Compile Data Set for Download or QSAR
maximum 50k data
Found 33 Enz. Inhib. hit(s) with all data for entry = 2833
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25138(2-cyano-pyrropyrimidine, 7d | 7-(2-cyclopentylethy...)
Affinity DataIC50:  5nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25136(2-cyano-pyrropyrimidine, 7b | 7-(2-cyclohexylethyl...)
Affinity DataIC50:  9nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25134(2-cyano-pyrropyrimidine, 2 | 7-(2-cyclohexylethyl)...)
Affinity DataIC50:  9nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Mus musculus (Mouse))
Novartis

LigandPNGBDBM25134(2-cyano-pyrropyrimidine, 2 | 7-(2-cyclohexylethyl)...)
Affinity DataIC50:  10nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25141(2-cyano-pyrropyrimidine, 7g | 7-[2-(4,4-difluorocy...)
Affinity DataIC50:  10nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25137(2-cyano-pyrropyrimidine, 7c | 7-(2-cyclohexylethyl...)
Affinity DataIC50:  11nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Mus musculus (Mouse))
Novartis

LigandPNGBDBM25135(2-cyano-pyrropyrimidine, 7a | 7-(2-cyclohexylethyl...)
Affinity DataIC50:  14nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25139(2-cyano-pyrropyrimidine, 7e | 7-[2-(4-chlorophenyl...)
Affinity DataIC50:  17nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25135(2-cyano-pyrropyrimidine, 7a | 7-(2-cyclohexylethyl...)
Affinity DataIC50:  18nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Mus musculus (Mouse))
Novartis

LigandPNGBDBM25141(2-cyano-pyrropyrimidine, 7g | 7-[2-(4,4-difluorocy...)
Affinity DataIC50:  20nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25140(2-cyano-pyrropyrimidine, 7f | 7-(2-cycloheptylethy...)
Affinity DataIC50:  50nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis

LigandPNGBDBM25138(2-cyano-pyrropyrimidine, 7d | 7-(2-cyclopentylethy...)
Affinity DataIC50:  79nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis

LigandPNGBDBM25137(2-cyano-pyrropyrimidine, 7c | 7-(2-cyclohexylethyl...)
Affinity DataIC50:  290nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis

LigandPNGBDBM25136(2-cyano-pyrropyrimidine, 7b | 7-(2-cyclohexylethyl...)
Affinity DataIC50: >1.00E+3nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis

LigandPNGBDBM25139(2-cyano-pyrropyrimidine, 7e | 7-[2-(4-chlorophenyl...)
Affinity DataIC50: >1.00E+3nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis

LigandPNGBDBM25139(2-cyano-pyrropyrimidine, 7e | 7-[2-(4-chlorophenyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis

LigandPNGBDBM25137(2-cyano-pyrropyrimidine, 7c | 7-(2-cyclohexylethyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis

LigandPNGBDBM25136(2-cyano-pyrropyrimidine, 7b | 7-(2-cyclohexylethyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis

LigandPNGBDBM25134(2-cyano-pyrropyrimidine, 2 | 7-(2-cyclohexylethyl)...)
Affinity DataIC50:  1.65E+3nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis

LigandPNGBDBM25140(2-cyano-pyrropyrimidine, 7f | 7-(2-cycloheptylethy...)
Affinity DataIC50: >2.00E+3nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis

LigandPNGBDBM25140(2-cyano-pyrropyrimidine, 7f | 7-(2-cycloheptylethy...)
Affinity DataIC50: >2.00E+3nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis

LigandPNGBDBM25138(2-cyano-pyrropyrimidine, 7d | 7-(2-cyclopentylethy...)
Affinity DataIC50:  2.30E+3nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis

LigandPNGBDBM25134(2-cyano-pyrropyrimidine, 2 | 7-(2-cyclohexylethyl)...)
Affinity DataIC50:  5.20E+3nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis

LigandPNGBDBM25141(2-cyano-pyrropyrimidine, 7g | 7-[2-(4,4-difluorocy...)
Affinity DataIC50:  5.40E+3nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis

LigandPNGBDBM25135(2-cyano-pyrropyrimidine, 7a | 7-(2-cyclohexylethyl...)
Affinity DataIC50:  5.90E+3nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis

LigandPNGBDBM25141(2-cyano-pyrropyrimidine, 7g | 7-[2-(4,4-difluorocy...)
Affinity DataIC50:  6.20E+3nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis

LigandPNGBDBM25135(2-cyano-pyrropyrimidine, 7a | 7-(2-cyclohexylethyl...)
Affinity DataIC50:  6.80E+3nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Rattus norvegicus)
Novartis

LigandPNGBDBM25141(2-cyano-pyrropyrimidine, 7g | 7-[2-(4,4-difluorocy...)
Affinity DataIC50: >1.00E+4nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Rattus norvegicus)
Novartis

LigandPNGBDBM25135(2-cyano-pyrropyrimidine, 7a | 7-(2-cyclohexylethyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Rattus norvegicus)
Novartis

LigandPNGBDBM25134(2-cyano-pyrropyrimidine, 2 | 7-(2-cyclohexylethyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Rattus norvegicus)
Novartis

LigandPNGBDBM25141(2-cyano-pyrropyrimidine, 7g | 7-[2-(4,4-difluorocy...)
Affinity DataIC50: >1.00E+4nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Rattus norvegicus)
Novartis

LigandPNGBDBM25135(2-cyano-pyrropyrimidine, 7a | 7-(2-cyclohexylethyl...)
Affinity DataIC50: >1.00E+4nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Rattus norvegicus)
Novartis

LigandPNGBDBM25134(2-cyano-pyrropyrimidine, 2 | 7-(2-cyclohexylethyl)...)
Affinity DataIC50: >1.00E+4nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed