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Found 39 Enz. Inhib. hit(s) with all data for entry = 50048064
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataKi:  20nMAssay Description:Binding affinity to Vanadate-sensitive ABCB1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50:  0.660nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 1000 ...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 500 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at 1000 nM...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  21nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 200 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human ABCB1 transfected in HEK293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 1...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  25nMAssay Description:Inhibition of human ABCB1 transfected in HEK293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at ...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  32nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at 500 nM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  44nMAssay Description:Inhibition of human ABCB1 transfected in HEK293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 1000 ...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  76nMAssay Description:Inhibition of human ABCB1 transfected in HEK293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  79nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  100nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 500 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  100nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 100 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  109nMAssay Description:Inhibition of human ABCB1 transfected in HEK293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  115nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  118nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at 200 nM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  188nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at 100 nM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  205nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 50 nM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  224nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  230nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  280nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 200 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  300nMAssay Description:Inhibition of human ABCB1-mediated efflux transfected in HEK293 cells assessed as accumulation of fluorescent dye by calcein-AM dye based FACS analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  304nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at 50 nM a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  550nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  571nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  700nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 100 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  970nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  1.31E+3nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  1.42E+3nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 50 nM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  2.66E+3nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  2.81E+3nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  3.22E+3nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50001285((E)-3-((3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)(...)
Affinity DataIC50:  5.22E+3nMAssay Description:Inhibition of human ABCC1 transfected in HEK293 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring etoposide IC50 at 25000...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50:  3.83E+4nMAssay Description:Inhibition of human ABCC1 transfected in HEK293 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring etoposide IC50 at 500 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed