Compile Data Set for Download or QSAR
maximum 50k data
Found 35 Enz. Inhib. hit(s) with all data for entry = 50032648
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataKi:  230nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325762(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataKi:  340nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332656(CHEMBL1631089 | ethyl 3-carbamoyl-1-(2'-(trifluoro...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332657(CHEMBL1631090 | N5-ethyl-1-(2'-(trifluoromethoxy)b...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332649(1-(5'-fluoro-2'-(2,2,3,3,3-pentafluoropropoxy)biph...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332652(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332650(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332647(1-(2'-fluoro-6'-(trifluoromethoxy)biphenyl-3-yl)-1...)
Affinity DataIC50:  106nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332662(1-(4'-fluoro-2'-(2,2,3,3,3-pentafluoropropoxy)biph...)
Affinity DataIC50:  106nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332654(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50:  115nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332655(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50:  132nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332651(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)
Affinity DataIC50:  147nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332649(1-(5'-fluoro-2'-(2,2,3,3,3-pentafluoropropoxy)biph...)
Affinity DataIC50:  149nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332659(1-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-pyrazole-...)
Affinity DataIC50:  155nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332653(5-methyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)
Affinity DataIC50:  185nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332658(1-(2',3'-dichlorobiphenyl-3-yl)-1H-pyrazole-3,5-di...)
Affinity DataIC50:  195nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332650(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)
Affinity DataIC50:  203nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325771(5-methyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)
Affinity DataIC50:  224nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332646(1-(2'-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-1...)
Affinity DataIC50:  282nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332651(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)
Affinity DataIC50:  299nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332648(1-(2'-(trifluoromethoxy)-5'-(trifluoromethyl)biphe...)
Affinity DataIC50:  325nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332661(1-(6-fluoro-2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)
Affinity DataIC50:  477nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332655(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50:  554nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332660(1-(2',6'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50:  715nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332647(1-(2'-fluoro-6'-(trifluoromethoxy)biphenyl-3-yl)-1...)
Affinity DataIC50:  802nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50:  810nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332659(1-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-pyrazole-...)
Affinity DataIC50:  915nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibition of Nav1.5 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50:  2.03E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: >2.50E+4nMAssay Description:Induction of PXRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332648(1-(2'-(trifluoromethoxy)-5'-(trifluoromethyl)biphe...)
Affinity DataIC50:  1.18E+6nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332646(1-(2'-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-1...)
Affinity DataIC50:  1.51E+6nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50:  2.00E+6nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed