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Compile Data Set for Download or QSAR

Found 112 hits Enz. Inhib. hit(s) with all data for entry = 7079   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173175
PNG
(US9096589, 8-Methoxy-5-methyl-2-{2-[1-(2-morpholin...)
Show SMILES COc1ccc(C)n2nc(CCc3nc(cn3CCN3CCOCC3)-c3cccs3)nc12
Show InChI InChI=1S/C23H28N6O2S/c1-17-5-6-19(30-2)23-25-21(26-29(17)23)7-8-22-24-18(20-4-3-15-32-20)16-28(22)10-9-27-11-13-31-14-12-27/h3-6,15-16H,7-14H2,1-2H3
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US Patent
n/an/a 0.330n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173179
PNG
(US9096589, 5,8-Dimethyl-2-[2-(1-methyl-4-thiophen-...)
Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3cccs3)nn12
Show InChI InChI=1S/C17H18N6S/c1-11-9-18-12(2)17-20-15(21-23(11)17)6-7-16-19-13(10-22(16)3)14-5-4-8-24-14/h4-5,8-10H,6-7H2,1-3H3
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US Patent
n/an/a 0.390n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173191
PNG
(US9096589, 5,8-Dimethyl-2-[2-(1-methyl-4-thiazol-4...)
Show SMILES Cc1ccc(C)n2nc(CCc3nc(cn3C)-c3cscn3)nc12
Show InChI InChI=1S/C17H18N6S/c1-11-4-5-12(2)23-17(11)20-15(21-23)6-7-16-19-13(8-22(16)3)14-9-24-10-18-14/h4-5,8-10H,6-7H2,1-3H3
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US Patent
n/an/a 0.400n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173192
PNG
(US9096589, 5,8-Dimethyl-2-[2-(1-methyl-4-pyrimidin...)
Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3cncnc3)nn12
Show InChI InChI=1S/C17H18N8/c1-11-6-20-12(2)17-22-15(23-25(11)17)4-5-16-21-14(9-24(16)3)13-7-18-10-19-8-13/h6-10H,4-5H2,1-3H3
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n/an/a 0.440n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173193
PNG
(US9096589, 5,8-Dimethyl-2-[2-(1-methyl-4-pyrazin-2...)
Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3cnccn3)nn12
Show InChI InChI=1S/C17H18N8/c1-11-8-20-12(2)17-22-15(23-25(11)17)4-5-16-21-14(10-24(16)3)13-9-18-6-7-19-13/h6-10H,4-5H2,1-3H3
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n/an/a 0.520n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173112
PNG
(US9096589, 5-Methyl-2-[2-(4-thiophen-2-yl-1H-imida...)
Show SMILES Cc1cccc2nc(CCc3nc(c[nH]3)-c3cccs3)nn12
Show InChI InChI=1S/C16H15N5S/c1-11-4-2-6-16-19-15(20-21(11)16)8-7-14-17-10-12(18-14)13-5-3-9-22-13/h2-6,9-10H,7-8H2,1H3,(H,17,18)
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n/an/a 0.540n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173194
PNG
(US9096589, 5,8-Dimethyl-2-[2-(1-methyl-4-pyridin-4...)
Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3ccncc3)nn12
Show InChI InChI=1S/C18H19N7/c1-12-10-20-13(2)18-22-16(23-25(12)18)4-5-17-21-15(11-24(17)3)14-6-8-19-9-7-14/h6-11H,4-5H2,1-3H3
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US Patent
n/an/a 0.550n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173113
PNG
(US9096589, 8-Methyl-2-[2-(4-thiophen-2-yl-1H-imida...)
Show SMILES Cc1cccn2nc(CCc3nc(c[nH]3)-c3cccs3)nc12
Show InChI InChI=1S/C16H15N5S/c1-11-4-2-8-21-16(11)19-15(20-21)7-6-14-17-10-12(18-14)13-5-3-9-22-13/h2-5,8-10H,6-7H2,1H3,(H,17,18)
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n/an/a 0.990n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173171
PNG
(US9096589, 5,8-Dimethyl-2-[2-(1-methyl-4-thiophen-...)
Show SMILES Cc1ccc(C)n2nc(CCc3nc(cn3C)-c3cccs3)nc12
Show InChI InChI=1S/C18H19N5S/c1-12-6-7-13(2)23-18(12)20-16(21-23)8-9-17-19-14(11-22(17)3)15-5-4-10-24-15/h4-7,10-11H,8-9H2,1-3H3
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n/an/a 1n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173170
PNG
(US9096589, 8-Methoxy-5-methyl-2-[2-(4-thiophen-2-y...)
Show SMILES COc1ccc(C)n2nc(CCc3nc(c[nH]3)-c3cccs3)nc12
Show InChI InChI=1S/C17H17N5OS/c1-11-5-6-13(23-2)17-20-16(21-22(11)17)8-7-15-18-10-12(19-15)14-4-3-9-24-14/h3-6,9-10H,7-8H2,1-2H3,(H,18,19)
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US Patent
n/an/a 1.10n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173172
PNG
(US9096589, 8-Methoxy-5-methyl-2-[2-(1-propyl-4-thi...)
Show SMILES CCCn1cc(nc1CCc1nc2c(OC)ccc(C)n2n1)-c1cccs1
Show InChI InChI=1S/C20H23N5OS/c1-4-11-24-13-15(17-6-5-12-27-17)21-19(24)10-9-18-22-20-16(26-3)8-7-14(2)25(20)23-18/h5-8,12-13H,4,9-11H2,1-3H3
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n/an/a 1.20n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173190
PNG
(US9096589, 5,8-Dimethyl-2-[2-(1-methyl-4-thiazol-4...)
Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3cscn3)nn12
Show InChI InChI=1S/C16H17N7S/c1-10-6-17-11(2)16-20-14(21-23(10)16)4-5-15-19-12(7-22(15)3)13-8-24-9-18-13/h6-9H,4-5H2,1-3H3
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n/an/a 1.29n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173140
PNG
(US9096589, 8-Methoxy-5-methyl-2-[2-(1-methyl-4-thi...)
Show SMILES COc1ccc(C)n2nc(CCc3nc(cn3C)-c3cccs3)nc12
Show InChI InChI=1S/C18H19N5OS/c1-12-6-7-14(24-3)18-20-16(21-23(12)18)8-9-17-19-13(11-22(17)2)15-5-4-10-25-15/h4-7,10-11H,8-9H2,1-3H3
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n/an/a 1.5n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173174
PNG
(US9096589, 4-{2-[2-(8-Methoxy-5-methyl-[1,2,4]tria...)
Show SMILES COc1ccc(C)n2nc(CCc3nc(cn3CCCC#N)-c3cccs3)nc12
Show InChI InChI=1S/C21H22N6OS/c1-15-7-8-17(28-2)21-24-19(25-27(15)21)9-10-20-23-16(18-6-5-13-29-18)14-26(20)12-4-3-11-22/h5-8,13-14H,3-4,9-10,12H2,1-2H3
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n/an/a 1.70n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173176
PNG
(US9096589, 8-Methoxy-5-methyl-2-[2-(1-methyl-4-thi...)
Show SMILES COc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccsc3)nc12
Show InChI InChI=1S/C18H19N5OS/c1-12-4-5-15(24-3)18-20-16(21-23(12)18)6-7-17-19-14(10-22(17)2)13-8-9-25-11-13/h4-5,8-11H,6-7H2,1-3H3
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n/an/a 1.70n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173180
PNG
(US9096589, 5,8-Dimethyl-2-[2-(1-methyl-4-thiazol-2...)
Show SMILES Cc1ccc(C)n2nc(CCc3nc(cn3C)-c3nccs3)nc12
Show InChI InChI=1S/C17H18N6S/c1-11-4-5-12(2)23-16(11)20-14(21-23)6-7-15-19-13(10-22(15)3)17-18-8-9-24-17/h4-5,8-10H,6-7H2,1-3H3
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n/an/a 2.30n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173181
PNG
(US9096589, 5,8-Dimethyl-2-[2-(1-methyl-4-thiazol-2...)
Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3nccs3)nn12
Show InChI InChI=1S/C16H17N7S/c1-10-8-18-11(2)15-20-13(21-23(10)15)4-5-14-19-12(9-22(14)3)16-17-6-7-24-16/h6-9H,4-5H2,1-3H3
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n/an/a 2.70n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173129
PNG
(US9096589, 8-Methoxy-5-methyl-2-[(E)-2-(1-methyl-4...)
Show SMILES COc1ccc(C)n2nc(\C=C\c3nc(cn3C)-c3cccs3)nc12
Show InChI InChI=1S/C18H17N5OS/c1-12-6-7-14(24-3)18-20-16(21-23(12)18)8-9-17-19-13(11-22(17)2)15-5-4-10-25-15/h4-11H,1-3H3/b9-8+
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n/an/a 2.70n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173137
PNG
(US9096589, (R)-1-Chloro-3-{2-[2-(5-methyl-[1,2,4]t...)
Show SMILES Cc1cccc2nc(CCc3nc(cn3C[C@@H](O)CCl)-c3cccs3)nn12
Show InChI InChI=1S/C19H20ClN5OS/c1-13-4-2-6-19-22-17(23-25(13)19)7-8-18-21-15(16-5-3-9-27-16)12-24(18)11-14(26)10-20/h2-6,9,12,14,26H,7-8,10-11H2,1H3/t14-/m0/s1
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n/an/a 2.80n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173187
PNG
(US9096589, 2-[2-(4-Furan-3-yl-1-methyl-1H-imidazol...)
Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3ccoc3)nn12
Show InChI InChI=1S/C17H18N6O/c1-11-8-18-12(2)17-20-15(21-23(11)17)4-5-16-19-14(9-22(16)3)13-6-7-24-10-13/h6-10H,4-5H2,1-3H3
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n/an/a 2.90n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173182
PNG
(US9096589, 8-Methoxy-5-methyl-2-{2-[1-methyl-4-(4-...)
Show SMILES COc1ccc(C)n2nc(CCc3nc(cn3C)-c3cscc3C)nc12
Show InChI InChI=1S/C19H21N5OS/c1-12-10-26-11-14(12)15-9-23(3)18(20-15)8-7-17-21-19-16(25-4)6-5-13(2)24(19)22-17/h5-6,9-11H,7-8H2,1-4H3
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n/an/a 3.10n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173102
PNG
(US9096589, 5,7-Dimethyl-2-[2-(1-propyl-4-thiophen-...)
Show SMILES CCCn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1
Show InChI InChI=1S/C20H23N5S/c1-4-9-24-13-17(18-6-5-10-26-18)23-19(24)8-7-16-12-25-15(3)11-14(2)21-20(25)22-16/h5-6,10-13H,4,7-9H2,1-3H3
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n/an/a 3.40n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173177
PNG
(US9096589, 2-[2-(4-Furan-3-yl-1-methyl-1H-imidazol...)
Show SMILES COc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccoc3)nc12
Show InChI InChI=1S/C18H19N5O2/c1-12-4-5-15(24-3)18-20-16(21-23(12)18)6-7-17-19-14(10-22(17)2)13-8-9-25-11-13/h4-5,8-11H,6-7H2,1-3H3
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n/an/a 4n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173173
PNG
(US9096589, 8-Methoxy-5-methyl-2-[2-(1-prop-2-ynyl-...)
Show SMILES COc1ccc(C)n2nc(CCc3nc(cn3CC#C)-c3cccs3)nc12
Show InChI InChI=1S/C20H19N5OS/c1-4-11-24-13-15(17-6-5-12-27-17)21-19(24)10-9-18-22-20-16(26-3)8-7-14(2)25(20)23-18/h1,5-8,12-13H,9-11H2,2-3H3
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n/an/a 4.10n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173185
PNG
(US9096589, 5,8-Dimethyl-2-{2-[1-methyl-4-(5-methyl...)
Show SMILES Cc1ccc(o1)-c1cn(C)c(CCc2nc3c(C)ccc(C)n3n2)n1
Show InChI InChI=1S/C19H21N5O/c1-12-5-6-13(2)24-19(12)21-17(22-24)9-10-18-20-15(11-23(18)4)16-8-7-14(3)25-16/h5-8,11H,9-10H2,1-4H3
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n/an/a 4.20n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173130
PNG
(US9096589, 5,7-Dimethyl-2-[2-(1-methyl-4-thiophen-...)
Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3C)-c3cccs3)nc2n1
Show InChI InChI=1S/C17H18N6S/c1-11-9-12(2)23-17(18-11)20-15(21-23)6-7-16-19-13(10-22(16)3)14-5-4-8-24-14/h4-5,8-10H,6-7H2,1-3H3
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n/an/a 4.20n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173131
PNG
(US9096589, 8-Methoxy-2-[2-(1-methyl-4-thiophen-2-y...)
Show SMILES COc1cccn2nc(CCc3nc(cn3C)-c3cccs3)nc12
Show InChI InChI=1S/C17H17N5OS/c1-21-11-12(14-6-4-10-24-14)18-16(21)8-7-15-19-17-13(23-2)5-3-9-22(17)20-15/h3-6,9-11H,7-8H2,1-2H3
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n/an/a 4.5n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173183
PNG
(US9096589, 5,8-Dimethyl-2-[2-(1-methyl-4-pyridin-3...)
Show SMILES Cc1ccc(C)n2nc(CCc3nc(cn3C)-c3cccnc3)nc12
Show InChI InChI=1S/C19H20N6/c1-13-6-7-14(2)25-19(13)22-17(23-25)8-9-18-21-16(12-24(18)3)15-5-4-10-20-11-15/h4-7,10-12H,8-9H2,1-3H3
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n/an/a 5.70n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173119
PNG
(US9096589, 5-Methyl-2-[2-(4-thiophen-3-yl-1H-imida...)
Show SMILES Cc1cccc2nc(CCc3nc(c[nH]3)-c3ccsc3)nn12
Show InChI InChI=1S/C16H15N5S/c1-11-3-2-4-16-19-15(20-21(11)16)6-5-14-17-9-13(18-14)12-7-8-22-10-12/h2-4,7-10H,5-6H2,1H3,(H,17,18)
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n/an/a 5.70n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173111
PNG
(US9096589, 1-(4-Chloro-phenyl)-2-{2-[2-(5,7-dimeth...)
Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3CC(O)c3ccc(Cl)cc3)-c3cncs3)nc2n1
Show InChI InChI=1S/C24H23ClN6OS/c1-15-9-16(2)31-11-19(28-24(31)27-15)7-8-23-29-20(22-10-26-14-33-22)12-30(23)13-21(32)17-3-5-18(25)6-4-17/h3-6,9-12,14,21,32H,7-8,13H2,1-2H3
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n/an/a 5.70n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173114
PNG
(US9096589, (S)-2-{2-[2-(5-Methyl-[1,2,4]triazolo[1...)
Show SMILES C[C@@H](CO)n1cc(nc1CCc1nc2cccc(C)n2n1)-c1cccs1
Show InChI InChI=1S/C19H21N5OS/c1-13-5-3-7-19-21-17(22-24(13)19)8-9-18-20-15(16-6-4-10-26-16)11-23(18)14(2)12-25/h3-7,10-11,14,25H,8-9,12H2,1-2H3/t14-/m0/s1
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n/an/a 6.40n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173178
PNG
(US9096589, 5,8-Dimethyl-2-{2-[1-methyl-4-(5-methyl...)
Show SMILES Cc1ccc(o1)-c1cn(C)c(CCc2nc3c(C)ncc(C)n3n2)n1
Show InChI InChI=1S/C18H20N6O/c1-11-9-19-13(3)18-21-16(22-24(11)18)7-8-17-20-14(10-23(17)4)15-6-5-12(2)25-15/h5-6,9-10H,7-8H2,1-4H3
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n/an/a 6.80n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173105
PNG
(US9096589, 5,7-Dimethyl-2-{2-[1-(3-methyl-butyl)-4...)
Show SMILES CC(C)CCn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1
Show InChI InChI=1S/C22H27N5S/c1-15(2)9-10-26-14-19(20-6-5-11-28-20)25-21(26)8-7-18-13-27-17(4)12-16(3)23-22(27)24-18/h5-6,11-15H,7-10H2,1-4H3
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n/an/a 6.80n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173189
PNG
(US9096589, 5,8-Dimethyl-2-[2-(1-methyl-4-thiazol-5...)
Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3cncs3)nn12
Show InChI InChI=1S/C16H17N7S/c1-10-6-18-11(2)16-20-14(21-23(10)16)4-5-15-19-12(8-22(15)3)13-7-17-9-24-13/h6-9H,4-5H2,1-3H3
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n/an/a 6.90n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173115
PNG
(US9096589, 1-Methoxy-3-{2-[2-(5-methyl-[1,2,4]tria...)
Show SMILES COCC(O)Cn1cc(nc1CCc1nc2cccc(C)n2n1)-c1cccs1
Show InChI InChI=1S/C20H23N5O2S/c1-14-5-3-7-20-22-18(23-25(14)20)8-9-19-21-16(17-6-4-10-28-17)12-24(19)11-15(26)13-27-2/h3-7,10,12,15,26H,8-9,11,13H2,1-2H3
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n/an/a 7.5n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173096
PNG
(US9096589, 5,7-Dimethyl-2-[2-(4-thiophen-2-yl-1H-i...)
Show SMILES Cc1cc(C)n2cc(CCc3nc(c[nH]3)-c3cccs3)nc2n1
Show InChI InChI=1S/C17H17N5S/c1-11-8-12(2)22-10-13(20-17(22)19-11)5-6-16-18-9-14(21-16)15-4-3-7-23-15/h3-4,7-10H,5-6H2,1-2H3,(H,18,21)
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n/an/a 7.60n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173101
PNG
(US9096589, 1-{2-[2-(5,7-Dimethyl-imidazo[1,2-a]pyr...)
Show SMILES COCC(O)Cn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1
Show InChI InChI=1S/C21H25N5O2S/c1-14-9-15(2)26-10-16(23-21(26)22-14)6-7-20-24-18(19-5-4-8-29-19)12-25(20)11-17(27)13-28-3/h4-5,8-10,12,17,27H,6-7,11,13H2,1-3H3
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n/an/a 7.90n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173161
PNG
(US9096589, 1-Methoxy-3-{2-[2-(8-methyl-[1,2,4]tria...)
Show SMILES COCC(O)Cn1cc(nc1CCc1nc2c(C)cccn2n1)-c1cccs1
Show InChI InChI=1S/C20H23N5O2S/c1-14-5-3-9-25-20(14)22-18(23-25)7-8-19-21-16(17-6-4-10-28-17)12-24(19)11-15(26)13-27-2/h3-6,9-10,12,15,26H,7-8,11,13H2,1-2H3
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n/an/a 8.40n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173083
PNG
(US9096589, 5,7-Dimethyl-2-[(E)-2-(1-methyl-4-thiop...)
Show SMILES Cc1cc(C)n2cc(\C=C\c3nc(cn3C)-c3cccs3)nc2n1
Show InChI InChI=1S/C18H17N5S/c1-12-9-13(2)23-10-14(20-18(23)19-12)6-7-17-21-15(11-22(17)3)16-5-4-8-24-16/h4-11H,1-3H3/b7-6+
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n/an/a 8.80n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173100
PNG
(US9096589, (S)-2-{2-[2-(5,7-Dimethyl-imidazo[1,2-a...)
Show SMILES C[C@@H](CO)n1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1
Show InChI InChI=1S/C20H23N5OS/c1-13-9-14(2)25-10-16(22-20(25)21-13)6-7-19-23-17(18-5-4-8-27-18)11-24(19)15(3)12-26/h4-5,8-11,15,26H,6-7,12H2,1-3H3/t15-/m0/s1
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n/an/a 8.80n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173153
PNG
(US9096589, [((S)-2-Hydroxy-3-{2-[2-(5-methyl-[1,2,...)
Show SMILES CN(CC#N)C[C@H](O)Cn1cc(nc1CCc1nc2cccc(C)n2n1)-c1cccs1
Show InChI InChI=1S/C22H25N7OS/c1-16-5-3-7-22-25-20(26-29(16)22)8-9-21-24-18(19-6-4-12-31-19)15-28(21)14-17(30)13-27(2)11-10-23/h3-7,12,15,17,30H,8-9,11,13-14H2,1-2H3/t17-/m0/s1
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n/an/a 8.80n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173184
PNG
(US9096589, 5,8-Dimethyl-2-[2-(1-methyl-4-pyridin-3...)
Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3cccnc3)nn12
Show InChI InChI=1S/C18H19N7/c1-12-9-20-13(2)18-22-16(23-25(12)18)6-7-17-21-15(11-24(17)3)14-5-4-8-19-10-14/h4-5,8-11H,6-7H2,1-3H3
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n/an/a 8.90n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173162
PNG
(US9096589, 5-Methyl-2-[2-(1-methyl-4-thiophen-2-yl...)
Show SMILES Cc1cccc2nc(CCc3nc(cn3C)-c3cccs3)nn12
Show InChI InChI=1S/C17H17N5S/c1-12-5-3-7-17-19-15(20-22(12)17)8-9-16-18-13(11-21(16)2)14-6-4-10-23-14/h3-7,10-11H,8-9H2,1-2H3
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n/an/a 9.20n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173168
PNG
(US9096589, 8-Methoxy-5-methyl-2-[2-(1-methyl-4-thi...)
Show SMILES COc1ccc(C)n2nc(CCc3nc(cn3C)-c3cncs3)nc12
Show InChI InChI=1S/C17H18N6OS/c1-11-4-5-13(24-3)17-20-15(21-23(11)17)6-7-16-19-12(9-22(16)2)14-8-18-10-25-14/h4-5,8-10H,6-7H2,1-3H3
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n/an/a 9.20n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173120
PNG
(US9096589, 5-Methyl-2-[2-(4-pyridin-3-yl-1H-imidaz...)
Show SMILES Cc1cccc2nc(CCc3nc(c[nH]3)-c3cccnc3)nn12
Show InChI InChI=1S/C17H16N6/c1-12-4-2-6-17-21-16(22-23(12)17)8-7-15-19-11-14(20-15)13-5-3-9-18-10-13/h2-6,9-11H,7-8H2,1H3,(H,19,20)
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n/an/a 9.60n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173095
PNG
(US9096589, 5,7-Dimethyl-2-{2-[4-thiophen-2-yl-1-(2...)
Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3COCC[Si](C)(C)C)-c3cccs3)nc2n1
Show InChI InChI=1S/C23H31N5OSSi/c1-17-13-18(2)28-14-19(25-23(28)24-17)8-9-22-26-20(21-7-6-11-30-21)15-27(22)16-29-10-12-31(3,4)5/h6-7,11,13-15H,8-10,12,16H2,1-5H3
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US Patent
n/an/a 9.60n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173120
PNG
(US9096589, 5-Methyl-2-[2-(4-pyridin-3-yl-1H-imidaz...)
Show SMILES Cc1cccc2nc(CCc3nc(c[nH]3)-c3cccnc3)nn12
Show InChI InChI=1S/C17H16N6/c1-12-4-2-6-17-21-16(22-23(12)17)8-7-15-19-11-14(20-15)13-5-3-9-18-10-13/h2-6,9-11H,7-8H2,1H3,(H,19,20)
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n/an/a 9.60n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173106
PNG
(US9096589, 2-[2-(1-Isobutyl-4-thiophen-2-yl-1H-imi...)
Show SMILES CC(C)Cn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1
Show InChI InChI=1S/C21H25N5S/c1-14(2)11-25-13-18(19-6-5-9-27-19)24-20(25)8-7-17-12-26-16(4)10-15(3)22-21(26)23-17/h5-6,9-10,12-14H,7-8,11H2,1-4H3
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n/an/a 12n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM60522
PNG
(US9096589, 5,8-Dimethyl-2-[2-(1-methyl-4-thiazol-2...)
Show SMILES Cc1cnc(C)n2nc(CCc3nc(cn3C)-c3nccs3)nc12
Show InChI InChI=1S/C16H17N7S/c1-10-8-18-11(2)23-15(10)20-13(21-23)4-5-14-19-12(9-22(14)3)16-17-6-7-24-16/h6-9H,4-5H2,1-3H3
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n/an/a 12n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173152
PNG
(US9096589, (S)-1-{2-[2-(5-Methyl-[1,2,4]triazolo[1...)
Show SMILES Cc1cccc2nc(CCc3nc(cn3C[C@@H](O)CN3CCOCC3)-c3cccs3)nn12
Show InChI InChI=1S/C23H28N6O2S/c1-17-4-2-6-23-25-21(26-29(17)23)7-8-22-24-19(20-5-3-13-32-20)16-28(22)15-18(30)14-27-9-11-31-12-10-27/h2-6,13,16,18,30H,7-12,14-15H2,1H3/t18-/m0/s1
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n/an/a 14n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair
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