI: 10.7270/Q2JW8G5M
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50419931
PNG
(CHEMBL1956902)
Show SMILES C1CN=C(N1)[C@H]1CO[C@@H](CO1)c1ccccc1
Show InChI InChI=1S/C13H16N2O2/c1-2-4-10(5-3-1)11-8-17-12(9-16-11)13-14-6-7-15-13/h1-5,11-12H,6-9H2,(H,14,15)/t11-,12+/m0/s1
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<1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human Alpha-2C adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting


Bioorg Med Chem 20: 2259-65 (2012)


Article DOI: 10.1016/j.bmc.2012.02.016
BindingDB Entry DOI: 10.7270/Q2JW8G5M
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50419927
PNG
(CHEMBL1956903)
Show SMILES C1CN=C(N1)[C@@H]1COC[C@@H](O1)c1ccccc1
Show InChI InChI=1S/C13H16N2O2/c1-2-4-10(5-3-1)11-8-16-9-12(17-11)13-14-6-7-15-13/h1-5,11-12H,6-9H2,(H,14,15)/t11-,12+/m1/s1
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<1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human Alpha-2C adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting


Bioorg Med Chem 20: 2259-65 (2012)


Article DOI: 10.1016/j.bmc.2012.02.016
BindingDB Entry DOI: 10.7270/Q2JW8G5M
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50419928
PNG
(CHEMBL1956904)
Show SMILES C1CN=C(N1)[C@@H]1COC[C@H](O1)c1ccccc1
Show InChI InChI=1S/C13H16N2O2/c1-2-4-10(5-3-1)11-8-16-9-12(17-11)13-14-6-7-15-13/h1-5,11-12H,6-9H2,(H,14,15)/t11-,12-/m0/s1
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<1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human Alpha-2C adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting


Bioorg Med Chem 20: 2259-65 (2012)


Article DOI: 10.1016/j.bmc.2012.02.016
BindingDB Entry DOI: 10.7270/Q2JW8G5M
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50387827
PNG
(CHEMBL2058635)
Show SMILES CC1CCC(N1)=Nc1ccc(I)cc1Cl
Show InChI InChI=1S/C11H12ClIN2/c1-7-2-5-11(14-7)15-10-4-3-8(13)6-9(10)12/h3-4,6-7H,2,5H2,1H3,(H,14,15)
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<1.00E+4n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821001 from human alpha2C adrenoceptor expressed in CHO cells after 60 mins by gamma counter


Bioorg Med Chem 20: 4710-5 (2012)


Article DOI: 10.1016/j.bmc.2012.06.008
BindingDB Entry DOI: 10.7270/Q26Q1Z9Q
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50387826
PNG
(CHEMBL2058634)
Show SMILES CC1CCC(N1)=Nc1ccccc1Cl
Show InChI InChI=1S/C11H13ClN2/c1-8-6-7-11(13-8)14-10-5-3-2-4-9(10)12/h2-5,8H,6-7H2,1H3,(H,13,14)
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<1.00E+4n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821001 from human alpha2C adrenoceptor expressed in CHO cells after 60 mins by gamma counter


Bioorg Med Chem 20: 4710-5 (2012)


Article DOI: 10.1016/j.bmc.2012.06.008
BindingDB Entry DOI: 10.7270/Q26Q1Z9Q
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50387824
PNG
(CHEMBL2058632)
Show SMILES CC1COC(N1)=NC(C1CC1)C1CC1
Show InChI InChI=1S/C11H18N2O/c1-7-6-14-11(12-7)13-10(8-2-3-8)9-4-5-9/h7-10H,2-6H2,1H3,(H,12,13)
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<1.00E+4n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821001 from human alpha2C adrenoceptor expressed in CHO cells after 60 mins by gamma counter


Bioorg Med Chem 20: 4710-5 (2012)


Article DOI: 10.1016/j.bmc.2012.06.008
BindingDB Entry DOI: 10.7270/Q26Q1Z9Q
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50097716
PNG
(CHEMBL3588908)
Show SMILES COc1ccccc1OCC1CNCCO1
Show InChI InChI=1S/C32H43FN6O4S/c1-4-6-7-8-9-10-16-37(3)29(41)22-39-20-26(30(42)36-32(39)44-23-24-11-13-27(33)14-12-24)17-25-18-35-31(43)38(19-25)21-28(40)34-15-5-2/h11-14,18-20H,4-10,15-17,21-23H2,1-3H3,(H,34,40)
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1.05E+4n/an/an/an/an/an/an/an/a



Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary.

Curated by ChEMBL


Assay Description
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun...


Bioorg Med Chem 23: 3991-9 (2015)


Article DOI: 10.1016/j.bmc.2015.01.013
BindingDB Entry DOI: 10.7270/Q2GM892T
More data for this
Ligand-Target Pair
Adrenergic receptor alpha


(Homo sapiens (Human))
BDBM50213349
PNG
(CHEMBL74342)
Show SMILES Brc1c(NC2=N[C@@H]3CCCC[C@@H]3N2)ccc2nccnc12
Show InChI InChI=1S/C15H16BrN5/c16-13-11(5-6-12-14(13)18-8-7-17-12)21-15-19-9-3-1-2-4-10(9)20-15/h5-10H,1-4H2,(H2,19,20,21)/t9-,10+
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1.15E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin


Citation and Details
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50097720
PNG
(CHEMBL3588912)
Show SMILES COc1ccc(cc1)C1NCCCn2cccc12
Show InChI InChI=1S/C30H39FN6O4S/c1-4-5-6-7-8-9-14-35(3)27(39)20-37-18-24(15-23-16-33-29(41)36(17-23)19-26(38)32-2)28(40)34-30(37)42-21-22-10-12-25(31)13-11-22/h10-13,16-18H,4-9,14-15,19-21H2,1-3H3,(H,32,38)
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1.38E+4n/an/an/an/an/an/an/an/a



Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary.

