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Compile Data Set for Download or QSAR

Found 83 hits of ic50 data for polymerid = 9339   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222186
PNG
(6-(Dimethylamino)-3-(4'-nitrophenyl)-2,3-dihyd...)
Show SMILES CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C19H17N3O4S/c1-21(2)16-11-10-15-18-14(16)4-3-5-17(18)27(25,26)20-19(15)12-6-8-13(9-7-12)22(23)24/h3-11,19-20H,1-2H3
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n/an/a 110n/an/an/an/a9.837



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50068225
PNG
(CHEMBL3403324)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N2O4S2/c1-11-2-6-14(7-3-11)22(19,20)16-10-12-4-8-13(9-5-12)21(15,17)18/h2-9,16H,10H2,1H3,(H2,15,17,18)
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n/an/a 115n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...


Bioorg Med Chem 23: 2435-44 (2015)


Article DOI: 10.1016/j.bmc.2015.03.054
BindingDB Entry DOI: 10.7270/Q2WW7KC8
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50068229
PNG
(CHEMBL3403327)
Show SMILES NS(=O)(=O)c1cccc(NS(=O)(=O)c2ccc(F)cc2)c1
Show InChI InChI=1S/C12H11FN2O4S2/c13-9-4-6-11(7-5-9)21(18,19)15-10-2-1-3-12(8-10)20(14,16)17/h1-8,15H,(H2,14,16,17)
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Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...


Bioorg Med Chem 23: 2435-44 (2015)


Article DOI: 10.1016/j.bmc.2015.03.054
BindingDB Entry DOI: 10.7270/Q2WW7KC8
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50165140
PNG
(CHEMBL3797297)
Show SMILES COC1Oc2ccc(C)cc2C(=O)\C1=C/Nc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C18H18N2O5S/c1-11-7-8-15-12(9-11)17(21)13(18(24-2)25-15)10-20-14-5-3-4-6-16(14)26(19,22)23/h3-10,18,20H,1-2H3,(H2,19,22,23)/b13-10+
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n/an/a 180n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine tissue non-specific alkaline phosphatase preincubated for 3 to 5 mins followed by CDP-star substrate addition measured after 15 ...


Eur J Med Chem 115: 484-94 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.073
BindingDB Entry DOI: 10.7270/Q2K939D7
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50428400
PNG
(CA inhibitor, 2 | CHEMBL182659 | [(4-Methylphenyl)...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C13H13NO2S/c1-11-7-9-13(10-8-11)17(15,16)14-12-5-3-2-4-6-12/h2-10,14H,1H3
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n/an/a 180n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...


Bioorg Med Chem 23: 2435-44 (2015)


Article DOI: 10.1016/j.bmc.2015.03.054
BindingDB Entry DOI: 10.7270/Q2WW7KC8
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222179
PNG
(6-(Dimethylamino)-3-phenyl-2,3-dihydronaphtho[1,8-...)
Show SMILES CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1ccccc1
Show InChI InChI=1S/C19H18N2O2S/c1-21(2)16-12-11-15-18-14(16)9-6-10-17(18)24(22,23)20-19(15)13-7-4-3-5-8-13/h3-12,19-20H,1-2H3
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n/an/a 190n/an/an/an/a9.837



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222188
PNG
(6-(Dimethylamino)-3-(4'-hydroxy-3'-methoxy...)
Show SMILES COc1cc(ccc1O)C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C
Show InChI InChI=1S/C20H20N2O4S/c1-22(2)15-9-8-14-19-13(15)5-4-6-18(19)27(24,25)21-20(14)12-7-10-16(23)17(11-12)26-3/h4-11,20-21,23H,1-3H3
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University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222189
PNG
(6-(Dimethylamino)-3-(3'-hydroxy-4'-methoxy...)
Show SMILES COc1ccc(cc1O)C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C
Show InChI InChI=1S/C20H20N2O4S/c1-22(2)15-9-8-14-19-13(15)5-4-6-18(19)27(24,25)21-20(14)12-7-10-17(26-3)16(23)11-12/h4-11,20-21,23H,1-3H3
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n/an/a 270n/an/an/an/a9.837



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222185
PNG
(6-(Dimethylamino)-3-(3',5'-dichloro-2-hydr...)
Show SMILES CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1cc(Cl)cc(Cl)c1O
Show InChI InChI=1S/C19H16Cl2N2O3S/c1-23(2)15-7-6-12-17-11(15)4-3-5-16(17)27(25,26)22-18(12)13-8-10(20)9-14(21)19(13)24/h3-9,18,22,24H,1-2H3
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n/an/a 270n/an/an/an/a9.837



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222190
PNG
(6-(Dimethylamino)-3-(3'-bromo-4'-methoxyph...)
Show SMILES COc1ccc(cc1Br)C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C
Show InChI InChI=1S/C20H19BrN2O3S/c1-23(2)16-9-8-14-19-13(16)5-4-6-18(19)27(24,25)22-20(14)12-7-10-17(26-3)15(21)11-12/h4-11,20,22H,1-3H3
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n/an/a 300n/an/an/an/a9.837



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50068230
PNG
(CHEMBL3403329)
Show SMILES CCOc1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C15H17NO3S/c1-3-19-14-8-6-13(7-9-14)16-20(17,18)15-10-4-12(2)5-11-15/h4-11,16H,3H2,1-2H3
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n/an/a 310n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...


Bioorg Med Chem 23: 2435-44 (2015)


Article DOI: 10.1016/j.bmc.2015.03.054
BindingDB Entry DOI: 10.7270/Q2WW7KC8
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222187
PNG
(6-(Dimethylamino)-3-(2'-methoxyphenyl)-2,3-dih...)
Show SMILES COc1ccccc1C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C
Show InChI InChI=1S/C20H20N2O3S/c1-22(2)16-12-11-15-19-13(16)8-6-10-18(19)26(23,24)21-20(15)14-7-4-5-9-17(14)25-3/h4-12,20-21H,1-3H3
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University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM223077
PNG
((E)-N'-(4'-Hydroxy-3-methoxybenzylidene)is...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccncc2)ccc1O
Show InChI InChI=1S/C14H13N3O3/c1-20-13-8-10(2-3-12(13)18)9-16-17-14(19)11-4-6-15-7-5-11/h2-9,18H,1H3,(H,17,19)/b16-9+
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n/an/a 350n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222180
PNG
(6-(Dimethylamino)-3-(4'-dichlorophenyl)-2,3-di...)
Show SMILES CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H17ClN2O2S/c1-22(2)16-11-10-15-18-14(16)4-3-5-17(18)25(23,24)21-19(15)12-6-8-13(20)9-7-12/h3-11,19,21H,1-2H3
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University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222191
PNG
(6-(Dimethylamino)-3-(5'-bromo-2'-hydroxy-3...)
Show SMILES COc1cc(Br)c(cc1O)C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C
Show InChI InChI=1S/C20H19BrN2O4S/c1-23(2)15-8-7-12-19-11(15)5-4-6-18(19)28(25,26)22-20(12)13-9-16(24)17(27-3)10-14(13)21/h4-10,20,22,24H,1-3H3
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University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222181
PNG
(6-(Dimethylamino)-3-(4'-methylphenyl)-2,3-dihy...)
Show SMILES CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1ccc(C)cc1
Show InChI InChI=1S/C20H20N2O2S/c1-13-7-9-14(10-8-13)20-16-11-12-17(22(2)3)15-5-4-6-18(19(15)16)25(23,24)21-20/h4-12,20-21H,1-3H3
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University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222182
PNG
(6-(Dimethylamino)-3-(4'-hydroxyphenyl)-2,3-dih...)
Show SMILES CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1ccc(O)cc1
Show InChI InChI=1S/C19H18N2O3S/c1-21(2)16-11-10-15-18-14(16)4-3-5-17(18)25(23,24)20-19(15)12-6-8-13(22)9-7-12/h3-11,19-20,22H,1-2H3
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University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222192
PNG
(6-(Dimethylamino)-3-(2',3',4'-trimetho...)
Show SMILES COc1ccc(C2NS(=O)(=O)c3cccc4c(ccc2c34)N(C)C)c(OC)c1OC
Show InChI InChI=1S/C22H24N2O5S/c1-24(2)16-11-9-14-19-13(16)7-6-8-18(19)30(25,26)23-20(14)15-10-12-17(27-3)22(29-5)21(15)28-4/h6-12,20,23H,1-5H3
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University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM223074
PNG
((E)-N'-(4'-Methoxybenzylidene)isonicotinoh...)
Show SMILES COc1ccc(\C=N\NC(=O)c2ccncc2)cc1
Show InChI InChI=1S/C14H13N3O2/c1-19-13-4-2-11(3-5-13)10-16-17-14(18)12-6-8-15-9-7-12/h2-10H,1H3,(H,17,18)/b16-10+
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Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50068220
PNG
(CHEMBL3403320)
Show SMILES NS(=O)(=O)c1ccc(CNC(=O)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C14H13FN2O3S/c15-12-5-3-11(4-6-12)14(18)17-9-10-1-7-13(8-2-10)21(16,19)20/h1-8H,9H2,(H,17,18)(H2,16,19,20)
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Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...


