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Compile Data Set for Download or QSAR

Found 68 hits Enz. Inhib. hit(s) with all data for entry = 50003006   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465552
PNG
(CHEMBL4291641 | US10501466, Example B29)
Show SMILES COc1cc(cc(OC)c1C)C(=O)N[C@@H]1CCc2ccc(cc12)-c1cn2CCCc2n1
Show InChI InChI=1S/C25H27N3O3/c1-15-22(30-2)12-18(13-23(15)31-3)25(29)27-20-9-8-16-6-7-17(11-19(16)20)21-14-28-10-4-5-24(28)26-21/h6-7,11-14,20H,4-5,8-10H2,1-3H3,(H,27,29)/t20-/m1/s1
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0.902n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465552
PNG
(CHEMBL4291641 | US10501466, Example B29)
Show SMILES COc1cc(cc(OC)c1C)C(=O)N[C@@H]1CCc2ccc(cc12)-c1cn2CCCc2n1
Show InChI InChI=1S/C25H27N3O3/c1-15-22(30-2)12-18(13-23(15)31-3)25(29)27-20-9-8-16-6-7-17(11-19(16)20)21-14-28-10-4-5-24(28)26-21/h6-7,11-14,20H,4-5,8-10H2,1-3H3,(H,27,29)/t20-/m1/s1
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<1n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465585
PNG
(CHEMBL4279907 | US10501466, Example B11)
Show SMILES Clc1ccc(CC(=O)N[C@@H]2CCc3ccc(cc23)-c2cn3CCCc3n2)cc1Cl
Show InChI InChI=1S/C23H21Cl2N3O/c24-18-7-3-14(10-19(18)25)11-23(29)27-20-8-6-15-4-5-16(12-17(15)20)21-13-28-9-1-2-22(28)26-21/h3-5,7,10,12-13,20H,1-2,6,8-9,11H2,(H,27,29)/t20-/m1/s1
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2.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465585
PNG
(CHEMBL4279907 | US10501466, Example B11)
Show SMILES Clc1ccc(CC(=O)N[C@@H]2CCc3ccc(cc23)-c2cn3CCCc3n2)cc1Cl
Show InChI InChI=1S/C23H21Cl2N3O/c24-18-7-3-14(10-19(18)25)11-23(29)27-20-8-6-15-4-5-16(12-17(15)20)21-13-28-9-1-2-22(28)26-21/h3-5,7,10,12-13,20H,1-2,6,8-9,11H2,(H,27,29)/t20-/m1/s1
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2.70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465584
PNG
(CHEMBL4293572)
Show SMILES Clc1ccc(CC(=O)NCc2cc(ccc2OC2CCC2)-c2cn3CCCc3n2)cc1Cl
Show InChI InChI=1S/C25H25Cl2N3O2/c26-20-8-6-16(11-21(20)27)12-25(31)28-14-18-13-17(7-9-23(18)32-19-3-1-4-19)22-15-30-10-2-5-24(30)29-22/h6-9,11,13,15,19H,1-5,10,12,14H2,(H,28,31)
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2.80n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465593
PNG
(CHEMBL4283374)
Show SMILES COc1cc(ccc1C)C(=O)N(CC1CC1)Cc1cc(ccc1OC1CCC1)-c1cn2CCCc2n1
Show InChI InChI=1S/C30H35N3O3/c1-20-8-11-23(16-28(20)35-2)30(34)33(17-21-9-10-21)18-24-15-22(12-13-27(24)36-25-5-3-6-25)26-19-32-14-4-7-29(32)31-26/h8,11-13,15-16,19,21,25H,3-7,9-10,14,17-18H2,1-2H3
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3.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465555
PNG
(CHEMBL4287817)
Show SMILES COc1cc(CC(=O)N[C@@H]2CCc3ccc(cc23)-c2cn3CCCc3n2)ccc1C
Show InChI InChI=1S/C25H27N3O2/c1-16-5-6-17(12-23(16)30-2)13-25(29)27-21-10-9-18-7-8-19(14-20(18)21)22-15-28-11-3-4-24(28)26-22/h5-8,12,14-15,21H,3-4,9-11,13H2,1-2H3,(H,27,29)/t21-/m1/s1
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4.90n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465555
PNG
(CHEMBL4287817)
Show SMILES COc1cc(CC(=O)N[C@@H]2CCc3ccc(cc23)-c2cn3CCCc3n2)ccc1C
Show InChI InChI=1S/C25H27N3O2/c1-16-5-6-17(12-23(16)30-2)13-25(29)27-21-10-9-18-7-8-19(14-20(18)21)22-15-28-11-3-4-24(28)26-22/h5-8,12,14-15,21H,3-4,9-11,13H2,1-2H3,(H,27,29)/t21-/m1/s1
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8.40n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465586
PNG
(CHEMBL4294174 | US10501466, Example B14)
Show SMILES COc1cc(ccc1C)C(=O)N[C@@H]1CCCc2ccc(cc12)-c1cn2CCCc2n1
Show InChI InChI=1S/C25H27N3O2/c1-16-8-9-19(14-23(16)30-2)25(29)27-21-6-3-5-17-10-11-18(13-20(17)21)22-15-28-12-4-7-24(28)26-22/h8-11,13-15,21H,3-7,12H2,1-2H3,(H,27,29)/t21-/m1/s1
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9.40n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465582
PNG
(CHEMBL4277864)
Show SMILES CC(C)Oc1ccc(cc1CNC(=O)Cc1ccc(Cl)c(Cl)c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C24H25Cl2N3O2/c1-15(2)31-22-8-6-17(21-14-29-9-3-4-23(29)28-21)12-18(22)13-27-24(30)11-16-5-7-19(25)20(26)10-16/h5-8,10,12,14-15H,3-4,9,11,13H2,1-2H3,(H,27,30)
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9.90n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465583
PNG
(CHEMBL4288521)
Show SMILES CC(C)Oc1ccc(cc1CN(CC1CC1)C(=O)Cc1ccc(Cl)c(Cl)c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C28H31Cl2N3O2/c1-18(2)35-26-10-8-21(25-17-32-11-3-4-27(32)31-25)14-22(26)16-33(15-19-5-6-19)28(34)13-20-7-9-23(29)24(30)12-20/h7-10,12,14,17-19H,3-6,11,13,15-16H2,1-2H3
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13n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465606
PNG
(CHEMBL4291223)
Show SMILES COc1cc(ccc1C)C(=O)NCc1cc(ccc1OC1CCC1)-c1cn2CCCc2n1
Show InChI InChI=1S/C26H29N3O3/c1-17-8-9-19(14-24(17)31-2)26(30)27-15-20-13-18(10-11-23(20)32-21-5-3-6-21)22-16-29-12-4-7-25(29)28-22/h8-11,13-14,16,21H,3-7,12,15H2,1-2H3,(H,27,30)
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16n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465603
PNG
(CHEMBL4285163)
Show SMILES Clc1ccc(CC(=O)NCc2cc(ccc2N2CCOCC2)-c2cn3CCCc3n2)cc1Cl
Show InChI InChI=1S/C25H26Cl2N4O2/c26-20-5-3-17(12-21(20)27)13-25(32)28-15-19-14-18(22-16-31-7-1-2-24(31)29-22)4-6-23(19)30-8-10-33-11-9-30/h3-6,12,14,16H,1-2,7-11,13,15H2,(H,28,32)
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21n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465579
PNG
(CHEMBL4294133)
Show SMILES COc1cccc(c1)C(=O)N(CC1CC1)Cc1cc(ccc1OC1CCC1)-c1cn2CCCc2n1
Show InChI InChI=1S/C29H33N3O3/c1-34-25-8-2-5-22(16-25)29(33)32(17-20-10-11-20)18-23-15-21(12-13-27(23)35-24-6-3-7-24)26-19-31-14-4-9-28(31)30-26/h2,5,8,12-13,15-16,19-20,24H,3-4,6-7,9-11,14,17-18H2,1H3
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23n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465586
PNG
(CHEMBL4294174 | US10501466, Example B14)
Show SMILES COc1cc(ccc1C)C(=O)N[C@@H]1CCCc2ccc(cc12)-c1cn2CCCc2n1
Show InChI InChI=1S/C25H27N3O2/c1-16-8-9-19(14-23(16)30-2)25(29)27-21-6-3-5-17-10-11-18(13-20(17)21)22-15-28-12-4-7-24(28)26-22/h8-11,13-15,21H,3-7,12H2,1-2H3,(H,27,29)/t21-/m1/s1
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27n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465554
PNG
(CHEMBL4286527)
Show SMILES COc1cccc(c1)C(=O)N(CC1CC1)Cc1cc(ccc1OC(C)C)-c1cn2CCCc2n1
Show InChI InChI=1S/C28H33N3O3/c1-19(2)34-26-12-11-21(25-18-30-13-5-8-27(30)29-25)14-23(26)17-31(16-20-9-10-20)28(32)22-6-4-7-24(15-22)33-3/h4,6-7,11-12,14-15,18-20H,5,8-10,13,16-17H2,1-3H3
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28n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465604
PNG
(CHEMBL4283339)
Show SMILES Clc1ccc(CC(=O)N(CC2CC2)Cc2cc(ccc2OC2CCC2)-c2cn3CCCc3n2)cc1Cl
Show InChI InChI=1S/C29H31Cl2N3O2/c30-24-10-8-20(13-25(24)31)14-29(35)34(16-19-6-7-19)17-22-15-21(9-11-27(22)36-23-3-1-4-23)26-18-33-12-2-5-28(33)32-26/h8-11,13,15,18-19,23H,1-7,12,14,16-17H2
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29n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465602
PNG
(CHEMBL4278618)
Show SMILES CCOc1ccc(cc1CN(CC1CC1)C(=O)c1cccc(OC)c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C27H31N3O3/c1-3-33-25-12-11-20(24-18-29-13-5-8-26(29)28-24)14-22(25)17-30(16-19-9-10-19)27(31)21-6-4-7-23(15-21)32-2/h4,6-7,11-12,14-15,18-19H,3,5,8-10,13,16-17H2,1-2H3
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43n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465581
PNG
(CHEMBL4292999)
Show SMILES CN(C)c1ccc(cc1CNC(=O)Cc1ccc(Cl)c(Cl)c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C23H24Cl2N4O/c1-28(2)21-8-6-16(20-14-29-9-3-4-22(29)27-20)12-17(21)13-26-23(30)11-15-5-7-18(24)19(25)10-15/h5-8,10,12,14H,3-4,9,11,13H2,1-2H3,(H,26,30)
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52n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465594
PNG
(CHEMBL4284408 | US10501466, Example B24)
Show SMILES Cc1cc(ccn1)C(=O)N[C@@H]1CCc2ccc(cc12)-c1cn2CCCc2n1
Show InChI InChI=1S/C22H22N4O/c1-14-11-17(8-9-23-14)22(27)25-19-7-6-15-4-5-16(12-18(15)19)20-13-26-10-2-3-21(26)24-20/h4-5,8-9,11-13,19H,2-3,6-7,10H2,1H3,(H,25,27)/t19-/m1/s1
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65n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465559
PNG
(CHEMBL4285902)
Show SMILES COc1cccc(c1)C(=O)NCc1cc(ccc1OC(C)C)-c1cn2CCCc2n1
Show InChI InChI=1S/C24H27N3O3/c1-16(2)30-22-10-9-17(21-15-27-11-5-8-23(27)26-21)12-19(22)14-25-24(28)18-6-4-7-20(13-18)29-3/h4,6-7,9-10,12-13,15-16H,5,8,11,14H2,1-3H3,(H,25,28)
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76n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465607
PNG
(CHEMBL4280428)
Show SMILES COc1cc(ccc1C)C(=O)NCc1cccc(c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C22H23N3O2/c1-15-8-9-18(12-20(15)27-2)22(26)23-13-16-5-3-6-17(11-16)19-14-25-10-4-7-21(25)24-19/h3,5-6,8-9,11-12,14H,4,7,10,13H2,1-2H3,(H,23,26)
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95n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465592
PNG
(CHEMBL4284733)
Show SMILES COc1cccc(c1)C(=O)NCc1cc(ccc1OC1CCC1)-c1cn2CCCc2n1
Show InChI InChI=1S/C25H27N3O3/c1-30-21-8-2-5-18(14-21)25(29)26-15-19-13-17(10-11-23(19)31-20-6-3-7-20)22-16-28-12-4-9-24(28)27-22/h2,5,8,10-11,13-14,16,20H,3-4,6-7,9,12,15H2,1H3,(H,26,29)
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105n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465599
PNG
(CHEMBL4288724)
Show SMILES Clc1ccc(CC(=O)NCc2cccc(c2)-c2cn3CCCc3n2)cc1Cl
Show InChI InChI=1S/C21H19Cl2N3O/c22-17-7-6-14(10-18(17)23)11-21(27)24-12-15-3-1-4-16(9-15)19-13-26-8-2-5-20(26)25-19/h1,3-4,6-7,9-10,13H,2,5,8,11-12H2,(H,24,27)
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118n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465578
PNG
(CHEMBL4288010)
Show SMILES COc1cccc(c1)C(=O)N(CC1CC1)Cc1cc(ccc1OC)-c1cn2CCCc2n1
Show InChI InChI=1S/C26H29N3O3/c1-31-22-6-3-5-20(14-22)26(30)29(15-18-8-9-18)16-21-13-19(10-11-24(21)32-2)23-17-28-12-4-7-25(28)27-23/h3,5-6,10-11,13-14,17-18H,4,7-9,12,15-16H2,1-2H3
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148n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465594
PNG
(CHEMBL4284408 | US10501466, Example B24)
Show SMILES Cc1cc(ccn1)C(=O)N[C@@H]1CCc2ccc(cc12)-c1cn2CCCc2n1
Show InChI InChI=1S/C22H22N4O/c1-14-11-17(8-9-23-14)22(27)25-19-7-6-15-4-5-16(12-18(15)19)20-13-26-10-2-3-21(26)24-20/h4-5,8-9,11-13,19H,2-3,6-7,10H2,1H3,(H,25,27)/t19-/m1/s1
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182n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465572
PNG
(CHEMBL4284948)
Show SMILES COc1cc(C)cc(c1)C(=O)NCc1cccc(c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C22H23N3O2/c1-15-9-18(12-19(10-15)27-2)22(26)23-13-16-5-3-6-17(11-16)20-14-25-8-4-7-21(25)24-20/h3,5-6,9-12,14H,4,7-8,13H2,1-2H3,(H,23,26)
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184n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465580
PNG
(CHEMBL4276791)
Show SMILES COc1cccc(c1)C(=O)NCc1cc(ccc1N(C)C)-c1cn2CCCc2n1
Show InChI InChI=1S/C23H26N4O2/c1-26(2)21-10-9-16(20-15-27-11-5-8-22(27)25-20)12-18(21)14-24-23(28)17-6-4-7-19(13-17)29-3/h4,6-7,9-10,12-13,15H,5,8,11,14H2,1-3H3,(H,24,28)
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185n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465591
PNG
(CHEMBL4294825)
Show SMILES COc1cccc(c1)C(=O)N(CC1CC1)Cc1cccc(c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C25H27N3O2/c1-30-22-8-3-7-21(14-22)25(29)28(15-18-10-11-18)16-19-5-2-6-20(13-19)23-17-27-12-4-9-24(27)26-23/h2-3,5-8,13-14,17-18H,4,9-12,15-16H2,1H3
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219n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465574
PNG
(CHEMBL4291414)
Show SMILES COc1cccc(c1)C(=O)N(C)Cc1cccc(c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C22H23N3O2/c1-24(22(26)18-8-4-9-19(13-18)27-2)14-16-6-3-7-17(12-16)20-15-25-11-5-10-21(25)23-20/h3-4,6-9,12-13,15H,5,10-11,14H2,1-2H3
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473n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465601
PNG
(CHEMBL4284629)
Show SMILES COc1cc(ccn1)C(=O)N(CC1CC1)Cc1cccc(c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C24H26N4O2/c1-30-23-13-20(9-10-25-23)24(29)28(14-17-7-8-17)15-18-4-2-5-19(12-18)21-16-27-11-3-6-22(27)26-21/h2,4-5,9-10,12-13,16-17H,3,6-8,11,14-15H2,1H3
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480n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465575
PNG
(CHEMBL4286932)
Show SMILES COc1cccc(c1)C(=O)N(Cc1cccc(c1)-c1cn2CCCc2n1)C(C)C
Show InChI InChI=1S/C24H27N3O2/c1-17(2)27(24(28)20-9-5-10-21(14-20)29-3)15-18-7-4-8-19(13-18)22-16-26-12-6-11-23(26)25-22/h4-5,7-10,13-14,16-17H,6,11-12,15H2,1-3H3
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503n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465569
PNG
(CHEMBL4278737)
