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Compile Data Set for Download or QSAR

Found 226 hits of ec50 for UniProtKB: P08172   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM50005363
PNG
((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Show SMILES Cc1noc(n1)C1CN2CCC1C2
Show InChI InChI=1S/C9H13N3O/c1-6-10-9(13-11-6)8-5-12-3-2-7(8)4-12/h7-8H,2-5H2,1H3
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n/an/an/an/a 0.0390n/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by Muscarinic M1 receptor)


J Med Chem 35: 911-6 (1992)


Article DOI: 10.1021/jm00083a016
BindingDB Entry DOI: 10.7270/Q2S75F81
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50072225
PNG
((1R,5R,6R)-6-[4-(3-Phenyl-prop-2-ynylsulfanyl)-[1,...)
Show SMILES C(Sc1nsnc1[C@H]1C[N@]2C[C@@H]1CCC2)C#Cc1ccccc1
Show InChI InChI=1S/C18H19N3S2/c1-2-6-14(7-3-1)8-5-11-22-18-17(19-23-20-18)16-13-21-10-4-9-15(16)12-21/h1-3,6-7,15-16H,4,9-13H2/t15-,16-/m0/s1
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n/an/an/an/a 2n/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Stimulation of cAMP in CHO cells expressing human m2 receptor


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM50005363
PNG
((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Show SMILES Cc1noc(n1)C1CN2CCC1C2
Show InChI InChI=1S/C9H13N3O/c1-6-10-9(13-11-6)8-5-12-3-2-7(8)4-12/h7-8H,2-5H2,1H3
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n/an/an/an/a 3.30n/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro negative chronotropic effect of the compound on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)


J Med Chem 35: 911-6 (1992)


Article DOI: 10.1021/jm00083a016
BindingDB Entry DOI: 10.7270/Q2S75F81
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50035277
PNG
(3-Prop-2-ynyloxy-5,6,7,8-tetrahydro-4H-isoxazolo[4...)
Show SMILES C#CCOc1noc2CCCNCc12
Show InChI InChI=1S/C10H12N2O2/c1-2-6-13-10-8-7-11-5-3-4-9(8)14-12-10/h1,11H,3-7H2
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n/an/an/an/a 6.70n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).


J Med Chem 38: 2188-95 (1995)


Article DOI: 10.1021/jm00012a019
BindingDB Entry DOI: 10.7270/Q28K7838
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM10759
PNG
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Show SMILES CC(=O)OCC[N+](C)(C)C
Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
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n/an/an/an/a 7n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay


Bioorg Med Chem Lett 25: 4158-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.011
BindingDB Entry DOI: 10.7270/Q2GM8938
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193819
PNG
(US9670209, Compound 321 1-((R)-3-(3-(cyclopropylme...)
Show SMILES C[C@H](CN1[C@H]2CC[C@@H]1C[C@@H](C2)OCC1CC1)Cn1ncc2cc(C)ccc12
Show InChI InChI=1S/C23H33N3O/c1-16-3-8-23-19(9-16)12-24-26(23)14-17(2)13-25-20-6-7-21(25)11-22(10-20)27-15-18-4-5-18/h3,8-9,12,17-18,20-22H,4-7,10-11,13-15H2,1-2H3/t17-,20-,21+,22+/m1/s1
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n/an/an/an/a 7.90n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50079583
PNG
((R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicy...)
Show SMILES CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2
Show InChI InChI=1S/C16H25N3OS/c1-2-3-4-5-10-21-16-15(17-7-8-18-16)20-14-12-19-9-6-13(14)11-19/h7-8,13-14H,2-6,9-12H2,1H3/t13?,14-/m0/s1
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n/an/an/an/a 8n/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro functional agonism against M2 muscarinic receptor (cAMP)


Bioorg Med Chem Lett 9: 1895-900 (1999)


Article DOI: 10.1016/s0960-894x(99)00313-3
BindingDB Entry DOI: 10.7270/Q2G161CX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50072227
PNG
((1R,5R,6R)-6-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]t...)
Show SMILES C(Oc1nsnc1[C@H]1C[N@]2C[C@@H]1CCC2)C#Cc1ccccc1
Show InChI InChI=1S/C18H19N3OS/c1-2-6-14(7-3-1)8-5-11-22-18-17(19-23-20-18)16-13-21-10-4-9-15(16)12-21/h1-3,6-7,15-16H,4,9-13H2/t15-,16-/m0/s1
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n/an/an/an/a 9n/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Stimulation of cAMP in CHO cells expressing human m2 receptor


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50072214
PNG
((R)-3-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiaz...)
Show SMILES C(Oc1nsnc1[C@H]1CN2CCC1C2)C#Cc1ccccc1
Show InChI InChI=1S/C17H17N3OS/c1-2-5-13(6-3-1)7-4-10-21-17-16(18-22-19-17)15-12-20-9-8-14(15)11-20/h1-3,5-6,14-15H,8-12H2/t14?,15-/m0/s1
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n/an/an/an/a 11n/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Stimulation of cAMP in CHO cells expressing human m2 receptor


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50275588
PNG
(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-...)
Show SMILES NC(=O)OCCN1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C20H29N5O3/c21-19(26)28-14-13-23-9-5-15(6-10-23)24-11-7-16(8-12-24)25-18-4-2-1-3-17(18)22-20(25)27/h1-4,15-16H,5-14H2,(H2,21,26)(H,22,27)
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n/an/an/an/a 11.9n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M2 receptor (unknown origin)


Bioorg Med Chem Lett 18: 5443-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.032
BindingDB Entry DOI: 10.7270/Q29K4B1C
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50263888
PNG
(CHEMBL491209 | Ethyl 4-(2-oxo-2,3-dihydro-1Hbenzo[...)
Show SMILES CCOC(=O)N1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C20H28N4O3/c1-2-27-20(26)23-13-7-15(8-14-23)22-11-9-16(10-12-22)24-18-6-4-3-5-17(18)21-19(24)25/h3-6,15-16H,2,7-14H2,1H3,(H,21,25)
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n/an/an/an/a 11.9n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M2 receptor (unknown origin)


Bioorg Med Chem Lett 18: 5439-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.023
BindingDB Entry DOI: 10.7270/Q2708198
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193825
PNG
(US9670209, Compound 324 1-((R)-3-((1R,3R,5S)-3-(2-...)
Show SMILES CCOCC[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@@H](C)Cn1ncc2ccc(C)cc12
Show InChI InChI=1S/C23H35N3O/c1-4-27-10-9-19-12-21-7-8-22(13-19)25(21)15-18(3)16-26-23-11-17(2)5-6-20(23)14-24-26/h5-6,11,14,18-19,21-22H,4,7-10,12-13,15-16H2,1-3H3/t18-,19-,21+,22-/m1/s1
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n/an/an/an/a 13n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50005364
PNG
((3S,4R)3-Methyl-3-(3-methyl-[1,2,4]oxadiazol-5-yl)...)
Show SMILES Cc1noc(n1)C1(C)CN2CCC1C2
Show InChI InChI=1S/C10H15N3O/c1-7-11-9(14-12-7)10(2)6-13-4-3-8(10)5-13/h8H,3-6H2,1-2H3
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n/an/an/an/a 14n/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro negative chronotropic effect of the compound on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)


J Med Chem 35: 911-6 (1992)


Article DOI: 10.1021/jm00083a016
BindingDB Entry DOI: 10.7270/Q2S75F81
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human)-HUMAN M3)
BDBM50226767
PNG
(CHEMBL160553)
Show SMILES [Br-].C[N+]1(CC#CCN2CCCC2=O)CC1
Show InChI InChI=1S/C11H17N2O.BrH/c1-13(9-10-13)8-3-2-6-12-7-4-5-11(12)14;/h4-10H2,1H3;1H/q+1;/p-1
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n/an/an/an/a 16n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effective dose (10 nM) to determine muscarinic nature of the contractile response in guinea pig ileum, when methylatropine was competitively anatgoni...


