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Compile Data Set for Download or QSAR

Found 2516 hits Enz. Inhib. hit(s) with all data for entry = 63   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM123799
PNG
(US9682141, 102)
Show SMILES CC(C)(C#N)c1ccc(Nc2ncnc3ccc(cc23)-c2ccc3oc(N)nc3c2)cc1
Show InChI InChI=1S/C25H20N6O/c1-25(2,13-26)17-5-7-18(8-6-17)30-23-19-11-15(3-9-20(19)28-14-29-23)16-4-10-22-21(12-16)31-24(27)32-22/h3-12,14H,1-2H3,(H2,27,31)(H,28,29,30)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM139753
PNG
(US9682141, 458)
Show SMILES Fc1cccc(c1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C25H30N6O5/c1-16-18(4-3-7-26-16)24(33)29-25-28-21-19(23-27-8-9-31(23)25)5-6-20(22(21)34-2)36-15-17(32)14-30-10-12-35-13-11-30/h3-7,17,32H,8-15H2,1-2H3,(H,28,29,33)/t17-/m0/s1
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM140279
PNG
(US9682141, 467)
Show SMILES COC1CN(C1)C(=O)c1cnc2ccc(cn12)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C19H17N5O3/c1-26-13-9-23(10-13)18(25)15-7-21-17-5-3-12(8-24(15)17)11-2-4-16-14(6-11)22-19(20)27-16/h2-8,13H,9-10H2,1H3,(H2,20,22)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM140977
PNG
(US9682141, 471)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CCC(F)(F)C3)n2c1
Show InChI InChI=1S/C19H15F2N5O2/c20-19(21)5-6-25(10-19)17(27)14-8-23-16-4-2-12(9-26(14)16)11-1-3-15-13(7-11)24-18(22)28-15/h1-4,7-9H,5-6,10H2,(H2,22,24)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM140979
PNG
(US9682141, 473)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CC(F)(F)C3)n2c1
Show InChI InChI=1S/C18H13F2N5O2/c19-18(20)8-24(9-18)16(26)13-6-22-15-4-2-11(7-25(13)15)10-1-3-14-12(5-10)23-17(21)27-14/h1-7H,8-9H2,(H2,21,23)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM140981
PNG
(US9682141, 475)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CC[C@@H](F)C3)n2c1
Show InChI InChI=1S/C19H16FN5O2/c20-13-5-6-24(10-13)18(26)15-8-22-17-4-2-12(9-25(15)17)11-1-3-16-14(7-11)23-19(21)27-16/h1-4,7-9,13H,5-6,10H2,(H2,21,23)/t13-/m1/s1
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM126955
PNG
(US9682141, 173)
Show SMILES CC1CN(CCO1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C20H19N5O2/c1-12-11-25(6-7-26-12)19-10-22-15-4-2-13(8-16(15)23-19)14-3-5-18-17(9-14)24-20(21)27-18/h2-5,8-10,12H,6-7,11H2,1H3,(H2,21,24)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM127057
PNG
(US9682141, 186)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CCCC3)n2c1
Show InChI InChI=1S/C19H17N5O2/c20-19-22-14-9-12(3-5-16(14)26-19)13-4-6-17-21-10-15(24(17)11-13)18(25)23-7-1-2-8-23/h3-6,9-11H,1-2,7-8H2,(H2,20,22)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM127064
PNG
(US9682141, 188)
Show SMILES CCNC(=O)c1cnc2ccc(cn12)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C17H15N5O2/c1-2-19-16(23)13-8-20-15-6-4-11(9-22(13)15)10-3-5-14-12(7-10)21-17(18)24-14/h3-9H,2H2,1H3,(H2,18,21)(H,19,23)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM127066
PNG
(US9682141, 190)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)Nc3cccnc3)n2c1
Show InChI InChI=1S/C20H14N6O2/c21-20-25-15-8-12(3-5-17(15)28-20)13-4-6-18-23-10-16(26(18)11-13)19(27)24-14-2-1-7-22-9-14/h1-11H,(H2,21,25)(H,24,27)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM127076
PNG
(US9682141, 194)
Show SMILES Cc1ccc(cn1)-c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C21H15N5O/c1-12-2-3-15(10-23-12)19-11-24-16-6-4-13(8-17(16)25-19)14-5-7-20-18(9-14)26-21(22)27-20/h2-11H,1H3,(H2,22,26)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM127466
PNG
(US9682141, 203)
Show SMILES CN1CCC(CC1)NC(=O)c1cnc2ccc(nn12)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C20H21N7O2/c1-26-8-6-13(7-9-26)23-19(28)16-11-22-18-5-3-14(25-27(16)18)12-2-4-17-15(10-12)24-20(21)29-17/h2-5,10-11,13H,6-9H2,1H3,(H2,21,24)(H,23,28)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM127486
PNG
(US9682141, 207)
Show SMILES C[C@H](N)C(=O)N1CCN(CC1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C22H23N7O2/c1-13(23)21(30)29-8-6-28(7-9-29)20-12-25-16-4-2-14(10-17(16)26-20)15-3-5-19-18(11-15)27-22(24)31-19/h2-5,10-13H,6-9,23H2,1H3,(H2,24,27)/t13-/m0/s1
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM141117
PNG
(US9682141, 504)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CC4CCC(C3)O4)n2c1
Show InChI InChI=1S/C21H19N5O3/c22-21-24-16-7-12(1-5-18(16)29-21)13-2-6-19-23-8-17(26(19)9-13)20(27)25-10-14-3-4-15(11-25)28-14/h1-2,5-9,14-15H,3-4,10-11H2,(H2,22,24)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM142026
PNG
(US9682141, 559 | US9682141, 567)
Show SMILES C[C@H](N)C(=O)N1CCN(CC1)c1cnc2ccc(nc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C21H22N8O2/c1-12(22)20(30)29-8-6-28(7-9-29)18-11-24-15-4-3-14(25-19(15)27-18)13-2-5-17-16(10-13)26-21(23)31-17/h2-5,10-12H,6-9,22H2,1H3,(H2,23,26)/t12-/m0/s1
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM141191
PNG
(US9682141, 535 | US9682141, 565)
Show SMILES CCOC(=O)N1CCN(CC1)c1cnc2ccc(nc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C21H21N7O3/c1-2-30-21(29)28-9-7-27(8-10-28)18-12-23-15-5-4-14(24-19(15)26-18)13-3-6-17-16(11-13)25-20(22)31-17/h3-6,11-12H,2,7-10H2,1H3,(H2,22,25)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM142747
PNG
(US9682141, 570 | US9682141, 571)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2n1)N1CCN(CC1)C(=O)C1(N)CC1
Show InChI InChI=1S/C22H22N8O2/c23-21-27-16-11-13(1-4-17(16)32-21)14-2-3-15-19(26-14)28-18(12-25-15)29-7-9-30(10-8-29)20(31)22(24)5-6-22/h1-4,11-12H,5-10,24H2,(H2,23,27)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM143032
PNG
(US9682141, 588)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(cc2n1)N1CC2CCC(C1)O2
Show InChI InChI=1S/C21H19N5O2/c22-21-25-19-7-12(1-6-20(19)28-21)16-4-5-17-18(24-16)8-13(9-23-17)26-10-14-2-3-15(11-26)27-14/h1,4-9,14-15H,2-3,10-11H2,(H2,22,25)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM135641
PNG
(US9682141, 286)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2c1)N1CCN(CC1)C(=O)C1(N)CCC1
Show InChI InChI=1S/C47H63N15O10/c1-26(64)56-33(15-9-17-53-47(49)50)41(67)61-37-21-39(65)52-16-8-7-14-32(40(48)66)57-43(69)35(19-28-22-54-31-13-6-5-12-30(28)31)59-46(72)38(24-63)62-42(68)34(18-27-10-3-2-4-11-27)58-44(70)36(60-45(37)71)20-29-23-51-25-55-29/h2-6,10-13,22-23,25,32-38,54,63H,7-9,14-21,24H2,1H3,(H2,48,66)(H,51,55)(H,52,65)(H,56,64)(H,57,69)(H,58,70)(H,59,72)(H,60,71)(H,61,67)(H,62,68)(H4,49,50,53)/t32-,33-,34+,35-,36-,37-,38-/m0/s1
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM135662
PNG
(US9682141, 299)
Show SMILES N[C@H](CO)C(=O)N1CCN(CC1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C53H78N16O9/c1-31(70)63-38(21-12-24-60-52(55)56)46(73)69-43-29-44(71)59-23-11-10-20-37(45(54)72)64-50(77)42(28-34-30-62-36-19-9-8-18-35(34)36)68-47(74)39(22-13-25-61-53(57)58)65-48(75)40(26-32-14-4-2-5-15-32)66-49(76)41(67-51(43)78)27-33-16-6-3-7-17-33/h2,4-5,8-9,14-15,18-19,30,33,37-43,62H,3,6-7,10-13,16-17,20-29H2,1H3,(H2,54,72)(H,59,71)(H,63,70)(H,64,77)(H,65,75)(H,66,76)(H,67,78)(H,68,74)(H,69,73)(H4,55,56,60)(H4,57,58,61)/t37-,38-,39-,40+,41+,42-,43-/m0/s1
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM143051
PNG
(US9682141, 593)
Show SMILES CN1CCN(CC1=O)C1CN(C1)c1cnc2ccc(nc2c1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C23H23N7O2/c1-28-6-7-29(13-22(28)31)16-11-30(12-16)15-9-19-18(25-10-15)4-3-17(26-19)14-2-5-21-20(8-14)27-23(24)32-21/h2-5,8-10,16H,6-7,11-13H2,1H3,(H2,24,27)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM142992
PNG
(US9682141, 578 | US9682141, 595)
Show SMILES C[C@@H]1COCCN1C1CN(C1)c1cnc2ccc(nc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C22H23N7O2/c1-13-12-30-7-6-29(13)15-10-28(11-15)20-9-24-17-4-3-16(25-21(17)27-20)14-2-5-19-18(8-14)26-22(23)31-19/h2-5,8-9,13,15H,6-7,10-12H2,1H3,(H2,23,26)/t13-/m1/s1
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM124947
PNG
(US9682141, 121 | US9682141, 225)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2c1)N1CCN(CC1)C(=O)C1CCCN1
Show InChI InChI=1S/C24H25N7O2/c25-24-29-20-13-16(4-6-21(20)33-24)15-3-5-17-19(12-15)28-22(14-27-17)30-8-10-31(11-9-30)23(32)18-2-1-7-26-18/h3-6,12-14,18,26H,1-2,7-11H2,(H2,25,29)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM125248
PNG
(US9682141, 129)
Show SMILES CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2ccc3oc(N)nc3c2)CC1
Show InChI InChI=1S/C23H27N7O4S2/c1-36(31,32)30-6-4-28(5-7-30)14-16-13-18-20(35-16)22(29-8-10-33-11-9-29)27-21(25-18)15-2-3-19-17(12-15)26-23(24)34-19/h2-3,12-13H,4-11,14H2,1H3,(H2,24,26)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM126534
PNG
(US9682141, 154)
Show SMILES CNC(=O)N1CCN(CC1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C21H21N7O2/c1-23-21(29)28-8-6-27(7-9-28)19-12-24-15-4-2-13(10-16(15)25-19)14-3-5-18-17(11-14)26-20(22)30-18/h2-5,10-12H,6-9H2,1H3,(H2,22,26)(H,23,29)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM125382
PNG
(US9682141, 143)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)NC3CC[C@H](O)CC3)n2c1
Show InChI InChI=1S/C21H21N5O3/c22-21-25-16-9-12(1-7-18(16)29-21)13-2-8-19-23-10-17(26(19)11-13)20(28)24-14-3-5-15(27)6-4-14/h1-2,7-11,14-15,27H,3-6H2,(H2,22,25)(H,24,28)/t14?,15-
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM118965
PNG
(US9682141, 17)
Show SMILES Nc1nc2cccc(-c3ccc4nccc(-c5ccncc5)c4c3)c2s1
Show InChI InChI=1S/C21H14N4S/c22-21-25-19-3-1-2-16(20(19)26-21)14-4-5-18-17(12-14)15(8-11-24-18)13-6-9-23-10-7-13/h1-12H,(H2,22,25)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM118971
PNG
(US9682141, 23)
Show SMILES CN1CCN(CC1)c1ncnc2ccc(cc12)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C20H20N6O/c1-25-6-8-26(9-7-25)19-15-10-13(2-4-16(15)22-12-23-19)14-3-5-18-17(11-14)24-20(21)27-18/h2-5,10-12H,6-9H2,1H3,(H2,21,24)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM119055
PNG
(US9682141, 27)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2nccc(CCN3CCOCC3)c2c1
Show InChI InChI=1S/C22H22N4O2/c23-22-25-20-14-17(2-4-21(20)28-22)16-1-3-19-18(13-16)15(5-7-24-19)6-8-26-9-11-27-12-10-26/h1-5,7,13-14H,6,8-12H2,(H2,23,25)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM119057
PNG
(US9682141, 29)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncnc(N3CCC(O)CC3)c2c1
Show InChI InChI=1S/C20H19N5O2/c21-20-24-17-10-13(2-4-18(17)27-20)12-1-3-16-15(9-12)19(23-11-22-16)25-7-5-14(26)6-8-25/h1-4,9-11,14,26H,5-8H2,(H2,21,24)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM119090
PNG
(US9682141, 31)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2nccc(-c3cccnc3)c2c1
Show InChI InChI=1S/C21H14N4O/c22-21-25-19-11-14(4-6-20(19)26-21)13-3-5-18-17(10-13)16(7-9-24-18)15-2-1-8-23-12-15/h1-12H,(H2,22,25)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM119346
PNG
(US9682141, 35)
Show SMILES CN1CCC(CC1)Nc1ncnc2ccc(cc12)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C21H22N6O/c1-27-8-6-15(7-9-27)25-20-16-10-13(2-4-17(16)23-12-24-20)14-3-5-19-18(11-14)26-21(22)28-19/h2-5,10-12,15H,6-9H2,1H3,(H2,22,26)(H,23,24,25)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM119515
PNG
(US9682141, 38)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(-c3cn[nH]c3)n2c1
Show InChI InChI=1S/C17H12N6O/c18-17-22-13-5-10(1-3-15(13)24-17)11-2-4-16-19-8-14(23(16)9-11)12-6-20-21-7-12/h1-9H,(H2,18,22)(H,20,21)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM119523
PNG
(US9682141, 46)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C#N)c(-c3ccncc3)c2c1
Show InChI InChI=1S/C22H13N5O/c23-11-16-12-26-18-3-1-14(9-17(18)21(16)13-5-7-25-8-6-13)15-2-4-20-19(10-15)27-22(24)28-20/h1-10,12H,(H2,24,27)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM119527
PNG
(US9682141, 50)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(-c3ccc4nc(N)oc4c3)n2c1
Show InChI InChI=1S/C21H14N6O2/c22-20-25-14-4-1-12(8-18(14)29-20)16-9-24-19-6-3-13(10-27(16)19)11-2-5-17-15(7-11)26-21(23)28-17/h1-10H,(H2,22,25)(H2,23,26)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM136810
PNG
(US9682141, 359)
Show SMILES Nc1nc2cc(cc(Cl)c2o1)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C10H10BrN/c11-8-5-4-7-2-1-3-10(12)9(7)6-8/h4-6,12H,1-3H2
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM127579
PNG
(US9682141, 216)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2c1)N1CC(O)C1
Show InChI InChI=1S/C18H15N5O2/c19-18-22-15-6-11(2-4-16(15)25-18)10-1-3-13-14(5-10)21-17(7-20-13)23-8-12(24)9-23/h1-7,12,24H,8-9H2,(H2,19,22)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM124947
PNG
(US9682141, 121 | US9682141, 225)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2c1)N1CCN(CC1)C(=O)C1CCCN1
Show InChI InChI=1S/C24H25N7O2/c25-24-29-20-13-16(4-6-21(20)33-24)15-3-5-17-19(12-15)28-22(14-27-17)30-8-10-31(11-9-30)23(32)18-2-1-7-26-18/h3-6,12-14,18,26H,1-2,7-11H2,(H2,25,29)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM141157
PNG
(US9682141, 523)
Show SMILES CC(C)N1CCC(CC1)n1cnc2ccc(cc2c1=O)-c1cnc(Cl)c(NS(C)(=O)=O)c1
Show InChI InChI=1S/C22H26ClN5O3S/c1-14(2)27-8-6-17(7-9-27)28-13-25-19-5-4-15(10-18(19)22(28)29)16-11-20(21(23)24-12-16)26-32(3,30)31/h4-5,10-14,17,26H,6-9H2,1-3H3
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM141172
PNG
(US9682141, 531 | US9682141, 551)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2n1)N1CCOCC1
Show InChI InChI=1S/C18H16N6O2/c19-18-22-14-9-11(1-4-15(14)26-18)12-2-3-13-17(21-12)23-16(10-20-13)24-5-7-25-8-6-24/h1-4,9-10H,5-8H2,(H2,19,22)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM128824
PNG
(US9682141, 241)
Show SMILES Nc1nc2ccc(cc2o1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C14H10N4O2/c15-13-17-9-3-1-8(6-12(9)20-13)7-2-4-11-10(5-7)18-14(16)19-11/h1-6H,(H2,15,17)(H2,16,18)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM128826
PNG
(US9682141, 243)
Show SMILES Nc1nc2ccc(cc2o1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C14H10N4OS/c15-13-17-9-3-1-7(5-11(9)19-13)8-2-4-10-12(6-8)20-14(16)18-10/h1-6H,(H2,15,17)(H2,16,18)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM141194
PNG
(US9682141, 538)
Show SMILES CCOC(=O)N1CCC(=CC1)c1cnc2ccc(nc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C22H20N6O3/c1-2-30-22(29)28-9-7-13(8-10-28)18-12-24-16-5-4-15(25-20(16)26-18)14-3-6-19-17(11-14)27-21(23)31-19/h3-7,11-12H,2,8-10H2,1H3,(H2,23,27)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM141225
PNG
(US9682141, 540)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2n1)C1=CCOCC1
Show InChI InChI=1S/C19H15N5O2/c20-19-24-15-9-12(1-4-17(15)26-19)13-2-3-14-18(22-13)23-16(10-21-14)11-5-7-25-8-6-11/h1-5,9-10H,6-8H2,(H2,20,24)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM141227
PNG
(US9682141, 542)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2n1)N1CCC(F)(F)CC1
Show InChI InChI=1S/C19H16F2N6O/c20-19(21)5-7-27(8-6-19)16-10-23-13-3-2-12(24-17(13)26-16)11-1-4-15-14(9-11)25-18(22)28-15/h1-4,9-10H,5-8H2,(H2,22,25)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM141229
PNG
(US9682141, 544)
Show SMILES C[C@H]1COCCN1c1cnc2ccc(nc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C19H18N6O2/c1-11-10-26-7-6-25(11)17-9-21-14-4-3-13(22-18(14)24-17)12-2-5-16-15(8-12)23-19(20)27-16/h2-5,8-9,11H,6-7,10H2,1H3,(H2,20,23)/t11-/m0/s1
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM141977
PNG
(US9682141, 548 | US9682141, 552)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2n1)N1C2CCC1COC2
Show InChI InChI=1S/C20H18N6O2/c21-20-24-16-7-11(1-6-17(16)28-20)14-4-5-15-19(23-14)25-18(8-22-15)26-12-2-3-13(26)10-27-9-12/h1,4-8,12-13H,2-3,9-10H2,(H2,21,24)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM129818
PNG
(US9682141, 250)
Show SMILES CC(=O)Nc1nc2cc(ccc2s1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C16H12N4O2S/c1-8(21)18-16-20-12-7-10(3-5-14(12)23-16)9-2-4-13-11(6-9)19-15(17)22-13/h2-7H,1H3,(H2,17,19)(H,18,20,21)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM130245
PNG
(US9682141, 265)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CC[C@@H](O)C3)n2c1
Show InChI InChI=1S/C19H17N5O3/c20-19-22-14-7-11(1-3-16(14)27-19)12-2-4-17-21-8-15(24(17)9-12)18(26)23-6-5-13(25)10-23/h1-4,7-9,13,25H,5-6,10H2,(H2,20,22)/t13-/m1/s1
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM119522
PNG
(US9682141, 45)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)NCCN3CCOCC3)n2c1
Show InChI InChI=1S/C21H22N6O3/c22-21-25-16-11-14(1-3-18(16)30-21)15-2-4-19-24-12-17(27(19)13-15)20(28)23-5-6-26-7-9-29-10-8-26/h1-4,11-13H,5-10H2,(H2,22,25)(H,23,28)
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n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)


Article DOI: 10.1021/jm960541s
BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
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