BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 35 hits Enz. Inhib. hit(s) with all data for entry = 609   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM3032
PNG
(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Show SMILES COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC
Show InChI InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 16n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM3531
PNG
(CHEMBL541586 | CHEMBL94431 | N-(3-fluorophenyl)-6,...)
Show SMILES COc1cc2ncnc(Nc3cccc(F)c3)c2cc1OC
Show InChI InChI=1S/C16H14FN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 90n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4403
PNG
(3-[(6-methylquinazolin-4-yl)amino]benzamide | 4-An...)
Show SMILES Cc1ccc2ncnc(Nc3cccc(c3)C(N)=O)c2c1
Show InChI InChI=1S/C16H14N4O/c1-10-5-6-14-13(7-10)16(19-9-18-14)20-12-4-2-3-11(8-12)15(17)21/h2-9H,1H3,(H2,17,21)(H,18,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4398
PNG
(4-Anilidoquinazoline deriv. 13a | N-(3-chloropheny...)
Show SMILES Cc1ccc2ncnc(Nc3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C15H12ClN3/c1-10-5-6-14-13(7-10)15(18-9-17-14)19-12-4-2-3-11(16)8-12/h2-9H,1H3,(H,17,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 600n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM3532
PNG
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 900n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM3533
PNG
(CHEMBL1204305 | CHEMBL96065 | N-(3-iodophenyl)-6,7...)
Show SMILES COc1cc2ncnc(Nc3cccc(I)c3)c2cc1OC
Show InChI InChI=1S/C16H14IN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 950n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4404
PNG
(3-[(6-methylquinazolin-4-yl)amino]benzoic acid | 4...)
Show SMILES Cc1ccc2ncnc(Nc3cccc(c3)C(O)=O)c2c1
Show InChI InChI=1S/C16H13N3O2/c1-10-5-6-14-13(7-10)15(18-9-17-14)19-12-4-2-3-11(8-12)16(20)21/h2-9H,1H3,(H,20,21)(H,17,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4399
PNG
(4-Anilidoquinazoline deriv. 14a | N-(3-bromophenyl...)
Show SMILES Cc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
Show InChI InChI=1S/C15H12BrN3/c1-10-5-6-14-13(7-10)15(18-9-17-14)19-12-4-2-3-11(16)8-12/h2-9H,1H3,(H,17,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.70E+3n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4400
PNG
(4-Anilidoquinazoline deriv. 15b | 6-methyl-N-[3-(t...)
Show SMILES Cc1ccc2ncnc(Nc3cccc(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C16H12F3N3/c1-10-5-6-14-13(7-10)15(21-9-20-14)22-12-4-2-3-11(8-12)16(17,18)19/h2-9H,1H3,(H,20,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.10E+3n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4397
PNG
(4-Anilidoquinazoline deriv. 12a | 6-chloro-N-(3-ch...)
Show SMILES Clc1cccc(Nc2ncnc3ccc(Cl)cc23)c1
Show InChI InChI=1S/C14H9Cl2N3/c15-9-2-1-3-11(6-9)19-14-12-7-10(16)4-5-13(12)17-8-18-14/h1-8H,(H,17,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.70E+3n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4420
PNG
(2-chloro-N-(3-chlorophenyl)-6,7-dimethoxyquinazoli...)
Show SMILES COc1cc2nc(Cl)nc(Nc3cccc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H13Cl2N3O2/c1-22-13-7-11-12(8-14(13)23-2)20-16(18)21-15(11)19-10-5-3-4-9(17)6-10/h3-8H,1-2H3,(H,19,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.80E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4395
PNG
(4-Anilidoquinazoline deriv. 10a | N-(3,5-dichlorop...)
Show SMILES COc1cc2ncnc(Nc3cc(Cl)cc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H13Cl2N3O2/c1-22-14-6-12-13(7-15(14)23-2)19-8-20-16(12)21-11-4-9(17)3-10(18)5-11/h3-8H,1-2H3,(H,19,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.00E+3n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM3263
PNG
(4-Anilino quinazoline deriv. 14 | CHEMBL329672 | C...)
Show SMILES Clc1cccc(Nc2ncnc3ccccc23)c1
Show InChI InChI=1S/C14H10ClN3/c15-10-4-3-5-11(8-10)18-14-12-6-1-2-7-13(12)16-9-17-14/h1-9H,(H,16,17,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.16E+3n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM3530
PNG
(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Show SMILES COc1cc2ncnc(Nc3ccccc3)c2cc1OC
Show InChI InChI=1S/C16H15N3O2/c1-20-14-8-12-13(9-15(14)21-2)17-10-18-16(12)19-11-6-4-3-5-7-11/h3-10H,1-2H3,(H,17,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5.10E+3n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4394
PNG
(4-Anilidoquinazoline deriv. 9a | 6,7-dimethoxy-N-(...)
