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Found 59 Enz. Inhib. hit(s) with all data for entry = 50019801
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207855(CHEMBL245744 | N-(3-isopropylphenyl)-4-methyl-3-(3...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207856(3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyrid...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207852(3-isopropyl-N-(4-methyl-3-(3-(4-(methylamino)-1,3,...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM14974(CHEMBL221484 | N-(3-(3-(Dimethylamino)propyl)-5-(t...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207850(3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyrim...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM14974(CHEMBL221484 | N-(3-(3-(Dimethylamino)propyl)-5-(t...)
Affinity DataIC50:  2nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207850(3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyrim...)
Affinity DataIC50:  2nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207859(CHEMBL245745 | N-(3-isopropylphenyl)-4-methyl-3-(3...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207858(CHEMBL394694 | N-(4-fluoro-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207862(3-isopropyl-N-(3-(3-(2-(methylamino)pyridin-4-yl)p...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207859(CHEMBL245745 | N-(3-isopropylphenyl)-4-methyl-3-(3...)
Affinity DataIC50:  5nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207852(3-isopropyl-N-(4-methyl-3-(3-(4-(methylamino)-1,3,...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207853(3-isopropyl-N-(3-(3-(4-(methylamino)-1,3,5-triazin...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207849(CHEMBL246151 | N-(2-chloro-5-(3-(2-(methylamino)py...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207848(CHEMBL246152 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207857(CHEMBL397090 | N-(4-methyl-3-(3-(2-(methylamino)py...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207849(CHEMBL246151 | N-(2-chloro-5-(3-(2-(methylamino)py...)
Affinity DataIC50:  9nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207856(3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyrid...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207857(CHEMBL397090 | N-(4-methyl-3-(3-(2-(methylamino)py...)
Affinity DataIC50:  13nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207847(CHEMBL394692 | N-(3-isopropylphenyl)-4-methyl-3-(3...)
Affinity DataIC50:  13nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207848(CHEMBL246152 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207851(CHEMBL246355 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  17nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207861(CHEMBL245549 | N-(4-methyl-3-(3-(pyrimidin-4-yl)py...)
Affinity DataIC50:  17nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207862(3-isopropyl-N-(3-(3-(2-(methylamino)pyridin-4-yl)p...)
Affinity DataIC50:  18nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207856(3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyrid...)
Affinity DataIC50:  18nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207860(CHEMBL397089 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207855(CHEMBL245744 | N-(3-isopropylphenyl)-4-methyl-3-(3...)
Affinity DataIC50:  20nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207851(CHEMBL246355 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  23nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  33nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207847(CHEMBL394692 | N-(3-isopropylphenyl)-4-methyl-3-(3...)
Affinity DataIC50:  38nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  47nMAssay Description:Inhibition of p38alpha by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207863(3-isopropyl-N-(3-(3-(4-(methylamino)-1,3,5-triazin...)
Affinity DataIC50:  55nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207861(CHEMBL245549 | N-(4-methyl-3-(3-(pyrimidin-4-yl)py...)
Affinity DataIC50:  61nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207853(3-isopropyl-N-(3-(3-(4-(methylamino)-1,3,5-triazin...)
Affinity DataIC50:  85nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207852(3-isopropyl-N-(4-methyl-3-(3-(4-(methylamino)-1,3,...)
Affinity DataIC50:  117nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207858(CHEMBL394694 | N-(4-fluoro-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  128nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  146nMAssay Description:Inhibition of Lck by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  194nMAssay Description:Inhibition of p38alpha in THP1 cells assessed as TNFalpha levelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207857(CHEMBL397090 | N-(4-methyl-3-(3-(2-(methylamino)py...)
Affinity DataIC50:  233nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207860(CHEMBL397089 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  309nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207848(CHEMBL246152 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  442nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207853(3-isopropyl-N-(3-(3-(4-(methylamino)-1,3,5-triazin...)
Affinity DataIC50:  456nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207848(CHEMBL246152 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  540nMAssay Description:Inhibition of KDR autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207857(CHEMBL397090 | N-(4-methyl-3-(3-(2-(methylamino)py...)
Affinity DataIC50:  943nMAssay Description:Inhibition of KDR autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207851(CHEMBL246355 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  1.13E+3nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of Jak2 by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of Src by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of KDR autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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