Compile Data Set for Download or QSAR
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Found 86 Enz. Inhib. hit(s) with all data for entry = 50043470
TargetMitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM24942(CEP-1347 | CHEMBL290352 | methyl (15S,16R,18R)-10,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of MLK2 (unknown origin) after 20 mins in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  4nMAssay Description:Inhibition of wild type human FLT3 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441571(CHEMBL2436982 | US10485800, Example 18 | US9814704...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human wild type LRRK2 by qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM24942(CEP-1347 | CHEMBL290352 | methyl (15S,16R,18R)-10,...)
Affinity DataIC50:  6nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of wild type human ABL1 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441571(CHEMBL2436982 | US10485800, Example 18 | US9814704...)
Affinity DataIC50:  7nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441570(CHEMBL2436976 | US10485800, Example 17 | US9814704...)
Affinity DataIC50:  9nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441566(CHEMBL2436977 | US10485800, Example 179)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of wild type human FLT3 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  11nMAssay Description:Inhibition of human wild type LRRK2 by qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  14nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441569(CHEMBL2436981 | US10485800, Example 4 | US9814704,...)
Affinity DataIC50:  19nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  19nMAssay Description:Inhibition of MLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441566(CHEMBL2436977 | US10485800, Example 179)
Affinity DataIC50:  21nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human wild type LRRK2 by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441573(CHEMBL2436979 | US10485800, Example 40 | US9814704...)
Affinity DataIC50:  40nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  42nMAssay Description:Inhibition of MLK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441569(CHEMBL2436981 | US10485800, Example 4 | US9814704,...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human wild type LRRK2 by qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441568(CHEMBL2436983 | US10485800, Example 9 | US9814704,...)
Affinity DataIC50:  78nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  85nMAssay Description:Inhibition of wild type human TRKA by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  108nMAssay Description:Inhibition of wild type human Aurora kinase A by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  111nMAssay Description:Inhibition of wild type human ROCK2 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Mus musculus)
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441571(CHEMBL2436982 | US10485800, Example 18 | US9814704...)
Affinity DataIC50:  120nMAssay Description:Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  123nMAssay Description:Inhibition of wild type human Aurora kinase B by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein delta homolog 1(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  150nMAssay Description:Inhibition of human wild type DLK by qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  177nMAssay Description:Inhibition of wild type human c-MET by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  200nMAssay Description:Inhibition of wild type human IR by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  201nMAssay Description:Inhibition of wild type human SGK1 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  217nMAssay Description:Inhibition of wild type human TRKB by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  257nMAssay Description:Inhibition of wild type human IKKb by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441566(CHEMBL2436977 | US10485800, Example 179)
Affinity DataIC50:  288nMAssay Description:Inhibition of wild type human IKKb by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  290nMAssay Description:Inhibition of wild type human Aurora kinase C kinase by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  307nMAssay Description:Inhibition of wild type human IGF1R by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441566(CHEMBL2436977 | US10485800, Example 179)
Affinity DataIC50:  330nMAssay Description:Inhibition of wild type human IKKa by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Mus musculus)
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441569(CHEMBL2436981 | US10485800, Example 4 | US9814704,...)
Affinity DataIC50:  430nMAssay Description:Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Mus musculus)
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  460nMAssay Description:Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Mus musculus)
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441568(CHEMBL2436983 | US10485800, Example 9 | US9814704,...)
Affinity DataIC50:  510nMAssay Description:Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  560nMAssay Description:Inhibition of FLT3-L-stimulated wild type full length human FLT3 autophosphorylation expressed in MEF preincubated for 90 mins followed by FLT3-L sti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  591nMAssay Description:Inhibition of wild type human IKKa by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 2(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  661nMAssay Description:Inhibition of wild type human MEKK2 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441566(CHEMBL2436977 | US10485800, Example 179)
Affinity DataIC50:  730nMAssay Description:Inhibition of FLT3-L-stimulated wild type full length human FLT3 autophosphorylation expressed in MEF preincubated for 90 mins followed by FLT3-L sti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  731nMAssay Description:Inhibition of wild type human SYK by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Mus musculus)
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441570(CHEMBL2436976 | US10485800, Example 17 | US9814704...)
Affinity DataIC50:  990nMAssay Description:Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of wild type human ROCK1 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  1.13E+3nMAssay Description:Inhibition of wild type human CDK1 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441566(CHEMBL2436977 | US10485800, Example 179)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of wild type human IR by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Mus musculus)
Califia Bio

Curated by ChEMBL
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441573(CHEMBL2436979 | US10485800, Example 40 | US9814704...)
Affinity DataIC50:  2.97E+3nMAssay Description:Inhibition of human wild type LRRK2 by qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441569(CHEMBL2436981 | US10485800, Example 4 | US9814704,...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as inhibition of diclofenac metabolism by HPLC/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  5.05E+3nMAssay Description:Inhibition of wild type human ZAP70 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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