Show SMILES COc1cccc(c1)C(=O)NCc1cccc(c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C21H21N3O2/c1-26-18-8-3-7-17(12-18)21(25)22-13-15-5-2-6-16(11-15)19-14-24-10-4-9-20(24)23-19/h2-3,5-8,11-12,14H,4,9-10,13H2,1H3,(H,22,25)
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665n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465608
PNG
(CHEMBL4288332)
Show SMILES COc1ccc(cc1OC)C(=O)NCc1cccc(c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C22H23N3O3/c1-27-19-9-8-17(12-20(19)28-2)22(26)23-13-15-5-3-6-16(11-15)18-14-25-10-4-7-21(25)24-18/h3,5-6,8-9,11-12,14H,4,7,10,13H2,1-2H3,(H,23,26)
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690n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465556
PNG
(CHEMBL4283572)
Show SMILES Cc1cncc(c1)C(=O)NCc1cccc(c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C20H20N4O/c1-14-8-17(12-21-10-14)20(25)22-11-15-4-2-5-16(9-15)18-13-24-7-3-6-19(24)23-18/h2,4-5,8-10,12-13H,3,6-7,11H2,1H3,(H,22,25)
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924n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465565
PNG
(CHEMBL4292418)
Show SMILES Fc1cccc(c1F)-c1ccc(cc1)-c1cn2CCCc2n1
Show InChI InChI=1S/C18H14F2N2/c19-15-4-1-3-14(18(15)20)12-6-8-13(9-7-12)16-11-22-10-2-5-17(22)21-16/h1,3-4,6-9,11H,2,5,10H2
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1.12E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465576
PNG
(CHEMBL4276691)
Show SMILES COc1cccc(c1)C(=O)N(CC1CCC1)Cc1cccc(c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C26H29N3O2/c1-31-23-11-4-10-22(15-23)26(30)29(16-19-6-2-7-19)17-20-8-3-9-21(14-20)24-18-28-13-5-12-25(28)27-24/h3-4,8-11,14-15,18-19H,2,5-7,12-13,16-17H2,1H3
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1.26E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465558
PNG
(CHEMBL4287245)
Show SMILES O=C(NCc1cccc(c1)-c1cn2CCCc2n1)c1ccncc1
Show InChI InChI=1S/C19H18N4O/c24-19(15-6-8-20-9-7-15)21-12-14-3-1-4-16(11-14)17-13-23-10-2-5-18(23)22-17/h1,3-4,6-9,11,13H,2,5,10,12H2,(H,21,24)
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1.38E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465577
PNG
(CHEMBL4280115)
Show SMILES COc1cccc(c1)C(=O)N(CC1CC1)Cc1cc(OC)cc(c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C26H29N3O3/c1-31-22-6-3-5-20(13-22)26(30)29(15-18-8-9-18)16-19-11-21(14-23(12-19)32-2)24-17-28-10-4-7-25(28)27-24/h3,5-6,11-14,17-18H,4,7-10,15-16H2,1-2H3
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1.46E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465557
PNG
(CHEMBL4281521)
Show SMILES Cc1cccc(c1)C(=O)NCc1cccc(c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C21H21N3O/c1-15-5-2-8-18(11-15)21(25)22-13-16-6-3-7-17(12-16)19-14-24-10-4-9-20(24)23-19/h2-3,5-8,11-12,14H,4,9-10,13H2,1H3,(H,22,25)
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2.60E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465570
PNG
(CHEMBL4292147)
Show SMILES COc1ccc(cc1)C(=O)NCc1cccc(c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C21H21N3O2/c1-26-18-9-7-16(8-10-18)21(25)22-13-15-4-2-5-17(12-15)19-14-24-11-3-6-20(24)23-19/h2,4-5,7-10,12,14H,3,6,11,13H2,1H3,(H,22,25)
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3.13E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465573
PNG
(CHEMBL4276998)
Show SMILES O=C(NCc1cccc(c1)-c1cn2CCCc2n1)c1ccccn1
Show InChI InChI=1S/C19H18N4O/c24-19(16-7-1-2-9-20-16)21-12-14-5-3-6-15(11-14)17-13-23-10-4-8-18(23)22-17/h1-3,5-7,9,11,13H,4,8,10,12H2,(H,21,24)
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3.91E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465600
PNG
(CHEMBL4295183)
Show SMILES O=C(NCc1cccc(c1)-c1cn2CCCc2n1)c1cccnc1
Show InChI InChI=1S/C19H18N4O/c24-19(16-6-2-8-20-12-16)21-11-14-4-1-5-15(10-14)17-13-23-9-3-7-18(23)22-17/h1-2,4-6,8,10,12-13H,3,7,9,11H2,(H,21,24)
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4.13E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465590
PNG
(CHEMBL4277278)
Show SMILES O=C(NCc1cccc(c1)-c1cn2CCCc2n1)c1ccccc1
Show InChI InChI=1S/C20H19N3O/c24-20(16-7-2-1-3-8-16)21-13-15-6-4-9-17(12-15)18-14-23-11-5-10-19(23)22-18/h1-4,6-9,12,14H,5,10-11,13H2,(H,21,24)
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7.21E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465598
PNG
(CHEMBL4289405)
Show SMILES O=C(NCc1cccc(c1)-c1cn2CCCc2n1)C1CCCCC1
Show InChI InChI=1S/C20H25N3O/c24-20(16-7-2-1-3-8-16)21-13-15-6-4-9-17(12-15)18-14-23-11-5-10-19(23)22-18/h4,6,9,12,14,16H,1-3,5,7-8,10-11,13H2,(H,21,24)
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7.54E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM49419
PNG
(2-(4-phenylphenyl)-6,7-dihydro-5H-pyrrol[1,2-a]imi...)
Show SMILES C1Cc2nc(cn2C1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H16N2/c1-2-5-14(6-3-1)15-8-10-16(11-9-15)17-13-20-12-4-7-18(20)19-17/h1-3,5-6,8-11,13H,4,7,12H2
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8.44E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465571
PNG
(CHEMBL4278066)
Show SMILES O=C(Cc1ccccc1)NCc1cccc(c1)-c1cn2CCCc2n1
Show InChI InChI=1S/C21H21N3O/c25-21(13-16-6-2-1-3-7-16)22-14-17-8-4-9-18(12-17)19-15-24-11-5-10-20(24)23-19/h1-4,6-9,12,15H,5,10-11,13-14H2,(H,22,25)
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1.76E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465605
PNG
(CHEMBL4287371)
Show SMILES CC(C)Oc1ccc(cc1)-c1cn2CCCc2n1
Show InChI InChI=1S/C15H18N2O/c1-11(2)18-13-7-5-12(6-8-13)14-10-17-9-3-4-15(17)16-14/h5-8,10-11H,3-4,9H2,1-2H3
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2.97E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465596
PNG
(CHEMBL1625120)
Show SMILES COc1ccc(cc1)-c1cn2CCCc2n1
Show InChI InChI=1S/C13H14N2O/c1-16-11-6-4-10(5-7-11)12-9-15-8-2-3-13(15)14-12/h4-7,9H,2-3,8H2,1H3
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6.10E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
WD repeat-containing protein 5


(Homo sapiens (Human))
BDBM50465566
PNG
(CHEMBL4289013)
Show SMILES C1Cc2nc(cn2C1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C13H12N2O2/c1-2-13-14-10(7-15(13)5-1)9-3-4-11-12(6-9)17-8-16-11/h3-4,6-7H,1-2,5,8H2
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6.40E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...


J Med Chem 61: 5623-5642 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00375
BindingDB Entry DOI: 10.7270/Q2KD21KT
More data for this
Ligand-Target Pair
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