Compile Data Set for Download or QSAR
(2D       Computed 3D by Vconf -m prep )

Data curated solely by BindingDB

Found 12 hits Enz. Inhib. hit(s) with all data for this article

Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	pH	Temp °C
Histamine H4 Receptor Rattus norvegicus (rat)	JNJ 7777120 (5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)	GoogleScholar KEGG UniProtKB/SwissProt	CHEBI CSLS PC cid PC sid	PubMed	2.700	-48.90	n/a	n/a	n/a	7.4	25
Abbott Laboratories					J Med Chem. 51: 6571-80 (2008)
Histamine H4 Receptor Homo sapiens (human)	JNJ 7777120 (5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)	DrugBank GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CHEBI CSLS PC cid PC sid	PubMed	12.00	-45.21	n/a	n/a	n/a	7.4	25
Abbott Laboratories					J Med Chem. 51: 6571-80 (2008)
Histamine H4 Receptor Homo sapiens (human)	2-Aminopyrimidine analog., 4 (4-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-y...)	DrugBank GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	35.00	-42.55	n/a	n/a	n/a	7.4	25
Abbott Laboratories					J Med Chem. 51: 6571-80 (2008)
Histamine H4 Receptor Homo sapiens (human)	2-Aminopyrimidine analog., 25 (4-[2-amino-6-(piperazin-1-yl)pyrimidin-4-yl]benzon...)	DrugBank GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	42.00	-42.10	n/a	n/a	n/a	7.4	25
Abbott Laboratories					J Med Chem. 51: 6571-80 (2008)
Histamine H3 Receptor Rattus norvegicus (rat)	2-Aminopyrimidine analog., 25 (4-[2-amino-6-(piperazin-1-yl)pyrimidin-4-yl]benzon...)	GoogleScholar KEGG UniProtKB/SwissProt	PC cid PC sid	PubMed	120.0	-39.50	n/a	n/a	n/a	7.4	25
Abbott Laboratories					J Med Chem. 51: 6571-80 (2008)
Histamine H3 Receptor Rattus norvegicus (rat)	2-Aminopyrimidine analog., 4 (4-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-y...)	GoogleScholar KEGG UniProtKB/SwissProt	PC cid PC sid	PubMed	245.0	-37.73	n/a	n/a	n/a	7.4	25
Abbott Laboratories					J Med Chem. 51: 6571-80 (2008)
Histamine H4 Receptor Rattus norvegicus (rat)	2-Aminopyrimidine analog., 4 (4-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-y...)	GoogleScholar KEGG UniProtKB/SwissProt	PC cid PC sid	PubMed	275.0	-37.44	n/a	n/a	n/a	7.4	25
Abbott Laboratories					J Med Chem. 51: 6571-80 (2008)
Histamine H4 Receptor Rattus norvegicus (rat)	2-Aminopyrimidine analog., 25 (4-[2-amino-6-(piperazin-1-yl)pyrimidin-4-yl]benzon...)	GoogleScholar KEGG UniProtKB/SwissProt	PC cid PC sid	PubMed	339.0	-36.92	n/a	n/a	n/a	7.4	25
Abbott Laboratories					J Med Chem. 51: 6571-80 (2008)
Histamine H3 Receptor Homo sapiens (human)	2-Aminopyrimidine analog., 25 (4-[2-amino-6-(piperazin-1-yl)pyrimidin-4-yl]benzon...)	DrugBank GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	933.0	-34.41	n/a	n/a	n/a	7.4	25
Abbott Laboratories					J Med Chem. 51: 6571-80 (2008)
Histamine H3 Receptor Homo sapiens (human)	2-Aminopyrimidine analog., 4 (4-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-y...)	DrugBank GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	1288	-33.61	n/a	n/a	n/a	7.4	25
Abbott Laboratories					J Med Chem. 51: 6571-80 (2008)
Histamine H3 Receptor Rattus norvegicus (rat)	JNJ 7777120 (5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)	GoogleScholar KEGG UniProtKB/SwissProt	CHEBI CSLS PC cid PC sid	PubMed	1318	-33.56	n/a	n/a	n/a	7.4	25
Abbott Laboratories					J Med Chem. 51: 6571-80 (2008)
Histamine H3 Receptor Homo sapiens (human)	JNJ 7777120 (5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)	DrugBank GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CHEBI CSLS PC cid PC sid	PubMed	2239	-32.24	n/a	n/a	n/a	7.4	25
Abbott Laboratories					J Med Chem. 51: 6571-80 (2008)

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