Affinity DataIC50: 0.190nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range : 0.53-0.70More data for this Ligand-Target Pair
Affinity DataIC50: 0.75nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range : 0.55-1.0More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range : 0.88-1.2More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range : 0.92-1.3More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range : 1.2-1.4More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range : 1.3-1.7More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range : 1.7-2.3More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined; Range : 2.9-3.9More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range : 3.6-4.4More data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range : 4.0-4.6More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range : 6.5-8.0More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataIC50: 7.90nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined; Range : 7.0-9.2More data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range : 6.2-11More data for this Ligand-Target Pair
Affinity DataIC50: 9.90nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range : 8.9-11More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range : 9.8-12More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range : 9.1-17More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range : 9.0-17More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range : 8-30More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range : 12-24More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range : 18-25More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range : 20-23More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range : 18-27More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range : 19-29More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range : 23-30More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range : 25-30More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range : 28-35More data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range : 32-47More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined; Range : 370-440More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined (reported by workers at Hoffman-LaRoche)More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range : 34-66More data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range : 58-110More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Concentration required to inhibit the human Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined; Range : 250-300More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range : 260-350More data for this Ligand-Target Pair
Affinity DataIC50: 580nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined; Range : 500-680More data for this Ligand-Target Pair
Affinity DataIC50: 770nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataIC50: 770nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined (reported by Hoffman-LaRoche group)More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Concentration required to inhibit the human Dihydrofolate reductase by 50% was determined (reported by workers at Hoffman-LaRoche)More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Concentration required to inhibit the human Dihydrofolate reductase by 50% was determined (reported by workers at Hoffman-LaRoche)More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined; Range : 1100-1200More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined; Range : 1100-1500More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined; Range : 1100-1800More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range : 2400-3300More data for this Ligand-Target Pair