Compile Data Set for Download or QSAR
maximum 50k data
Found 5 Enz. Inhib. hit(s) with all data for entry = 50009936
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50089193(4-Fluoro-N-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-y...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of Abeta42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of hum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50089190(CHEMBL450926 | Thiophene-2-sulfonic acid (1,3,3-tr...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of Abeta42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of hum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50089192(4-Fluoro-N-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-y...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of Abeta42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of hum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50089189(4-Bromo-N-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Abeta42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of hum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50089191(4-Chloro-N-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-y...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of Abeta42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of hum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed