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Compile Data Set for Download or QSAR

Found 34 hits Enz. Inhib. hit(s) with all data for entry = 50039599   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380711
PNG
(CHEMBL2017668)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1C(C)C
Show InChI InChI=1S/C23H27F2O3PS/c1-5-27-29(26,28-6-2)20(14-16-11-12-18(24)19(25)13-16)23-22(15(3)4)17-9-7-8-10-21(17)30-23/h7-13,15,20H,5-6,14H2,1-4H3
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n/an/a 12n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380694
PNG
(CHEMBL2017510)
Show SMILES CCOP(=O)(OCC)C(Cc1cccc(Cl)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H24ClO3PS/c1-4-24-26(23,25-5-2)19(14-16-9-8-10-17(22)13-16)21-15(3)18-11-6-7-12-20(18)27-21/h6-13,19H,4-5,14H2,1-3H3
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n/an/a 22n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380713
PNG
(CHEMBL2017671)
Show SMILES CC(C)OP(=O)(OC(C)C)C(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C23H27F2O3PS/c1-14(2)27-29(26,28-15(3)4)21(13-17-10-11-19(24)20(25)12-17)23-16(5)18-8-6-7-9-22(18)30-23/h6-12,14-15,21H,13H2,1-5H3
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n/an/a 24n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380709
PNG
(CHEMBL2017665)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1C1CCCC1
Show InChI InChI=1S/C25H29F2O3PS/c1-3-29-31(28,30-4-2)22(16-17-13-14-20(26)21(27)15-17)25-24(18-9-5-6-10-18)19-11-7-8-12-23(19)32-25/h7-8,11-15,18,22H,3-6,9-10,16H2,1-2H3
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n/an/a 26n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380692
PNG
(CHEMBL2017508)
Show SMILES CCOP(=O)(OCC)C(Cc1cccc(F)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H24FO3PS/c1-4-24-26(23,25-5-2)19(14-16-9-8-10-17(22)13-16)21-15(3)18-11-6-7-12-20(18)27-21/h6-13,19H,4-5,14H2,1-3H3
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n/an/a 31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380701
PNG
(CHEMBL2017657)
Show SMILES CCOP(=O)(OCC)C(Cc1cc(F)cc(F)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H23F2O3PS/c1-4-25-27(24,26-5-2)19(12-15-10-16(22)13-17(23)11-15)21-14(3)18-8-6-7-9-20(18)28-21/h6-11,13,19H,4-5,12H2,1-3H3
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n/an/a 58n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380702
PNG
(CHEMBL2017658)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H23F2O3PS/c1-4-25-27(24,26-5-2)19(13-15-10-11-17(22)18(23)12-15)21-14(3)16-8-6-7-9-20(16)28-21/h6-12,19H,4-5,13H2,1-3H3
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n/an/a 64n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380696
PNG
(CHEMBL2017512)
Show SMILES CCOP(=O)(OCC)C(Cc1cccc(C)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C22H27O3PS/c1-5-24-26(23,25-6-2)20(15-18-11-9-10-16(3)14-18)22-17(4)19-12-7-8-13-21(19)27-22/h7-14,20H,5-6,15H2,1-4H3
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n/an/a 65n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380693
PNG
(CHEMBL2017509)
Show SMILES CCOP(=O)(OCC)C(Cc1ccccc1F)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H24FO3PS/c1-4-24-26(23,25-5-2)19(14-16-10-6-8-12-18(16)22)21-15(3)17-11-7-9-13-20(17)27-21/h6-13,19H,4-5,14H2,1-3H3
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n/an/a 114n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380707
PNG
(CHEMBL2017663)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1C1CC1
Show InChI InChI=1S/C23H25F2O3PS/c1-3-27-29(26,28-4-2)20(14-15-9-12-18(24)19(25)13-15)23-22(16-10-11-16)17-7-5-6-8-21(17)30-23/h5-9,12-13,16,20H,3-4,10-11,14H2,1-2H3
KEGG

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n/an/a 116n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380687
PNG
(CHEMBL2017502)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)cc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C22H24FO3P/c1-3-25-27(24,26-4-2)22(15-17-9-13-21(23)14-10-17)20-12-11-18-7-5-6-8-19(18)16-20/h5-14,16,22H,3-4,15H2,1-2H3
KEGG

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n/an/a 120n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380705
PNG
(CHEMBL2017661)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1C
Show InChI InChI=1S/C22H23F4O3PS/c1-4-28-30(27,29-5-2)19(21-14(3)16-8-6-7-9-20(16)31-21)13-15-10-11-18(23)17(12-15)22(24,25)26/h6-12,19H,4-5,13H2,1-3H3
KEGG

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n/an/a 120n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380698
PNG
(CHEMBL2017514)
Show SMILES CCOP(=O)(OCC)C(Cc1cccc(OC)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C22H27O4PS/c1-5-25-27(23,26-6-2)20(15-17-10-9-11-18(14-17)24-4)22-16(3)19-12-7-8-13-21(19)28-22/h7-14,20H,5-6,15H2,1-4H3
KEGG

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n/an/a 121n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380714
PNG
(CHEMBL2017672)
Show SMILES CC(C)CP(=O)(CC(C)C)C(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C25H31F2OPS/c1-16(2)14-29(28,15-17(3)4)23(13-19-10-11-21(26)22(27)12-19)25-18(5)20-8-6-7-9-24(20)30-25/h6-12,16-17,23H,13-15H2,1-5H3
KEGG

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n/an/a 123n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380697
PNG
(CHEMBL2017513)
Show SMILES CCOP(=O)(OCC)C(Cc1cccc(c1)C(F)(F)F)c1sc2ccccc2c1C
Show InChI InChI=1S/C22H24F3O3PS/c1-4-27-29(26,28-5-2)19(14-16-9-8-10-17(13-16)22(23,24)25)21-15(3)18-11-6-7-12-20(18)30-21/h6-13,19H,4-5,14H2,1-3H3
KEGG

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n/an/a 138n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380695
PNG
(CHEMBL2017511)
Show SMILES CCOP(=O)(OCC)C(Cc1cccc(Br)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H24BrO3PS/c1-4-24-26(23,25-5-2)19(14-16-9-8-10-17(22)13-16)21-15(3)18-11-6-7-12-20(18)27-21/h6-13,19H,4-5,14H2,1-3H3
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n/an/a 145n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380708
PNG
(CHEMBL2017664)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1C1CCC1
Show InChI InChI=1S/C24H27F2O3PS/c1-3-28-30(27,29-4-2)21(15-16-12-13-19(25)20(26)14-16)24-23(17-8-7-9-17)18-10-5-6-11-22(18)31-24/h5-6,10-14,17,21H,3-4,7-9,15H2,1-2H3
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n/an/a 146n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380710
PNG
(CHEMBL2017667)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1CC(C)(C)C
Show InChI InChI=1S/C25H31F2O3PS/c1-6-29-31(28,30-7-2)22(15-17-12-13-20(26)21(27)14-17)24-19(16-25(3,4)5)18-10-8-9-11-23(18)32-24/h8-14,22H,6-7,15-16H2,1-5H3
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n/an/a 160n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380712
PNG
(CHEMBL2017670)
Show SMILES CCCP(=O)(CCC)C(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C23H27F2OPS/c1-4-12-27(26,13-5-2)21(15-17-10-11-19(24)20(25)14-17)23-16(3)18-8-6-7-9-22(18)28-23/h6-11,14,21H,4-5,12-13,15H2,1-3H3
KEGG

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n/an/a 165n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380690
PNG
(CHEMBL2017505)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)cc1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H24FO3PS/c1-4-24-26(23,25-5-2)19(14-16-10-12-17(22)13-11-16)21-15(3)18-8-6-7-9-20(18)27-21/h6-13,19H,4-5,14H2,1-3H3
KEGG

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n/an/a 184n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380700
PNG
(CHEMBL2017656)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(OC(F)(F)F)cc1)c1sc2ccccc2c1C
Show InChI InChI=1S/C22H24F3O4PS/c1-4-27-30(26,28-5-2)19(21-15(3)18-8-6-7-9-20(18)31-21)14-16-10-12-17(13-11-16)29-22(23,24)25/h6-13,19H,4-5,14H2,1-3H3
KEGG

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n/an/a 240n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380689
PNG
(CHEMBL2017504)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)cc1)c1cc2ccccc2s1
Show InChI InChI=1S/C20H22FO3PS/c1-3-23-25(22,24-4-2)18(13-15-9-11-17(21)12-10-15)20-14-16-7-5-6-8-19(16)26-20/h5-12,14,18H,3-4,13H2,1-2H3
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n/an/a 250n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380703
PNG
(CHEMBL2017659)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(Cl)c(Cl)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H23Cl2O3PS/c1-4-25-27(24,26-5-2)19(13-15-10-11-17(22)18(23)12-15)21-14(3)16-8-6-7-9-20(16)28-21/h6-12,19H,4-5,13H2,1-3H3
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380684
PNG
(CHEMBL2017666)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1C1CCCCC1
Show InChI InChI=1S/C26H31F2O3PS/c1-3-30-32(29,31-4-2)23(17-18-14-15-21(27)22(28)16-18)26-25(19-10-6-5-7-11-19)20-12-8-9-13-24(20)33-26/h8-9,12-16,19,23H,3-7,10-11,17H2,1-2H3
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380683
PNG
(CHEMBL2017507)
Show SMILES CCOP(=O)(OCC)C(Cc1ccccc1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H25O3PS/c1-4-23-25(22,24-5-2)19(15-17-11-7-6-8-12-17)21-16(3)18-13-9-10-14-20(18)26-21/h6-14,19H,4-5,15H2,1-3H3
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380699
PNG
(CHEMBL2017655)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(cc1)C(F)(F)F)c1sc2ccccc2c1C
Show InChI InChI=1S/C22H24F3O3PS/c1-4-27-29(26,28-5-2)19(14-16-10-12-17(13-11-16)22(23,24)25)21-15(3)18-8-6-7-9-20(18)30-21/h6-13,19H,4-5,14H2,1-3H3
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380706
PNG
(CHEMBL2017662)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)c(F)c1)c1cc2ccccc2s1
Show InChI InChI=1S/C20H21F2O3PS/c1-3-24-26(23,25-4-2)18(12-14-9-10-16(21)17(22)11-14)20-13-15-7-5-6-8-19(15)27-20/h5-11,13,18H,3-4,12H2,1-2H3
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380691
PNG
(CHEMBL2017506)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)cc1)c1cc2ccccc2o1
Show InChI InChI=1S/C20H22FO4P/c1-3-23-26(22,24-4-2)20(13-15-9-11-17(21)12-10-15)19-14-16-7-5-6-8-18(16)25-19/h5-12,14,20H,3-4,13H2,1-2H3
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380688
PNG
(CHEMBL2017503)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)cc1)c1cccc2ccccc12
Show InChI InChI=1S/C22H24FO3P/c1-3-25-27(24,26-4-2)22(16-17-12-14-19(23)15-13-17)21-11-7-9-18-8-5-6-10-20(18)21/h5-15,22H,3-4,16H2,1-2H3
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380704
PNG
(CHEMBL2017660)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(Cl)c(c1)C(F)(F)F)c1sc2ccccc2c1C
Show InChI InChI=1S/C22H23ClF3O3PS/c1-4-28-30(27,29-5-2)19(21-14(3)16-8-6-7-9-20(16)31-21)13-15-10-11-18(23)17(12-15)22(24,25)26/h6-12,19H,4-5,13H2,1-3H3
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Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380686
PNG
(CHEMBL2017501)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)cc1)c1csc2ccc(F)cc12
Show InChI InChI=1S/C20H21F2O3PS/c1-3-24-26(23,25-4-2)19(11-14-5-7-15(21)8-6-14)18-13-27-20-10-9-16(22)12-17(18)20/h5-10,12-13,19H,3-4,11H2,1-2H3
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n/an/a 700n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380716
PNG
(CHEMBL2016589)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(Br)cc1)c1ccccc1
Show InChI InChI=1S/C18H22BrO3P/c1-3-21-23(20,22-4-2)18(16-8-6-5-7-9-16)14-15-10-12-17(19)13-11-15/h5-13,18H,3-4,14H2,1-2H3
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n/an/a 950n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380685
PNG
(CHEMBL2017500)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)cc1)c1cn(-c2ccccc2)c2ccc(Cl)cc12
Show InChI InChI=1S/C26H26ClFNO3P/c1-3-31-33(30,32-4-2)26(16-19-10-13-21(28)14-11-19)24-18-29(22-8-6-5-7-9-22)25-15-12-20(27)17-23(24)25/h5-15,17-18,26H,3-4,16H2,1-2H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))
BDBM50380715
PNG
(CHEMBL2017673)
Show SMILES CCOP(=O)(OCC)C(c1ccccc1)c1ccc(Br)cc1
Show InChI InChI=1S/C17H20BrO3P/c1-3-20-22(19,21-4-2)17(14-8-6-5-7-9-14)15-10-12-16(18)13-11-15/h5-13,17H,3-4H2,1-2H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair