Compile Data Set for Download or QSAR
Found 13 Enz. Inhib. hit(s) with all data for entry = 7193
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sunshine Lake Pharma Co., Ltd

US Patent
LigandPNGBDBM180278(US9133162, Example 9)
Show SMILES Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)cc2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H30N4O5/c1-20-28(30(37)35(34(20)4)22-8-6-5-7-9-22)29(36)33-21-10-12-23(13-11-21)40-27-16-17-32-26-18-24(14-15-25(26)27)39-19-31(2,3)38/h5-18,38H,19H2,1-4H3,(H,33,36)
Affinity DataIC50: 5nMpH: 7.0 T: 2°CAssay Description:Axl (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. 5...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sunshine Lake Pharma Co., Ltd

US Patent
LigandPNGBDBM180271(US9133162, Example 2)
Show SMILES C[C@@H](O)COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C30H27FN4O5/c1-18(36)17-39-22-10-11-23-25(16-22)32-14-13-26(23)40-27-12-9-20(15-24(27)31)33-29(37)28-19(2)34(3)35(30(28)38)21-7-5-4-6-8-21/h4-16,18,36H,17H2,1-3H3,(H,33,37)/t18-/m1/s1
Affinity DataIC50: 7nMpH: 7.0 T: 2°CAssay Description:Met (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. ...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sunshine Lake Pharma Co., Ltd

US Patent
LigandPNGBDBM180273(US9133162, Example 4)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2cc1OCC(C)(C)O
Show InChI InChI=1S/C32H31FN4O6/c1-19-29(31(39)37(36(19)4)21-9-7-6-8-10-21)30(38)35-20-11-12-26(23(33)15-20)43-25-13-14-34-24-17-28(42-18-32(2,3)40)27(41-5)16-22(24)25/h6-17,40H,18H2,1-5H3,(H,35,38)
Affinity DataIC50: 10nMpH: 7.0 T: 2°CAssay Description:Met (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sunshine Lake Pharma Co., Ltd

US Patent
LigandPNGBDBM180270(US9133162, Example 1)
Show SMILES Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H29FN4O5/c1-19-28(30(38)36(35(19)4)21-8-6-5-7-9-21)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(11-12-23(25)26)40-18-31(2,3)39/h5-17,39H,18H2,1-4H3,(H,34,37)
Affinity DataIC50: 11nMpH: 7.0 T: 2°CAssay Description:Axl (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. 5...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sunshine Lake Pharma Co., Ltd

US Patent
LigandPNGBDBM180278(US9133162, Example 9)
Show SMILES Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)cc2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H30N4O5/c1-20-28(30(37)35(34(20)4)22-8-6-5-7-9-22)29(36)33-21-10-12-23(13-11-21)40-27-16-17-32-26-18-24(14-15-25(26)27)39-19-31(2,3)38/h5-18,38H,19H2,1-4H3,(H,33,36)
Affinity DataIC50: 13nMpH: 7.0 T: 2°CAssay Description:Met (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. ...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sunshine Lake Pharma Co., Ltd

US Patent
LigandPNGBDBM180281(US9133162, Example 12)
Show SMILES C[C@H](O)COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3)ccnc2c1
Show InChI InChI=1S/C30H28N4O5/c1-19(35)18-38-24-13-14-25-26(17-24)31-16-15-27(25)39-23-11-9-21(10-12-23)32-29(36)28-20(2)33(3)34(30(28)37)22-7-5-4-6-8-22/h4-17,19,35H,18H2,1-3H3,(H,32,36)/t19-/m0/s1
Affinity DataIC50: 13nMpH: 7.0 T: 2°CAssay Description:Met (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. ...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sunshine Lake Pharma Co., Ltd

US Patent
LigandPNGBDBM180280(US9133162, Example 11)
Show SMILES C[C@@H](O)COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3)ccnc2c1
Show InChI InChI=1S/C30H28N4O5/c1-19(35)18-38-24-13-14-25-26(17-24)31-16-15-27(25)39-23-11-9-21(10-12-23)32-29(36)28-20(2)33(3)34(30(28)37)22-7-5-4-6-8-22/h4-17,19,35H,18H2,1-3H3,(H,32,36)/t19-/m1/s1
Affinity DataIC50: 15nMpH: 7.0 T: 2°CAssay Description:Met (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sunshine Lake Pharma Co., Ltd

US Patent
LigandPNGBDBM180273(US9133162, Example 4)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2cc1OCC(C)(C)O
Show InChI InChI=1S/C32H31FN4O6/c1-19-29(31(39)37(36(19)4)21-9-7-6-8-10-21)30(38)35-20-11-12-26(23(33)15-20)43-25-13-14-34-24-17-28(42-18-32(2,3)40)27(41-5)16-22(24)25/h6-17,40H,18H2,1-5H3,(H,35,38)
Affinity DataIC50: 17nMpH: 7.0 T: 2°CAssay Description:Axl (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. 5...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sunshine Lake Pharma Co., Ltd

US Patent
LigandPNGBDBM180270(US9133162, Example 1)
Show SMILES Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H29FN4O5/c1-19-28(30(38)36(35(19)4)21-8-6-5-7-9-21)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(11-12-23(25)26)40-18-31(2,3)39/h5-17,39H,18H2,1-4H3,(H,34,37)
Affinity DataIC50: 19nMpH: 7.0 T: 2°CAssay Description:Met (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Sunshine Lake Pharma Co., Ltd

US Patent
LigandPNGBDBM180271(US9133162, Example 2)
Show SMILES C[C@@H](O)COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C30H27FN4O5/c1-18(36)17-39-22-10-11-23-25(16-22)32-14-13-26(23)40-27-12-9-20(15-24(27)31)33-29(37)28-19(2)34(3)35(30(28)38)21-7-5-4-6-8-21/h4-16,18,36H,17H2,1-3H3,(H,33,37)/t18-/m1/s1
Affinity DataIC50: 23nMpH: 7.0 T: 2°CAssay Description:KDR (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM MgAcetate and [γ-33P-ATP] (specific activity app...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sunshine Lake Pharma Co., Ltd

US Patent
LigandPNGBDBM180283(US9133162, Example 14)
Show SMILES Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OC(C)(C)CO)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H29FN4O5/c1-19-28(30(39)36(35(19)4)21-8-6-5-7-9-21)29(38)34-20-10-13-27(24(32)16-20)40-26-14-15-33-25-17-22(11-12-23(25)26)41-31(2,3)18-37/h5-17,37H,18H2,1-4H3,(H,34,38)
Affinity DataIC50: 27nMpH: 7.0 T: 2°CAssay Description:Met (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Sunshine Lake Pharma Co., Ltd

US Patent
LigandPNGBDBM180270(US9133162, Example 1)
Show SMILES Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H29FN4O5/c1-19-28(30(38)36(35(19)4)21-8-6-5-7-9-21)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(11-12-23(25)26)40-18-31(2,3)39/h5-17,39H,18H2,1-4H3,(H,34,37)
Affinity DataIC50: 37nMpH: 7.0 T: 2°CAssay Description:KDR (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM MgAcetate and [γ-33P-ATP] (specific activity app...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Sunshine Lake Pharma Co., Ltd

US Patent
LigandPNGBDBM180273(US9133162, Example 4)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2cc1OCC(C)(C)O
Show InChI InChI=1S/C32H31FN4O6/c1-19-29(31(39)37(36(19)4)21-9-7-6-8-10-21)30(38)35-20-11-12-26(23(33)15-20)43-25-13-14-34-24-17-28(42-18-32(2,3)40)27(41-5)16-22(24)25/h6-17,40H,18H2,1-5H3,(H,35,38)
Affinity DataIC50: 40nMpH: 7.0 T: 2°CAssay Description:KDR (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM MgAcetate and [γ-33P-ATP] (specific activity app...More data for this Ligand-Target Pair