Curated by ChEMBL


Assay Description
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun...


Bioorg Med Chem 23: 3991-9 (2015)


Article DOI: 10.1016/j.bmc.2015.01.013
BindingDB Entry DOI: 10.7270/Q2GM892T
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50051838
PNG
(CHEMBL1327)
Show SMILES OC(Cn1ccnc1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C11H10Cl2N2O/c12-8-1-2-9(10(13)5-8)11(16)6-15-4-3-14-7-15/h1-5,7,11,16H,6H2
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1.51E+4n/an/an/an/an/an/an/an/a



Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary.

Curated by ChEMBL


Assay Description
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun...


Bioorg Med Chem 23: 3991-9 (2015)


Article DOI: 10.1016/j.bmc.2015.01.013
BindingDB Entry DOI: 10.7270/Q2GM892T
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50097715
PNG
(CHEMBL3588909)
Show SMILES NCC(=O)Nc1ccccc1Oc1ccccc1
Show InChI InChI=1S/C31H41FN6O5S/c1-3-4-5-6-7-8-14-36(2)28(41)21-38-19-25(29(42)35-31(38)44-22-23-9-11-26(32)12-10-23)16-24-17-34-30(43)37(18-24)20-27(40)33-13-15-39/h9-12,17-19,39H,3-8,13-16,20-22H2,1-2H3,(H,33,40)
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1.55E+4n/an/an/an/an/an/an/an/a



Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary.

Curated by ChEMBL


Assay Description
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun...


Bioorg Med Chem 23: 3991-9 (2015)


Article DOI: 10.1016/j.bmc.2015.01.013
BindingDB Entry DOI: 10.7270/Q2GM892T
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50097714
PNG
(CHEMBL3588910)
Show SMILES O=C(CCC1CCCC1)N1CCSC11CCNCC1
Show InChI InChI=1S/C28H36FN5O3S/c1-4-5-6-7-8-9-14-32(2)25(35)19-34-18-23(15-22-16-30-27(37)33(3)17-22)26(36)31-28(34)38-20-21-10-12-24(29)13-11-21/h10-13,16-18H,4-9,14-15,19-20H2,1-3H3
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1.55E+4n/an/an/an/an/an/an/an/a



Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary.

Curated by ChEMBL


Assay Description
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun...


Bioorg Med Chem 23: 3991-9 (2015)


Article DOI: 10.1016/j.bmc.2015.01.013
BindingDB Entry DOI: 10.7270/Q2GM892T
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50212994
PNG
(CHEMBL75201)
Show SMILES C1CN=C(O1)N1CCOCC1
Show InChI InChI=1S/C7H12N2O2/c1-4-11-7(8-1)9-2-5-10-6-3-9/h1-6H2
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1.66E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscine


Citation and Details
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50050094
PNG
(3-Isopropyl-bicyclo[2.2.1]hept-2-ylamine | CHEMBL4...)
Show SMILES CC(C)C1C2CCC(C2)C1N
Show InChI InChI=1S/C10H19N/c1-6(2)9-7-3-4-8(5-7)10(9)11/h6-10H,3-5,11H2,1-2H3
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>2.00E+4n/an/an/an/an/an/an/an/a



Allergan Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity for human Alpha-2C adrenergic receptor


J Med Chem 39: 1193-5 (1996)


Article DOI: 10.1021/jm960012o
BindingDB Entry DOI: 10.7270/Q2NZ889J
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50097713
PNG
(CHEMBL3588911)
Show SMILES CC(C)NCc1nccn1Cc1ccccc1C
Show InChI InChI=1S/C35H48FN5O5S/c1-4-6-7-8-9-10-11-12-13-14-19-39(3)31(42)24-41-23-29(20-28-21-37-34(45)40(22-28)25-32(43)46-5-2)33(44)38-35(41)47-26-27-15-17-30(36)18-16-27/h15-18,21-23H,4-14,19-20,24-26H2,1-3H3
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2.24E+4n/an/an/an/an/an/an/an/a



Gedeon Richter Plc., Gy�mroi�t 19-21, Budapest H-1103, Hungary.

Curated by ChEMBL


Assay Description
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun...


Bioorg Med Chem 23: 3991-9 (2015)


Article DOI: 10.1016/j.bmc.2015.01.013
BindingDB Entry DOI: 10.7270/Q2GM892T
More data for this
Ligand-Target Pair
Adrenergic receptor alpha


(Homo sapiens (Human))
BDBM50213350
PNG
(CHEMBL73392)
Show SMILES Brc1c(NC2=NCCS2)ccc2nccnc12
Show InChI InChI=1S/C11H9BrN4S/c12-9-7(16-11-15-5-6-17-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H,15,16)
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2.82E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin


Citation and Details
More data for this
Ligand-Target Pair
Adrenergic receptor alpha


(Homo sapiens (Human))
BDBM50213346
PNG
(CHEMBL73164)
Show SMILES Brc1c(NC2=NCCO2)ccc2nccnc12
Show InChI InChI=1S/C11H9BrN4O/c12-9-7(16-11-15-5-6-17-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H,15,16)
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4.90E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin


Citation and Details
More data for this
Ligand-Target Pair
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