Show SMILES COc1cccc(Nc2ncnc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1S/C17H17N3O3/c1-21-12-6-4-5-11(7-12)20-17-13-8-15(22-2)16(23-3)9-14(13)18-10-19-17/h4-10H,1-3H3,(H,18,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.30E+3n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4405
PNG
(4-Anilidoquinazoline deriv. 21a | N-(3,4-dimethylp...)
Show SMILES Cc1ccc2ncnc(Nc3ccc(C)c(C)c3)c2c1
Show InChI InChI=1S/C17H17N3/c1-11-4-7-16-15(8-11)17(19-10-18-16)20-14-6-5-12(2)13(3)9-14/h4-10H,1-3H3,(H,18,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.90E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4411
PNG
(4-Anilidoquinazoline deriv. 27a | N-(4-methoxyphen...)
Show SMILES COc1ccc(Nc2ncnc3ccc(C)cc23)cc1
Show InChI InChI=1S/C16H15N3O/c1-11-3-8-15-14(9-11)16(18-10-17-15)19-12-4-6-13(20-2)7-5-12/h3-10H,1-2H3,(H,17,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.00E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4412
PNG
(4-Anilidoquinazoline deriv. 28b | 6-methyl-N-(4-me...)
Show SMILES Cc1ccc(Nc2ncnc3ccc(C)cc23)cc1
Show InChI InChI=1S/C16H15N3/c1-11-3-6-13(7-4-11)19-16-14-9-12(2)5-8-15(14)17-10-18-16/h3-10H,1-2H3,(H,17,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4413
PNG
(4-Anilidoquinazoline deriv. 29b | 6-methyl-N-pheny...)
Show SMILES Cc1ccc2ncnc(Nc3ccccc3)c2c1
Show InChI InChI=1S/C15H13N3/c1-11-7-8-14-13(9-11)15(17-10-16-14)18-12-5-3-2-4-6-12/h2-10H,1H3,(H,16,17,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.13E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4414
PNG
(2-[(6-methylquinazolin-4-yl)amino]phenol | 4-Anili...)
Show SMILES Cc1ccc2ncnc(Nc3ccccc3O)c2c1
Show InChI InChI=1S/C15H13N3O/c1-10-6-7-12-11(8-10)15(17-9-16-12)18-13-4-2-3-5-14(13)19/h2-9,19H,1H3,(H,16,17,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4408
PNG
(4-Anilidoquinazoline deriv. 24a | 4-[(6-methylquin...)
Show SMILES Cc1ccc2ncnc(Nc3ccc(O)cc3)c2c1
Show InChI InChI=1S/C15H13N3O/c1-10-2-7-14-13(8-10)15(17-9-16-14)18-11-3-5-12(19)6-4-11/h2-9,19H,1H3,(H,16,17,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.50E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4388
PNG
(4-Anilidoquinazoline deriv. 3b | N-(2-chlorophenyl...)
Show SMILES Clc1ccccc1Nc1ncnc2ccccc12
Show InChI InChI=1S/C14H10ClN3/c15-11-6-2-4-8-13(11)18-14-10-5-1-3-7-12(10)16-9-17-14/h1-9H,(H,16,17,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.53E+4n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4415
PNG
(2-chloro-6,7-dimethoxy-N-(4-methylphenyl)quinazoli...)
Show SMILES COc1cc2nc(Cl)nc(Nc3ccc(C)cc3)c2cc1OC
Show InChI InChI=1S/C17H16ClN3O2/c1-10-4-6-11(7-5-10)19-16-12-8-14(22-2)15(23-3)9-13(12)20-17(18)21-16/h4-9H,1-3H3,(H,19,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.60E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4407
PNG
(4-Anilidoquinazoline deriv. 23a | 6-methyl-N-(2-me...)
Show SMILES Cc1ccc2ncnc(Nc3ccccc3C)c2c1
Show InChI InChI=1S/C16H15N3/c1-11-7-8-15-13(9-11)16(18-10-17-15)19-14-6-4-3-5-12(14)2/h3-10H,1-2H3,(H,17,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.10E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4402
PNG
(4-Anilidoquinazoline deriv. 18a | 4-[(6-methylquin...)
Show SMILES Cc1ccc2ncnc(Nc3ccc(cc3)C#N)c2c1
Show InChI InChI=1S/C16H12N4/c1-11-2-7-15-14(8-11)16(19-10-18-15)20-13-5-3-12(9-17)4-6-13/h2-8,10H,1H3,(H,18,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20E+4n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4410
PNG
(4-Anilidoquinazoline deriv. 26a | 4-[(6-methylquin...)
Show SMILES Cc1ccc2ncnc(Nc3ccc(cc3)C(O)=O)c2c1
Show InChI InChI=1S/C16H13N3O2/c1-10-2-7-14-13(8-10)15(18-9-17-14)19-12-5-3-11(4-6-12)16(20)21/h2-9H,1H3,(H,20,21)(H,17,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4401
PNG
(4-Anilidoquinazoline deriv. 17a | N-(4-iodophenyl)...)
Show SMILES Cc1ccc2ncnc(Nc3ccc(I)cc3)c2c1
Show InChI InChI=1S/C15H12IN3/c1-10-2-7-14-13(8-10)15(18-9-17-14)19-12-5-3-11(16)4-6-12/h2-9H,1H3,(H,17,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4419
PNG
(4-Anilidoquinazoline deriv. 35b | N-(3-chloropheny...)
Show SMILES COc1cc2nc(nc(Nc3cccc(Cl)c3)c2cc1OC)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C26H26ClN5O2/c1-33-23-16-21-22(17-24(23)34-2)29-26(30-25(21)28-19-8-6-7-18(27)15-19)32-13-11-31(12-14-32)20-9-4-3-5-10-20/h3-10,15-17H,11-14H2,1-2H3,(H,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4418
PNG
(2-N,4-N-bis(3-chlorophenyl)-6,7-dimethoxyquinazoli...)
Show SMILES COc1cc2nc(Nc3cccc(Cl)c3)nc(Nc3cccc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C22H18Cl2N4O2/c1-29-19-11-17-18(12-20(19)30-2)27-22(26-16-8-4-6-14(24)10-16)28-21(17)25-15-7-3-5-13(23)9-15/h3-12H,1-2H3,(H2,25,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4417
PNG
(4-Anilidoquinazoline deriv. 33b | N-(3-chloropheny...)
Show SMILES COc1cc2nc(nc(Nc3cccc(Cl)c3)c2cc1OC)N1CCN(C)CC1
Show InChI InChI=1S/C21H24ClN5O2/c1-26-7-9-27(10-8-26)21-24-17-13-19(29-3)18(28-2)12-16(17)20(25-21)23-15-6-4-5-14(22)11-15/h4-6,11-13H,7-10H2,1-3H3,(H,23,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4416
PNG
(4-Anilidoquinazoline deriv. 32b | 6,7-dimethoxy-2-...)
Show SMILES COc1cc2nc(Nc3ccc(C)cc3)nc(Nc3ccc(C)cc3)c2cc1OC
Show InChI InChI=1S/C24H24N4O2/c1-15-5-9-17(10-6-15)25-23-19-13-21(29-3)22(30-4)14-20(19)27-24(28-23)26-18-11-7-16(2)8-12-18/h5-14H,1-4H3,(H2,25,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4396
PNG
(4-Anilidoquinazoline deriv. 11b | N-(3-chloropheny...)
Show SMILES COc1cc2c(Nc3cccc(Cl)c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C17H16ClN3O3/c1-22-13-8-12-14(16(24-3)15(13)23-2)19-9-20-17(12)21-11-6-4-5-10(18)7-11/h4-9H,1-3H3,(H,19,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4386
PNG
(4-Anilidoquinazoline deriv. 1a | N-(3-chlorophenyl...)
Show SMILES Cc1cccc2c(Nc3cccc(Cl)c3)ncnc12
Show InChI InChI=1S/C15H12ClN3/c1-10-4-2-7-13-14(10)17-9-18-15(13)19-12-6-3-5-11(16)8-12/h2-9H,1H3,(H,17,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4406
PNG
(4-Anilidoquinazoline deriv. 22b | N-(2H-1,3-benzod...)
Show SMILES Cc1ccc2ncnc(Nc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C16H13N3O2/c1-10-2-4-13-12(6-10)16(18-8-17-13)19-11-3-5-14-15(7-11)21-9-20-14/h2-8H,9H2,1H3,(H,17,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4409
PNG
(4-Anilidoquinazoline deriv. 25b | N-(2-chloropheny...)
Show SMILES Cc1ccc2ncnc(Nc3ccccc3Cl)c2c1
Show InChI InChI=1S/C15H12ClN3/c1-10-6-7-13-11(8-10)15(18-9-17-13)19-14-5-3-2-4-12(14)16/h2-9H,1H3,(H,17,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Bioorg Med Chem 4: 1203-7 (1996)


Article DOI: 10.1021/jm060466d
BindingDB Entry DOI: 10.7270/Q2BC3WR8
More data for this
Ligand-Target Pair