Bioorg Med Chem 23: 2435-44 (2015)


Article DOI: 10.1016/j.bmc.2015.03.054
BindingDB Entry DOI: 10.7270/Q2WW7KC8
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222191
PNG
(6-(Dimethylamino)-3-(5'-bromo-2'-hydroxy-3...)
Show SMILES COc1cc(Br)c(cc1O)C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C
Show InChI InChI=1S/C20H19BrN2O4S/c1-23(2)15-8-7-12-19-11(15)5-4-6-18(19)28(25,26)22-20(12)13-9-16(24)17(27-3)10-14(13)21/h4-10,20,22,24H,1-3H3
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University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM223080
PNG
((E)-N'-(1-(3-(4-fluorophenyl)-5-phenyl-4,5-dih...)
Show SMILES C\C(=N/NC(=O)c1ccncc1)N1N=C(CC1c1ccccc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H20FN5O/c1-16(26-27-23(30)19-11-13-25-14-12-19)29-22(18-5-3-2-4-6-18)15-21(28-29)17-7-9-20(24)10-8-17/h2-14,22H,15H2,1H3,(H,27,30)/b26-16+
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n/an/a 1.06E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222192
PNG
(6-(Dimethylamino)-3-(2',3',4'-trimetho...)
Show SMILES COc1ccc(C2NS(=O)(=O)c3cccc4c(ccc2c34)N(C)C)c(OC)c1OC
Show InChI InChI=1S/C22H24N2O5S/c1-24(2)16-11-9-14-19-13(16)7-6-8-18(19)30(25,26)23-20(14)15-10-12-17(27-3)22(29-5)21(15)28-4/h6-12,20,23H,1-5H3
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n/an/a 1.19E+3n/an/an/an/a9.837



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50234702
PNG
(CHEMBL4066927)
Show SMILES CC(c1ccccc1)n1c(-c2ccc(C)cc2)c(Br)c(=O)c2cc(ccc12)[N+]([O-])=O
Show InChI InChI=1S/C24H19BrN2O3/c1-15-8-10-18(11-9-15)23-22(25)24(28)20-14-19(27(29)30)12-13-21(20)26(23)16(2)17-6-4-3-5-7-17/h3-14,16H,1-2H3
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n/an/a 1.34E+3n/an/an/an/an/an/a



Universit£t Rostock

Curated by ChEMBL


Assay Description
Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...


Eur J Med Chem 126: 408-420 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.036
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222184
PNG
(6-(Dimethylamino)-3-(3'-nitrophenyl)-2,3-dihyd...)
Show SMILES CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C19H17N3O4S/c1-21(2)16-10-9-15-18-14(16)7-4-8-17(18)27(25,26)20-19(15)12-5-3-6-13(11-12)22(23)24/h3-11,19-20H,1-2H3
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n/an/a 1.45E+3n/an/an/an/a9.837



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50165131
PNG
(CHEMBL3797468)
Show SMILES COC1Oc2ccc(F)cc2C(=O)\C1=C/Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C17H15FN2O5S/c1-24-17-14(16(21)13-7-10(18)5-6-15(13)25-17)9-20-11-3-2-4-12(8-11)26(19,22)23/h2-9,17,20H,1H3,(H2,19,22,23)/b14-9+
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n/an/a 1.46E+3n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine tissue non-specific alkaline phosphatase preincubated for 3 to 5 mins followed by CDP-star substrate addition measured after 15 ...


Eur J Med Chem 115: 484-94 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.073
BindingDB Entry DOI: 10.7270/Q2K939D7
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50234719
PNG
(CHEMBL4062180)
Show SMILES CCCCCc1cc(=O)c2cc(ccc2n1Cc1ccc(OC)cc1)[N+]([O-])=O
Show InChI InChI=1S/C22H24N2O4/c1-3-4-5-6-17-14-22(25)20-13-18(24(26)27)9-12-21(20)23(17)15-16-7-10-19(28-2)11-8-16/h7-14H,3-6,15H2,1-2H3
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n/an/a 1.51E+3n/an/an/an/an/an/a



Universit£t Rostock

Curated by ChEMBL


Assay Description
Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...


Eur J Med Chem 126: 408-420 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.036
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50234703
PNG
(CHEMBL4104578)
Show SMILES CCc1ccc(cc1)-c1c(-c2ccc(C)cc2)n(Cc2ccc(OC)cc2)c2ccc(cc2c1=O)[N+]([O-])=O
Show InChI InChI=1S/C32H28N2O4/c1-4-22-7-13-24(14-8-22)30-31(25-11-5-21(2)6-12-25)33(20-23-9-16-27(38-3)17-10-23)29-18-15-26(34(36)37)19-28(29)32(30)35/h5-19H,4,20H2,1-3H3
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n/an/a 1.66E+3n/an/an/an/an/an/a



Universit£t Rostock

Curated by ChEMBL


Assay Description
Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...


Eur J Med Chem 126: 408-420 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.036
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222189
PNG
(6-(Dimethylamino)-3-(3'-hydroxy-4'-methoxy...)
Show SMILES COc1ccc(cc1O)C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C
Show InChI InChI=1S/C20H20N2O4S/c1-22(2)15-9-8-14-19-13(15)5-4-6-18(19)27(24,25)21-20(14)12-7-10-17(26-3)16(23)11-12/h4-11,20-21,23H,1-3H3
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n/an/a 1.69E+3n/an/an/an/a9.837



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM223076
PNG
((E)-N'-(3'-Nitrobenzylidene)isonicotinohyd...)
Show SMILES [O-][N+](=O)c1cccc(\C=N\NC(=O)c2ccncc2)c1
Show InChI InChI=1S/C13H10N4O3/c18-13(11-4-6-14-7-5-11)16-15-9-10-2-1-3-12(8-10)17(19)20/h1-9H,(H,16,18)/b15-9+
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n/an/a 1.82E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50068227
PNG
(CHEMBL3403325)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C13H14N2O4S2/c1-10-5-7-12(8-6-10)21(18,19)15-11-3-2-4-13(9-11)20(14,16)17/h2-9,15H,1H3,(H2,14,16,17)
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n/an/a 2.24E+3n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...


Bioorg Med Chem 23: 2435-44 (2015)


Article DOI: 10.1016/j.bmc.2015.03.054
BindingDB Entry DOI: 10.7270/Q2WW7KC8
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM223073
PNG
((E)-N'-(4'-Fluorobenzylidene)isonicotinohy...)
Show SMILES Fc1ccc(\C=N\NC(=O)c2ccncc2)cc1
Show InChI InChI=1S/C13H10FN3O/c14-12-3-1-10(2-4-12)9-16-17-13(18)11-5-7-15-8-6-11/h1-9H,(H,17,18)/b16-9+
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n/an/a 2.26E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50234721
PNG
(CHEMBL4081390)
Show SMILES COc1ccc(Cn2c(-c3ccc(C)cc3)c(-c3ccccc3C=O)c(=O)c3cc(ccc23)[N+]([O-])=O)cc1
Show InChI InChI=1S/C31H24N2O5/c1-20-7-11-22(12-8-20)30-29(26-6-4-3-5-23(26)19-34)31(35)27-17-24(33(36)37)13-16-28(27)32(30)18-21-9-14-25(38-2)15-10-21/h3-17,19H,18H2,1-2H3
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n/an/a 2.35E+3n/an/an/an/an/an/a



Universit£t Rostock

Curated by ChEMBL


Assay Description
Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...


Eur J Med Chem 126: 408-420 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.036
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM223079
PNG
((E)-N'-(Pyridin-3'-ylmethylene)isonicotino...)
Show SMILES O=C(N\N=C\c1cccnc1)c1ccncc1
Show InChI InChI=1S/C12H10N4O/c17-12(11-3-6-13-7-4-11)16-15-9-10-2-1-5-14-8-10/h1-9H,(H,16,17)/b15-9+
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n/an/a 2.43E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50234710
PNG
(CHEMBL4084870)
Show SMILES Cc1ccc(cc1)-c1cc(=O)c2cc(ccc2[nH]1)[N+]([O-])=O
Show InChI InChI=1S/C16H12N2O3/c1-10-2-4-11(5-3-10)15-9-16(19)13-8-12(18(20)21)6-7-14(13)17-15/h2-9H,1H3,(H,17,19)
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n/an/a 2.56E+3n/an/an/an/an/an/a



Universit£t Rostock

Curated by ChEMBL


Assay Description
Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...


Eur J Med Chem 126: 408-420 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.036
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50234713
PNG
(CHEMBL4077772)
Show SMILES Cc1ccc(cc1)-c1[nH]c2ccc(cc2c(=O)c1-c1ccc(cc1)C(F)(F)F)[N+]([O-])=O
Show InChI InChI=1S/C23H15F3N2O3/c1-13-2-4-15(5-3-13)21-20(14-6-8-16(9-7-14)23(24,25)26)22(29)18-12-17(28(30)31)10-11-19(18)27-21/h2-12H,1H3,(H,27,29)
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n/an/a 2.69E+3n/an/an/an/an/an/a



Universit£t Rostock

Curated by ChEMBL


Assay Description
Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...


Eur J Med Chem 126: 408-420 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.036
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50068228
PNG
(CHEMBL3403317)
Show SMILES NS(=O)(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O3S/c15-20(18,19)13-8-6-11(7-9-13)10-16-14(17)12-4-2-1-3-5-12/h1-9H,10H2,(H,16,17)(H2,15,18,19)
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n/an/a 2.87E+3n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...


Bioorg Med Chem 23: 2435-44 (2015)


Article DOI: 10.1016/j.bmc.2015.03.054
BindingDB Entry DOI: 10.7270/Q2WW7KC8
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50247721
PNG
(4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide |...)
Show SMILES NS(=O)(=O)c1ccc(CNS(=O)(=O)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C13H13FN2O4S2/c14-11-3-7-13(8-4-11)22(19,20)16-9-10-1-5-12(6-2-10)21(15,17)18/h1-8,16H,9H2,(H2,15,17,18)
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n/an/a 2.94E+3n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...


Bioorg Med Chem 23: 2435-44 (2015)


Article DOI: 10.1016/j.bmc.2015.03.054
BindingDB Entry DOI: 10.7270/Q2WW7KC8
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM16661
PNG
(1-N-(4-fluorobenzene)benzene-1,4-disulfonamide | a...)
Show SMILES NS(=O)(=O)c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C12H11FN2O4S2/c13-9-1-5-12(6-2-9)21(18,19)15-10-3-7-11(8-4-10)20(14,16)17/h1-8,15H,(H2,14,16,17)
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n/an/a 3.26E+3n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...


Bioorg Med Chem 23: 2435-44 (2015)


Article DOI: 10.1016/j.bmc.2015.03.054
BindingDB Entry DOI: 10.7270/Q2WW7KC8
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM222190
PNG
(6-(Dimethylamino)-3-(3'-bromo-4'-methoxyph...)
Show SMILES COc1ccc(cc1Br)C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C
Show InChI InChI=1S/C20H19BrN2O3S/c1-23(2)16-9-8-14-19-13(16)5-4-6-18(19)27(24,25)22-20(14)12-7-10-17(26-3)15(21)11-12/h4-11,20,22H,1-3H3
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n/an/a 3.48E+3n/an/an/an/a9.837



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50165136
PNG
(CHEMBL3800429)
Show SMILES COC1Oc2c(Cl)cc(Cl)cc2C(=O)\C1=C/Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C17H14Cl2N2O5S/c1-25-17-13(8-21-10-3-2-4-11(7-10)27(20,23)24)15(22)12-5-9(18)6-14(19)16(12)26-17/h2-8,17,21H,1H3,(H2,20,23,24)/b13-8+
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n/an/a 3.52E+3n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine tissue non-specific alkaline phosphatase preincubated for 3 to 5 mins followed by CDP-star substrate addition measured after 15 ...


Eur J Med Chem 115: 484-94 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.073
BindingDB Entry DOI: 10.7270/Q2K939D7
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM223072
PNG
((E)-N'-(4'-Bromobenzylidene)isonicotinohyd...)
Show SMILES Brc1ccc(\C=N\NC(=O)c2ccncc2)cc1
Show InChI InChI=1S/C13H10BrN3O/c14-12-3-1-10(2-4-12)9-16-17-13(18)11-5-7-15-8-6-11/h1-9H,(H,17,18)/b16-9+
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n/an/a 4.13E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50234701
PNG
(CHEMBL4094414)
Show SMILES COc1ccc(Cn2c(-c3ccc(C)cc3)c(Br)c(=O)c3cc(ccc23)[N+]([O-])=O)cc1
Show InChI InChI=1S/C24H19BrN2O4/c1-15-3-7-17(8-4-15)23-22(25)24(28)20-13-18(27(29)30)9-12-21(20)26(23)14-16-5-10-19(31-2)11-6-16/h3-13H,14H2,1-2H3
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n/an/a 4.22E+3n/an/an/an/an/an/a



Universit£t Rostock

Curated by ChEMBL


Assay Description
Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...


Eur J Med Chem 126: 408-420 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.036
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50234709
PNG
(CHEMBL4090195)
Show SMILES COc1ccc(Cn2c(-c3ccc(C)cc3)c(c(=O)c3cc(ccc23)[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C25H19F3N2O4/c1-15-3-7-17(8-4-15)23-22(25(26,27)28)24(31)20-13-18(30(32)33)9-12-21(20)29(23)14-16-5-10-19(34-2)11-6-16/h3-13H,14H2,1-2H3
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n/an/a 4.53E+3n/an/an/an/an/an/a



Universit£t Rostock

Curated by ChEMBL


Assay Description
Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...


Eur J Med Chem 126: 408-420 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.036
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50165145
PNG
(CHEMBL3800455)
Show SMILES CCCCOC1Oc2ccccc2C(=O)\C1=C/Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C20H22N2O5S/c1-2-3-12-26-20-17(19(23)16-6-4-5-7-18(16)27-20)13-22-14-8-10-15(11-9-14)28(21,24)25/h4-11,13,20,22H,2-3,12H2,1H3,(H2,21,24,25)/b17-13+
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n/an/a 4.57E+3n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine tissue non-specific alkaline phosphatase preincubated for 3 to 5 mins followed by CDP-star substrate addition measured after 15 ...


Eur J Med Chem 115: 484-94 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.073
BindingDB Entry DOI: 10.7270/Q2K939D7
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50234704
PNG
(CHEMBL4096018)
Show SMILES COc1ccc(Cn2c(-c3ccc(C)cc3)c(-c3cc(C)cc(C)c3)c(=O)c3cc(ccc23)[N+]([O-])=O)cc1
Show InChI InChI=1S/C32H28N2O4/c1-20-5-9-24(10-6-20)31-30(25-16-21(2)15-22(3)17-25)32(35)28-18-26(34(36)37)11-14-29(28)33(31)19-23-7-12-27(38-4)13-8-23/h5-18H,19H2,1-4H3
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n/an/a 4.74E+3n/an/an/an/an/an/a



Universit£t Rostock

Curated by ChEMBL


Assay Description
Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...


Eur J Med Chem 126: 408-420 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.036
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50165137
PNG
(CHEMBL3800324)
Show SMILES COC1Oc2c(Cl)cc(Cl)cc2C(=O)\C1=C/Nc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C17H14Cl2N2O5S/c1-25-17-11(8-21-13-4-2-3-5-14(13)27(20,23)24)15(22)10-6-9(18)7-12(19)16(10)26-17/h2-8,17,21H,1H3,(H2,20,23,24)/b11-8+
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n/an/a 5.36E+3n/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine tissue non-specific alkaline phosphatase preincubated for 3 to 5 mins followed by CDP-star substrate addition measured after 15 ...


Eur J Med Chem 115: 484-94 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.073
BindingDB Entry DOI: 10.7270/Q2K939D7
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50234716
PNG
(CHEMBL4104441)
Show SMILES Cc1ccc(cc1)-c1[nH]c2ccc(NC(=O)C(F)(F)F)cc2c(=O)c1-c1ccc(C)cc1
Show InChI InChI=1S/C25H19F3N2O2/c1-14-3-7-16(8-4-14)21-22(17-9-5-15(2)6-10-17)30-20-12-11-18(13-19(20)23(21)31)29-24(32)25(26,27)28/h3-13H,1-2H3,(H,29,32)(H,30,31)
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n/an/a 6.02E+3n/an/an/an/an/an/a



Universit£t Rostock

Curated by ChEMBL


Assay Description
Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...


Eur J Med Chem 126: 408-420 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.036
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50234705
PNG
(CHEMBL4062042)
Show SMILES COc1ccc(Cn2c(-c3ccc(C)cc3)c(-c3ccc(cc3)C(F)(F)F)c(=O)c3cc(ccc23)[N+]([O-])=O)cc1
Show InChI InChI=1S/C31H23F3N2O4/c1-19-3-7-22(8-4-19)29-28(21-9-11-23(12-10-21)31(32,33)34)30(37)26-17-24(36(38)39)13-16-27(26)35(29)18-20-5-14-25(40-2)15-6-20/h3-17H,18H2,1-2H3
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n/an/a 6.19E+3n/an/an/an/an/an/a



Universit£t Rostock

Curated by ChEMBL


Assay Description
Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...


Eur J Med Chem 126: 408-420 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.036
More data for this
Ligand-Target Pair
Tissue non-specific alkaline phosphatase (TNAP)


(Bos taurus (Cattle))
BDBM50234711
PNG
(CHEMBL4066789)
Show SMILES Cc1ccc(cc1)-c1[nH]c2ccc(cc2c(=O)c1Br)[N+]([O-])=O
Show InChI InChI=1S/C16H11BrN2O3/c1-9-2-4-10(5-3-9)15-14(17)16(20)12-8-11(19(21)22)6-7-13(12)18-15/h2-8H,1H3,(H,18,20)
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n/an/a 6.47E+3n/an/an/an/an/an/a



Universit£t Rostock

Curated by ChEMBL


Assay Description
Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...


Eur J Med Chem 126: 408-420 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.036
More data for this
Ligand-Target Pair
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