Compile Data Set for Download or QSAR
maximum 50k data
Found 12 Enz. Inhib. hit(s) with all data for entry = 6899
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  55nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158155(US10081622, Compound 4 | US9029356, 4 | US9255087,...)
Affinity DataIC50:  207nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  263nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  338nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158156(US10081622, Compound 26 | US9029356, 26 | US925508...)
Affinity DataIC50:  411nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158155(US10081622, Compound 4 | US9029356, 4 | US9255087,...)
Affinity DataIC50:  484nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158156(US10081622, Compound 26 | US9029356, 26 | US925508...)
Affinity DataIC50:  568nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158156(US10081622, Compound 26 | US9029356, 26 | US925508...)
Affinity DataIC50:  1.10E+3nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158157(US10081622, Compound 18 | US9029356, 18 | US925508...)
Affinity DataIC50:  1.77E+3nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158155(US10081622, Compound 4 | US9029356, 4 | US9255087,...)
Affinity DataIC50:  2.35E+3nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158157(US10081622, Compound 18 | US9029356, 18 | US925508...)
Affinity DataIC50:  3.23E+3nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158157(US10081622, Compound 18 | US9029356, 18 | US925508...)
Affinity DataIC50:  6.07E+3nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In DepthDetails US Patent