J Med Chem 30: 852-4 (1987)


Article DOI: 10.1021/jm00388a018
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193823
PNG
(US9670209, Compound 323 1-((R)-3-((1R,3R,5S)-3-(2-...)
Show SMILES CCOCC[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@@H](C)Cn1ncc2ccccc12
Show InChI InChI=1S/C22H33N3O/c1-3-26-11-10-18-12-20-8-9-21(13-18)24(20)15-17(2)16-25-22-7-5-4-6-19(22)14-23-25/h4-7,14,17-18,20-21H,3,8-13,15-16H2,1-2H3/t17-,18-,20+,21-/m1/s1
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n/an/an/an/a 16n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50005363
PNG
((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Show SMILES Cc1noc(n1)C1CN2CCC1C2
Show InChI InChI=1S/C9H13N3O/c1-6-10-9(13-11-6)8-5-12-3-2-7(8)4-12/h7-8H,2-5H2,1H3
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n/an/an/an/a 19n/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro negative chronotropic effect of the compound on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)


J Med Chem 35: 911-6 (1992)


Article DOI: 10.1021/jm00083a016
BindingDB Entry DOI: 10.7270/Q2S75F81
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50004665
PNG
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Show SMILES O=C1CCCN1CC#CCN1CCCC1
Show InChI InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
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n/an/an/an/a 19n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).


J Med Chem 38: 2188-95 (1995)


Article DOI: 10.1021/jm00012a019
BindingDB Entry DOI: 10.7270/Q28K7838
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50416732
PNG
(CHEMBL1223754)
Show SMILES CCCO[C@H]1CC[C@@](C)(CC1)N1CCC(CC1)n1c2cc(C)c(F)cc2[nH]c1=O
Show InChI InChI=1S/C23H34FN3O2/c1-4-13-29-18-5-9-23(3,10-6-18)26-11-7-17(8-12-26)27-21-14-16(2)19(24)15-20(21)25-22(27)28/h14-15,17-18H,4-13H2,1-3H3,(H,25,28)/t18-,23-
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n/an/an/an/a 19.9n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimaeric G-protein assessed as effect on calcium mobiliza...


Bioorg Med Chem Lett 20: 5434-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.097
BindingDB Entry DOI: 10.7270/Q2MG7QR7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193789
PNG
(US9670209, Compound 307 1-((R)-3-(3-(Cyclopropylme...)
Show SMILES C[C@H](CN1[C@H]2CC[C@@H]1C[C@@H](C2)OCC1CC1)Cn1ncc2ccc(F)cc12
Show InChI InChI=1S/C22H30FN3O/c1-15(13-26-22-8-18(23)5-4-17(22)11-24-26)12-25-19-6-7-20(25)10-21(9-19)27-14-16-2-3-16/h4-5,8,11,15-16,19-21H,2-3,6-7,9-10,12-14H2,1H3/t15-,19-,20+,21+/m1/s1
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n/an/an/an/a 20n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50119647
PNG
(CHEMBL3616504)
Show SMILES CN1CCCC\C1=N/c1ccc2C[C@@H](O)[C@H](NC(=O)c3ccc(Br)cc3)c2c1
Show InChI InChI=1S/C22H24BrN3O2/c1-26-11-3-2-4-20(26)24-17-10-7-15-12-19(27)21(18(15)13-17)25-22(28)14-5-8-16(23)9-6-14/h5-10,13,19,21,27H,2-4,11-12H2,1H3,(H,25,28)/b24-20+/t19-,21-/m1/s1
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n/an/an/an/a 24n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay


Bioorg Med Chem Lett 25: 4158-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.011
BindingDB Entry DOI: 10.7270/Q2GM8938
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193787
PNG
(US9670209, Compound 304 1-((R)-3-(3-(Cyclopropylme...)
Show SMILES C[C@H](CN1[C@H]2CC[C@@H]1C[C@@H](C2)OCC1CC1)Cn1ncc2ccc(C)cc12
Show InChI InChI=1S/C23H33N3O/c1-16-3-6-19-12-24-26(23(19)9-16)14-17(2)13-25-20-7-8-21(25)11-22(10-20)27-15-18-4-5-18/h3,6,9,12,17-18,20-22H,4-5,7-8,10-11,13-15H2,1-2H3/t17-,20-,21+,22+/m1/s1
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n/an/an/an/a 25n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193787
PNG
(US9670209, Compound 304 1-((R)-3-(3-(Cyclopropylme...)
Show SMILES C[C@H](CN1[C@H]2CC[C@@H]1C[C@@H](C2)OCC1CC1)Cn1ncc2ccc(C)cc12
Show InChI InChI=1S/C23H33N3O/c1-16-3-6-19-12-24-26(23(19)9-16)14-17(2)13-25-20-7-8-21(25)11-22(10-20)27-15-18-4-5-18/h3,6,9,12,17-18,20-22H,4-5,7-8,10-11,13-15H2,1-2H3/t17-,20-,21+,22+/m1/s1
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n/an/an/an/a 25n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193784
PNG
(US9670209, Compound 302 1-((R)-3-((1R,3R,5S)-3-(cy...)
Show SMILES C[C@H](CN1[C@H]2CC[C@@H]1C[C@@H](C2)OCC1CC1)Cn1ncc2ccccc12
Show InChI InChI=1S/C22H31N3O/c1-16(14-25-22-5-3-2-4-18(22)12-23-25)13-24-19-8-9-20(24)11-21(10-19)26-15-17-6-7-17/h2-5,12,16-17,19-21H,6-11,13-15H2,1H3/t16-,19-,20+,21+/m1/s1
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n/an/an/an/a 25n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM46858
PNG
(1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid...)
Show SMILES COC(=O)C1=CCCN(C)C1
Show InChI InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3
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n/an/an/an/a 25n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).


J Med Chem 38: 2188-95 (1995)


Article DOI: 10.1021/jm00012a019
BindingDB Entry DOI: 10.7270/Q28K7838
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50072227
PNG
((1R,5R,6R)-6-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]t...)
Show SMILES C(Oc1nsnc1[C@H]1C[N@]2C[C@@H]1CCC2)C#Cc1ccccc1
Show InChI InChI=1S/C18H19N3OS/c1-2-6-14(7-3-1)8-5-11-22-18-17(19-23-20-18)16-13-21-10-4-9-15(16)12-21/h1-3,6-7,15-16H,4,9-13H2/t15-,16-/m0/s1
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n/an/an/an/a 29n/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Stimulation of cAMP in CHO cells expressing human m2 receptor


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193815
PNG
(US9670209, Compound 319 1-((R)-3-(3-(propoxy)-8-az...)
Show SMILES CCCO[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@@H](C)Cn1ncc2ccccc12
Show InChI InChI=1S/C21H31N3O/c1-3-10-25-20-11-18-8-9-19(12-20)23(18)14-16(2)15-24-21-7-5-4-6-17(21)13-22-24/h4-7,13,16,18-20H,3,8-12,14-15H2,1-2H3/t16-,18-,19+,20+/m1/s1
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n/an/an/an/a 32n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human)-HUMAN M3)
BDBM50046728
PNG
(1-Methyl-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-1,2,3,...)
Show SMILES CN1CCC=C(C1)c1nc(C)no1
Show InChI InChI=1S/C9H13N3O/c1-7-10-9(13-11-7)8-4-3-5-12(2)6-8/h4H,3,5-6H2,1-2H3
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n/an/an/an/a 32n/an/an/an/a



Ferrosan A/S

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.


J Med Chem 34: 687-92 (1991)


Article DOI: 10.1021/jm00106a033
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193791
PNG
(US9670209, Compound 309 1-((R)-3-(3-(2-Methoxyethy...)
Show SMILES COCC[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@@H](C)Cn1ncc2ccc(F)cc12
Show InChI InChI=1S/C21H30FN3O/c1-15(14-25-21-11-18(22)4-3-17(21)12-23-25)13-24-19-5-6-20(24)10-16(9-19)7-8-26-2/h3-4,11-12,15-16,19-20H,5-10,13-14H2,1-2H3/t15-,16-,19+,20-/m1/s1
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n/an/an/an/a 32n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193802
PNG
(US9670209, Compound 312 1-((R)-3-(3-(cyclopropylme...)
Show SMILES COCC[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@@H](C)Cn1ncc2ccc(C)cc12
Show InChI InChI=1S/C22H33N3O/c1-16-4-5-19-13-23-25(22(19)10-16)15-17(2)14-24-20-6-7-21(24)12-18(11-20)8-9-26-3/h4-5,10,13,17-18,20-21H,6-9,11-12,14-15H2,1-3H3/t17-,18-,20+,21-/m1/s1
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n/an/an/an/a 32n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193790
PNG
(US9670209, Compound 308 1-((R)-3-(3-(Allyloxy)-8-a...)
Show SMILES C[C@H](CN1[C@H]2CC[C@@H]1C[C@@H](C2)OCC=C)Cn1ncc2ccc(F)cc12
Show InChI InChI=1S/C21H28FN3O/c1-3-8-26-20-10-18-6-7-19(11-20)24(18)13-15(2)14-25-21-9-17(22)5-4-16(21)12-23-25/h3-5,9,12,15,18-20H,1,6-8,10-11,13-14H2,2H3/t15-,18-,19+,20+/m1/s1
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n/an/an/an/a 40n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50035278
PNG
(3-Ethoxy-5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]aze...)
Show SMILES CCOc1noc2CCCNCc12
Show InChI InChI=1S/C9H14N2O2/c1-2-12-9-7-6-10-5-3-4-8(7)13-11-9/h10H,2-6H2,1H3
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n/an/an/an/a 41n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).


J Med Chem 38: 2188-95 (1995)


Article DOI: 10.1021/jm00012a019
BindingDB Entry DOI: 10.7270/Q28K7838
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50035279
PNG
(3-Methoxy-5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]az...)
Show SMILES COc1noc2CCCNCc12
Show InChI InChI=1S/C8H12N2O2/c1-11-8-6-5-9-4-2-3-7(6)12-10-8/h9H,2-5H2,1H3
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n/an/an/an/a 43n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).


J Med Chem 38: 2188-95 (1995)


Article DOI: 10.1021/jm00012a019
BindingDB Entry DOI: 10.7270/Q28K7838
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193803
PNG
(US9670209, Compound 313 1-((R)-3-((1R,3R,58)-3-(2-...)
Show SMILES COCC[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@@H](C)Cn1ncc2ccc(OC)cc12
Show InChI InChI=1S/C22H33N3O2/c1-16(15-25-22-12-21(27-3)7-4-18(22)13-23-25)14-24-19-5-6-20(24)11-17(10-19)8-9-26-2/h4,7,12-13,16-17,19-20H,5-6,8-11,14-15H2,1-3H3/t16-,17-,19+,20-/m1/s1
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n/an/an/an/a 50n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193804
PNG
(US9670209, Compound 314 1-((R)-3-((1R,3R,58)-3-(cy...)
Show SMILES C[C@H](CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC1CCCC1)Cn1ncc2ccccc12
Show InChI InChI=1S/C23H33N3O/c1-17(16-26-23-9-5-2-6-18(23)14-24-26)15-25-19-10-11-20(25)13-22(12-19)27-21-7-3-4-8-21/h2,5-6,9,14,17,19-22H,3-4,7-8,10-13,15-16H2,1H3/t17-,19-,20+,22+/m1/s1
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n/an/an/an/a 50n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193805
PNG
(US9670209, Compound 315 1-((R)-3-(3-(cyclobutylmet...)
Show SMILES C[C@H](CN1[C@H]2CC[C@@H]1C[C@@H](C2)OCC1CCC1)Cn1ncc2ccccc12
Show InChI InChI=1S/C23H33N3O/c1-17(15-26-23-8-3-2-7-19(23)13-24-26)14-25-20-9-10-21(25)12-22(11-20)27-16-18-5-4-6-18/h2-3,7-8,13,17-18,20-22H,4-6,9-12,14-16H2,1H3/t17-,20-,21+,22+/m1/s1
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n/an/an/an/a 50n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50072228
PNG
(3-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3...)
Show SMILES C(Oc1nsnc1C1CN2CCC1CC2)C#Cc1ccccc1
Show InChI InChI=1S/C18H19N3OS/c1-2-5-14(6-3-1)7-4-12-22-18-17(19-23-20-18)16-13-21-10-8-15(16)9-11-21/h1-3,5-6,15-16H,8-13H2
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n/an/an/an/a 62n/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Stimulation of cAMP in CHO cells expressing human m2 receptor


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50061705
PNG
((R)-1-Aza-bicyclo[2.2.2]oct-3-yl-[(Z)-methoxyimino...)
Show SMILES CO\N=C(/C#N)[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C10H15N3O/c1-14-12-10(6-11)9-7-13-4-2-8(9)3-5-13/h8-9H,2-5,7H2,1H3/b12-10+/t9-/m0/s1
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n/an/an/an/a 62n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay


Bioorg Med Chem Lett 25: 4158-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.011
BindingDB Entry DOI: 10.7270/Q2GM8938
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193818
PNG
(US9670209, Compound 320 1-((R)-3-((1R,3R,58)-3-(2-...)
Show SMILES COC\C=C1\C[C@@H]2CC[C@H](C1)N2C[C@@H](C)Cn1ncc2ccccc12
Show InChI InChI=1S/C21H29N3O/c1-16(15-24-21-6-4-3-5-18(21)13-22-24)14-23-19-7-8-20(23)12-17(11-19)9-10-25-2/h3-6,9,13,16,19-20H,7-8,10-12,14-15H2,1-2H3/b17-9-/t16-,19+,20-/m1/s1
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n/an/an/an/a 63n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193808
PNG
(US9670209, Compound 318 1-((R)-3-((1R,3R,5S)-3-(pr...)
Show SMILES C[C@H](CN1[C@H]2CC[C@@H]1C[C@@H](C2)OCC#C)Cn1ncc2ccccc12
Show InChI InChI=1S/C21H27N3O/c1-3-10-25-20-11-18-8-9-19(12-20)23(18)14-16(2)15-24-21-7-5-4-6-17(21)13-22-24/h1,4-7,13,16,18-20H,8-12,14-15H2,2H3/t16-,18-,19+,20+/m1/s1
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n/an/an/an/a 63n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50416733
PNG
(CHEMBL1223803)
Show SMILES CCCO[C@H]1CC[C@@](C)(CC1)N1CCC(CC1)N1C(=O)Cc2ccc(C)cc12
Show InChI InChI=1S/C24H36N2O2/c1-4-15-28-21-7-11-24(3,12-8-21)25-13-9-20(10-14-25)26-22-16-18(2)5-6-19(22)17-23(26)27/h5-6,16,20-21H,4,7-15,17H2,1-3H3/t21-,24-
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n/an/an/an/a 63.1n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimaeric G-protein assessed as effect on calcium mobiliza...


Bioorg Med Chem Lett 20: 5434-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.097
BindingDB Entry DOI: 10.7270/Q2MG7QR7
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50119644
PNG
(CHEMBL3616499)
Show SMILES CN(Cc1ccc(F)cc1)C(\C)=N\c1ccc2C[C@@H](O)[C@H](NC(=O)c3ccc(C)cc3)c2c1
Show InChI InChI=1S/C27H28FN3O2/c1-17-4-8-20(9-5-17)27(33)30-26-24-15-23(13-10-21(24)14-25(26)32)29-18(2)31(3)16-19-6-11-22(28)12-7-19/h4-13,15,25-26,32H,14,16H2,1-3H3,(H,30,33)/b29-18+/t25-,26-/m1/s1
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n/an/an/an/a 65n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay


Bioorg Med Chem Lett 25: 4158-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.011
BindingDB Entry DOI: 10.7270/Q2GM8938
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50119641
PNG
(CHEMBL3618450)
Show SMILES CN(Cc1ccc(F)cc1)C(\C)=N\c1ccc2C[C@@H](O)[C@H](NC(=O)c3ccc(Cl)cc3)c2c1
Show InChI InChI=1S/C26H25ClFN3O2/c1-16(31(2)15-17-3-10-21(28)11-4-17)29-22-12-7-19-13-24(32)25(23(19)14-22)30-26(33)18-5-8-20(27)9-6-18/h3-12,14,24-25,32H,13,15H2,1-2H3,(H,30,33)/b29-16+/t24-,25-/m1/s1
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n/an/an/an/a 66n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay


Bioorg Med Chem Lett 25: 4158-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.011
BindingDB Entry DOI: 10.7270/Q2GM8938
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50119626
PNG
(CHEMBL3618440)
Show SMILES C\C(NCc1ccc(F)cc1)=N/c1ccc2C[C@@H](O)[C@H](NC(=O)c3ccc(Br)cc3)c2c1
Show InChI InChI=1S/C25H23BrFN3O2/c1-15(28-14-16-2-9-20(27)10-3-16)29-21-11-6-18-12-23(31)24(22(18)13-21)30-25(32)17-4-7-19(26)8-5-17/h2-11,13,23-24,31H,12,14H2,1H3,(H,28,29)(H,30,32)/t23-,24-/m1/s1
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n/an/an/an/a 72n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay


Bioorg Med Chem Lett 25: 4158-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.011
BindingDB Entry DOI: 10.7270/Q2GM8938
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human)-HUMAN M3)
BDBM46858
PNG
(1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid...)
Show SMILES COC(=O)C1=CCCN(C)C1
Show InChI InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3
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n/an/an/an/a 73n/an/an/an/a



Ferrosan A/S

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.


J Med Chem 34: 687-92 (1991)


Article DOI: 10.1021/jm00106a033
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50004656
PNG
((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Show SMILES C[N+](C)(C)CCOC(N)=O
Show InChI InChI=1S/C6H14N2O2/c1-8(2,3)4-5-10-6(7)9/h4-5H2,1-3H3,(H-,7,9)/p+1
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n/an/an/an/a 74n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).


J Med Chem 38: 2188-95 (1995)


Article DOI: 10.1021/jm00012a019
BindingDB Entry DOI: 10.7270/Q28K7838
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193834
PNG
(US9670209, Comparative compound 2)
Show SMILES CC(C)(C)OC(=O)N1C2CC[C@H]1C[C@@H](O)C2
Show InChI InChI=1S/C12H21NO3/c1-12(2,3)16-11(15)13-8-4-5-9(13)7-10(14)6-8/h8-10,14H,4-7H2,1-3H3/t8-,9?,10+/m0/s1
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n/an/an/an/a 79n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193785
PNG
(US9670209, Compound 303 1-((R)-3-((1R,3R,5S)-3-(2-...)
Show SMILES COCC[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@@H](C)Cn1ncc2ccccc12
Show InChI InChI=1S/C21H31N3O/c1-16(15-24-21-6-4-3-5-18(21)13-22-24)14-23-19-7-8-20(23)12-17(11-19)9-10-25-2/h3-6,13,16-17,19-20H,7-12,14-15H2,1-2H3/t16-,17-,19+,20-/m1/s1
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n/an/an/an/a 79n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM193820
PNG
(US9670209, Compound 322 1-((R)-3-((1R,3R,5S)-3-(pr...)
Show SMILES COc1ccc2cnn(C[C@H](C)CN3[C@H]4CC[C@@H]3C[C@@H](C4)OCC#C)c2c1
Show InChI InChI=1S/C22H29N3O2/c1-4-9-27-21-10-18-6-7-19(11-21)24(18)14-16(2)15-25-22-12-20(26-3)8-5-17(22)13-23-25/h1,5,8,12-13,16,18-19,21H,6-7,9-11,14-15H2,2-3H3/t16-,18-,19+,21+/m1/s1
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n/an/an/an/a 79n/an/an/an/a



ACADIA PHARMACEUTICALS INC.; ALLERGAN, INC.

US Patent


Assay Description
NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...


US Patent US9670209 (2017)


BindingDB Entry DOI: 10.7270/Q2MS3QX2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50391743
PNG
(CHEMBL2146597)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C18H25N3O/c22-18-19-16-8-4-5-9-17(16)21(18)15-10-12-20(13-11-15)14-6-2-1-3-7-14/h4-5,8-9,14-15H,1-3,6-7,10-13H2,(H,19,22)
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n/an/an/an/a 79.4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization ...


ACS Med Chem Lett 1: 244-248 (2010)


Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50077561
PNG
(1-{4-[3-(4-Chloro-phenyl)-prop-2-ynylsulfanyl]-[1,...)
Show SMILES Clc1ccc(cc1)C#CCSc1nsnc1C12CN3CC1C2C3
Show InChI InChI=1S/C17H14ClN3S2/c18-12-5-3-11(4-6-12)2-1-7-22-16-15(19-23-20-16)17-10-21-8-13(17)14(17)9-21/h3-6,13-14H,7-10H2
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n/an/an/an/a 80n/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor


J Med Chem 42: 1999-2006 (1999)


Article DOI: 10.1021/jm9910019
BindingDB Entry DOI: 10.7270/Q2XD12BT
More data for this
Ligand-Target Pair
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