Compile Data Set for Download or QSAR
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Found 71 Enz. Inhib. hit(s) with all data for entry = 50038068
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231755(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231728(5-methoxy-2-phenylethynyl-5,6,7,8-tetrahydro-quino...)
Affinity DataKi:  139nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231738(7,7-dimethyl-2-pyridin-2-ylethynyl-7,8-dihydro-6H-...)
Affinity DataKi:  210nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231741(2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...)
Affinity DataKi:  800nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231751(6-phenylethynyl-nicotinic acid methyl ester | CHEM...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231753(2-phenylethynyl-5,6,7,8-tetrahydro-quinoline | CHE...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231721(2-pyridin-2-ylethynyl-7,8-dihydro-6H-quinolin-5-on...)
Affinity DataKi:  2.36E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231747((R)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)
Affinity DataKi:  4.71E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231719(2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-ol |...)
Affinity DataKi:  7.60E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231759((S)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)
Affinity DataKi:  9.28E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231750((3-ethyl-2-methylquinolin-6-yl)(4-methoxycyclohexy...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231744(CHEMBL399160 | NPS 2390 | quinoxaline-2-carboxylic...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231749(6-ethyl-5-methyl-3-(1,2,4,5-tetrahydrobenzo[d]azep...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231755(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)
Affinity DataIC50:  23nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231748(CHEMBL253347 | quinoline-3-carboxylic acid adamant...)
Affinity DataIC50:  52nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231758(2-cyclopentylamino-7,7-dimethyl-5-oxo-5,6,7,8-tetr...)
Affinity DataIC50:  78nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231728(5-methoxy-2-phenylethynyl-5,6,7,8-tetrahydro-quino...)
Affinity DataIC50:  80nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231757(2-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl...)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231743(7,7-dimethyl-5-oxo-2-(4-phenyl-piperazin-1-yl)-5,6...)
Affinity DataIC50:  130nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231764(2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-7,7-dimethy...)
Affinity DataIC50:  160nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231752(CHEMBL399161 | quinoline-2-carboxylic acid adamant...)
Affinity DataIC50:  440nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231753(2-phenylethynyl-5,6,7,8-tetrahydro-quinoline | CHE...)
Affinity DataIC50:  510nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50003013(CHEMBL401270)
Affinity DataIC50: <1.00E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231742(2-(3,4-dihydro-1H-isoquinolin-2-yl)-7,7-dimethyl-5...)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231736(2-butylamino-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro...)
Affinity DataIC50:  1.70E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231740(2-benzyloxy-7,8-dihydro-6H-quinolin-5-one | CHEMBL...)
Affinity DataIC50:  1.90E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231735(2-(indan-2-ylamino)-7,7-dimethyl-5-oxo-5,6,7,8-tet...)
Affinity DataIC50:  1.90E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231733(7,7-dimethyl-5-oxo-2-propylamino-5,6,7,8-tetrahydr...)
Affinity DataIC50:  2.30E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231720(2-benzylamino-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydr...)
Affinity DataIC50:  2.50E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231722(2-hexylamino-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro...)
Affinity DataIC50:  2.60E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231738(7,7-dimethyl-2-pyridin-2-ylethynyl-7,8-dihydro-6H-...)
Affinity DataIC50:  2.60E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231730(2-cyclohexylamino-5-oxo-5,6,7,8-tetrahydroquinolin...)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231756(2-cyclohexylamino-7,7-dimethyl-5-oxo-5,6,7,8-tetra...)
Affinity DataIC50:  4.00E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231751(6-phenylethynyl-nicotinic acid methyl ester | CHEM...)
Affinity DataIC50:  4.60E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231723(2-benzylsulfanyl-7,7-dimethyl-5-oxo-5,6,7,8-tetrah...)
Affinity DataIC50:  4.80E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231760(2-(benzyl-methyl-amino)-7,7-dimethyl-5-oxo-5,6,7,8...)
Affinity DataIC50:  5.30E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231727(CHEMBL253348 | cid_2931812 | pyrazine-2-carboxylic...)
Affinity DataIC50:  7.00E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231731(2-azepanyl-5-oxo-5,6,7,8-tetrahydroquinoline-3-car...)
Affinity DataIC50:  7.40E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231746(2-[4-(4-methoxy-phenyl)-piperazin-1-yl]-7,7-dimeth...)
Affinity DataIC50:  7.60E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231724(3-chloro-2-cyclopentylamino-7,7-dimethyl-7,8-dihyd...)
Affinity DataIC50:  7.90E+3nMAssay Description:Antagonist activity at rat mGluR1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231729(2-benzylamino-7,7-dimethyl-7,8-dihydro-6H-quinolin...)
Affinity DataIC50:  8.10E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231739(2-(4-phenyl-piperazin-1-yl)-7,8-dihydro-6H-quinoli...)
Affinity DataIC50:  1.04E+4nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231732(7,7-dimethyl-3-nitro-2-(4-phenyl-3,6-dihydro-2H-py...)
Affinity DataIC50:  1.20E+4nMAssay Description:Antagonist activity at rat mGluR1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50371237(CHEMBL1204390)
Affinity DataIC50:  1.20E+4nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231765(2-(cyclopentylamino)-7,7-dimethyl-3-(2H-tetrazol-5...)
Affinity DataIC50:  1.30E+4nMAssay Description:Antagonist activity at rat mGluR1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231766(2-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl...)
Affinity DataIC50:  1.50E+4nMAssay Description:Antagonist activity at rat mGluR1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231725(2-cyclopentylamino-7,7-dimethyl-5-oxo-5,6,7,8-tetr...)
Affinity DataIC50:  2.10E+4nMAssay Description:Antagonist activity at rat mGluR1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50371237(CHEMBL1204390)
Affinity DataIC50:  2.10E+4nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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